• Journal of Nutrition and Health
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• 제17권4호
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• pp.305-312
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• 1984

The effect of exercise on serum cholesterol and triglyceride concentration and on urinary creatinine and 3-methylhistidine excretion was studied in eight healthy women, aged 21 to 25yr. Subjects were tested before and after a 3-day experimental period, during which 1000 times rope-jumping a day were performed. Serum cholesterol and triglyceride levels decreased significantly after exercise. Urinary excretion of creatinine and 3-methylhistidine slightly increased after exorcise.

• 한국식생활문화학회지
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• 제16권5호
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• pp.416-422
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• 2001

This study was conducted to investigate the effects of corn peptide(CP) on lipid metabolism. Sprague-Dawley(S.D) male rats were assigned to three dietary groups {control diet(CD), high fat diet (HFD) & high fat com peptide diet(FCD)} and fed 4 weeks to examine the effects of CP. There were no significantly different in cholesterol concentrations in the liver among the groups. However, triglyceride(TG) concentrations of the FCD & CD significantly lower than the HFD. Fecal excretion of neutral steroids & bile acids of the FCD significantly higher than the CD & HFD. Serum total cholesterol TG & LDL-cholesterol concentrations of the FCD & CD significantly lower than the HFD. These results suggest the improvement of lipid composition in serum by CP might be inhibit of lipid absorption in intestine & increment of neutral steroids & bile acids excretion in feces.

• 한국수산과학회지
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• 제33권5호
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• pp.393-398
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• 2000

Alginate의 기능적 특성을 개선하여 이용성을 확대할 목적으로 가열에 의한 저분자화를 시도하였으며, 저분자 alginate가 랫드의 cholesterol, glucose 및 카드뮴의 체외배출효과에 미치는 영향을 검토하였다. 랫드에 있어서 HAG-10, HAG-50, HAG-100 및 alginate의 cholesterol의 체외배출 효과는 HAG-50과 HAG-100에서 높았고, 다음으로 alginate였으며 HAG-10은 거의 효과를 나타내지 않았다. 혈청중 glucose 함량은 HAG-50에서 그 농도가 가장 낮았고 이후에도 계속적으로 혈당의 농도가 저하하였으며, 혈칭중의 insulin의 함량도 HAG-50에서 초기에 증가한 후에 계속 저하하였다. 카드뮴의 체외배출 효과는 HAG-50에서 가장 높았고, 다음으로 HAG-100과 alginate 및 HAG-10의 순으로 HAG-10에서는 거의 효과가 없었다. 이상의 결과로 부터, HAG-50은 랫드에 있어서 cholesterol과 카드뮴의 체외배출을 촉진하였으며, 혈중 glucose 농도론 저하시키는데 뚜렷한 효과를 나타내었다.

• 한국식품영양과학회지
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• 제18권4호
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• pp.430-434
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• 1989

알팔파 뿌리에서 사포닌을 추출, 단리하여서, 콜레스테롤 무첨가식이에 0.2% 및 0.4% 첨가군과 콜레스테롤 첨가식이에 0.4% 군을 설정, 80g 전후의 Wistar계 흰쥐수컷에 21일간 급여하였다. 그 결과 혈청지질과 분중지질 배설량을 측정한 결과 다음과 같다. 1. 알팔파 사포닌중 Medicagenic acid함량은 36.4%이었다. 2. 알팔파 사포닌 급여에 의하여 분중 콜레스테롤 배설량은 증가하였으나, 담즙산은 증가하지 않았다. 3. 알팔파 사포닌은 콜레스테롤 첨가, 무첨가식이에서 0.4%첨가에 의해 혈청콜레스테롤 저하작용을 나타내었지만, 0.2% 첨가에서는 관찰되지 않았다. 4. 사포닌의 혈청 콜레스테롤 저하작용은 소화관내에서의 콜레스테롤 흡수저하에 기인되는 것으로 여겨진다.

