• Title/Summary/Keyword: chemical testing

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A Three-step Method of Immunotoxicity Assessment

  • Lee, Jeong-Woon;Shin, Ki-Duk;Kim, Kap-Ho;Kim, Eun-Joo;Han, Sang-Seop;Jeong, Tae-Cheon;Koh, Woo-Suk
    • Toxicological Research
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    • v.16 no.4
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    • pp.317-323
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    • 2000
  • The immunosuppressive effects of thirty nine chemicals chosen by their potential toxicity were evaluated using a three-step testing method. The immunotoxicity test method developed in this study consisted of three simple assays of lymphoproliferation, mixed leukocyte response, and interleukin (IL)-2 production. The first step was mitogen-induced proliferation assay. Ten chemicals showed the inhibitory effects on the mitogen (lipopolysaccharide or concanavalin A)-induced proliferation in dose-dependent manners. The second step was mixed lymphocyte response. This step crosschecked the growth-suppressive effects detected at the first step. All of 10 chemicals, which showed suppression of lymphoproliferation, also exhibited the suppressive effects on the mixed lymphocyte response in the similar range of chemical concentration. The third step was planned to determine whether or not this growth suppression was mediated through an early activation of T-cell, which could be represented with IL-2 production. Six out of 10 chemicals decreased the interleukin-2 production in the similar concentration range used in the step 1 and 2. These results suggest that those 6 chemicals might have their targets on the signal transduction path-way toward the IL-2 production. In the meantime the other 4 chemicals might have their targets after the IL-2 production signal. Taken all together, the three-step test would be simple, fast, and efficient to deter-mine whether or not the chemical has immunosuppressive effects.

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Failure Mechanism and Long-Term Hydrostatic Behavior of Linear Low Density Polyethylene Tubing (선형저밀도 폴리에틸렌 튜빙의 파손 메커니즘과 장기 정수압 거동)

  • Weon, Jong-Il;Chung, Yu-Kyoung;Shin, Sei-Moon;Choi, Kil-Yeong
    • Polymer(Korea)
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    • v.32 no.5
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    • pp.440-445
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    • 2008
  • The failure mechanism and failure morphology of linear low density polyethylene (LLDPE) tubing under hydrostatic pressure were investigated. Microscopic observations using video microscope and scanning electron microscope indicate that the failure mode is a brittle fracture including cracks propagated from inner wall to outer wall. In addition, oxidation induction time and Fourier transform infrared spectroscopy results show the presence of exothermic peak and the increase in carbonyl index on the surface of fractured LLDPE tubing, due to thermal-degradation. An accelerated life test methodology and testing system for LLDPE tubing are developed using the relationship between stresses and life characteristics by means of thermal acceleration. Statistical approaches using the Arrhenius model and Weibull distribution are implemented to estimate the long-term life time of LLDPE tubing under hydrostatic pressure. Consequently, the long-term life time of LLDPE tubing at the operating temperature of $25^{\circ}C$ could be predicted and also be analyzed.

Development of an On-line Measurement Method for Clean Biofuel Based on Near Infrared Spectroscopy and Chemometrics (근적외선 분광학과 화학계량학에 기반한 청정 바이오연료 실시간 품질 측정 기술 개발)

  • Cho, Hyeong-Su;Ryu, Jun-Hyung;Liu, J. Jay
    • Clean Technology
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    • v.17 no.3
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    • pp.215-224
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    • 2011
  • It is an important issue to develop quality assessing system for biofuel for the purpose of accelerating the mass production of biofuel. It is particularly challenging to conduct testing method in the mass production of bioethanol while meeting quality specifications such as ASTM (American Society for Testing & Materials) D4806-10. In order to address this challenge, this paper proposes on-line spectroscopic quality assesment system based on Near Infrared spectrum and Partial Least Squares method in Chemometrics. As a result of testing a number of preprocessing methods and Partial Least Squares, it was found out that Savitzky-Golay method showed the best performance in terms of spectrum correction, noise reduction, and model maintenance. The proposed system allows us to assess multiple quality components continuously using spectroscopic facilities with the cheap cost. Since the value of R2 is more than 0.99, it is possible to replace the laboratory analysis.

