• 대한한방내과학회지
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• 제31권3호
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• pp.578-585
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• 2010

Objectives : Coldness of hands and feet has been regarded to be associated with blood circulation. This study was performed to assess the correlation between erythrocyte deformability and coldness of hands and feet. Methods : 145 patients who had taken an erythrocyte deformability test were selected for this study among hospitalized patients within 4 weeks after their cerebral infarction at the Internal Medical Department at Kyunghee Oriental Medical Center from August 2008 to August 2009. We divided the selected patients into two groups, with and without of coldness of hands and feet groups. The two groups were compared on risk factors for atherosclerosis and examined for variables including erythrocyte deformability. Results : 1. On demographic variables of the patients, only body mass index was significantly lower in the coldness of hands and feet group than the control group. There was no significant difference of the rate of hypertension, diabetes mellitus, hyperlipidemia, ischemic heart disease, smoking, drinking and carotid artery stenosis between the two groups. 2. According to blood test, the coldness of hands and feet group showed significantly lower erythrocyte deformability index than the control group. 3. Body mass index and erythrocyte deformability index showed a close relationship with coldness of hands and feet in multivariate analysis. Conclusions : The correlation between the erythrocyte deformability and coldness of hands and feet in cerebral infarction patients were decreased erythrocyte deformability participated in the mechanism of coldness of hands and feet.

• 대한한방내과학회지
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• 제28권1호
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• pp.34-46
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• 2007

Objectives: This study was to assess characteristics in acute stroke patients according to Sasangconstitution (SC). Methods : We assessed the type of SC of acute stroke patients in $2^{nd}$ Department of Internal Medicine at KyungHee University Oriental Hospital from October 2005 to September 2006. Each subject's SC type was confirmed when the result of QSCC II+ was in accordance with the opinion of the Sasangconstitutional medicine specialist. We investigated general characteristics, stroke type, blood test results, alcohol drinking, smoking and dietary preferences according to SC. Results: 108 subjects were included in the final analysis. This study showed that out of the total patients, the proportion of So-yang to Tae-eum to So-eum was equal to 5.5 to 3.5 to 1. Especially, men were higher proportion So-yang while women recorded a more significant ratio of Tae-eum. Also, the BMI, waist circumference, hip circumference, and WC/HC ratio recorded significantly high results. The result indicated that even though the Tae-eum let on the highest numerical value in the aspect of their past history and the final diagnosis, no significant difference was revealed according to SC. The ratio of cerebral infarction to cerebral hemorrhage was 9 to 1. SVO, LAA, SUE are the 3 types of cerebral infarction classified by TOAST; SVO ranked the highest while SUE ranked the lowest in all constitutions. The blood test result displayed that averages of both TL and the T-chol were the highest in Tae-eum while that of hematocrit in So-yangand that of HDL-chol in So-eum. However, there was no significant difference. There were no significant differences classified by gender or by SC in the aspect of the alcohol drinking and smoking history. The majority of So-yang and Tae-eum demonstrated a preference for meat while So-eum and So-yang displayed high preferences for sea food. Conclusions : With respect to these results. we could observe the general disposition of various characteristic distributions according to SC of acute stroke patients. For further research in this field. it seems necessary to construct fundamental databases for the prevention and treatment of stroke by increasing the number of patients observed and by analyzing delicate characteristics of each constitution type.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2005년도 생물공학의 동향(XVII)
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• pp.870-870
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• 2005

• 동아시아식생활학회지
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• 제15권3호
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• pp.283-291
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• 2005

This study was penonned to provide basic data that predict the usefulness of Gastrodiae rhizoma as food materials for oriental medicinal cuisine(YakSun). We measured the changes of regional cerebral blood flow(rCBF) and blood pressure(BP) in rats, following the intravenous injection of Gastrodiae rhizoma water extract The measurement was continually monitored by laser-doppler flowmeter and pressure transducer in anesthetized adult Sprague-Dawley rats for about two to two and half hours through the data acquisition system composed of MacLab and Macintosh computer. The results of this experiment were as follows. Gastrodiae rhizoma increased the changes of rCBF in rats significantly. The rCBF of Gastrodiae rhizoma did not change by pretreated propranolol, atropin, methylene blue and indomethacin. But the rCBF of Gastrodiae rhizoma was increased by pretreated L-NNA. Gastrodiae rhizaoma decreased the changes of BP significantly. The BP of Gastrodiae rhizoma did not change by pretreated propranolol, atropin, methylene blue and indomethacin. But the BP of Gastrodiae rhizoma was decreased by pretreated L-NNA. These results indicated that Gastrodiae rhizoma might increase the rCBF and the BP which related to nitric oxide synthesis. Also these results indicate that Gastrodiae rhizoma can be used as a safe and clinically applicable to diet therapy of cerebral cardiovascular disease.

