• Journal of Sasang Constitutional Medicine
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• v.10 no.1
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• pp.215-233
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• 1998

The object of this study is 27 patients who had been treated in the Oriental Medical Hospital at Dong Eui Medical Center during 6 months from January 1998 to June 1998. We proceeded the judgment of Sasang Constitution by Questionaire of Sasang Constitution Classification II(QSCC II). The following conclusion were made in comparison with Questionaire of Sasang Constitution Classification II(QSCC II) and Questionaire of Pusan Sasang seminar. 1. The subject of "the facial type is small and sharp" is significant differences in Sasang Constitution classification. The frequency of Soeumin group is more than Taeumin group and Soyangin group. 2. The subject of "the walking form is fast and shake the body" is significant differences in Sasang Constitution classification. The frequency of Taeumin group and Soeumin group is less than Soyangin group. 3. The subject of "the skin type is white and thin" is significant differences in Sasang Constitution classification. The frequency of Soeumin group is more than Soyangin group, and the frequency of Taeumin group is low marks. 4. The subject of "the skin type is tender and dry" is significant differences in Sasang Constitution classification. The frequency of Taeumin group and Soyangin group is less than Soeumin group. 5. The subject of "the image of face is smart" is significant differences in Sasang Constitution classification. The frequency of Soeumin group is more than Taeumin group and the frequency of Soyangin group is low marks. 6. The subject of "the sweating type is not sweatier" is significant differences in Sasang Constitution classification. The frequency of Taeumin group and Soeumin group is less than Soyangin group. 7. The subject of "the desire of eating is changeable accoding to emotion" is significant differences in Sasang Constitution classification. The frequency of Soeumin group is more than Taeumin group and Soyangin group. 8. The subject of "the health is changeable accoding to the type of stool" is significant differences in Sasang Constitution classification. The frequency of Soeumin group is more than Soyangin group and the frequency of Taeumin group is low marks. 9. The subject of "the type of voiding is changeable accoding to the drinking when they have a fever" is significant differences in Sasang Constitution classification. The frequency of Taeumin group and Soyangin group is less than Soeumin group. 10. The subject of "the skin type is soft" is significant differences in Sasang Constitution classification. The frequency of Soeumin group is more than Taeumin group and Soyangin group. 11. The subject of "the chief complaint is the forgetfulness" is significant differences in Sasang Constitution classification. The frequency of Soeumin group is less than Taeumin group and Soyangin group.

• Environmental Analysis Health and Toxicology
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• v.29
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• pp.4.1-4.10
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• 2014

Objectives Effects of nanoparticles including zinc oxide nanoparticles, titanium oxide nanoparticles, and their mixtures on skin corrosion and irritation were investigated by using in vitro 3D human skin models ($KeraSkin^{TM}$) and the results were compared to those of an in vivo animal test. Methods Skin models were incubated with nanoparticles for a definite time period and cell viability was measured by the 3-(4, 5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide method. Skin corrosion and irritation were identified by the decreased viability based on the pre-determined threshold. Results Cell viability after exposure to nanomaterial was not decreased to the pre-determined threshold level, which was 15% after 60 minutes exposure in corrosion test and 50% after 45 minutes exposure in the irritation test. IL-$1{\alpha}$ release and histopathological findings support the results of cell viability test. In vivo test using rabbits also showed non-corrosive and non-irritant results. Conclusions The findings provide the evidence that zinc oxide nanoparticles, titanium oxide nanoparticles and their mixture are 'non corrosive' and 'non-irritant' to the human skin by a globally harmonized classification system. In vivo test using animals can be replaced by an alternative in vitro test.

