• Near Infrared Analysis
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• 제1권2호
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• pp.1-8
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• 2000

Using the net analyte signal, hybrid linear analysis was proposed to predict chemical concentration. In this paper, we select a sample from training set and apply orthogonal signal correction to obtain an improved pseudo unit spectrum for hybrid least analysis. using the mean spectrum of a calibration training set, we first show the calibration by hybrid least analysis is effective to the prediction of not only chemical concentrations but also physical property variables. Then, a pseudo unit spectrum from a training set is also tested with and without orthogonal signal correction. We use two data sets, one including five chemical concentrations and the other including ten physical property variables, to compare the performance of partial least squares and modified hybrid least analysis calibration methods. The results show that the hybrid least analysis with a selected training spectrum instead of well-measured pure spectrum still gives good performances, which is a little better than partial least squares.

• Bulletin of the Korean Chemical Society
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• 제29권1호
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• pp.252-254
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• 2008

• Bulletin of the Korean Chemical Society
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• 제35권8호
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• pp.2555-2558
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• 2014

• Bulletin of the Korean Chemical Society
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• 제30권8호
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• pp.1891-1892
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• 2009

• Applied Biological Chemistry
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• 제48권3호
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• pp.267-272
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• 2005

계피(계지, Cinnanmomum cassia)의 주요성분인, trans-cinnamaldehyde를 $^1H-NMR$ 분광법을 이용하여 정량분석하였다. 핵자기 공명법을 이용한 정량분석의 응용가능성을 확인하기 위하여, t-cinnamaldehyde의 $^1H-NMR$ 스펙트럼에서 시료의 농도와 측정온도를 변화시킴에 따라 chemical shift의 변화와 적분값의 변화를 관찰하였다. t-Cinnamaldehyde(7.1429 mg/ml)를 19, 25, 30, 40 및 $50^{\circ}C$ 하에서 $^1H-NMR$ 측정한 결과, aldehyde methine signal(doublet)의 chemical shift가 9.7202, 9.7184, 9.7169, 9.7142 및 9.7124 ppm에서 관측되었다. 이는 측정온도는 signal의 chemical shift의 변화에 중요한 변수가 되지 않는다는 것을 의미하였다. 또한, aldehyde signal의 적분값이 $1.37(19^{\circ}C),\;1.37(25^{\circ}C),\;1.37(30^{\circ}C),\;1.37(40^{\circ}C)$ 및 $1.37(50^{\circ}C)$로써, 측정온도가 signal의 적분값에는 전혀 영향을 미치지 않는 것으로 나타났다. 동일한 온도 $25^{\circ}C$에서 0.4464, 0.8929, 1.7857, 3.5714, 7.1429 및 14.286 mg/ml의 농도의 시료에 대한 $^1H-NMR$ 측정 결과, aldehyde기의 chemical shifts는 각각 9.7206, 9.7201, 9.7196, 9.7192, 9.7185 및 9.7174 ppm에서 나타났다. 이는 각 시료의 농도가 증가함에 따라서 aldehyde의 signal이 고자장으로 약간 이동하는 것으로 나타났다. Aldehyde기의 doublet methine signal의 적분값과 각 시료의 농도에 따른 calibration curve는 직선으로 나타났으며, 매우 높은 회귀율($r^2=1.0000$)을 보였다. t-Cinnamaldehyde와 aldehyde기를 갖는 물질로써, C. cassia의 또 다른 구성성분인 t-2-methoxycinnamaldehyde($7.1429\;mg/ml\;CDCl_3,\;25^{\circ}C$)에 대해서, $^1H-NMR$ 스펙트럼을 측정한 결과, t-cinnamaldehyde는 ${\delta}_H$ 9.7174(9.7078, 9.7270)서 관측되었다. t-2-Methoxycinnamaldehyde는 ${\delta}_H$ 9.6936(9.6839, 9.7032)에서 관측되었다. 따라서, 두 화합물의 chemical shift의 차이는 resolution 값이 0.45 Hz인 NMR 스펙트럼 상에서 충분히 구분할 수 있을 정도로 나타났다. 위의 방법을 이용하여, 추출용매에 따른 C. cassia 내의 t-cinnamaldehyde의 함량을 분석한 결과, n-hexane, $CHCl_3$ 및 EtOAc로 추출하였을 때에, 각각 94.2 mg/g(0.94%), 137.6 mg/g(1.38%), 140.1 mg/g(1.40%)으로 결정되었다.

