• Molecules and Cells
• /
• v.39 no.4
• /
• pp.322-329
• /
• 2016

Voltage-gated $Ca^{2+}$ ($Ca_V$) channels are dynamically modulated by Gprotein-coupled receptors (GPCR). The $M_1$ muscarinic receptor stimulation is known to enhance $Ca_V2.3$ channel gating through the activation of protein kinase C (PKC). Here, we found that $M_1$ receptors also inhibit $Ca_V2.3$ currents when the channels are fully activated by PKC. In whole-cell configuration, the application of phorbol 12-myristate 13-acetate (PMA), a PKC activator, potentiated $Ca_V2.3$ currents by ~two-fold. After the PMA-induced potentiation, stimulation of $M_1$ receptors decreased the $Ca_V2.3$ currents by $52{\pm}8%$. We examined whether the depletion of phosphatidylinositol 4,5-bisphosphate ($PI(4,5)P_2$) is responsible for the muscarinic suppression of $Ca_V2.3$ currents by using two methods: the Danio rerio voltage-sensing phosphatase (Dr-VSP) system and the rapamycin-induced translocatable pseudojanin (PJ) system. First, dephosphorylation of $PI(4,5)P_2$ to phosphatidylinositol 4-phosphate (PI(4)P) by Dr-VSP significantly suppressed $Ca_V2.3$ currents, by $53{\pm}3%$. Next, dephosphorylation of both PI(4)P and $PI(4,5)P_2$ to PI by PJ translocation further decreased the current by up to $66{\pm}3%$. The results suggest that $Ca_V2.3$ currents are modulated by the $M_1$ receptor in a dual mode-that is, potentiation through the activation of PKC and suppression by the depletion of membrane $PI(4,5)P_2$. Our results also suggest that there is rapid turnover between PI(4)P and $PI(4,5)P_2$ in the plasma membrane.

• Journal of Biomedical Engineering Research
• /
• v.27 no.4
• /
• pp.154-163
• /
• 2006

A 64-channel magnetocardiogram (MCG) system using low-noise superconducting quantum interference device (SQUID) planar gradiometers was developed for the measurements of cardiac magnetic fields generated by the heart electric activity. Owing to high flux-to-voltage transfers of double relaxation oscillation SQUID (DROS) sensors, the flux-locked loop electronics for SQUID operation could be made simpler than that of conventional DC SQUIDs, and the SQUID control was done automatically through a fiber-optic cable. The pickup coils are first-order planar gradiometers with a baseline of 4 em. The insert has 64 planar gradiometers as the sensing channels and were arranged to measure MCG field components tangential to the chest surface. When the 64-channel insert was in operation everyday, the average boil-off rate of the dewar was 3.6 Lid. The noise spectrum of the SQUID planar gradiometer system was about 5 fT$_{rms}$/$\checkmark$Hz at 100 Hz, operated inside a moderately shielded room. The MCG measurements were done at a sampling rate of 500 Hz or 1 kHz, and realtime display of MCG traces and heart rate were displayed. After the acquisition, magnetic field mapping and current mapping could be done. From the magnetic and current information, parameters for the diagnosis of myocardial ischemia were evaluated to be compared with other diagnostic methods.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.21 no.12
• /
• pp.702-708
• /
• 2020

Recently, as LED display systems have become larger, research on effective power control methods for the systems has been in progress. This paper proposes a power control method to minimize power loss due to the difference in LED characteristics for each channel of a backlight unit (BLU) system. The proposed LED driver IC has a power optimization function and detects the minimum headroom voltage for constant current operation of all channels and linearly controls the DC-DC converter output. Thus, it minimizes power consumption due to unnecessary additional voltage. In addition, it does not require a voltage sensing comparator or a voltage generation circuit for each channel. This has a great advantage in reducing the chip size and for stabilization when implementing an integrated circuit. In order to verify the proposed function, an IC was designed using Cadence and Synopsys' design tools, and it was fabricated with a Magnachip 0.35um 5V/40V CMOS process. The experiments confirmed that the proposed power control method controls the minimum required voltage of the BLU system.

