• Structural Monitoring and Maintenance
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• v.9 no.4
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• pp.359-371
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• 2022

Bridges are critical to the civil engineering infrastructure network as they facilitate movement of people, the transportation of goods and services. Given the aging of bridge infrastructure, federal officials mandate visual inspections biennially to identify necessary repair actions which are time, cost, and labor-intensive. Additionally, the expansion joints of bridges are rarely monitored due to cost. However, expansion joints are critical as they absorb movement from thermal effects, loadings strains, impact, abutment settlement, and vehicle motion movement. Thus, the need to monitor bridge expansion joints efficiently, at a low cost, and wirelessly is desired. This paper addresses bridge joint monitoring needs to develop a cost-effective, real-time wireless system that can be validated in a full-scale bridge structure. To this end, a wireless expansion joint monitoring was developed using commercial-off-the-shelf (COTS) sensors. An in-service bridge was selected as a testbed to validate the performance of the developed system compared with traditional displacement sensor, LVDT, temperature and humidity sensors. The short-term monitoring campaign with the wireless sensor system with the internet protocol version 6 over the time slotted channel hopping mode of IEEE 802.15.4e (6TiSCH) network showed reliable results, providing high potential of the developed system for effective joint monitoring at a low cost.

• Journal of Ginseng Research
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• v.39 no.4
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• pp.314-321
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• 2015

Background: Ginseng belongs to the genus Panax. Its main active ingredients are the ginsenosides. Interstitial cells of Cajal (ICCs) are the pacemaker cells of the gastrointestinal (GI) tract. To understand the effects of ginsenoside Re (GRe) on GI motility, the authors investigated its effects on the pacemaker activity of ICCs of the murine small intestine. Methods: Interstitial cells of Cajal were dissociated from mouse small intestines by enzymatic digestion. The whole-cell patch clamp configuration was used to record pacemaker potentials in cultured ICCs. Changes in cyclic guanosine monophosphate (cGMP) content induced by GRe were investigated. Results: Ginsenoside Re ($20-40{\mu}M$) decreased the amplitude and frequency of ICC pacemaker activity in a concentration-dependent manner. This action was blocked by guanosine 50-[${\beta}-thio$]diphosphate [a guanosine-5'-triphosphate (GTP)-binding protein inhibitor] and by glibenclamide [an adenosine triphosphate (ATP)-sensitive $K^{+}$ channel blocker]. To study the GRe-induced signaling pathway in ICCs, the effects of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (a guanylate cyclase inhibitor) and RP-8-CPT-cGMPS (a protein kinase G inhibitor) were examined. Both inhibitors blocked the inhibitory effect of GRe on ICC pacemaker activity. L-NG-nitroarginine methyl ester ($100{\mu}M$), which is a nonselective nitric oxide synthase (NOS) inhibitor, blocked the effects of GRe on ICC pacemaker activity and GRe-stimulated cGMP production in ICCs. Conclusion: In cultured murine ICCs, GRe inhibits the pacemaker activity of ICCs via the ATP-sensitive potassium ($K^{+}$) channel and the cGMP/NO-dependent pathway. Ginsenoside Re may be a basis for developing novel spasmolytic agents to prevent or alleviate GI motility dysfunction.

• Journal of Digital Convergence
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• v.19 no.6
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• pp.419-427
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• 2021

The purpose of this study is to identify the recognition and utilization of health information by acquisition channels for preliminary and elderly people. For the survey data of 200 people aged 55 to 64 and 200 seniors aged 65 or older, the chi-square test and Fisher's precision test were performed using MINITAB17. Although the two age groups were similar in obtaining health information through health professionals, preliminary elderly were more likely to obtain health information through mass media and Internet sites. In particular, the collection of health information through internet sites was more than four times higher than that of the elderly. While the preliminary people focused on searching the information on the health care and prevention, older people explored comprehensive information on health, including disease prevention and treatment, through each channel. Both groups showed positive recognition about the acquired health information. The results of this study confirmed that all channels, including internet sites, can be usefully used in the delivery of health-related information to the elderly in the future. In addition, it is suggested to consider age characteristics and health information utilized by each channel in the development of various contents for the improvement of self-health management of the elderly.

