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Protective Effects of Ginsenosides on Cyanide-induced Neurotoxicity in Cultured Rat Cerebellar Granule Cells

  • Seong, yeon-Hee;Koh, Sang-Bum;Jo, Soon-Ok
    • Journal of Ginseng Research
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    • v.24 no.4
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    • pp.196-201
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    • 2000
  • Effects of ginsenosides on NaCN-induced neuronal cell death were studied in cultured rat cerebellar granule cells. NaCN produced a concentration-dependent (1-10 mM) reduction of cell viability (measured by frypan blue exclusion test), that was blocked by N-methyl-D-aspartate receptor antagonist (MK-801) and L-type Ca$\^$2+/ channel blocker (verapamil). Pretreatment with ginsenosides (Rb$_1$, Rc, Re, Rf and Rg$_1$) significantly decreased the neuronal cell death in a concentration range of 0.5∼5$\mu\textrm{g}$/ml. Ginsenosides Rb$_1$ and Rc (5 $\mu\textrm{g}$/ml) inhibited glutamate release into medium induced by NaCN (5 mM). NaCN (1 mM)-induced increase of [Ca$\^$2+/], was significantly inhibited by the pretreatment of Rb$_1$ and Rc (5 $\mu\textrm{g}$/ml). Other ginsenosides caused relatively little inhibition on the elevation of glutamate release and of (Ca$\^$2+/). These results suggest that the NaCN-induced neurotoxicity was related to a series of cell responses consisting of glutamate release and [Ca$\^$2+/]i elevation via glutamate (NMDA and kainate) receptors and resultant cell death, and that ginsenosides, especially Rb$_1$ and Rc, prevented the neuronal cell death by the blockade of the NaCN-induced Ca$\^$2+/influx.

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DEVELOPMENT OF THE READOUT CONTROLLER FOR INFRARED ARRAY (적외선검출기 READOUT CONTROLLER 개발)

  • Cho, Seoung-Hyun;Jin, Ho;Nam, Uk-Won;Cha, Sang-Mok;Lee, Sung-Ho;Yuk, In-Soo;Park, Young-Sik;Pak, Soo-Jong;Han, Won-Yong;Kim, Sung-Soo
    • Publications of The Korean Astronomical Society
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    • v.21 no.2
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    • pp.67-74
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    • 2006
  • We have developed a control electronics system for an infrared detector array of KASINICS (KASI Near Infrared Camera System), which is a new ground-based instrument of the Korea Astronomy and Space science Institute (KASI). Equipped with a $512{\times}512$ InSb array (ALADDIN III Quadrant, manufactured by Raytheon) sensitive from 1 to $5{\mu}m$, KASINICS will be used at J, H, Ks, and L-bands. The controller consists of DSP(Digital Signal Processor), Bias, Clock, and Video boards which are installed on a single VME-bus backplane. TMS320C6713DSP, FPGA(Field Programmable Gate Array), and 384-MB SDRAM(Synchronous Dynamic Random Access Memory) are included in the DSP board. DSP board manages entire electronics system, generates digital clock patterns and communicates with a PC using USB 2.0 interface. The clock patterns are downloaded from a PC and stored on the FPGA. UART is used for the communication with peripherals. Video board has 4 channel ADC which converts video signal into 16-bit digital numbers. Two video boards are installed on the controller for ALADDIN array. The Bias board provides 16 dc bias voltages and the Clock board has 15 clock channels. We have also coded a DSP firmware and a test version of control software in C-language. The controller is flexible enough to operate a wide range of IR array and CCD. Operational tests of the controller have been successfully finished using a test ROIC (Read-Out Integrated Circuit).

