• Journal of Nutrition and Health
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• v.32 no.5
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• pp.519-525
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• 1999

The effects of Ganoderma Lucidum consumption (GL) on the liver function and lipid metabolic disorder induced by alcohol consuming were studied in rats using GL powder(1%, 2%, 4%) and 10% ethly alcohol. Thirty-five rats(Sprague-Dawley, male) were divided into five groups and fed experimental diets for seven weeks. The concentrations of serum cholesterol, HDL-cholesterol and triglyceride were the highest in the alcohol group, while the levels were apparently reduced by in groups fed GL. The atherogenic indices(AI) also tended to be higher in the alcohol group. Glutamic oxaloacetic transaminase(GOT) activities were significantly lower in body alcohol + 2% GL and alcohol + 4% GL groups, and glutamic pyruvic transaminase(GPT)activities lower only in the alcohol + 2% GL compared with the alcohol group. Alkaline phosphatase(ALP) activities were not significantly different among the groups. The elevated levels of liver cholesterol and triglyceride due to alcohol consumption, were apparently reduced by GL supplementation. On microscopic observation of liver tissues, fat droplets appeared extensively on the liver-lobule in the alcohol group, while fat droplets appeared only on the central vein in the alcohol + 1% GL group. However, in groups administered 2% and 4% GL, fat droplets appeared similar to the alcohol group. The concentrations of fecal bile acid were significantly increased in groups fed GL. These results indicate that GL exerted some beneficial effects on lipid metabolic disorder caused by long-term alcohol consumption. Thus, it seems that GL may be effective in preventing or curing some aspects of alcohol toxicity. More detailed studies are needed in order to determine proper dietary levels of GL for combating alcohol toxicity.

• Journal of Veterinary Clinics
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• v.37 no.6
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• pp.317-323
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• 2020

The aims of this study were to describe the appearance and size of the normal canine prostate using magnetic resonance (MR) imaging and to calculate the apparent diffusion coefficient (ADC) values. MR images were obtained from seven intact male beagle dogs using a 1.5 T MR unit. The sequences included pre- and post-contrast T1- and T2-weighted imaging with and without fat saturation. The signal intensity of the prostate was compared with the adjacent musculature, fat, and urine in the urinary bladder. We recorded the mean prostatic length, width, and height and the length of the sixth lumbar vertebral body (L6). In addition, the prostatic length (rL), width (rW), and height (rH) ratios to L6 were calculated. Diffusion-weighted images of the prostate were obtained and ADC values were calculated. The prostate was bilobed and oval-shaped, homogenous on T1-weighted images, and heterogeneous with radiating lines on T2-weighted images. Post-contrast T1-weighted sequences showed contrast enhancement of the central and radiating striations. The prostatic capsule was clearly identified on post-contrast T1-weighted images with fat saturation. The ADC values were 1.72-2.04 × 10-3mm2/sec (mean, 1.88 × 10-3mm2/sec). Knowledge of the normal appearance of the prostate on MR images is essential to assess prostatic diseases in dogs.

• Proceedings of the KIPE Conference
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• 2018.11a
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• pp.109-110
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• 2018

ITER 토카막의 초전도코일에 전원을 공급하는 Plant는 CCPS (Correction Coil Power Supply System), TFPS(Toroidal Field Power Supply System), PFCS(Poloidal Field & Central Solenoid)으로 구성되어 있다. 각 Plant의 AC/DC 컨버터는 초전도 코일에 막대한 전류를 흘려 토카막 내에서 1억도에 달하는 열과 전자장의 압력으로 플라즈마상태의 수소를 결합시켜 핵융합에 도달하도록 한다. MCS(Master Control System)은 플라즈마가 핵융합을 잘 구현할 수 있도록 초전도 코일에 공급하는 전원을 총괄적으로 제어한다. 특히 PFCS MCS는 토카막 장치에서 다른 Plant와의 Interface가 복잡하여 설계 및 제작에 어려움이 많다. 본 논문에서는 PFCS MCS가 ITER의 설계요건과 국제기술기준에 맞게 설계하고, 제작하였는지를 확인하기 위해 공장에서 최종 검사하는 FAT(Factory Acceptance Test) 절차를 소개하고 여러 가지 시험을 통하여 평가한 내용을 보이고자 한다.