• Toxicological Research
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• v.32 no.4
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• pp.311-316
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• 2016

Effects of nanoparticles (NPs) on skin corrosion and irritation using three-dimensional human skin models were investigated based on the test guidelines of Organization for Economic Co-operation and Development (OECD TG431 and TG439). EpiDerm$^{TM}$ skin was incubated with NPs including those harboring iron (FeNPs), aluminum oxide (AlNPs), titanium oxide (TNPs), and silver (AgNPs) for a defined time according to the test guidelines. Cell viabilities of EpiDerm$^{TM}$ skins were measured by the 3-(4, 5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide based method. FeNPs, AlNPs, TNPs, and AgNPs were non-corrosive because the viability was more than 50% after 3 min exposure and more than 15% after 60 min exposure, which are the non-corrosive criteria. All NPs were also non-irritants, based on viability exceeding 50% after 60 min exposure and 42 hr post-incubation. Release of interleukin 1-alpha and histopathological analysis supported the cell viability results. These findings suggest that FeNPs, AlNPs, TNPs, and AgNPs are 'non-corrosive' and 'non-irritant' to human skin by a globally harmonized classification system.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.27 no.2
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• pp.1-13
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• 2014

Objective : The purpose of this study is to understand conspicuous features of geroderma with visceral manifestation theory(臟象論). Methods : We categorized skin aging into wrinkles, hyperpigmentation, dry skin and face flush. After investigating the reason, histological changes and mechanism of each classification in western medicine, we interpreted them according to the malfunction of five viscera(五臟) in Korean medicine. Result : The results are as follows. 1. Pathologic change of dermis and subcutaneous fat makes wrinkles. We consider wrinkles as the malfunction of the spleen(脾). 2. Irregular synthesis and disproportion of melanin makes hyperpigmentation. We consider hyperpigmentation as the malfunction of the liver(肝). 3. Dry skin is attributed to a subtle disorder of epidermal maturation. We consider dry skin as the malfunction of the lung(肺). 4. Facial flush is detected in rosacea and menopausal hot flush, which are both related with blood vessel abnormality. We consider facial flush as the malfunction of the heart(心) Conclusion : We interpreted the pathologic changes and mechanism of skin aging in western medicine as the decrease of five viscera(五臟) in visceral manifestation theory(臟象論) of Korean medicine. Further studies are needed to apply these hypothesis to clinical diagnosis and treatment.

• The Korea Journal of Herbology
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• v.34 no.3
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• pp.37-44
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• 2019

Objectives : Acne is a common disease that affects more than 70% of adolescents. Acne patients have a poor quality of life compared to patients with other skin diseases. We tried to demonstrate the effectiveness of acne treatment using cleansing soap which is easily used in daily life. Methods : We selected 20 students with acne symptoms on their facial skin. We made herbal Cp (Cold process) soaps using Seosiokyongsan, Kyungohkgo, Hwangryunhaedoktang and Baeksoooh and distributed them to experiment participants. We let them wash their face in the morning and evening for 6 weeks using herbal Cp soap. Prior to the experiment, their skin condition was checked and assessed using A-ONE Smart One-Click Automatic Facial Diagnosis System three times at 3-week intervals. Acne status was classified into 6 stages according to KAGS and acne status was also measured 3 times in total. After the experiment, the changes of skin were analyzed through facial analysis test. Results : Based on the KAGS classification, the condition of acne has improved as a whole. The state of moisture was gradually increased and the state of skin oil was significantly decreased after 6 weeks of using soap compared to before using soap. Conclusions : Cp soaps made from four kinds of herbal medicine are believed to improve the condition of acne by increasing the moisture of the facial skin and decreasing the skin oil content.

• Journal of Sasang Constitutional Medicine
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• v.17 no.2
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• pp.46-51
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• 2005

1. Objectives The purpose of this study is to objectify the diagnosis of Sasang Constitution. Using the methods of this study, it will improve to classificate Sasang Constitution. 2. Methods 1) Automatic feature extraction of human frontal faces for Sasang Constitution classification. 2) Color feature extraction of human frontal faces (1)Erosion filtering (skin-white, the other-black) (2) Median median 3. Results and Conclusions Observing a person's shape has been the major method for Sasang Constitution classification, which usually has been dependent upon doctor's intuition as of these days. We are developing an automatic system which provides objective basic data for Sasang Constitution classification. For this, in this paper, firstly, the signal processing techniques are applied to automatic feature extraction of human frontal faces for Sasang Constitution classification. The experiment is conducted to verify the effectiveness of the proposed system.

