• 제목/요약/키워드: changes in the value of family

검색결과 119건 처리시간 0.024초

Anticancer Activity of Bispidinone Derivative by Induction of Apoptosis

  • Lee, Man Gi;Kwon, Ryong
    • 대한의생명과학회지
    • /
    • 제26권4호
    • /
    • pp.336-343
    • /
    • 2020
  • The present study was carried out to investigate the possibility that bispidinone derivative makes anticancer drug availability to human cervical carcinoma cell. The B8 has the lowest IC50 value among B8, B9 and B10 which are bispidinone analogue with bromide. According to cytotoxic test through WST-8 assay, B8 shows the most magnificent cytotoxicity effectiveness with 76 μM of IC50 value. In human cervical carcinoma cell treated with B8, it noticeably controlled cellular multiplication by increase of concentration and time. Furthermore, morphological changes like cellular shrink, disruption and nuclear condensation, feature of apoptosis, are observed. Annexin V-FITC/PI double staining assay test proved that B8 can cause apoptosis. Moreover, after treatment with 76 μM of B8, flow cytometry analysis shows that increase of active oxygen species are induced and membrane potential in mitochondria is decreased. Manifestation of Bcl-2 family and caspase cascades protein provides evidence that B8 induces apoptosis through mitochondria and caspase-related pathway. Taken together, we suggested that B8 reduced membrane potential in mitochondria and induce apoptosis through the pathway depended on mitochondria and caspase.

家禮書에 나타난 혼례관 고찰 (The Study on Wedding View in Literatures of the Customary Proprieties of a Fmaily)

  • 이길표
    • 가정과삶의질연구
    • /
    • 제17권4호
    • /
    • pp.15-30
    • /
    • 1999
  • This paper aims to accomplish the work of finding and recreating factors of evelasting wedding view through studying literatures($\ulcorner$Ka-ryae$\lrcorner$.$\ulcorner$Ka-ryae-jip-ram$\lrcorner$.$\ulcorner$Sa-ryae-pyun-ram$\lrcorner$) of customary proprieties of a family The results of this study are as follows: The norm and meanings of wedding by way of education appear self-cultivation sincerity and carefulness ancestor worship morality of husband and wife filial duty to parents and parents-in-law rank and order simplicity. From this study on wedding view the efforts to accomlish the work of finding and recreating the factors everlasting inheriting value which would not be changed by social changes have to be made from now on.

  • PDF

소비자 교육프로그램의 체계화에 관한 연구 -교육내용을 중심으로- (On systematizing the Educational Programs for Consumers- With Special Attention to the Contents of Education-)

  • 박재선;문숙재
    • 가정과삶의질연구
    • /
    • 제3권1호
    • /
    • pp.51-67
    • /
    • 1985
  • The purpose of the present paper is to review the content of the Consumer Education Programs, is to establish a hypothetical model regarding the contents of the consumer Education programs, and is also to analyze the contents of the Consumer Education Programs seen from the various angles of the value of our home life. For this, we have researched literatures and habe made the hypothetical model for the desirable contents of the consumer education programs, and also have conducted a case study together with and analysis bearing the actual evidence. Form what we have studied regarding the results of the research, conclusions that can be derived are as follows; First, the contents of the consumer education programs of Korea are not sufficient to improve the quality of the environments of our houses, family life, and decision making. Secondly, the contents of the consumer education do not meet the societal and economic changes. Third, since the contents of the consumer program of Korea emphasize the theory-oriented discussion, they are not suitable to educate the consumers who are really in need of consumer education.

  • PDF

횡단면 자료를 이용한 가구소비 결정요인에 관한 연구 - 유동성 제약과 가구별 특성을 중심으로 - (Exploration into the Determinants of Household Consumption: Liquidity Constraint and Family Characteristics)