• 한국임상약학회지
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• 제27권3호
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• pp.136-142
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• 2017

Background: Dementia is one of important social and economic healthcare issues in the aging age. Therefore, it signifies to analyze the relationship between chronic disease or cardiovascular drug use and the incidence of dementia to establish a basis for increasing or preventing the risk of dementia. The purpose of this study was to investigate the correlation between the prevalence of chronic diseases and the use of cardiovascular drugs in patients diagnosed with dementia. Methods: In this study, we used data from sample of elderly patients from the Health Insurance Review and Assessment Service. We analyzed by logistic regression analysis with age, gender, and medication as covariates. KCD-7 was used to diagnosis of the disease, and drugs were analyzed using ATC codes and Korean standardized drug classification codes. Results: A total of 1,276,331 patients were analyzed in the sample of the elderly population, of which 532,075 (41.7%) were male and 744,256 (58.3%) were female. The patients have the higher risk of dementia in the older, women, and lower socioeconomically status. Cerebral infarction and ischemic heart disease increases risk of dementia. Patients taking statins, angiotensin converting enzyme inhibitor (ACEI) or angiotensin II receptor antagonists (ARB) showed low incidence of dementia. Conclusion: This study has been shown that ACEI, ARB, and statin drugs may associate with lower incidence of Alzheimer's and other dementia except vascular dementia.

• 한국임상약학회지
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• 제29권2호
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• pp.109-114
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• 2019

Background: Rheumatoid arthritis (RA) is a systemic inflammatory disease that manifests as joint damage or athletic disability via sustained inflammation of the synovial membrane. The risk of cardiovascular disease (CVD) is higher in RA patients. This study aimed at evaluating the association between CVD comorbidities and RA by comparing a pharmacotherapy group with a non-pharmacotherapy group. Methods: Patient sample data from the Health Insurance Review and Assessment Service (HIRA-NPS-2016) were used. Inverse probability of treatment weighting (IPTW) using the propensity score was used to minimize the differences in patient characteristics. Logistic regression analysis was used to evaluate the risk of CVD comorbidities. Results: The analyses included 1,207,213 patients, of which 33,122 (2.8%) had RA. The odds ratios (OR) of CVD comorbidities were increased in RA patients; ischemic heart disease (IHD: OR 1.75; 95% CI 1.73, 1.77), cerebral infarction (CERI: OR 1.28; 95% CI 1.26, 1.30), hypertension (HTN: OR 1.44; 95% CI 1.43, 1.45), diabetes mellitus (DM: OR 2.04; 95% CI 2.03, 2.06), and dyslipidemia (DL: OR 3.49; 95% CI 3.47, 3.51). The ORs of IHD, CERI, HTN, and DM in the traditional DMARD and biologic treatment groups were decreased, compared with those in the non-pharmacotherapy group. Conclusions: Thus, CVD risk was higher in RA patients, considering age, sex, and socioeconomic status. Appropriate pharmacotherapy could decrease the risk of CVD comorbidities in RA patients.

• 보건교육건강증진학회지
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• 제23권2호
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• pp.109-119
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• 2006

Objectives: A number of studies in economically developed countries have shown occurrence of stroke and cardiovascular disease to be inversely related to socioeconomic class. The purpose of this study is to investigate socioeconomic differentials in stroke and cardiovascular disease mortality in Korea. Methods: Two data from two sources, registry data from National Health Insurance Corporation and death certification data from National Statistics Office, were used to calculate mortality rate for five socioeconomic classes. Poisson regression analysis was used to calculate relative indices of inequality as a measure of mortality differentials between socioeconomic classes. Results: For males, graded socioeconomic differentials in mortality were observed with higher mortality rates related to lower socioeconomic class for intracerebral hemorrhage, cerebral infarct, hypertension, ischemic heart disease, myocardial infarct, and arrhythmia. The relative index of inequality for stroke and cardiovascular disease was 1.61(95% CI=1.54-1.68). For females, these differentials were observed for arrhythmia and intracerebral hemorrhage. The relative index of inequality was 1.06(95% CI=1.02-1.11). Conclusions: This socioeconomic differential in mortality, consistent with the results of other studies performed in economically developed countries suggest that Socioeconomic class can influence mortality regardless of the developmental stage of the country.

