• 한국가스학회지
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• 제19권6호
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• pp.92-98
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• 2015

독성가스는 고압가스안전관리법에 의해 관리된다. 독성가스는 "고압가스안전관리법에서 규정한, 31종의 가스와 $LC_{50}$이 5000 ppm 이하인 가스"이다. 전자산업의 발달에 따라 우리나라 독성가스 사용량은 폭발적으로 증가하였다. 이에 국내 대학교 실험실의 독성가스 관련 연구 수요도 함께 증가해 왔다. 그러나 국내 실험실 독성가스 안전관리와 관련한 연구는 전무한 상태이다. 본 연구에서는 국내 대학 실험실의 실태조사를 통해 독성가스 안전관리에 있어서의 약점들을 파악하였다. 이 같은 약점을 극복하기 위해 독성가스 안전관리 방안을 제시하였다. 또한 제시된 방안에 따라 독성가스 시설이 안전하게 관리되는지를 확인하고, 이를 통한 개선을 위해 표준 체크리스트를 개발하였다. 이 연구 결과는 국내 대학 실험실에서 독성가스 시설의 안전관리를 강화할 것이며, 이를 모든 실험실에 대한 안전 지침으로 제공한다.

• 한국축산식품학회지
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• 제39권5호
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• pp.844-861
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• 2019

Over the last few years, marine environment was found to be a source of surplus natural products and microorganisms with new bioactive secondary metabolites of interest which can divulge nutritional and biological impact on the host. This study aims to assess the possible, inherent and functional probiotic properties of a novel probiotic strain Enterococcus durans F3 (E. durans F3) isolated from the gut of fresh water fish Catla catla. Parameters for evaluating and describing the probiotics described in FAD/WHO guidelines were followed. E. durans F3 demonstrated affirmative results including simulated bile, acid and gastric juice tolerance with exhibited significant bactericidal effect against pathogens Staphylococcus aureus, Salmonella Typhi, Escherichia coli and Pseudomonas aeruginosa. This can be due to the enterocin produced by E. durans F3 strain, which was resolute by sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) gel with amplification of the anticipated fragment of a structural gene; enterocin A, followed by antibiotic susceptibility assessment. Effective antioxidant potentiality against ${\alpha}$-diphenyl-${\alpha}$-picrylhydrazyl free radicals including lipase, bile salt hydrolase activity with auto-aggregation and cell surface hydrophobicity was similarly observed. Results are proving the potentiality of E. durans F3, which can also be used as probiotic starter culture in dairy industries for manufacturing new products that imparts health benefits to the host. Finding the potent and novel probiotic strains will also satisfy the current developing market demand for probiotics.

• 대한치과보철학회지
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• 제57권1호
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• pp.75-80
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• 2019

낙상에 의해 치아 및 주변 조직이 손상되어 구강 내 경조직 및 연조직의 상실이 발생한 경우 이를 재건하기 위한 방법으로 외과적 접근법과 보철적 접근법이 제시될 수 있다. 치은부가 포함된 보철물을 이용하는 보철적 접근법은 외과적 수술을 생략함으로써 치료 과정을 단순화 하고 치료 시간과 비용을 줄일 수 있다는 장점이 있다. 특히, 상악 전치부 치아 및 치조골의 상실을 보철적으로 재건하는 경우 치은부가 포함된 보철물에 의해 확실한 안면부 지지를 제공하게 되어 안모의 심미적 결손을 보상할 수 있고 상 하악의 관계를 개선시킬 수 있다. 본 증례는 낙상으로 인해 상악 전치부에 광범위한 손상을 입은 노인 환자에서 수술을 배제하고, 치은 색상의 도재가 포함된 고정성 보철물을 이용하여 수복함으로써 예지성 있는 심미적 결과를 얻었기에 이를 보고하고자 한다.