Assessment of Drainage Properties of PBDs(Prefabricated Board Drains) for Soft Soil Reinforcement

  • Jeon, Han-Yong;Kim, Hong-Gwan;Chang, Yong-Chai;Chung, Chin-Gyo
    • Proceedings of the Korean Fiber Society Conference
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    • 2003.10a
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    • pp.105-105
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    • 2003
  • Theoretical studies have been performed for drainage and filtration characteristics, low consolidation rate of sandmat and prefabricated horizontal and vertical drain. Discussion on quality control and methodology, cost analysis for sandmat and prefabricated horizontal drains were performed.

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Current Researches on The Weathering of Wood (목재의 기상열화에 관한 최근의 연구 동향)

  • Kim, Yeong-Suk
    • Journal of the Korean Wood Science and Technology
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    • v.45 no.5
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    • pp.483-494
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    • 2017
  • This was reviewed on the characteristics (changes of color, microscopic structures, and chemical degradations) that appears on wood surface, when wood is exposed to outdoors and weathering testing methods applicable for assessment of wood weatherability in outside environment through literature reviews.

Mechanical Properties of Carbon Nanofiber Reinforced Hybrid Composites (탄소나노섬유가 강화된 하이브리드 복합재료의 기계적 물성)

  • Kong Jin-Woo;Chung Sang-Su;Kim Tae-Wook
    • Proceedings of the Korean Society For Composite Materials Conference
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    • 2004.10a
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    • pp.31-34
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    • 2004
  • Carbon nanofiber exhibits superior and often unique characteristics of mechanical, electrical chemical and thermal properties. In this study, For improvement of the mechanical properties of composites, carbon nanofiber reinforced hybrid composites was investigated. For the effect of dispersion, The dispersion methods of solution blending and mechanical mixing were used. The mixing of solution blending method was used using ultrasonic. Dispersion of carbon nanofiber was observed by scanning electron microscope (SEM). Mechanical properties were measured by universal testing Machine (UTM).

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ENHANCED SOLUBILIZATION BY SYNTHETIC AND BIOSURFACT ANT ADDITION IN THE REMEDIATION OF PHENANTHRENE

  • Shin, Kyung-Hee;Lee, Byung-Tae;Kim, Kyoung-Woong
    • Proceedings of the KSEEG Conference
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    • 2003.04a
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    • pp.66-68
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    • 2003
  • Polycyclic Aromatic Hydrocarbons (PAHs) are hydrophobic and most are practically insoluble in water contributing to their persistence in the environment. In addition, most exist in strongly adsorbed forms when they are introduced into the soils. Their removal efficiency can be limited in low mass transfer phases, such as PAHs-contaminated soils, because most chemical and biological remediation technologies require transfer from NAPs (Non-Aqueous Phase Liquids) into the mobile phase. (omitted)

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Failure Analysis of Circulating Water Pump Shaft in Power Plant (발전 계획에서 순환 물 펌프 고장 분석)

  • Lee, Jaehong;Jung, Nam-gun
    • KEPCO Journal on Electric Power and Energy
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    • v.7 no.1
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    • pp.125-128
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    • 2021
  • This paper presents the root cause failure analysis of the circulating water pump in the 560 MW thermal power plant. A fractured austenitic stainless-steel shaft operated for 24 years was examined. Fracture morphology was investigated by micro and macro-fractographic analysis. The metallurgical analyses including chemical analysis, metallography and hardness testing were performed. The analysis reveals that the pump shaft was fractured due to the reverse bending load with combination of rotating bending load. Corrective actions for plant operator was recommended based on the analysis.