• The Korean Journal of Physiology and Pharmacology
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• 제3권1호
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• pp.1-10
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• 1999

We sought to find out the mechanism of vascular relaxation by extracellular $K^+$ concentration $([K^+]_o)$ in the cerebral resistant arteriole from rabbit. Single cells were isolated from the cerebral resistant arteriole, and using voltage-clamp technique barium-sensitive $K^+$ currents were recorded, and their characteristics were observed. Afterwards, the changes in membrane potential and currents through the membrane caused by the change in $[K^+]_o$ was observed. In the smooth muscle cells of cerebral resistant arteriole, ion currents that are blocked by barium, 4-aminopyridine (4-AP), and tetraethylammonium (TEA) exist. Currents that were blocked by barium showed inward rectification. When the $[K^+]_o$ were 6, 20, 60, and 140 mM, the reversal potentials were $-82.7{\pm}1.0,\;-49.5{\pm}1.86,\;-26{\pm}1.14,\;-5.18{\pm}1.17$ mV, respectively, and these values were almost identical to the calculated $K^+$ equilibrium potential. The inhibition of barium-sensitive inward currents by barium depended on the membrane potential. At the membrane potentials of -140, -100, and -60 mV, $K_d$ values were 0.44, 1.19, and 4.82 ${\mu}M,$ respectively. When $[K^+]_o$ was elevatedfrom 6 mM to 15 mM, membrane potential hyperpolarized to -50 mV from -40 mV. Hyperpolarization by $K^+$ was inhibited by barium but not by ouabain. When the membrane potential was held at resting membrane potential and the $[K^+]_o$ was elevated from 6 mM to 15 mM, outward currents increased; when elevated to 25 mM, inward currents increased. Fixing the membrane potential at resting membrane potential and comparing the barium-sensitive outward currents at $[K^+]_o$ of 6 and 15 mM showed that the barium- sensitive outward current increased at 15 mM $K^+.$ From the above results the following were concluded. Barium-sensitive $K^+$?channel activity increased when $[K^+]_o$ is elevated and this leads to an increase in $K^+-outward$ current. Consequently, the membrane potential hyperpolarizes, leading to the relaxation of resistant arteries, and this is thought to contribute to an increase in the local blood flow of brain.

• 한국수자원학회논문집
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• 제50권1호
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• pp.55-64
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• 2017

본 연구에서는 ULTIMATE 기법을 이용하여 밀도류 층적분 모형의 해석을 위한 수치모형을 제시하였다. 개발된 모형을 경사부와 평탄부로 이루어진 실내 실험에 적용하여 경사부에 유입된 부유사 밀도류의 전파 특성에 대해 분석하였다. ULTIMATE 기법의 범용제한자로 인하여 밀도류의 선단부가 수치진동 없이 비교적 급한 형태로 전파되는 것을 모의하였다. 그리고 사류로 전파되고 수로 끝에서부터 상류로 변화되는 밀도류의 내부 도수 발생 과정을 재현하였다. 이러한 내부 도수는 ULTIMATE 제한자를 사용하면 Courant 수가 1 미만일 때 안정적으로 모의되는 것을 확인하였다. 또한 밀도류의 전파 속도에 영향을 주는 인자에 대하여 분석하였다. 입자의 크기는 $9{\mu}m$ 이하일 때 밀도류의 전파 속도에 큰 영향을 주지 않는 반면, 부력 흐름률은 확연한 영향을 주는 것을 확인하였다. 마지막으로 부유사 밀도류에 의한 하상변동에 대해 검토하였다. 수치모형으로 부유사 밀도류의 전파에 의한 하상변동을 정량적으로 적절히 모의하였으며, 도수로 인한 부유사 연행의 차이와 이로 인한 하상의 불연속적인 형태를 관찰할 수 있었다.

• 대한전기학회논문지:전기기기및에너지변환시스템부문B
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• 제52권6호
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• pp.271-277
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• 2003

It is important to control layer current distributions of coaxial multi-layer HTS cables, because a homogeneous layer current distribution decreases AC loss and can supply the largest operational current. We have extended the theory that treat the operational current more than the critical current by considering V-I nonlinear characteristics of HTS tapes including flux flow resistance and contacting resistance between the cable and terminals. It is important to investigate the current distribution under the condition of operational current more than the critical current of cable, because the cable has experiences of fault current. In order to verify the extended theory, we have fabricated a two layers cable with the same twisting layer pitch. It was observed that almost all the operational current less than the critical current flowed on the outer layer because of its lower inductance. In case of operational current more than critical currents of layers, the flux flow resistances affect strongly current waveform and thereby the currents of layers were determined by the flux flow resistances. And we investigated breakdown characteristics in $LN_{2}$/paper composite insulation system for the application to a HTS cable. In this experiment, we got some information out of that the electrical characteristics of the insulation materials depends on the condition of butt gap.