• Journal of Chest Surgery
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• 제35권3호
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• pp.231-234
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• 2002

모야모야 병은 혈관 내막의 이형성증으로 인하여 양측 내경동맥의 원위부나 뇌혈관의 근위부 폐쇄와 이로인한 측부 혈관의 발달로 인한 비정상적인 혈관망을 가지는 질환이다. 그러나 모야모야 병이 전신 혈관을 침범하는 질환이라는 보고들이 나오고 있으며, 실제로 신동맥이나 관상동맥을 침범한 모야모야 환자들에 대하여 보고가 되고 있다. 고려대학교 구로병원 흉부외과학 교실에서는 관상동맥을 침범한 모야모야 병 환자 1례를 경험하였다. 환자는 35세 여자로 내원 6개월 전부터 NYHA class ll의 호흡 곤란과 흉통이 있었고, 내월 1개월 전부터는 신체 우측 부위의 감각 이상이 발생되어 내원하였다. 내원하여 시행한 뇌혈관 조영술과 관상동맥 조영술 등의 검사에서 뇌혈관계의 이상을 보이는 모야모야 병과 이로 인한 뇌경색 및 좌측 관상동맥 기시부의 협착으로 인한 협심증을 진단받았으며, 뇌경색에 대하여는 약물 치료를, 협심증에 대하여는 관상동맥 우회술을 시행하였다. 수술 시야에서의 관상동맥 소견은 해부학적 이상 소견이나 전형적인 혈전이나 동맥 경화의 소견 등은 관찰되지 않았고, 전반적으로 부드럽고 혈관 내벽의 비후 소견을 보이는 등 모야모야 병의 병리학적 특성을 보여주어 이 환자의 협심증은 모야모야 병이 관상동맥을 침범하여 발생된 것으로 결론지었다. 따라서 모야모야 병 환자의 경우에는 전신 혈관에 대한 검사 및 치료가 병행되어야 할 것이며, 위와 같은 경험은 아마도 국내의 첫 보고인 것으로 사료된다.

• 대한한방내과학회지
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• 제30권4호
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• pp.806-812
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• 2009

Objective : The aim of this study was to provide basic background information on stroke by evaluation various etiological factors on the basis that the Tongue fur color of acute stroke patients. Method : We studied patients hospitalized within 4 weeks after their ictus who were admitted at Kyunghee University Oriental Medical Center, Dongguk University Oriental Medical Center, Kyungwon University Songpa Oriental Medical Center, and Kyungwon University Incheon Oriental Medical Center from April 2008 to August 2009. We compared the general characteristics of acute stroke patients according to tongue fur color. Result : Tongue fur color showed significant difference for past history of hypertension, hyperlipidemia, stroke, HDL-chol, BUN, Hg, and pulse pattern. Conclusion : The above results show that the overall tendency of acute stage cerebral infarction patients varies according to their tongue fur color. Further studies will be needed to better understand the difference between yellow fur group and white fur among acute stroke patients.

• 한국방사선학회논문지
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• 제13권4호
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• pp.495-502
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• 2019

혈관 질환을 검사하기 위한 방법으로 방사선 장비를 이용한 검사들이 주를 이루기 때문에 본 연구를 통해 뇌혈관 질환 검사에 있어 혈관 질환 검사에 사용되는 뇌혈관 조영술과 뇌혈관 전산화단층촬영검사의 입사표면선량(ESD; Entrance Surface Dose)을 비교 분석하여 뇌혈관 질환 검사 시 사용된 선량 결과에 따른 최적의 검사 방법 선택 유도 및 선량 저감화 방안에 대해 알아보고자 하였으며, 조영제 사용량을 측정 및 평가하여 조영제로 인한 부작용 발생 우려 시 권장 할 수 있는 검사선택 방법에 대해 알아보고자 연구를 진행하게 되었다. 대상으로는 2018년 6월부터 2018년 12월까지 여수지역 병원에서 뇌혈관 전산화 단층 촬영 검사를 시행한 70명 (남43, 여27)과 2018년 6월부터 2018년 11월까지 평택지역 병원에서 뇌혈관 조영술을 시행한 61 (남34, 여27)명을 대상으로 하였고, 분석 방법으로는 입사표면선량 데이터 값을 M-view와 PACS PLUS를 통해 후향적으로 획득하였으며 조영제 측정은 실제 사용된 량을 측정하는 방법으로 진행하였다. SPSS를 이용한 T-검정 분석결과 뇌혈관 조영술의 선량이 $245.74{\pm}71.91mGy$로 전산화 단층 촬영검사의 선량 $277.79{\pm}79.65mGy$보다 $32.05{\pm}7.74mGy$만큼 낮았으며 t=3.249, p=0.017로 통계적으로 유의했고(p<0.05) 조영제 총 사용량 비교 분석 결과에선 뇌혈관 조영술 시 사용된 평균 조영제 사용량이 $55.05{\pm}17.68ml$로 전산화 단층 촬영 검사에서 사용된 70 ml의 조영제 양보다 약 14.95 ml만큼 적었으며 t=-4.548, p<0.001로 통계적으로 유의했다. 결론적으로 뇌혈관 조영술의 선량이 전산화 단층 촬영검사보다 통계적으로 유의하게 낮았고, 조영제 사용량 또한 전산화 단층 촬영검사보다 유의할 만큼 적었으므로 뇌혈관 질환 검사에 있어 뇌혈관 조영술의 활용을 늘리는 방안이 피폭선량 저감화를 위한 방법임과 동시에 조영제 사용량을 감소시킬 수 있는 방안이라 생각된다.