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PROTECTION EFFECT OF GINSENG EXTRACT AGAINST APOPTOTIC CELL DEATH INDUCED BY 2,2,5,5-TETRACHLOROBIPHENYL IN NEURONAL SK-N-MC CELLS

  • Lee, Ji-Young;Kim, Jae-Won;Song, Ji-Eun;Kim, Soo-Jung;Chung, Weon-Gu;Kim, Yong-Hoon;Lee, Bo-Ram;Kim, Jin-Hee;Choi, Young-Keun;Joo, Woo-Hong;Cho, Yong-Kweon;Moon, Ja-Young
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2001년도 International Symposium on Dietary and Medicinal Antimutgens and Anticarcinogens
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    • pp.112-112
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    • 2001
  • Oxidative stress plays an important role in the pathological process of neurodegenerative diseases. Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants, some of which may be neurotoxic. Our previous studies showed that 2,2',5,5'-TetracWorobiphenyl (PCB 52) induced apoptotic death in human neuronal SK-N-MC cells, which was demonstrated on gel electrophoresis by visualization of the proteolytic cleavages of $\beta$-catenin and poly (ADP-ribose) polymerase (PARP) and of the production of characteristic ladder patterns of DNA fragmentation.

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