  • 허석균
    • KDI Journal of Economic Policy
    • /
    • 제27권1호
    • /
    • pp.1-38
    • /
    • 2005
  • 본 연구는 유동성제약과 가구별 특성을 고려한 가구소비함수의 추정을 목적으로 한다. 우리나라의 횡단면 자료인 "가구소비실태조사"를 이용하여 분석한 결과 가구원수, 가구 내 취업자 및 취학 아동수, 가구주의 교육수준 및 연령 등으로 표현되는 가구별 특성이 소비결정에 유의하게 작용함을 알 수 있다. 특히, 가구원수가 소비결정에 미치는 영향이 지대한 것으로 나타났는데, 이는 가구원수가 가구소득의 생애주기와 관련되어 있을 뿐 아니라 소비규모를 결정함에 있어서도 직접적인 영향을 미치기 때문인 것으로 보인다. 반면 가구원수 이외의 가구특성 변수들은 소비결정에 직접적으로 작용하기보다는 소득의 변화를 통해 간접적으로(하지만 여전히 유의하게) 소비에 영향을 미친다. 또한 본 연구에서는 유동성제약의 존재 유무를 판별하는 기존의 연구와는 달리 유동성제약의 강도를 파악하는 데 초점을 맞춤으로써 소비함수 추정식의 설명력을 획기적으로 높일 수 있었다. 유동성제약의 강도는 인적자본의 현재가치를 가구별 특성의 함수로 상정한 후 그 가치가 자본시장에서 과소평가되는 정도를 살펴봄으로써 측정된다. 이렇듯 유동성제약의 강도를 구분하는 추정방식은 현실에 존재하는 여러 형태의 자산들을 유동성을 기준으로 하여 세분할 수 있도록 도와준다. 끝으로 본 연구에서는 사용된 소비함수 추정식을 이용하여 외환위기 이후 우리나라 유동성제약의 완화 경향을 확인하고 이에 따른 소비불평등도의 감소를 횡단면 분산분해방식을 이용하여 같은 기간의 소득불평등도 증가 및 가구특성 변화 현상과 분리하여 논의한다.

  • PDF

기혼여성의 출산의향에 영향을 미치는 요인에 관한 연구 (A Study on the Effects of Married Women's Intention of Childbirth)

  • 은선경;박효진
    • 한국산학기술학회논문지
    • /
    • 제21권4호
    • /
    • pp.210-217
    • /
    • 2020
  • 본 연구의 목적은 배우자의 가사노동시간, 결혼만족도, 자녀에 대한 가치관, 전통적 성역할, 저출산 관련 사회서비스 정책이 기혼여성의 출산의향에 영향을 미치는지를 파악하고자 함에 있다. 기혼여성 1,000명을 대상으로 설문을 조사하였으며, 이중에서 향후 출산의향이 있다고 응답한 482명을 대상으로 로지스틱 회귀분석을 수행하였으며, 연구결과는 다음과 같다. 인구사회학적 요인으로서 연령이 유의미하였는데, 연령이 낮을수록 출산의향이 높았다. 또한 가족에 관련한 변인을 보면, 자녀 수, 배우자의 가사노동시간, 결혼만족도가 유의미한 변인으로서 자녀 수가 적을수록, 배우자가 가사노동에 할애하는 시간이 많을수록, 결혼만족도가 높을수록 출산의향이 높았다. 그리고 자녀에 대한 가치관, 출산지원정책에 대한 인지도가 영향을 미치는 요인으로 나타났는데, 잔에 대해 긍정적인 가치를 부여하고 있을수록, 정부의 출산지원정책에 대한 인지정도가 낮을수록 출산의향이 높았다. 특히 정부의 출산지원정책에 대한 인지도는 출산휴가와 난임지원에 집중되어 있었고 다른 정책에 대해 잘 모르는 경우가 많았다. 따라서 출산의향을 증진시키기 위해서 성역할과 가사노동에 대한 배우자의 분담에 대한 인식의 개선과 인식변화의 이행을 위한 일-가정양립 지원체계의 강화, 그리고 난임지원에 대한 확대 및 저출산관련 서비스정책에 대한 홍보 강화가 필요하다.