• Korean Journal of Acupuncture
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• v.33 no.4
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• pp.204-212
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• 2016

Objectives : The aim of the study is to investigate the effects of moxibustion on the pain behavior and expression of TRPM8 in the dorsal root ganglion(DRG) in the rat model of ambient cold(AC) exposed osteoarthritis(OA). Methods : OA was induced by the injection of $50{\mu}l$ of 2% monosodium iodoacetate(MIA) into the knee joint cavity. To examine the level of pain, weight bearing forces(WBFs) of affected limb was measured. For the AC exposure, the animals were housed in 6 h/day at $4^{\circ}C$ for 14 days after MIA injection. Moxibustion treatment was performed at EX-LE4 and EX-LE5 with 5 cons(1, 7 or 10 mg) per day for 13 days from 5 days after MIA injection. The expressions of TRPM8 in DRG were measured by western blotting analysis. Results : The WBFs of MIA-AC group were decreased significantly compared to MIA group at 2, 3, 6, 7, 8 and 9 days after arthritis induction. After the first 6 h-AC exposure, expressions of TRPM8 in MIA-AC group were increased significantly compared to those of naive group. After moxibustion treatment, only the WBFs of 7 mg treated group were restored significantly. Moreover, the over-expressions of TRPM8 were attenuated by the moxibustion treatment in AC exposed rats. Conclusions : The data suggest that AC can increase arthritic knee pain via up-regulated TRPM8 and moxibustion treatment improve the arthritic pain via modulation of TRPM8 expression in DRG in the rat model of AC exposed MIA induced arthritis.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.31 no.6
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• pp.359-366
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• 2018

Social infrastructure facilities that have been under construction since the country's high-growth period are undergoing rapid aging, and safety assessments of large structures such as bridge tunnels, which can be directly linked to large-scale casualties in the event of an accident, are necessary. Wireless smart sensor networks that improve SHM(Structural Health Monitoring) based on existing wire sensors are difficult to construct economical and efficient system due to short signal reach. The LPWAN, Low Power Wide Area Network, is becoming popular with the Internet of Things and it is possible to construct economical and efficient SHM by applying it to structural health monitoring. This study examines the applicability of LoRa LPWAN to structural health monitoring and proposes a channel usage pre-planning based LoRa network operation method that can efficiently utilize bandwidth while resolving conflicts between channels caused by using license - exempt communication band.

• International Area Studies Review
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• v.13 no.3
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• pp.239-267
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• 2009

Investment in health through an array of public health policies will lead to improvement of health at all levels, and the improved health can reduce the socioeconomic costs incurred with diseases. And finally, with reduced healthcare costs associated with diseases and health problems, economy will be able to achieve economic growth and development. Using simultaneous equations model, this study aims to identify this possible channel from public health policies to economic growth. Specifically, the policy effect is investigated on a basis of main disease groups and aging groups. The public health policies are proved to reduce healthcare costs related with disease groups including respiratory, digestive, circulative, and infectious disease, and with all age groups except 20~39 group. And the reduced healthcare costs have shown to increase the real gross domestic products in those group above.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.5
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• pp.608-616
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• 2017

The purpose of this study was to compare how three kinds of emotionally different music impacted on the emotion and arousal by measuring EEG. The research method was to compare the measurement of the background EEG on Fp1 and Fp2 before, while and after listening using a 2-channel EEG device with various experimental groups aging from 20s to 50s. The results were as follows. 1) At both Fp1 and Fp2, the amplitude of alpha(8-13Hz), SMR(12-15Hz), low beta, high beta, and ${\alpha}/-{\beta}$significantly increased in all music, while at Fp2 only, theta and ??/SMR increased meaningfully.2) At right prefrontal cortex(Fp2), all bands of EEG predominated while and after listening to all songs over Fp1 except for the delta of funeral march which predominated while listening to Fp1.3) The music with a noticeably high alpha value and increased activity was Prelude. These results suggested that Prelude induced brain activity along with relaxation, and the emotionally heavy burden of funeral march decreased the activity of the left brain. This research revealed that feeling emotional change by listening to music was due to the fact that music influenced the brain activity inducing the change of emotion and arousal.

• Journal of Korean Tunnelling and Underground Space Association
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• v.25 no.6
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• pp.479-493
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• 2023

The need for safety management has arisen due to the increasing number of years of operated underground structures, such as tunnels and utility tunnels, and accidents caused by those aging infrastructures. However, in the case of privately managed underground utility ducts, there is a lack of detailed guidelines for facility safety and maintenance, resulting in inadequate safety management. Furthermore, the absence of basic design information and the limited space for safety assessments make applying currently used non-destructive testing methods challenging. Therefore, this study suggests non-destructive inspection methods using ultrasonic and impact-echo techniques to assess the quality of underground structures. Thickness, presence of rebars, depth of rebars, and the presence and depth of internal defects are assessed to provide fundamental data for the safety assessment of box-type general underground structures. To validate the proposed methodology, different conditions of concrete specimens are designed and cured to simulate actual field conditions. Applying ultrasonic and impact signals and collecting data through multi-channel accelerometers determine the thickness of the simulated specimens, the depth of embedded rebar, and the extent of defects. The predicted results are well agreed upon compared with actual measurements. The proposed methodology is expected to contribute to developing safety diagnostic methods applicable to general underground structures in practical field conditions.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.2
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• pp.529-541
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• 2003