• Journal of Nutrition and Health
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• 제31권2호
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• pp.143-152
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• 1998

This study was conducted to investigate the effects of chitosan, chitosan oligomer and beef tallow of different levels on lipid metabolism in rats, Seventy male rats of the Sprague-Dawley strain were blocked into 10 groups according to body weight , and were raised for 4 weeks. Dietary fat levels were 20% en and 40% en, and chitosan and chitosan oligomer were given at levels of 05, 3%, and 5%(wt/wt) of diet. The results are summarized as follows, chitosan oligomer supplement decreased serum total lipid, as chitosan 양, and exhibited a tendency to decrease serum total cholesterol. Chitosan oligomer supplement tended to increase the HDL cholesterol ; total cholesterol ration as chitosan did. Liver total lipid and triglyceride concentration were lower in high fat groups than in low fat groups. Liver total lipid concentrations was decreased slightly by chitosan and sigfnificantly by chitosna ligomer. Epididymal fat pad total lipid. total cholesterol and triglyceride concentration were slightly decreased by chitosan and chitosan oligomer supplement, especially in high fat groups. fat absorptivity was decreased by low fat level, chitisan and chitosan oligamer supplement. Fecal excretion of total lipid and triglyceride were increased by high fat level, chitosan and chi샌무 oligomer supplement. However, fecal excretion of total cholesterol was increased by high fat level and chitosan supplement. This indicated that chitosan and chitosan oligomer were effective in interfering with lipid and triglyceride absorption, In conclusion, chitosan oligomer at levels of 3% and 5% has more effective lipid, cholesterol and triglyceride lowering activity than chitosan.

• 한국식품영양과학회지
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• 제26권5호
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• pp.927-935
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• 1997

This study was conducted to investigate the effect of nondigestable substances and calcium such as oligosaccharide, agar, saponin, tannin and calcium on the reduction of lipid status in rats fed high fat diet. In order to make the observation, the lipid content in plasma, liver and the feces, and bile acid excretion were measured of r 4 weeks. the results obtained from this research are as follows. Concentration of total lipid in plasma seemed highest in the control group and were significantly lower in groups oil-gosaccharide, agar and calcium-tannin, compared to the control group. Concentration of total cholesterol in plasma was significantly lower in groups oligosaccharide, agar, calcium and calcium-saponin, compared to the control group. The improvement in lipid status seems to be insignificant with oligosaccharide, showed increase in total bile acids excretion in feces and decrease in total cholesterol in plasma, compared to the control group. These evidence seems to indicate improvement of the plasma lipid status by calcium and agar supplementation.

• 생약학회지
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• 제25권4호통권99호
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• pp.368-381
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• 1994

This study was attempted to investigate the effect of Gardeniae Fructus on GOT, GPT, Al.p, LDH activities and level of total cholesterol in serum of $CCl_{4}$ and $_{D}-galactosamine$ intoxicated rats, and bile excretion. The geniposide and extract caused a remarkabel decrease of GPT activities, level of total cholesterol in serum of $CCl_{4}$ intoxicated rats at EtOH Ex. 300, 500 mg/kg p.o., MeOH Ex. and geniposide 100 mg/kg p.o., and GOT, Al.p, LDH activities were significantly decreased compared with control group. It caused a remarkable decrese of GPT, Al.p, LDH activities in serum of $_{D}-galactosamine$ intoxicated rats, and GOT activities was significantly decreased compared with control group. The geniposide and extract caused a remarkable increase of bile excretion, when administration of EtOH extract 500 mg/kg p.o., MeOH extract 100 mg/kg i.d., MeOH extract 50 mg and geniposide 50 mg/kg i. v. compared with normal-control group.