• Journal of Society of Preventive Korean Medicine
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• v.22 no.1
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• pp.107-127
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• 2018

Objectives : The present study investigated the anti-obese and blood flow improvement activities of aqueous extracts of ginseng berry (GBe) on the mild diabetic obese mice as compared with metformin. Methods : After end of 56 days of continuous oral administrations of GBe 150, 100 and 50 mg/kg, or metformin 250 mg/kg, anti-obese and blood flow improvement effects - the changes of body weights, body and abdominal fat density by in live dual-energy x-ray absorptionmetry (DEXA), tail bleeding time, prothrombin time (PT), activated partial thromboplastin time (aPTT), serum total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL) levels, aorta and serum cyclic guanosine monophosphate (cGMP), nitric oxide (NO) and endothelin (ET)-1 levels, aorta phosphorylated PI3K (pPI3K), phosphorylated Akt (pAkt) and phosphorylated p38 MAPK (pp38 MAPK) levels were systemically analyzed. In addition, aorta vascular dilation and constriction related gene mRNA expressions - PI3K, Akt, eNOS, p38 MAPK and ET-1 were also analyzed by realtime RT-PCR. Results : The obesity and related blood flow impairment, induced by 84 days of continuous HFD supply, were significantly inhibited by 56 days of continuous oral treatment of GBe 150, 100 and 50mg/kg, dose-dependently, and they also dramatically normalized the changes of the aorta vascular dilation and constriction related gene mRNA expressions, also dose-dependently. Especially, GBe 150 mg/kg constantly showed favorable inhibitory activities against type II diabetes related obesity and vascular disorders through PI3K/Akt pathway and p38 MAPK mediated cGMP, NO and ET-1 expression modulatory activities, as comparable to those of metformin 250 mg/kg in HFD mice. Conclusion : By assessing the key parameters for anti-obese and blood flow improvement activities on the HFD-induced mild diabetic obese mice, the present work demonstrated that GBe 150, 100 and 50 mg/kg showed favorable anti-obese and blood flow improvement effects in HFD-induced type II diabetic mice, through PI3K/Akt pathway and p38 MAPK mediated cGMP, NO and ET-1 expression modulatory activities.

• The Korean Journal of Food And Nutrition
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• v.33 no.5
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• pp.524-531
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• 2020

The purpose of this study was to evaluate the quality properties of Meju prepared by inoculating two strains of Bacillus amyloliquefaciens HJ5-2, and Aspergillus oryzae PS03. The three soybean varieties that include Daewonkong, Daechan, and Saedanbaek were used in this experiment. The fermentation temperature during the Meju aging varied at 20℃, 30℃, and 40℃, respectively. The physicochemical analysis of the soybeans, showed that the cured protein and fat contents were 34.83~43.49% and 12.91~18.90%, respectively. The pH and total acidity were 6.47~6.93 and 0.11~1.22%, respectively. The change in appearance of the Meju was that the yellow-green mold was well formed on seven days at fermentation temperature of 20℃ and 30℃, but at 40℃, there was minimal mold formation and cracking of the surface. The amino nitrogen content was highest on the Daechan Meju at 621.83 mg% for seven days. The amylase increased as the fermentation period increased in all samples, and the protease increased rapidly until the first day of the fermentation, and then gradually increased thereafter. The total number of bacteria increased or decreased as the fermentation proceeded to 6.66~10.07 log CFU/g. The mold counts increased with increasing fermentation period in the range of 6.38~8.79 log CFU/g.

• The Korean Journal of Food And Nutrition
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• v.31 no.6
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• pp.949-956
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• 2018

This study investigated chemical components, antioxidant compounds, and activity of brown rice cultivars, to select good cultivar to be used for processing of mixed-rice in the food industry. Proximate compositions, phytic acid, phenolic compounds, and antioxidant activity of brown rice were significantly different among cultivars. Moisture, crude ash, fat, protein, and carbohydrate contents of brown rice were 9.51~12.82, 1.05~1.93, 1.84~6.24, 5.90~9.60 and 71.75~80.34 g/100 g, respectively. Phytic acid content of brown rice cultivars was 7.39~0.87 mg/g. Total polyphenol content of Joeunheukmi and Geonganghongmi cultivars, were 615.25 and $311.14{\mu}g\;GAE/g$, total flavonoid content was 267.75 and $100.67{\mu}g\;CE/g$, respectively. DPPH radical scavenging activity of Geonganghongmi, Joeunheukmi and Hyeugkwang cultivars was 89.17, 87.94 and 43.17%, ABTS radical scavenging activity was 113.57, 113.34, and $93.53{\mu}mol\;TE/g$, and ferric reducing antioxidant potential was 951.67, 1,075.75, and $508.33{\mu}M/g$, respectively. As a result, phenolic compounds and antioxidant activities of pigmented brown rice were high, and it could be used as a functional material.

• International Journal of Industrial Entomology and Biomaterials
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• v.17 no.1
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• pp.109-113
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• 2008

Realizing the scope of utilizing by-products of silk cocoons by applying appropriate methods is the immediate crave to optimize returns. The nutritive value of pupae suits for human diet, feed for poultry, carps, fish, rabbits, piggery and dogs. The pupal skin, fat, oil, cocoon palade have applications in oleo chemical, soap, glycerin, cosmetic, artificial fibres, membranes and n-triacontanol isolation. The pupal proteins Chitin, Shinki fibroin, Serrapeptidase, glucosamine are latent precursors of post surgical, anti-carcinogenic, anti-inflammative, anti-bacterial, anti-histaminic, gastric, hepatitis, pancreatitis, leukocytopenia, neurological, ophthalmic, blood pressure, cardiac and diabetic medicines and for preparation of vitamins A, E and K. The silk and its proteins sericin and fibroin are potentially used for wound healing, diabetes, impotence, sinusitis, arthritis, edema, cystitis, epididymitis, tissue regeneration, cancer, post-surgical trauma and used as anti-oxidatives, bio-adhesives, ultra violet screens and bio-active textiles. The waste cocoons can be used in making art crafts like garlands, carpets, overcoats, decoratives and greeting cards. The in-depth research towards utility optimization and make aware this reality to sericulturists, reelers, weavers, traders, entrepreneurs, policy makers etc., is the upright want of the today's Sericulture industry.

