• 근관절건강학회지
• /
• 제23권3호
• /
• pp.179-186
• /
• 2016

Purpose: The purpose of this study was to identify factors that influence dietary compliance in patients with liver cirrhosis. Methods: This study used a cross-sectional design and was conducted with a survey of 141 patients in liver cirrhosis who were treated at D-university hospital in Busan. For data analysis, descriptive statistics, Pearson's correlation coefficients, and a multiple regression were performed using SPSS/WIN 20.0 Program for windows. Results: The mean score was 3.47 in dietary compliance. Dietary compliance had a positive correlation with self-efficacy, perceived-benefit medical staff support, age, drink or not but had a negative correlation with perceived barrier. As a result of multiple regression analysis, self-efficacy and perceived-benefits explained 30.1% (F=7.69, p<.001) of the variance of dietary compliance. Conclusion: Dietary compliance was suggested to consider self-efficacy and perceived-benefits when developing a nutritional education programs for patients with liver cirrhosis.

• 대한핵의학회지
• /
• 제3권1호
• /
• pp.59-67
• /
• 1969

Correlation between the blood clearance half time and findings of liver scan using the colloidal radiogold in patients of liver cirrhosis is observed through the scoring system, in which the more changes in size, shape and density in the liver scan, the more points are given (table 1). Results: 1) Within the increase in severity of hepatocellular dysfunction in liver cirrhosis, the degree and frequency of following changes in liver scan (done with colloidal radiogold) were increased in order. a) generalized hepatomegaly b) enlargement of the left lobe & reduction of the right lobe c) relatively increased radiodensity in the left lobe and 4) visualization of spleen. 2) Frequency of the normal scan in liver cirrhosis was $12{\pm}3.56%$, frequency of normal value in blood clearance half time of the radiogold was $5.0{\pm}2.34%$ and frequency of normal scan & normal blood clearance rate in liver cirrhosis was $3.6{\pm}2.06%$.

• 약학회지
• /
• 제41권5호
• /
• pp.622-628
• /
• 1997

Hepatic cirrhosis is a common response to chronic liver injury from many causes and is one of the most common cause of all deaths. This study was carried out to compare experimental hepatic cirrhosis in rats to understand this disease and to apply for the pharmacokinetics in disease state. Following three kinds of experimental models were induced; 1) Bile duct ligation/scission (BDL/S), 2) N, N-dimethylnitrosamine(DMN), 3) Carbon tetrachloride. The hepatic cirrhosis was characterized by examing the liver/body weight ratio, serum biochemical values, hydroxyproline content in liver and histopathological lesions in cirrhotic rat liver. The results are as follows : (1) In BDL/S, the liver was enlarged to 250% of normal liver. In contrast the liver was shrinked to 48% and 78% of the normal liver in DMN and carbon tetrachloride, respectively. (2) In carbon tetrachloride and BDL/S, the serum ALT, AST, ALP and total bilirubin levels were significantly increased to 200~300% of normal level, while ALT and total bilirubin levels were significantly increased in DMN group. (3) Hydroxyproline content in cirrhotic rat liver was significantly 200~500% higher than that of normal liver. (4) Nodular formation with fibrosis was observed in BDL/S, DMN, carbon tetrachloride induced cirrhotic rat liver.

• 대한한방내과학회지
• /
• 제37권2호
• /
• pp.182-188
• /
• 2016

Objective: This study was designed to assess the clinical effect of traditional Korean medicine on primary biliary cirrhosis.Method: We provided herbal medicine and acupuncture therapy to a 38-year-old male patient who complained about jaundice, itching, and fatigue. During a six-day hospital stay, we checked any changes in symptoms and conducted liver function tests (such as aspartate aminotransferase [AST], alanine aminotransferase [ALT], alkaline phosphatase [ALP], and gamma-glutamyl transferase [GGT], among others) to evaluate any improvement.Results: We observed that herbal medicine and acupuncture therapy appeared to decrease the symptoms of primary biliary cirrhosis. During each hospital stay, the symptoms and liver function test both showed improvement, especially in ALP.Conclusion: Based on the therapeutic results of the six-day hospital stay, we report improved primary biliary cirrhosis symptoms and a decreasing tendency in ALP and GGP levels following treatment with traditional Korean medicine.

• 기본간호학회지
• /
• 제25권3호
• /
• pp.165-175
• /
• 2018

Purpose: The purposes of this study were to examine symptom experiences, perceived health status, disease status, and self-care compliance of patients with liver cirrhosis and to identify the factors that affect their self-care compliance. Methods: The study design was a cross-sectional design and 148 patients who were being treated at D-university hospital in Busan participated in the survey. The data were analyzed using t-test, ANOVA, Bonferroni test, Pearson correlation coefficients, and multiple linear regression analysis. Results: The factors affecting self-care compliance were symptom experiences, disease status, age, and gender. These factors explained 21.6% of the variance in self-care compliance of patients with liver cirrhosis. Conclusion: The findings indicate that nursing interventions that prevent patients' symptoms are needed to promote self-care compliance in patients with liver cirrhosis. The patient should also be helped to recognize the need for self-care compliance from an early stage.

• 대한한방내과학회지
• /
• 제45권2호
• /
• pp.270-277
• /
• 2024

Objectives: This study identified the effects of Korean medicine treatment on a patient with alcohol-associated cirrhosis. Methods: A 50-year-old male with alcohol-associated cirrhosis was treated with Cheongganhaeju-tang from 10 November 2023 to 18 January 2024 to reduce fatigue, dyspepsia, anorexia, and weight loss and to improve laboratory findings, such as liver enzymes. We observed changes in the patient's symptoms and laboratory findings during a treatment period of approximately 2 months. Results: With Cheongganhaeju-tang treatment, serum levels of liver enzymes remained stable, clinical symptoms improved, and alcohol cravings decreased. Conclusion: This case points to Cheongganhaeju-tang as a therapeutic option to manage alcohol-associated cirrhosis.