• Journal of Industrial Technology
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• v.28 no.B
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• pp.143-148
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• 2008

A real-time face detection is to find human faces robustly under the cluttered background free from the effect of occlusion by other objects or various lightening conditions. We propose a face detection system for real-time applications using wavelet decomposition method based on Gabor features. Firstly, skin candidate regions are extracted from the given image by skin color filtering and projection method. Then Gabor-feature based template matching is performed to choose face cadidate from the skin candidate regions. The chosen face candidate region is transformed into 2-level wavelet decomposition images, from which feature vectors are extracted for classification. Based on the extracted feature vectors, the face candidate region is finally classified into either face or nonface class by the Levenberg-Marguardt back-propagation neural network.

• Proceedings of the KIEE Conference
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• 2005.10b
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• pp.186-188
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• 2005

Hand region detection in images is an important process in many computer vision applications. It is a process that usually starts at a pixel-level, and that involves a pre-process of color space transformation followed by a classification process. A color space transformation is assumed to increase separability between skin classes for hands and non-skin classes for other parts, to increase similarity among different skin tones, and to bring a robust performance under varying illumination conditions, without any sound reasonings. In this work, we examine if the color space transformation does bring those benefits to the problem of hand region detection on a dataset of images with different hand postures, backgrounds, people, and illuminations. Results indicate that best of the color space is the normalized RGB.

• Proceedings of the Korean Information Science Society Conference
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• 2004.04b
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• pp.601-603
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• 2004

인터넷은 유익하고 건전한 정보의 유통이 대부분이지만 최근에는 익명성과 상업성으로 인해 유해 정보가 급속하게 늘어나고 있는 추세이다. 이러한 부정적인 영향으로부터 청소년들과 어린이들을 보호하기 위하여, 본 논문은 유해사이트 분류를 자동으로 할 수 있는 시스템을 제안한다. 기존의 유해사이트 구축은 검색 요원들이 유해사이트를 돌아다니며 일일이 데이터를 수집하여 분류하거나 유해사이트의 내용 중에 텍스트만을 추출하여 패턴 매칭 방법으로 분류하는 것이 대부분이었지만, 본 논문은 기존 방법의 문제점을 해결하기 위하여 형태소 분석을 이용한 사이트의 유해도 측정과 Skin-Color 분포의 분석 결과를 병합하여 95% 이상의 정확도(Precision) 성능을 보이며. 신뢰도가 높은 유해사이트 자동 분류 시스템을 구현할 수 있다는 것을 증명하였다.

• The Korean Journal of Pesticide Science
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• v.20 no.4
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• pp.326-340
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• 2016

GHS was compared with that of current RDA directives in skin and eye irritation for plant protection products (PPPs). According to the result of evaluation and classification of skin and eye irritation by RDA directives and GHS for 59 PPPs, 25.5% of PPPs were changed the classification of skin irritation from slightly and moderately by RDA directives to Not Classified by GHS, and 45.8% of PPPs were changed the classification of eye irritation from slightly by RDA directives to Not Classified by GHS. 6.8% of PPPs in skin irritation and 5.1% in eye irritation were classified more highly as category 1 by GHS because of irreversible effect. According to the result of comparison with GHS classification by data of irritation study for PPPs and by GHS classification and concentration of active substances, 25.5% was changed more lowly and 3.4% more highly in skin irritation, and 25.4% was changed more lowly and 11.9% more highly in eye irritation. It is needed to draw a plan to supplement for other results between GHS and RDA directives.