A Study on the Necessity of the Resurrection of Administration Organization for the Realization of Super Nation of Maritime and Fishery (해양강국 실천을 위한 행정조직 부활의 필요성 연구)

  • Kim, Hong-Seop
    • Journal of Korea Port Economic Association
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    • v.27 no.4
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    • pp.313-346
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    • 2011
  • The Roman thinker, Cicero said, "The Nations that rule the sea, rule the world". In the world history, the countries done critical roles, have emphasized the importance of the sea. The world history is called as the histories of the countries which governed the sea, such as Phoenicia, Greece, Carthago, Roma, Portugal, Spain, England, and USA. The sea is not only the political, economical, social and cultural basis, serving as the origin of resources and channel of communication, logistics and distribution but also the area of dreams and imaginations and ground of potentiality and visions. This paper reviewed the major countries and their histories to realize the vision of Korea, super power country of maritime and fishery. Main maritime policies and its core issues and prospects of Korea were reviewed. And on the basis of these reviews, the vision of super power country of maritime and fishery was suggested. The vision, the 5th super power country of maritime and fishery in 2020, and 10th country of maritime technology level in 2020 and their details were proposed also. For achieving the vision, the resurrection of MOMAF is necessary and its reasons and 5 necessities were suggested. And the directions of the resurrection of MOMAF were proposed in terms of two viewpoints, policy/functional and institutional basis. I think Korea, the super power country of maritime and fishery, can be realized only when MOMAF may be resurrected.

AWG device characteristic dependence on the fabrication error limit (도파폭 공정오차에 따른 광도파 특성변화와 소자성능 저하)

  • 박순룡;오범환
    • Korean Journal of Optics and Photonics
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    • v.10 no.4
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    • pp.342-347
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    • 1999
  • As the waveguide width and the radius of curvature get smaller for the effort of monolithic fabrication of integrated photonic devices, the waveguide characteristics change significantly according to the change of the waveguide width or the radius of curvature. Especially, variation of the waveguide width due to fabrication process errors induces a phase error for each waveguide from the change of the propagation constant. Therefore, it is important to quantify these variation effects on the device characteristics for the design and fabrication of highly integrated photonic devices. Here, we analyze four different types of waveguides to get general characteristics in propagation constant change by utilizing the effective index method and the analytic solution method. Futhermore, the output characteristics of two AWG(Arrayed Waveguide Grating) devices are simulated by a highly-functional computer code. The simulated results have been found to be similar to the realistic device characteristics. The required fabrication error limit for the ridge-type InP-AWG device should be smaller than 0.02 ${\mu}{\textrm}{m}$ to get better channel crosstalk than-25 dB, while the required fabrication error limit for rib-type silica-AWG devices may be allowed up to 0.1 ${\mu}{\textrm}{m}$ to obtain better crosstalk than -30 dB.

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Origin and Distribution of Cut and Fill Structures in the Southwestern Margin of Ulleung Basin, East Sea (동해 울릉분지 남서주변부에 발달하는 침식충전구조의 기원 및 분포)

  • Park, Yong Joon;Kang, Nyeon Keon;Yi, Bo Yeon;Yoo, Dong Geun
    • Geophysics and Geophysical Exploration
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    • v.18 no.2
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    • pp.39-53
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    • 2015
  • Analysis of multi-channel seismic reflection profiles acquired from the southwestern margin of Ulleung Basin reveals that the cut and fill structures, which show U-shaped or V-shaped morphology, occur on variable size. The cut and fill structure mostly consists of fine-grained sediments on the well data and is characterized by transparent or semitransparent seismic facies on the seismic section. Such cut and fill structures dominantly occur in the syn-compressional megasequence (MSQ3), which was deposited during basin deformation of late Miocene, among the four megasequences of the study area. These cut and fill structures can be divided into three groups based on their size and formation time. The cut and fill structures of Group I were formed when Dolgorae structure was active, and occurred on a small scale. The cut and fill structures of group II were formed when both Dolgorae structure and Gorae V structure were active, and the number and size of those increased compared with group I. The cut and fill structures of group III were formed when Dolgorae structure was weaken gradually but Gorae V structure kept active, and the number and size of those decreased in comparison with group II. Consequently the cut and fill structures in the southwestern margin of Ulleung basin are interpreted as submarine canyon based on spatial distribution, size and fill sediment. They were controlled by the tectonic movement in response to basin closure and tectonic-induced sediment supply variation.