• Korean Chemical Engineering Research
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• 제55권4호
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• pp.556-560
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• 2017

A hemoglobin/silver nanoparticle heterolayer was fabricated for bioelectronic device with electrochemical signal-enhancement effect. As a device element, a hemoglobin, the metalloprotein, contained the heme group that showed the redox property was introduced for charge storage element. For electron transfer facilitation, a silver nanoparticle was introduced for electrochemical signal facilitation, the hemoglobin was immobilized onto Au substrate using chemical linker 6-mercaptohexanoic acid (6-MHA). Then, the silver nanoparticle was immobilized onto fabricated hemoglobin/6-MHA heterolayers by layer-by-layer (LbL) method. The surface morphology and surface roughness of fabricated heterolayer were investigated by atomic force microscopy (AFM). The redox property of hemoglobin/silver nanoparticle heterolayer was investigated by a cyclic voltammetry (CV) experiment for obtaining an oxidation potential and reduction potential. Moreover, for the assessing charge storage function, a chronoamperometry (CA) experiment was conducted to hemoglobin/silver nanoparticle-modified heterolayer electrode using oxidation and reduction potentials, respectively. Based on the results, the fabricated hemoglobin/silver nanoparticle heterolayer showed that an increased charge storage effect compared to hemoglobin monolayer-modified electrode.

• 분석과학
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• 제21권5호
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• pp.438-441
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• 2008

We have developed an alternative to the internal chemical reference based on a calibrated reference signal which is not a real NMR line but an electronically produced signal (HERETIC) and determined the phosphorus concentration using this method. The area ratio of HERETIC and sample peaks obtained from the standard samples was used to measure the concentrations of different samples directly. The analysis of phosphorus by this method showed the excellent linear regression coefficient ($R^2=0.9999$) for the concentration range from 20 ppm to 500 ppm with HERETIC peak as reference.

• 한국의학물리학회지:의학물리
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• 제7권1호
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• pp.19-23
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• 1996

정상조직과 지방조직의 화학적 결합의 차이는 화학적 이동 artifact를 발생시킨다. 이러한 화학적 이동으로 생긴 결과는 주로 공명신호 위치의 부정확으로 나타나지만 횡적완화시간의 변화도 일으키게 된다. 물분자 수소원자핵의 횡적완화시간 T$_2$ 과 지방분자 수소원자핵의 횡적완화시간 T$_{2}$$^{*}$ 를 신호대 잡음비, 신호응답도, 그리고 영상시간에 각각 넣어 비교해 보았다. 그 결과 신호대 잡음비와 신호응답도는 각각 약 5%와 8%가 감소하였고, 영상시간은 약 10% 가량 증가하였다. 따라서, 화학적 이동은 영상의 왜곡 외에도 영상과정의 효율을 저하시킴을 알았다.

• The Journal of the Acoustical Society of Korea
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• 제17권1E호
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• pp.30-35
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• 1998

Given a noisy sampled at equispaced points with white noise, we consider problems where the signal to be recovered is known to be positive; for example, images, chemical spectra or other measurements of intensities. Shrinking noisy wavelet coefficients via thresholding offers very attractive alternatives to existing methods of recovering signals from noisy data. In this paper, we propose a method of recovering the original signal from a corrupted noisy signal, guaranteeing the recovered signal positive. We first obtain wavelet coefficients by thresholding, and use a nonlinear optimization to find the denoised signal which must be positive. Numerical examples are used to illustrate the performance of the proposed algorithm.

• KIEE International Transactions on Electrophysics and Applications
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• 제2C권5호
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• pp.262-267
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• 2002

In this paper, we first studied the factors affecting the motor current (MC) signal, which was strongly affected by the systematic hardware noises depending on polishing such as pad conditioning and arm oscillation of platen and recipe, head motor. Next, we studied the end point detection (EPD) for the chemical mechanical polishing (CMP) process of shallow trench isolation (STI) with reverse moat structure. The MC signal showed a high amplitude peak in the fore part caused by the reverse meal. pattern. We also found that the EP could not be detected properly and reproducibly due to the pad conditioning effect, especially when conventional low selectivity slurry was used. Even when there was no pad conditioning effect, the EPD method could not be applied, since the measured end points were always the same due to the characteristics of the reverse moat structure with an open nitride layer.