• Journal of the Korean Institute of Navigation
• /
• v.24 no.5
• /
• pp.443-450
• /
• 2000

Before some experiments were carried out with analog bandpass filter which used for filtering the noise included in sound source signal. And this filter was constituted by condenser, register and operational amplifier. Hut these elements made the phase characteristics to differentiate in each sensing channel and cause a little of measurement error. We made new measurement system that was substituted digital filter for the analog filter in order to develop the optimal system which could find the time delay between each sensors with high accuracy. This paper describes the new system's constitution and the function of each parts. Specially three digital filters were designed and applied to the digital signal processing Part. And a series of experiments were carried out with the source＇s distance 9.53meters and the random bearing interval within the limits of $0^{\circ}$ ~ $180^{\circ}$. As a result, we have recognized that the accuracy of measurements were differentiated by the methods what kind of digital filter were adopted. And we have confirmed the facts that IIR LPF was suitable for sound source's bearing measurement and FIR LPF reduced the range measurement error.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• v.10 no.7
• /
• pp.3414-3434
• /
• 2016

Classical key generation is complicated to update and key distribution generally requires fixed infrastructures. In order to eliminate these restrictions researchers have focused much attention on physical-layer (PHY-layer) based key generation methods. In this paper, we present a PHY-layer fingerprints based fuzzy key generation scheme, which works to prevent primary user emulation (PUE) attacks and spectrum sensing data falsification (SSDF) attacks, with multi-node collaborative defense strategies. We also propose two algorithms, the EA algorithm and the TA algorithm, to defend against eavesdropping attacks and tampering attacks in mobile cognitive radio networks (CRNs). We give security analyses of these algorithms in both the spatial and temporal domains, and prove the upper bound of the entropy loss in theory. We present a simulation result based on a MIMO-OFDM communication system which shows that the channel response characteristics received by legitimates tend to be consistent and phase characteristics are much more robust for key generation in mobile CRNs. In addition, NIST statistical tests show that the generated key in our proposed approach is secure and reliable.

• Physical Therapy Rehabilitation Science
• /
• v.10 no.3
• /
• pp.374-378
• /
• 2021

Objective: Bilateral movement training is an effective method for upper extremity rehabilitation of stroke. An approach to induce bilateral movement through functional electrical stimulation is attempted. The purpose of this study is to develop an EMG-triggered functional electrical stimulation device for upper extremity bilateral movement training in stroke patients and test its feasibility. Design: Feasibility and Pilot study design. Methods: We assessed muscle activation and kinematic data of the affected and unaffected upper extremities of a stroke patient during wrist flexion and extension with and without the device. Wireless EMG was used to evaluate muscle activity, and 12 3D infrared cameras were used to evaluate kinematic data. Results: We developed an EMG-triggered functional electrical stimulation device to enable bilateral arm training in stroke patients. A system for controlling functional electrical stimulation with signals received through a 2-channel EMG sensor was developed. The device consists of an EMG sensing unit, a functional electrical stimulation unit, and a control unit. There was asymmetry of movement between the two sides during wrist flexion and extension. With the device, the asymmetry was lowest at 60% of the threshold of the unaffected side. Conclusions: In this study, we developed an EMG-triggered FES device, and the pilot study result showed that the device reduces asymmetry.

• Korean Journal of Remote Sensing
• /
• v.30 no.5
• /
• pp.627-639
• /
• 2014

Accurate correction of surface effect from back scattered solar radiance is one of key issue to retrieve aerosol information from satellite measurements. In this study, two different methods are applied to retrieve surface reflectance by using single visible channel measurement from meteorological imager onboard COMS. The first one is minimum reflectance method, which composes the minimum value among previously measured reflectances at each pixel over a certain search window length. This method assumes that the darkest pixel corresponds to the aerosol-free condition, and deduces surface reflectance by correcting atmospheric scattering from the measured visible reflectance. The second method, named as the "atmospheric correction method" in this study, estimates the result by correcting aerosol and atmospheric scattering with ground-based observation of aerosol optical properties. The purpose of this study is to investigate the retrieval accuracy of the widelyused minimum reflectance method. Also, the retrieval error caused by the loading of background aerosol is mainly estimated. The comparison between surface reflectances retrieved from the two methods shows good agreement with the correlation coefficient of 0.87. However, the results from the minimum reflectance method are slightly overestimated than the values from the atmospheric correction method when surface reflectance is lower than 0.2. The average difference between the two results is 0.012 without the background aerosol correction. By considering the background aerosol effect, however, the difference is reduced to 0.010.