• 국제물리치료학회지
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• 제5권2호
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• pp.752-756
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• 2014

This study investigated the effects of changes to the pulsation factor of pulsed direct currents on wound healing. Patients with a pressure ulcer at a care hospital for the elderly were randomly divided into three groups: Group 1 involved the application of $100{\mu}s$ in pulse duration, 10 ms in pulse period, 100 pps in a pulsation factor, 15 mA in pulse amplitude, and polarity red+ by using pulsed direct currents; Group 2 involved a change of pulse period to 8 ms; and Group 3 received general wound management. Although there were no statistically significant differences in the changing stages of pressure ulcers among the groups, all the groups dropped in numerical stages. In the two groups to which pulsed direct currents were applied, there was a statistically significant reduction in the stages of pressure ulcers from the initial assessment to the 12-week assessment (p<.05). Even though there were no statistically significant differences in changes to the area of pressure ulcers among the groups, a statistically significant decrease was found in pulsed direct current group 2 whose pulse period was shortened (p<.05). There was no difference in the healing rate of pressure ulcers among the groups, but it made a numerical increase in pulsed direct current group 1 and group 2 and a numerical decrease in group 3. There were no significant differences in the characteristics of those who had a full recovery among the groups. Those findings indicate that pulsed direct currents have positive effects on the wound healing of patients with a pressure ulcer and that a treatment with pulsed direct currents whose pulsation factor is raised by reducing the pulse duration is especially effective.

• 한국연소학회지
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• 제3권1호
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• pp.71-78
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• 1998

The flame stabilization and the combustion characteristics of diffusion flame formed in the wake of a cylindrical bluff body with fuel injection are studied. With the turbulence generator, the flame stability limits and ion currents were measured and analyzed. The results from this experimental study are summarized as follows. The region with highest average value of ion currents in the middle of flame is moved to the upstream side by the turbulent components of main stream. The flame mass with partially active reaction is moved fast for uniform flow and turbulence generator G3, but the flame mass with relatively slow reaction is moved slowly for turbulence generator G1. If the turbulence generator with strong turbulent component is installed, the turbulent time scale is increased with movement from main stream side to recirculation zone as well as the flame stability limits is deteriorated. Though the special dominant frequency is not appeared in the eddy which exists in flame, high frequency characteristics are appeared in uniform flow and turbulence generator G3, and low frequency characteristics are appeared in uniform flow, turbulence generator G3 and G1.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1986년도 하계학술대회논문집
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• pp.337-340
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• 1986

• 한국해양학회지
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• 제29권2호
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• pp.95-106
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• 1994

김 등 (1993)에 의해 개발된 3차원 해수유동 수치모델을 사용하여 진해만의 조류 및 취송류를 해석하였다. 만내의 흐름은 주로 지형, 바람 및 하천유출에 의해 지배되 며, 만 입구의 수로보다 내만에서 바람 의 영향을 더 강하게 받는다. 계산된 조류는 현장관측과 잘 일치한다. 조류 및 조석잔차류의 수평 및 연직 유속은 만 입구의 수로 에서는 강하나, 진해만의 서부해역과 북부해역에서는 상대적으로 약하게 일어났다. 저 층과 표층 사이에 유속우 위상차가 일어나며, 위상차는 소조기보다 소조기보다 대조기 에 더 뚜렷하게 나타났다. 또한 만내에서 표층흐름은 바람 및 하천유출류에 의해 강하 게 지배되며, 이러한 현상은 대조기보다 소조기에 더 뚜렷하게 나타났다.

• Journal of Electrical Engineering and Technology
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• 제5권4호
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• pp.640-645
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• 2010