• 대한영상의학회지
• /
• 제84권3호
• /
• pp.750-756
• /
• 2023

자발적 동맥 출혈은 드물며, 속가슴동맥의 자발적 파열에 의한 혈종은 이전에 보고된 바가 없다. 간경화증이 있거나 과음하는 환자는 출혈의 위험성이 더 큰 것으로 알려져 있다. 저자들은 알코올성 간경화증을 가진 39세 여성에서 자발적 속가슴동맥 출혈로 인해 발생한 거대한 종격동 혈종의 증례를 보고하고자 한다.

• 혜화의학회지
• /
• 제9권1호
• /
• pp.379-386
• /
• 2000

1. There two parts of alcohol's metabolic system the first one is alcoholdehydrogenase(ADH), and second is microsomal ethanol oxidizing system(MEOS). 2. Alcoholic cirrhosis(fibrosis) leads from cytotoxin, malnutrition, and immunue reaction. 3. In the Oriental medical point of view alcohol has strong heat and toxin, which can cause judal, ju-ka, ju-beack, ju-juck, and ko-chang in other words these means that it can cause hepatasis, fatty liver, fibrosis, and liver cirrhosis. 4. About the Liver cirrhosis(fibrosis) pathological system, in the oriental medical point of view, it effects the liver, kidney and spleen which causes Uy-heulGin-guk(瘀血 積), seup-yeul ne-oun(濕熱內蘊), and in the long term it can cause kansinyumhu(肝腎陰虛), kanbeyumhu(肝脾陰虛). Because of the expand of alcohol liver disease, in the future there must be more studies about these disease in Oriental medicine point of view.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권1호
• /
• pp.275-277
• /
• 2012

Objective: The objective of our present study was to assess the efficacy of carcinoembryonic antigen (CEA) for differentiating and diagnosis of pancreatic and liver diseases in Pokhara valley. Materials and methods: A hospital based retrospective study was carried out using data retrieved from the register maintained in the Department of Biochemistry of the Manipal Teaching Hospital, Pokhara, Nepal between 1st January, 2011 and 31st October, 2011. Estimation of CEA was performed by ELISA reader for all cases. Approval for the study was obtained from the institutional research ethical committee. Results: Of the 771 subjects, 208 (27%), 60(7.8%), 240(31.1%), 54(7.0%), 75(9.7%), 59(7.7%), 75(9.7%) cases were of active chronic hepatitis, cryptogenic cirrhosis, alcoholic cirrhosis, primary biliary cirrhosis, hepatoma, acute or chronic pancreatitis, carcinoma of pancreas respectively. The majority of cases (104) of active chronic hepatitis had CEA levels <5ng/ml(50%). CEA levels were found to be increased in cases of alcoholic cirrhosis with maximum number of cases (106) in range of 10 to 20 ng/ml (44%). There were no cases having more than 20ng/ml of CEA in primary biliary cirrhosis and acute or chronic pancreatitis. In cases of pancreatic cancer, maximum number of cases (35) were having CEA >20ng/ml(47%). Conclusion: High levels of CEA are associated with advanced stage of disease. CEA can thus provide an important improvement in the diagnosis by differentiating pancreatic cancer especially from chronic pancreatitis when there is a high suspicion of malignancy. Increased CEA levels may also signify progression from benign to malignant transformation in the liver.

• Journal of Nutrition and Health
• /
• 제36권6호
• /
• pp.577-588
• /
• 2003

Severe protein-calorie malnutrition, common in patients with advanced liver disease, can seriously undermine the capacity for regeneration and functional restoration of liver. Nutritional supplementation for these patients can improve biochemical and hormonal abnormalities. However, these effects were not identified in patient with nonalcoholic liver cirrhosis. To determine effects of nutritional supplementation in patients with nonalcoholic liver cirrhosis, 77 subjects aged 29 to 69 years participated in this study for 12 weeks and were subdivided into three groups; normal diet group (Control group, n ＝ 16), branched-chain amino acid supplementation group (BCAA group, n ＝ 31), nutritional supplementation group (NS group, n ＝ 30). Anthropometric parameters, hemoglobin, hematocrit, blood cell counts, serum levels of lipids, vitamins, minerals and fatty acid composition, and plasma amino acids were examined. The mean values of age and height, and the initial values of weight and body mass index (BMI) were not different among all groups. After 12 weeks, there were no significant changes in these values in Control group. Only NS group showed significant increases in weight, lean body mass, midarm circumference, triceps skinfold thickness. Serum transferrins were increased both in BCAA and NS groups. Plasma levels of branched-chain amino acids, urea amino acids and glutamic acid were also significantly increased in these groups, but plasma levels of ammonia, serum LDL cholesterol and atherogenic index were decreased. However, there were no significant changes in serum levels of vitamin and mineral and composition of fatty acids in phospholipids in these groups. These results showed that the nutritional supplementation for patients with nonalcoholic liver cirrhosis can more improve nutritional status in these people together with increases of weight, body fat and lean body mass, compared to only BCAA supplementation. To ascertain and investigate the appropriate nutritional supplementation for patients with nonalcoholic liver cirrhosis, further studies are necessary.