• Healthcare Informatics Research
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• 제24권4호
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• pp.317-326
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• 2018

Objectives: The demand for hospice has been increasing among patients with cancer. This study examined the current hospice referral scenario for terminally ill cancer patients and created a data form to collect hospice information and a modified health information exchange (HIE) form for a more efficient referral system for terminally ill cancer patients. Methods: Surveys were conducted asking detailed information such as medical instruments and patient admission policies of hospices, and interviews were held to examine the current referral flow and any additional requirements. A task force team was organized to analyze the results of the interviews and surveys. Results: Six hospices completed the survey, and 3 physicians, 2 nurses, and 2 hospital staff from a tertiary hospital were interviewed. Seven categories were defined as essential for establishing hospice data. Ten categories and 40 data items were newly suggested for the existing HIE document form. An implementation guide for the Consolidated Clinical Document Architecture developed by Health Level 7 (HL7 CCDA) was also proposed. It is an international standard for interoperability that provides a framework for the exchange, integration, sharing, and retrieval of electronic health information. Based on these changes, a hospice referral scenario for terminally ill cancer patients was designed. Conclusions: Our findings show potential improvements that can be made to the current hospice referral system for terminally ill cancer patients. To make the referral system useful in practice, governmental efforts and investments are needed.

• International Journal of Advanced Culture Technology
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• 제6권4호
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• pp.275-283
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• 2018

Cancer show distinct pattern of gene expression when it is compared to normal. This difference results malignant characteristic of cancer. Many cancer drugs are targeting this difference so that it can selectively kill cancer cells. One of the recent demand for personalized treating cancer is retrieving normal tissue from a patient so that the gene expression difference between cancer and normal be assessed. However, in most clinical situation it is hard to retrieve normal tissue from a patient. This is because biopsy of normal tissues may cause damage to the organ function or a risk of infection or side effect what a patient to take. Thus, there is a challenge to estimate normal cell's gene expression where cancers are originated from without taking additional biopsy. In this paper, we propose in-silico based prediction of normal cell's gene expression from gene expression data of a tumor sample. We call this challenge as reverting the cancer into normal. We divided this challenge into two parts. The first part is making a generator that is able to fool a pretrained discriminator. Pretrained discriminator is from the training of public data (9,601 cancers, 7,240 normals) which shows 0.997 of accuracy to discriminate if a given gene expression pattern is cancer or normal. Deceiving this pretrained discriminator means our method is capable of generating very normal-like gene expression data. The second part of the challenge is to address whether generated normal is similar to true reverse form of the input cancer data. We used, cycle-consistent adversarial networks to approach our challenges, since this network is capable of translating one domain to the other while maintaining original domain's feature and at the same time adding the new domain's feature. We evaluated that, if we put cancer data into a cycle-consistent adversarial network, it could retain most of the information from the input (cancer) and at the same time change the data into normal. We also evaluated if this generated gene expression of normal tissue would be the biological reverse form of the gene expression of cancer used as an input.

• 한국임상수의학회지
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• 제36권1호
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• pp.1-6
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• 2019

This study reviewed the trends and prospect of the market for veterinary medical devices in Korea. The registration of veterinary medical devices has sharply increased since 2013, and a total of 2,133 products from 348 companies were registered by 2018. Of these products, the proportion of the instrument, in vitro diagnostic (IVD) reagents, medical only used for animal and supplies were 51.6%, 35.7%, 7.6% and 5.1%, respectively. The sales amount of veterinary medical devices is approximately 95.8 billion won in 2017. The sales of domestic consumption and imports were 53.9 and 41.9 billion won, respectively. They are increasing 14.9% (CAGR) in the domestic consumption, and 44.0% (CAGR) in the export from 2011 to 2017, respectively. The proportion of IVD reagents, instrument, medical only used for animal and supplies were 54.2%, 41.0%, 3.8%, and 1.0%, respectively. The top 10 items with high sales were IVD reagents for clinical immunochemistry, visceral function testing instrument, hematological testing apparatus, syringes, IVD reagents for molecular genetics, etc. They are widely used from 3,926 animal hospitals in 2017. This study suggested that registration and sales of veterinary medical devices have gradually increased since 2013 as the demand of health care services for various animals. Therefore, the veterinary medical devices industry is expected to grow in the future.

• 대한치과의사협회지
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• 제57권10호
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• pp.579-587
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• 2019

Korea became an aged society as of 2018, and will have plunged into a super-aged society by 2025. For the dental treatment of elderly patients, their general conditions are to be considered to make appropriate treatment plans and strategies, based on advanced knowledge of geriatric dentistry and clinical experience. In this study, the social demand for geriatric dental specialists for the treatment of the elderly of Korea is investigated by looking at their general health conditions, ADL (Activities of Daily Living), and IADL (Instrumental Activities of Daily Living), along with the review of the advanced training programs of geriatric dentistry in other countries.