Yukmijihwang-tang has been widely used as an and-aging herbal medicine for hundred years in Asian countries. Numerous studies show that Yukmijihwangtang has anti-oxidative effect both in vivo and in vitro. It has been reported that Moutan Cortex Radicis extract (MCR) was the most effective herb in Yukmijihwang-tang on undifferentiated PC12 cells upon oxidative-stressed with hydrogen peroxide. The purpose of this study is to; 1) evaluate the recovery of neuronal damage by assessing the anti-oxidant effect of MCR on PC12 cells differentiated with nerve growth factor (NGF), 2) identify candidate genes responsible for anti-oxidative effect on differentiated PC12 cells by oligonucleotide chip microarray. PC12 cells, which were differentiated by treating with NGF, were treated without or with hydrogen peroxide in the presence or absence of various concentration of MCR. Cell survival was determined by using MTS assay. Measurement of intracellular reactive oxygen species (ROS) generation was determined using the H2DCFDA assay The viability of cells treated with MCR was significantly recovered from stressed PC12 cell. In addition, wide rage of concentrations of MCR shows dose-dependent inhibitory effect on ROS production in oxidative-stressed cells. Total RNAs of cells without treatment(Control group), only treated with H₂O₂ (stressed group) and treated with both H₂O₂ and of MCR (MCR group) were isolated, and cDNAs was synthesized using oligoT7(dT) primer. The fragmented cRNAs, synthesized from cDNAs, were applied to Affymetrix GeneChip Rat Neurobiology U34 Array. mRNA of Calcium/calmodulin-dependent protein kinase II delta subunit(CaMKII), neuron glucose transporter (GLUT3) and myelin/oligodendrocyte glycoprotein(MOG) were downregulated in Stressed group comparing to Control group. P2X2-5 receptor (P2X2R-5), P2X2-4 receptor (P2X2R-4), c-fos, 25 kDa synaptosomal attachment protein(SNAP-25a) and GLUT3 were downregulated, whereas A2 adenosine receptor (A2AR), cathechol-O-methyltransferase(COMT), glucose transporter 1 (GLUT1), EST223333, heme oxygenase (HO), VGF, UI-R-CO-ja-a-07-0-Ul.s1 and macrophage migration inhibitory factor (MIF) were upregulated in MCA group comparing to Control group. Expression of Putative potassium channel subunit protein (ACK4), P2X2A-5, P2X2A-4, Interferon-gamma inducing factor isoform alpha precursor (IL-18α), EST199031, P2XR, P2X2 purinoceptor isoform e (P2X2R-e), Precursor interleukin 18 (IL-18) were downregulated, whereas MOO, EST223333, GLUT-1, MIF, Neuronatin alpha, UI-R-C0-ja-a-07-0-Ul.s1, A2. adenosine receptor, COMT, neuron-specific enolase (NSE), HO, VGF, A rat novel protein which is expressed with nerve injury (E12625) were upregulated in MCR group comparing to Stressed group. The results suggest that decreased viability and AOS production of PC12 cell by H₂O₂ may be, at lease, mediated by impaired glucose transporter expression. It is implicated that the MCR treatment protect PC12 cell from oxidative stress via following mechanisms; improving glucose transport into the cell, enhancing expression of anti-oxidative genes and protecting from dopamine cytotoxicity by increment of COMT and MIF expression. The list of differentially expressed genes may implicate further insight on the action and mechanism behind the anti-oxidative effects of herbal extract Moutan Cortex Radicis.

• The Journal of Internal Korean Medicine
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• v.16 no.2
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• pp.146-177
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• 1995