농촌여성의 생활실태분석과 생활만족도에 영향을 미치는 요인 (A Study on the Living Conditions of Rural Women and the Determinants of Their Life Satisfaction)

  • 배정인;박응임;이혜상;안건미;정운선
    • 한국지역사회생활과학회지
    • /
    • 제24권4호
    • /
    • pp.485-495
    • /
    • 2013
  • As rural life has shifted with the long term changes in the internal and external conditions of rural communities, this study aims to investigate the living conditions and life satisfaction of rural women. 70 questionnaires in health, clothing, food, shelter, economic conditions and child-rearing fields were used for a survey of 393 rural women from five rural areas in the northern region of Gyeongsangbuk-Do. Statistical techniques of frequency analysis, descriptive statistics, ANOVA, t-test and regression analysis were employed through 'SPSS Statistics 21'. Participants were divided into 3 groups, with Group A with income less than 15 million won, Group B with income of at least 15 million won and less than 30 million won, and Group C with at least 30 million won. For the life satisfaction and health conditions, Group C showed higher scores than Group A. The food security status of rural women in the research area was worse than that in the Korea National Health and Nutrition Examination Survey, and food consumption by Group C was higher than that of Group A and Group B. For the satisfaction of kitchen, bathroom facilities and heating system, the income of 15 million won seemed to be the divisive value where richer groups were more satisfied. Job satisfaction seemed more related with the income amount rather than with the job itself. The parenting efficacy and child-rearing satisfaction were higher for Group C than for Group A. Determinants of life satisfaction turned out to be health conditions, heat susceptibility, fruit consumption, kitchen unit satisfaction, job satisfaction and parenting efficacy.

혈액투석 환자의 자기관리 수행도와 이에 영향을 미치는 요인 (Self-Care and Associating Factors in Hemodialysis Patients)

  • 전진호;강혜경
    • 보건교육건강증진학회지
    • /
    • 제16권1호
    • /
    • pp.149-166
    • /
    • 1999
  • Self-care and the performance of their own role might be important for the prevention of complications and improvement of quality of life in hemodialysis patients with chronic renal failure(CRF). To improve well-being and quality of life for the patients, the author estimated the level of self-care and associating factors through a questionnaire. The information was composed of the knowledge for hemodialysis and renal disease, the level of self-care, health belief, supports from the family, disease-related stresses, personal characteristics, medical history, relationships with medical personnel, etc. The data was gathered from 126 hemodialysis patients who were undergoing hemodialysis in one university hospital and five hospitals in Kyungsangnam-Do area from December 1997 to January 1998, and was analyzed by PC SAS program(version 6.12) with the level of significance($\alpha$=0.05). The mean age of subjects was 47.0$\pm$13.5years with no significant difference in gender distribution. The mean duration of hemodialysis was 39.0 months, and their frequencies of hemodialysis were more than three times per week(77.0%). Only 21.4% had the specific education on hemodialysis and CRF. In the level which was expressed as the score out of 100, the mean of knowledge was 90.7$\pm$9.1 and the mean of self-care was 73.9$\pm$12.7, that means, they only partially carried their knowledge into practice. They showed a significant correlation between knowledge and health belief($\gamma$=0.282); self-care and health belief($\gamma$=0.357), family supports and knowledge($\gamma$=0.221), self-care($\gamma$=0.402), health belief($\gamma$=0.431); and health belief and stress($\gamma$=-0.361). Age, religion, marrital status, education, and relationships with medical personnel showed positive correlations, and smoking showed negative correlation with self-care. In the multiple regression with the level of self-care as dependent variable, and each of the characeristics as independent variables, supports from the family($\beta$=6.615=0.158), the experience of disease specific education($\beta$=4.959), relationships with medical personnel($\beta$=6.615), current smoking($\beta$=-6.986), and current drinking ($\beta$=-7.095) were detected as significant factors. The value of R-square was 34%. In summary, to promote the level self-care and to improve the well beings and Quality of life for the hemodialysis patients, it would be emphasized that they terminate smoking and drinking, and it would be recommended that the education programs and supports from the family be strengthened. And, because there was a considerable difference between the level of knowledge and self-care, it would also be emphasized to propose the education programs which focused on execution. In addition to that, there is a need to improve relationships between the patients and medical personnel through positive changes in the attitudes of the medical personnel.