• The Journal of the Institute of Internet, Broadcasting and Communication
• /
• v.11 no.3
• /
• pp.23-30
• /
• 2011

In the wireless sensor network(WSN), the detection of precise location of sensor nodes is essential for efficiently utilizing the sensing data acquired from sensor nodes. Among various location methods, the received signal strength (RSS) based localization scheme is mostly preferable in many applications since it can be easily implemented without any additional hardware cost. Since the RSS localization method is mainly effected by radio channel between two nodes, outlier data can be included in the received signal strength measurement specially when some obstacles move around the link between nodes. The outlier data can have bad effect on estimating the distance between two nodes such that it can cause location errors. In this paper, we propose a RSS-based localization method using Robust Statistic and Gaussian filter algorithm for enhancing the accuracy of RSS-based localization. In the proposed algorithm, the outlier data can be eliminated from samples by using the Robust Statistics as well as the Gaussian filter such that the accuracy of localization can be achieved. Through simulation, it is shown that the proposed algorithm can increase the accuracy of localization and is more robust to non gaussian noise channels.

• Proceedings of the KSRS Conference
• /
• 2007.10a
• /
• pp.22-24
• /
• 2007

Waterline extraction is the one of widely used methods for studying changes in tidal flat environment and coastlines using multi-temporal optical images such as Landsat TM and Landsat ETM+. High dynamics of tidal currents and land reclamation which accelerate sedimentation and/or erosion cause waterline change in tidal flats. The amount of sediment deposited or eroded can be evaluated by precisely estimating waterline changes in tidal flats. The objective of this study is to detect the change of waterlines during 17 years and analyze the trends of erosion and sedimentation in the study areas. The Ganghwado tidal flat on the west coast of the Korean Peninsula was selected. The study area is famous for high dynamics of tidal currents and vast tidal flats. Land reclamation which has been carried out on a large scale is also considered as one of elements that have accelerated the environmental changes in this tidal flat. In this study, we acquired 26 waterlines from Landsat TM and Landsat ETM+ images. We extracted the waterline from each satellite image to generate a digital elevation map (DEM) which was used for reference and to compare with the other waterline which was extracted from DEM having a same tide. The result of comparison well depicted the areas of dominant sedimentation and erosion, and general trends of sedimentation and erosion according to sub-regions are also revealed during the investigation time. Results showed that erosion during a decade was dominant at the west of the Southern Ganghwado tidal flat, while sedimentation was dominant at the wide channel between the Southern Ganghwado tidal flat and the Yeongjongdo tidal flat. This area has been commonly affected by high currents and sedimentation energy. Although we were not able to verify the accuracy of the waterline changes, this result clearly showed the waterline change and therefore, the waterline extraction method used in this study has proven as an effective tool for long term tidal change estimation.

• The Journal of the Korea institute of electronic communication sciences
• /
• v.10 no.12
• /
• pp.1315-1320
• /
• 2015

In this paper Communication data link equipment on a high speed-hopping method to use the frequency resources efficiently for the frequency environment is introduced such as sensing techniques, using the same frequency band by using the received two-channel technique and the receive filter bank unit applied to be shared with other equipment such as radar and so on. The real-time measurement and analysis were operated for measurement the frequency environment of the operating band in advance. and primarily equipment to develop is analyzed how the interference effect to the radar minimize the operation of radar equipment. In reverse, to use the same frequency band the methods such as frequency sharing techniques are presented in this paper. Finally, by design of the main items of the RF transceiver NF, transmission output, and a simulation of the IMD, such as whether the key is verified prior to meet specifications.