The purpose of this study was to investigate the relationship between the teeth and Zhang-Fu(臟腑), dental diseases, and the hygiene of the mouth through the literature of oriental medicine. First, the relatonship between the teeth and Zhang-Fu is reviewed as follows: The teeth are influenced by Shen(腎) because they are the end of bone and Biao(標) of Shen. Gingiva is related to Wei(胃) and Da-Chang(大腸) because it is passed by Yangming-Channel(陽明經). The growth and nutrition of teeth depends on Shen. The pathological condition of Shen causes the gingival atrophy, the loose of teeth, dedentition due to aging, withering of teeth, and tartar: whereas the pathological condition of Wei and Da-Chang causes toothache, gingivitis, inflamed gums, bad breath, and gingival hemorrhage. Second, the causes and therapies of dental diseases through the literature can be summarized as follows: The major causes of toothache are the pathogenic condition of wind-heat and wind-cold, the heat syndrome of Wei, the damp-heat of intestine, flaring-up of fire of deficiency type, rotten tooth, etc... The principal causes of dedentition and the shaking and loose of teeth are the deficiency of Shen, and the rest of causes are the damp-heat of Yangming. Gingival atrophy is caused by the deficiency of Shen, whereas the gingival hemorrhage comes from the factors in the pathogenic factor of wind-heat of Yangming-Channel, the heat syndrome of stomach, and the deficiency of Shen. The causes of grinding of teeth during sleeping are stomach-heat, and the delayed dentition and the withering result from the deficiency of Shen-Jing.(腎精) The principal therapies of toothache are removing wind and heat, clearing away heat and prompting diuresis, clearing away the stomach-heat, replenishing vital essence to tonify the Shen, relieving superficial syndrome by wind-cold, and alleviating pain by destroying parasites. For the prescription of the principal therapies, there are Xijio Dihuang Tang, Jiajian Ganlu Yin, Qufeng Wan, Qingwei San, Tiaowei Chenggi Tang Shengong Wan, Liangge San Qingwei Tang Yunu Jian, Liuwei Dihuang Wan Zuogui Yin Bawei Wan Wanshao Dan, Xixin San Badou Wan Gianghuo Fuzi Tang, Jiuzi Tang Badou Wan, etc... The therapies of dedentition and the shaking and loose of teeth are replenishing vital essence to tonify the Shen, and warming and recuperating the Shen-Yang: as the prescription, there are Liuwei Dihuang Wana Zuogui Yin, and Bawei Wan Anshen Wan Wanshao Dan Yougui Wan etc... The therapies of gingival hemorrhage are clearing away the stomach-heat, replenishing vital essence to tonify the Shen, warming and recuperating the Shen-Yang(腎陽), and moisturing and purging intence heat with the prescription of Tiaowei Chenggi Tang Xijiao Dihuang Tang, Liuwei Dihuang Wan Zuogui Yin, Bawei Wan Anshen Wan, and Yunu Jian. The therapy of gingival atrophy is replenishing vital essence to tonify the Shen in the prescription of Liuwei Wan Bawei Wan Ziyin Dabu Wan. The therapies of grinding of teeth during sleeping are clearing away the stomach-heat and purging intense heat, and invigorating the spleen through eliminating dampness in the prescription of Qingwei San, Wumei Wan, etc... The therapy of delaed dentition is replenishing vital essence to tonify the Shen with the prescription of Liuwei Wan Buyin Jian, etc... Third, clinical treatment reports of dental diseases are reviewed as follows: The toothache due to stomach-heat was treated by medical herbs like Gypsum, Natrir Sulfas, Rehmanniae, Schizonepetal Herba, Menthae Folium, Cimicifugae Rhizoma, and Scrophulariae Radix. The therapies of toothache due to flaring-up of fire in deficiency type from deficiency of Shen provided with replenishment of vital essence to tonify the Shen and clean ministerial fire, and the prescription was the kind of Liuwei Wan, which worked very well. The therapy of dedentition and loose of teeth due to deficiency of Shen was done to stablize the teeth as tonifing the Shen with the prescription of Guchi Wan. The rate of imrovement was over 90%. The destruction of periodontal tissue due to periodonititis was cured of dispelling wind, reducing heat, and alleviating pain, It was improved by taking Zizhi Xingiong Tang, Guchi Xiaotong San, Yunii Jian, and Qingwei San about 3-7 days, and the rate of improvement was over 80%. Fourth, the prevention and regimens are reviewed as follows: As a physical and breathing exercise of the teeth, tapping teeth which stimulates the circulation of Qi(氣) and Xue(血) had been used. The tapping time of 14, 17, 36, etc... has been reported, and it should be applied based on the body condition. The medical herbs for gargling and brushing teeth have been used. Specifically, Cimicifugae Rhizoma, Gypsum, Gypsum Fibrosum, and Indigo pulrelrata Lereis have been used to reduce heat, Coptidis Rhizama and Yang Jinggu to eliminate damp-heat, Amomi Semen, Cyperi Rhizoma, Flos Caryophylli, Asari Radix, Piperis Longi Fructus, Santali Albae Lignum, Meliae Fructus, Moschus, Aquillaiae Lignum, and Borneol to promote the circulation of Qi and to relieve pain, Ligustici Radix, Angelice Radix, Rhizoma Nardostachydis, Tribuli Semen to relieve superficial syndrome by means of diaphiresis, and Cnidii Rhizoma, Angelicae sinensis Radix, and Olibanum to promote blood circulation to stop pain.