• Journal of Nutrition and Health
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• 제36권5호
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• pp.425-436
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• 2003

The present study was conducted to evaluate the usefulness of common Korean legumes as a high-fiber supplement in therapeutic diets for diabetic patients. Streptozotocin-induced diabetic rats were used as animal models and four kinds of legumes, black soybean (BS), yellow soybean (YS), green pea (GP) and soybean curd residue (SCR) were tested as high-fiber supplements. Seven groups of normal and streptozotocin-induced diabetic rats were fed isocaloric experimental diets containing 8％ dietary fiber from one of four legumes or purified cellulose and pectin for 6 weeks. The effects of the legumes on the glucose and lipid metabolism of diabetic rats was examined and compared with the effects of cellulose and pectin. The legume supplementation did not show any beneficial effect on glucose tolerance, however, it exhibited a plasma cholesterol-lowering effect in diabetic rats. The cholesterol-lowering action was especially strong in BS and the degree of the effect was comparable to that of pectin. The levels of total lipids, cholesterol, and triglyceride in the hepatic tissues of rats fed legume diets were similar to those of the pectin group. All legume supplements induced an increase in fecal steroid excretion. The fecal cholesterol contents were significantly high following the supplementations of YS and SCR (p < 0.05). The excretion of fecal bile acids in the BS and YS groups was significantly higher than it was in the pectin group (p < 0.05). Concentration of lipid peroxidation products in the blood and urine of diabetic animals was lower in the legume groups than in the cellulose group. The levels of hepatic lipid peroxidation products were significantly lower in the BS and YS groups than in the pectin group (p < 0.05). From the results of this study, the plasma cholesterol-lowering effect of BS is possibly due to the significant (p < 0.05) in-crease in fecal steroid excretion, which suggests that BS could be beneficial in improving abnormal lipid metabolism in diabetic rats. (Korean J Nutrition 36(5): 425∼436, 2003)

• Journal of Nutrition and Health
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• 제28권2호
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• pp.107-114
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• 1995

These works were designed to examine the effects of dietary fiber sources and levels on lipid metabolism in rats fed high lard diet. Rats were divided into three($\alpha$-cellulose, polydextrose, carrageenan) groups and were fed with containing 6% fiber diet. Serum, liver and fecal lipid contents were examined after four weeks of dieting. Also, in order to investigate whether hypocholesterolemic effect of dietary fiber at 4 weeks is continued at 8 weeks, rats were fed with diets containing same sources with different levels of each dietary fiber and were sacrificed after eight weeks of dieting. Serum cholesterol in rats fed carrageenan diet and polydextrose diet were reduced compared with $\alpha$-cellulose-fed group at both four and eight weeks dieting. Liver cholesterol in both polydextrose-fed and carrageenan-fed group were lower than $\alpha$-cellulose-fed group. Fecal total group were increased compared with $\alpha$-cellulose-fed group. On the other hand, there was no significant difference between polydextrose-fed and carrageenan-fed group. On the basis of the results, it was suggested that the hypocholesterolemic effect of soluble fiber used in this study (polydextrose, carageenan) on rats was due to the inhibition of cholesterol absorption on the intestinal lumen and acceleration of cholesterol catabolism in the liver and enhancement of bile acids excretion. On the other hand, insoluble fiber($\alpha$-cellulose) showed no hypo-cholesterolemic effect.

• Preventive Nutrition and Food Science
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• 제18권3호
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• pp.210-213
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• 2013

The aim of this study was to investigate the effects of isolated protein from white rice on lipid metabolism in a hypercholesterolemic animal model. Male Sprague-Dawley rats were divided into three groups and fed either a normal diet or a high-cholesterol diet (HCD) containing either casein or isolated rice protein for 4 weeks. Compared with rats fed a HCD with casein, the total cholesterol (TC) level in the plasma was significantly reduced in the rats fed rice protein. However, no significant differences were observed in the triglycerides, high-density lipoprotein (HDL), and glucose levels among the experimental groups. Hepatic total lipids and TC levels were significantly decreased by supplementation with rice protein. In addition, rice protein significantly increased the levels of TC and bile acids in the feces. These results suggest that rice protein may improve HCD-induced hypercholesterolemia by enhancing fecal excretion of cholesterol.