Performance Analysis of a Cell - Cluster - Based Call Control Procedure for Wireless ATM Networks (셀집단화 방식에 근거한 무선 ATM 호제어절차의 성능분석)

  • Cho, Young-Jong;Kim, Sung-Soo
    • The Transactions of the Korea Information Processing Society
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    • v.4 no.7
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    • pp.1804-1820
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    • 1997
  • In this paper, an efficient call control procedure is presented for next generation wireless ATM networks and its performance is mathematically analyzed using the open queueing network. This procedure is based on a new scheme called as the cell clustering. When we use the cell clustering scheme, at the time that a mobile connection is admitted to the network, a virtual cell is constructed by choosing a group of neighboring base stations to which the call may probabilistically hand over and by assigning to the call a collection of virtual paths between the base stations. Within a microcell/picocell environment, it is seen that the cell clustering can support effectively a very high rate of handovers, provides very high system capacity, and guarantees a high degree of frequency reuse over the same geographical region without requiring the intervention of the network call control processor each time a handover occurs. But since mobiles, once admitted, are free to roam within the virtual cell, overload condition occurs in which the number of calls to be handled by one base station to exceed that cell site's capacity of radio channel. When an overload condition happens, the quality of service is abruptly degraded. We refer to this as the overload state and in order to quantify the degree of degradation we define two metrics, the probability of overload and the normalized average time spent in the overload state. By using the open network queueing model, we derive closed form expressions for the maximum number of calls that can be admitted into the virtual cell such that the two defined metrics are used as the acceptance criteria for call admission control.

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Study on Heat Transfer Characteristics of Internal Heat Exchanger for $CO_2$ Heat Pump under Heating Operating Condition (난방운전 조건하에서 $CO_2$ 열펌프용 내부 열교환기의 열전달 특성에 대한 연구)

  • Kim, Dae-Hoon;Lee, Sang-Jae;Choi, Jun-Young;Lee, Jae-Heon;Kwon, Young-Chul
    • Journal of Energy Engineering
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    • v.17 no.2
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    • pp.116-123
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    • 2008
  • In order to study the heat transfer, effectiveness and pressure drop of an internal heat exchanger (IHX) for $CO_2$, heat pump under heating condition, the experiment and numerical analysis were performed. Four kinds of IHXs were used. The section-by-section method and Hardy-Cross method were used for the numerical analysis. The effects of IHX on the flow rate of refrigerant, the IHX length, the operating condition of a gas-cooler and an evaporator and the type of IHXs were investigated. With increasing the flow rate, the heat transfer rate increased about 25%. The heat transfer of the micro-channel tube was larger about 100% than that of the coaxial tube. With increasing the IHX length, the heat transfer rate decreased. The low-side pressure drop was larger compared with that of the high-side. And the pressure drop of the microchannel tube was larger about 100% than that of the coaxial tube. With increasing the high-side temperature and decreasing the low-side temperature, the heat transfer rate increased about 3%. From this study, we can see that new correlation on $CO_2$ heat transfer characteristics and tube type is necessary.

A Case Study on Seismic Refraction Tomography Survey for Subsurface Structure Interpretation (지하구조 해석을 위한 탄성파 굴절법 토모그라피 탐사 사례연구)

  • 유영준;유인걸;송무영
    • The Journal of Engineering Geology
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    • v.11 no.2
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    • pp.163-174
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    • 2001
  • For quantitative evaluation of geotechnical engineering properties such as rippability and diggability, clear interpretation on the subsUJiace velocity structures should be preceded by figuring out top soil, weathered and soft rock layers, shape of basement, fracture zones, geologic boundary and etC. from the seismic refraction data. It is very important to set up suitable field parameters, which are the configuration of profile and its length, spacings of geophones and sources and topographic conditions, for increasing field data Quality. Geophone spacing of 3 to 5m is reconunended in the land slope area of house land development site. In refraction tomography technique, the number of source points should be more than a Cluarter of available channel number of instrument and the subsurface structure interpretation can be decreased the artifact of inversion by topographic effect. Compared with core logging data, it is shown that the velocity range of the soil is less than 700m/s, weathered rock 700~1,200m/s, soft rock 1,200~1,800m/s on the velocity tomogram section. And the upper limit of P-wave velocity for rippability is estimated 1,200 to 1,800m/s in land slope area of gneiss.