• 융합정보논문지
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• 제11권2호
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• pp.47-56
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• 2021

본 연구는 증강현실 기반 수술간호 실습 교육 애플리케이션을 개발하기 위한 방법론적 연구로서, 연구과정은 ADDIE 모형에 따라 분석, 설계, 개발, 구현, 평가의 5단계로 구성되었다. 요구도 분석 결과 나온 세부 항목 중 전문가 집단과 간호대학생 집단에서 공통적으로 요구도가 높은 항목은 수술 기구 항목이었다. 요구도를 기반으로 수술실에서 가장 빈번하게 사용하며 진료과에 구분 없이 보편적으로 사용되는 7가지 분류의 51개의 수술기구를 선정하여 AR Book으로 제작하였다. 증강현실기반 애플리케이션은 Unity 3D 엔진을 기반으로 제작하였으며, Android OS로 애플리케이션을 빌드하여 대상자가 이용할 수 있도록 하였다. 전문가 평가 결과 전체 평균은 73.4±4.3으로 전체적으로 높게 나타났으며, 학습자 만족도 조사 결과 높은 만족도를 보였다. 제작된 증강현실 기반 수술간호 콘텐츠는 이전의 다른 학습 방법과는 달리 현실성과 휴대성, 접근성, 간편함을 갖춘 새로운 방식의 수술 기구 학습 애플리케이션을 처음으로 개발한 부분에 그 의의가 있다.

• Imaging Science in Dentistry
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• 제51권4호
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• pp.429-438
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• 2021

Purpose: This study investigated the accuracy of laser-scanned models and 3-dimensional(3D) rendered cone-beam computed tomography (CBCT) compared to the gold standard (plaster casts) for linear measurements on dental arches. Materials and Methods: CBCT scans and plaster models from 30 patients were retrieved. Plaster models were scanned by an Emerald laser scanner (Planmeca, Helsinki, Finland). Sixteen different measurements, encompassing the mesiodistal width of teeth and both arches' length and width, were calculated using various landmarks. Linear measurements were made on laser-scanned models using Autodesk Meshmixer software v. 3.0 (Autodesk, Mill Valley, CA, USA), on 3D-rendered CBCT models using OnDemand 3D v. 1.0 (Cybermed, Seoul, Korea) and on plaster casts by a digital caliper. Descriptive statistics, the paired t-test, and intra- and inter-class correlation coefficients were used to analyze the data. Results: There were statistically significant differences between some measurements on plaster casts and laser-scanned or 3D-rendered CBCT models (P<0.05). Molar mesiodistal width and mandibular anterior arch width deviated significantly different from the gold standard in both methods. The largest mean differences of laser-scanned and 3D-rendered CBCT models compared to the gold standard were 0.12±0.23 mm and 0.42±0.53 mm, respectively. Most of the mean differences were not clinically significant. The intra- and inter-class correlation results were acceptable for all measurements(>0.830) and between observers(>0.801). Conclusion: The 3D-rendered CBCT images and laser-scanned models were useful and accurate alternatives to conventional plaster models. They could be used for clinical purposes in orthodontics and prostheses.

• 한국직업건강간호학회지
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• 제30권2호
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• pp.46-56
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• 2021

Purpose: This study aimed to determine the factors influencing the turnover intention of nurses in coronavirus disease (COVID-19) and general wards. Methods: Data were collected through a survey of 340 nurses at seven public hospitals in Gyeonggi Province from October 12 to October 30 in 2020. The data were analyzed using descriptive statistics, t-tests, ANOVA, Pearson correlation coefficient and multiple regression. Results: The job demand stress of nurses in COVID-19 wards was 63.99±8.05 points, which was lower than 65.77±7.35 points of nurses in general wards. The turnover intention of nurses in COVID-19 wards was 3.24±0.74 points, which was higher than the 3.06±0.67 points of those in general wards. The multiple regression analysis indicates that the factors affecting the turnover intention of the two groups (COVID-19 and general wards) were type of wards (β=-.15, p<.001), age (COVID-19 wards: β=-.37, p<.001, General wards: β=-.40, p<.001), job resource stress (COVID-19 wards: β=.52, p<.001, general indicates: β=.60, p<.001), and clinical experience in present wards (COVID-19: β=.13, p=.021). Conclusion: The results indicate that nurses who care for COVID-19 patients have higher turnover intentions than general nurses and suggests that a decrease in the job resource stress is vital for reducing nurse turnover intentions.