• Title/Summary/Keyword: central hole

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Central nervous system depressant activity of Leucas aspera root

  • Rahman Shafiur;Sarder Mokaddez;Ali Yusuf;Rashid Abdur
    • Advances in Traditional Medicine
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    • v.6 no.3
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    • pp.174-178
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    • 2006
  • The ethanolic extract of Leucas aspera root was studied for its effect on the central nervous system (CNS) using pentobarbitone induced sleeping time test, the open field test and the hole cross test in Swiss albino mice. The present investigation revealed that the extract at the doses of 250 and 500 mg/kg, significantly prolonged the pentobarbitone induced sleeping time in mice though the onset of sleep was delayed as compared to control. In open field test the depressing effect was prominent from the second observation period (30 min) and persisted throughout the entire experimental period (240 min). In the hole cross test, the depressing effect was observed significant from the third observation period (60 min) and persisted up to the seventh observation period (240 min) except at fourth observation (90 min) for 250 mg dose group and depressing effect was significant from second observation (30 min) up to seventh observation period (240 min) for 500 mg dose group. These results support the finding that Leucas aspera root may contain biologically active constituent(s) having CNS activity.

Central nervous system depressant activity of Diospyros peregrina bark

  • Shilpi, Jamil Ahmad;Uddin, Shaikh Jamal;Rouf, Razina;Billah, Md. Morsaline
    • Advances in Traditional Medicine
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    • v.4 no.4
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    • pp.249-252
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    • 2004
  • The methanol extract of Diospyros peregrina bark was studied for its effect on the central nervous system (CNS) using the pentobarbitone induced sleeping time test, the open field test and the hole cross test in Swiss albino mice. The present investigation revealed that the extract, at the doses of 250 and 500 mg/kg, significantly prolonged the pentobarbitone induced sleeping time in mice though the onset of sleep was delayed as compared to the control. In open field test, the depressing effect was prominent from the second observation period (30 min) and persisted throughout the entire experimental period (240 min). In the hole cross test, the depressing effect was observed from the second observation period (30 min) and persisted up to fifth observation period (120 min) for 250 mg dose group and up to sixth observation period (180 min) for 500 mg dose group. These results support the finding that D. peregrina bark extract at the above doses has CNS depressing effects and indicate that D. peregrina bark may contain biologically active constituent(s) having CNS depressant activity.

AN AXISYMMETRIC, NONSTATIONARY BLACK HOLE MAGNETOSPHERE

  • PARK SEOK JAE
    • Journal of The Korean Astronomical Society
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    • v.33 no.1
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    • pp.19-28
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    • 2000
  • In the earlier papers we analyzed the axisymmetric, nonstationary electrodynamics of the central black hole and a surrounding thin accretion disk in an active galactic nucleus. In this paper we analyze the axisymmetric, nonstationary electrodynamics of the black hole magnetosphere in a similar way. In the earlier papers we employed the poloidal component of the plasma velocity which is confined only to the radial direction of the cylindrical coordinate system. In this paper we employ a more general poloidal velocity and get the Grad-Shafranov equation of the force-free magnetosphere of a Kerr black hole. The equation is consistent with the previous ones and is more general in many aspects as it should be. We also show in more general approaches that the angular velocity of the magnetic field lines anchored on the accreting matter tends to become close to that of the black hole at the equatorial zone of the hole.

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Deformation of a rectangular plate with an arbitrarily located circular hole under in-plane pure shear loading

  • Yang, Yeong-Bin;Kang, Jae-Hoon
    • Structural Engineering and Mechanics
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    • v.60 no.2
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    • pp.351-363
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    • 2016
  • Exact solutions for stresses, strains, displacements, and the stress concentration factors of a rectangular plate perforated by an arbitrarily located circular hole subjected to in-plane pure shear loading are investigated by two-dimensional theory of elasticity using the Airy stress function. The hoop stresses, strains, and displacements occurring at the edge of the circular hole are computed and plotted. Comparisons are made for the hoop stresses and the stress concentration factors from the present study and those from a rectangular plate with a circular hole under uni-axial and bi-axial uniform tensions and in-plane pure bending moments on two opposite edges.

Ant lion optimizer for optimization of finite perforated metallic plate

  • Chaleshtaria, Mohammad H. Bayati;Jafari, Mohammad
    • Structural Engineering and Mechanics
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    • v.69 no.6
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    • pp.667-676
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    • 2019
  • Minimizing the stress concentration around hypotrochoid hole in finite metallic plates under in-plane loading is an important consideration in engineering design. In the analysis of finite metallic plate, the effective factors on stress distribution around holes include curvature radius of the corner of the hole, hole orientation, plate's aspect ratio, and hole size. This paper aims to investigate the impact of these factors on stress analysis of finite metallic plate with central hypotrochoid hole. To obtain the lowest value of stress around a hypotrochoid hole, a swarm intelligence optimization method named ant lion optimizer is used. In this study, with the hypothesis of plane stress circumstances, analytical solution of Muskhelishvili's complex variable method and conformal mapping is employed. The plate is taken into account to be finite, isotropic and linearly elastic. By applying suitable boundary conditions and least square boundary collocation technique, undefined coefficients of stress function are found. The results revealed that by choosing the above-mentioned factor correctly, the lowest value of stress would be obtained around the hole allowing to an increment in load-bearing capacity of the structure.

A Study on Central Bursting Defects in Forward Extrusion by the Finite Element Method (유한요소법을 이용한 전방압출공정의 내부결함에 관한 연구)

  • Kim, T.H.;Lee, J.H.;Kwon, H.H.;Kim, B.M.;Kang, B.S.;Choi, J.C.
    • Transactions of Materials Processing
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    • v.1 no.1
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    • pp.66-74
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    • 1992
  • According to the variation of hydrostatic pressure on the central axis of deformable material, the V-shaped central bursting defect may be created in extrusion or drawing processes. The process factors which affect the generation of defects are semi-angle of die, reduction ratio of cross-sectional area, friction factor, material properties and so on. The combination of these factors can determine the possibility of defect creation and the shape of various round holes which have been created inside already. By the rigid plastic finite element method, this paper describes the observations of change in shape of round holes with process conditions such as semi-angle of die, reduction ratio of cross-sectional area and friction factor at the non-steady state of axisymmetrical extrusion process when the round hole is already existed inside the original billet. Also, the effects of process factors are investigated to prevent the possible defects.

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