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Engineering Geological Characteristics of volcanic rocks of the Northwestern Cheju Island, Korea (제주도 북서부 지역 화산암체의 지질공학 특성)

  • 김영기;최옥곤
    • The Journal of Engineering Geology
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    • v.1 no.1
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    • pp.19-37
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    • 1991
  • The geology of the northwestern Cheju Island consist of Pleistocene to Holocene volcanic rocks which could be devided into basalt layers, the Sungsan Formation composed mainly of volcaniclastic debris exposed along the shoreline, and more than 30 cinder cones. Columnar joints and vesicles are dominant in the basalts of the Pyeosunri and the Sihungri basalt Formations. Volcaniclast and clay layers are intercalated in basaltic layers. When volcaniclast of the interlayers would be swept away by ground water and some caves of channel shape would be formaed. Overlying lavas cracked by columnar joints could be easily destroyed, collapsed and/or sunk. Geomechananical nature of the rocks such as strength may be controlled by the vesicularity(size, shape, and orientation of the vesicles) of the rocks. On the basis of vesicularity as a factor of strength, the effective strength ratio(Ke) could be calculated as Ke=0.3-0.72, in which the smaller Ke value reflects the lower in internal stress. In the studied area, the strength of the rocks tends to decrease as increasing in altitude of provenance of the rocks. The rocks in the area show relatively low values in angle of failure strength($\phi$) ranging from 10$^{\circ}$ to 30$^{\circ}$. In conclnsion, the rocks in question, majority of which the critical value exceeds 0.33, belong to the unstable rocks in the aspect of engineering geology.

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Analysis of the key Factors that Influence Emotional Web Design and its Effects on Brand Attitude - focus on Fastfood WebSites - (웹에서의 감성디자인이 브랜드태도에 미치는 효과와 영향요인 분석 - 패스트푸드 사이트를 중심으로 -)

  • 윤다연;이현주
    • Archives of design research
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    • v.17 no.1
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    • pp.153-162
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    • 2004
  • This paper focused on the effect of Kansei design on the web in branding as well as its influence factors. As a key of this research, it classified web users' Kansei into five categories; 1) functional Kansei, 2) sensoryKansei, 3) psychological Kansei, 4) relational Kansei and 5) cultural Kansei, and organized relevant factors. Online surveys were conducted on seven websites of the fast food brands in Korea (Lotteria, Mcdonald, BurgerKing, Popeyes, KFC, Pizza Hut, Domino's) which are targeting 463 male and females in 20s. As a result, an average of 58% responded that they had a positive Kansei experience and could enhanceits brand preference. Of the sensory Kansei, visual design factors were the one that gave the greatest effect on brand preference enhancement. Regarding the functional Kansei satisfaction, such as user convenience and access speed were also one of the most crucial variables for the whole Kansei satisfaction. Moreover, the preference enhancement brought not only a positive effect on its reliability but also its brand image and consumers' purchasing desire. Based on the survey results, the additional FGI (Focus Group Interview) had been conducted and determined \circled1 what kind of major Kansei that users wanted to have satisfied, \circled2 what type of design can give strong Kansei appeal to its users, and \circled3what design factors gave an effect on sensory emotion. In the course of this research, Itried to renew the awareness of the web importance as a major channel in non-mass interactive marketing, and suggest the effect and its possibility of emotional branding through Kansei design in the web as well as design principles of strategic Kansei design.

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