  • PDF

중년후기 여성의 건강증진행위 모형구축 (A Model for Health Promoting Behaviors in Late-middle Aged Woman)

  • 박재순
    • 여성건강간호학회지
    • /
    • 제2권2호
    • /
    • pp.298-331
    • /
    • 1996
  • Recent improvements in living standard and development in medical care led to an increased interest in life expectancy and personal health, and also led to a more demand for higher quality of life. Thus, the problem of women's health draw a fresh interest nowadays. Since late-middle aged women experience various physical and socio-psychological changes and tend to have chronic illnesses, these women have to take initiatives for their health control by realizing their own responsibility. The basic elements for a healthy life of these women are understanding of their physical and psychological changes and acceptance of these changes. Health promoting behaviors of an individual or a group are actions toward increasing the level of well-being and self-actualization, and are affected by various variables. In Pender's health promoting model, variables are categorized into cognitive factors(individual perceptions), modifying factors, and variables affecting the likelihood for actions, and the model assumes the health promoting behaviors are affected by cognitive factors which are again affected by demographic factors. Since Pender's model was proposed based on a tool broad conceptual frame, many studies done afterwards have included only a limited number of variables of Pender's model. Furthermore, Pender's model did not precisely explain the possibilities of direct and indirect paths effects. The objectives of this study are to evaluate Pender's model and thus propose a model that explains health promoting behaviors among late-middle aged women in order to facilitate nursing intervention for this group of population. The hypothetical model was developed based on the Pender's health promoting model and the findings from past studies on women's health. Data were collected by self-reported questionnaires from 417 women living in Seoul, between July and November 1994. Questionnaires were developed based on instruments of Walker and others' health promotion lifestyle profile, Wallston and others' multidimensional health locus of control, Maoz's menopausal symptom check list and Speake and others' health self-rating scale. IN addition, items measuring self-efficacy were made by the present author based on past studies. In a pretest, the questionnaire items were reliable with Cronbach's alpha ranging from .786 to .934. The models for health promoting behaviors were tested by using structural equation modelling technique with LISREL 7.20. The results were summarized as follows : 1. The overall fit of the hypothetical model to the data was good (chi-square=4.42, df=5, p=.490, GFI=.995, AGFI=.962, RMSR=.024). 2. Paths of the model were modified by considering both its theoretical implication and statistical significance of the parameter estimates. Compared to the hypothetical model, the revised model has become parsimonious and had a better fit to the data (chi-square =4.55, df=6, p=.602, GFI=.995, AGFI=.967, RMSR=.024). 3. The results of statistical testing were as follows : 1) Family function internal health locus of control, self-efficacy, and education level exerted significant effects on health promoting behaviors(${\gamma}_{43}$=.272, T=3.714; ${\beta}_[41}$=.211, T=2.797; ${\beta}_{42}$=.199, T=2.717; ${\gamma}_{41}$=.136, T=1.986). The effect of economic status, physical menopausal symptoms, and perceived health status on health promoting behavior were insignificant(${\gamma}_{42}$=.095, T=1.456; ${\gamma}_{44}$=.101, T=1.143; ${\gamma}_{43}$=.082, T=.967). 2) Family function had a significance direct effect on internal health locus of control (${\gamma}_{13}$=.307, T=3.784). The direct effect of education level on internal health locus of control was insignificant(${\gamma}_{11}$=-.006, T=-.081). 3) The directs effects of family functions & internal health locus of control on self-efficacy were significant(${\gamma}_{23}$=.208, T=2.607; ${\beta}_{21}$=.191, T=2.2693). But education level and economic status did not exert a significant effect on self-efficacy(${\gamma}_{21}$=.137, T=1.814; ${\beta}_{22}$=.137, T=1.814; ${\gamma}_{22}$=.112, T=1.499). 4) Education level had a direct and positive effect on perceived health status, but physical menopausal symptoms had a negative effect on perceived health status and these effects were all significant(${\gamma}_{31}$=.171, T=2.496; ${\gamma}_{34}$=.524, T=-7.120). Internal health locus and self-efficacy had an insignificant direct effect on perceived health status(${\beta}_{31}$=.028, T=.363; ${\beta}_{32}$=.041, T=.557). 5) All predictive variables of health promoting behaviors explained 51.8% of the total variance in the model. The above findings show that health promoting behaviors are explained by personal, environmental and perceptual factors : family function, internal health locus of control, self-efficacy, and education level had stronger effects on health promoting behaviors than predictors in the model. A significant effect of family function on health promoting behaviors reflects an important role of the Korean late-middle aged women in family relationships. Therefore, health professionals first need to have a proper evaluation of family function in order to reflect the family function style into nursing interventions and development of strategies. These interventions and strategies will enhance internal health locus of control and self-efficacy for promoting health behaviors. Possible strategies include management of health promoting programs, use of a health information booklets, and individual health counseling, which will enhance internal health locus of control and self-efficacy of the late-middle aged women by making them aware of health responsibilities and value for oneself. In this study, an insignificant effect of physical menopausal symptoms and perceived health status on health promoting behaviors implies that they are not motive factors for health promoting behaviors. Further analytic researches are required to clarify the influence of physical menopausal symptoms and perceived health status on health promoting behaviors with-middle aged women.