• Proceedings of the Ginseng society Conference
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• 1993.09a
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• pp.110-112
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• 1993

Acidic polysaccharide from Korean red ginseng was found to inhibit pancreatic lipase activity and cause reduction of plasma triglyceride level after oral administration of corn oil emulsion to rats. Thus acidic polysaccharide may reduce plasma triglyceride through its inhibitory action on pancreatic lipase and successive inhibition of intestinal absorption of fat due to reduction of lipolysis. In the course of this experiment, we found an unknown ninhydrin positive substance in Korean red ginseng. The unknown substance was identified to be arginyl-fructosyl glucose(Arg - Fru - Glc). Coment of this new compound was $5.37\%$ in Korean red ginseng powder. Sucrase and maltase activities in mucous layer of rat jejunum were found to be inhibited by Arg-Fru-Glc. Physiological significance of the new compound was discussed based on these experimental results.

• The Korean Journal of Pharmacology
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• v.5 no.2
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• pp.93-103
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• 1969

Saponin, essential oil, fat oil and alkaloidal fraction were fractionated from the ethanol extract of fanax ginseng. Effect of each fraction of Panax ginseng upon the temperature response induced by reserpine, chlorpromazine and nembutal was investigated in mice, so as to secure some hidden facets of each fraction of Panax ginseng acting upon central nervous system. The authors could arrive at some results, that is: (1) Inhibitory effect of Panax ginseng upon temperature decline induced by nembutal and chlorpromazine and potentiating action upon hyperthermia induced by reserpine reside mainly in saponin fraction and slightly in essential oil fraction. (2) The effect of Ginseng saponin on temperature response in nice seems to be related with the liberation of serotonin and histamine.

• Proceedings of the Korean Society of Crop Science Conference
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• 2017.06a
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• pp.73-73
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• 2017

To set an optimal harvest time of main 7 whole crop silage rice cultivars, Nokyang(Ny), Mogwoo(Mw), Mogyang(My), Jungmo1029(Jm1029), Jungmo1038(Jm1038), Nokwoo(Nw) and Yeongwoo(Yw), based on feed value, we analyzed their feed values such as percent crude protein(CP), crude fat(CF), crude ash(CA), neutral detergent fiber(NDF), acid detergent fiber(ADF) and lignin. It was evaluated every 10 days from heading to 40 days after heading(DAH). Total digestible nutrient(TDN) and relative feed value(RFV) was also calculated from ADF and NDF. As results, CP was generally in decline as increasing DAH in Ny, My, Jm1029, Jm1038 and Yw and decreased to 20 DAH in Mw, decreased after increasing to 30 days in Nw. The CP content of Ny was relatively the highest ranged from 5.3% to 10.1% and Mw the lowest 4.5% to 5.2%, compared to others. CF content tend to decrease as DAH increase in Ny, My and Nw and decreased after increasing to 30 days Jm1029, increased after decreasing to 20 days Jm1038 but was not shown distinct trend of increase or decrease in Mw. Especially, that of Yw's CF gradually increased as harvest time late but relative content the lowest from 1.46% to 2.29% among 7 cultivars. The CA content of Ny, My, Jm1029 and Jm1038 approximately decreased as DAH increased and that of Mw was similar to others after heading, Nw decreased after 10 days and Yw increased after flowering. In all 7 cultivars, NDF and ADF had a tendency to decrease as days accumulated, in particular, Yw was the lowest on 30 DAH and so the content of Yw's TDN the highest(71.5%), while the lowest(67.2%) in Nw. For lignin, particularly, Mw tend to be in decline as DAH increase and was the lowest ranged from 1.34% to 1.87%. ADF analyses allows for the evaluation of in vivo digestible dry matter(DDM) and energy availability and NDF analyses provides the best indication of dry matter intake(DMI). Ultimately, the two factors can be combined to derive RFV for forage. RFV in general increased as DAH increased in all cultivars and was in order, Yw>My>Ny> Jm1038>Mw>Jm1029>Nw on 30 DAH. Taken together when these results, despite a slight increase of TDN after 30 DAH except Yw, considering forage yield potential, digestibility of grains and gradual decrease of CP and CF, the yellow ripe stage, about 30 DAH, was appropriate to harvest whole crop rice for silage use.