This paper describes the power generating property of hydrothermally grown ZnO nanorods on a flexible polyethersulfone (PES) substrate. The piezoelectric currents generated by the ZnO nanorods were measured when bending the ZnO nanorod by using I-AFM, and the measured piezoelectric currents ranged from 60 to 100 pA. When the PtIr coated tip bends a ZnO nanorod, piezoelectrical asymmetric potential is created on the nanorod surface. The Schottky barrier at the ZnO-metal interface accumulates elecntrons and then release very quickly generating the currents when the tip moves from tensile to compressed part of ZnO nanorod. These ZnO nanorods were grown almost vertically with the length of 300-500 nm and the diameter of 30-60 nm on the Ag/Ti/PES substrate at $90^{\circ}C$ for 6 hours by hydrothermal method. The metal-semiconductor interface property was evaluated by using a HP 4145B Semiconductor Parameter Analyzer and the piezoelectric effect of the ZnO nanorods were evaluated by using an I-AFM. From the measured I-V characteristics, it was observed that ZnO-Ag and ZnO-Au metal-semiconductor interfaces showed an ohmic and a Schottky contact characteristics, respectively. ANSYS finite element simulation was performed in order to understand the power generation mechanism of the ZnO nanorods under applied external stress theoretically.

• The Korean Journal of Physiology and Pharmacology
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• 제8권6호
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• pp.335-338
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• 2004

There are numerous studies on transepithelial transports in duct cells including $Cl^-$ and/or $HCO_3^-$. However, studies on transepithelial $K^+$ transport of normal duct cells in exocrine glands are scarce. In the present study, we examined the characteristics of $K^+$ currents in single duct cells isolated from guinea pig pancreas, using a whole-cell patch clamp technique. Both $Cl^-$ and $K^+$ conductance were found with KCI rich pipette solutions. When the bath solution was changed to low $Cl^-$, reversal potentials shifted to the negative side, $-75{\pm}4\;mV$, suggesting that this current is dominantly selective to $K^+$. We then characterized this outward rectifying $K^+$ current and examined its $Ca^{2+}$ dependency. The $K^+$ currents were activated by intracellular $Ca^{2+}$. 100 nM or 500 nM $Ca^{2+}$ in pipette significantly (P<0.05) increased outward currents (currents were normalized, $76.8{\pm}7.9\;pA$, n=4 or $107.9{\pm}35.5\;pA$, n=6) at +100 mV membrane potential, compared to those with 0 nM $Ca^{2+}$ in pipette $(27.8{\pm}3.7\;pA,\;n=6)$. We next examined whether this $K^+$ current, recorded with 100 nM $Ca^{2+}$ in pipette, was inhibited by various inhibitors, including $Ba^{2+}$, TEA and iberiotoxin. The currents were inhibited by $40.4{\pm}%$ (n=3), $87.0{\pm}%$ (n=5) and $82.5{\pm}%$ (n=9) by 1 mM $Ba^{2+}$, 5 mM TEA and 100 nM iberiotoxin, respectively. Particularly, an almost complete inhibition of the current by 100 nM iberiotoxin further confirmed that this current was activated by intracellular $Ca^{2+}$. The $K^+$ current may play a role in secretory process, slnce recycling of $K^+$ is critical for the initiation and sustaining of $CI^-$ or $HCO_3^-$ secretion in these cells.

• International Journal of Oral Biology
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• 제38권1호
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• pp.13-19
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• 2013

Various voltage-gated $K^+$ currents were recently described in dorsal root ganglion (DRG) neurons. However, the characterization and diversity of voltage-gated $K^+$ currents have not been well studied in trigeminal root ganglion (TRG) neurons, which are similar to the DRG neurons in terms of physiological roles and anatomy. This study was aimed to investigate the characteristics and diversity of voltage-gated $K^+$ currents in acutely isolated TRG neurons of rat using whole cell patch clamp techniques. The first type (type I) had a rapid, transient outward current ($I_A$) with the largest current size having a slow inactivation rate and a sustained delayed rectifier outward current ($I_K$) that was small in size having a fast inactivation rate. The $I_A$ currents of this type were mostly blocked by TEA and 4-AP, K channel blockers whereas the $I_K$ current was inhibited by TEA but not by 4-AP. The second type had a large $I_A$ current with a slow inactivation rate and a medium size-sustained delayed $I_K$ current with a slow inactivation rate. In this second type (type II), the sensitivities of the $I_A$ or $I_K$ current by TEA and 4-AP were similar to those of the type I. The third type (type III) had a medium sized $I_A$ current with a fast inactivation rate and a large sustained $I_K$ current with the slow inactivation rate. In type III current, TEA decreased both $I_A$ and $I_K$ but 4-AP only blocked $I_A$ current. The fourth type (type IV) had a smallest $I_A$ with a fast inactivation rate and a large $I_K$ current with a slow inactivation rate. TEA or 4-AP similarly decreased the $I_A$ but the $I_K$ was only blocked by 4-AP. These findings suggest that at least four different voltage-gated $K^+$ currents in biophysical and pharmacological properties exist in the TRG neurons of rats.