  • PDF

서울시 주택 예상투자이익 추정과 영향요인에 대한 시론적 분석 - 2010-2018년 주택 실거래가를 중심으로 - (Estimation and Determinants on Residential Investment Profits in Seoul: A Focus on Housing Transaction Price from 2010 to 2018)

  • 안혜성;강창덕
    • 지역연구
    • /
    • 제36권1호
    • /
    • pp.37-50
    • /
    • 2020
  • 이 연구는 투자이론에서 활용되고 있는 토빈의 Q 개념을 적용하여 투자이익을 측정하고 이를 통해 서울 주택시장을 이해하고자 한다. 구체적으로 서울시 아파트와 연립·다세대주택을 대상으로 2010년부터 2018년까지 투자이익을 추정하고 공간계량모형을 이용하여 투자이익에 영향을 주는 요인들을 살펴보았다. 투자이익은 실거래가격에서 대체비용(토지비용+건축비용)을 빼는 방식과 실거래가격 대비 대체비용의 비율로 각각 추정하였다. 분석결과를 보면, 투자이익은 2018년으로 갈수록 더 커졌고 강남·서초구 및 한강 주변에서 투자이익이 높게 나타났으나 투자이익의 시공간적 변화양상은 아파트의 경우 뚜렷한 반면에 연립·다세대주택은 산발적·국지적으로 나타났다. 공간계량모형 분석결과는 주택유형과 상관없이 고밀·신축개발이 많은 지역에서 투자이익이 높았다. 이 연구의 접근방법과 결과는 향후 주택 공급 정책, 투자이익 환수, 지역 경쟁력 측정, 가격 거품 측정 등에 대한 논의를 위한 기초 자료가 될 것이다.

The Effects of Peroxiredoxin III on Human HeLa Cell Proliferation

  • Choi, Soonyoung;Kang, Sangwon
    • IMMUNE NETWORK
    • /
    • 제3권4호
    • /
    • pp.276-280
    • /
    • 2003
  • Background: Peroxidases (Prx) of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol respectively. Hydrogen peroxide is implicated as an intracellular messenger in various cellular responses such as proliferation and differentiation. And Prx I activity is regulated by Cdc-2 mediated phosphorylation. This work was undertaken to investigate the proliferation role of peroxiredoxin III as a member of Prx family in Prx III overexpressed HeLa cell line. Methods: To provide further evidence of proliferation, we selected Prx III stably expressed HeLa Tet-off cell lines. Cell proliferation was examined by using proliferation reagent WST-1 in the presence or absence of doxycycline. Prx III, 2-cys Prx enzymes exist as homodimer. The activation of Prx III heterodimer with induced and endogenous Prx III was examined by immunoprecipitation. Results: Immunoprecipitation analysis of the induced and endogenous Prx III with anti-myc showed that the induced wild type (WT) and dominant negative (DN) Prx III from HeLa Prx III Tet-off stable cell heterodimerized with endogenous Prx III each other. And the expression level of induced Prx III was examined after addition of doxycycline. By 72 hr, the expression level of induced Prx III was diminished gradually and the half-life of the induced wild type Prx III was approximately 17 hr. The proliferation experiment demonstrated that the relative proliferation value of induced and endogenous WT Prx III stable cell has no changes but the DN Prx III induced HeLa Tet-off stable cells were lower than endogenous Prx III. Conclusion: In conclusion, the HeLa dominant negative Prx III Tet-off stable cells were decreased the proliferation.