• Bulletin of the Korean Chemical Society
• /
• 제28권3호
• /
• pp.379-385
• /
• 2007

Receptor-oriented pharmacophore-based in silico screening is a powerful tool for rapidly screening large number of compounds for interactions with a given protein. Inhibition of the enzyme catechol-Omethyltransferase (COMT) offers a novel possibility for treating Parkinson's disease. Bisubstrate inhibitors of COMT containing the adenine of S-adenosylmethionine (SAM) and a catechol moiety are a new class of potent and selective inhibitor. In the present study, we used receptor-oriented pharmacophore-based in silico screening to examine the interactions between the active site of human COMT and bisubstrate inhibitors. We generated 20 pharmacophore maps, of which 4 maps reproduced the docking model of hCOMT and a bisubstrate inhibitor. Only one of these four, pharmacophore map I, effectively described the common features of a series of bisubstrate inhibitors. Pharmacophore map I consisted of one hydrogen bond acceptor (to Mg2+), three hydrogen bond donors (to Glu199, Glu90, and Gln120), and one hydrophobic feature (an active site region surrounded by several aromatic and hydrophobic residues). This map represented the most essential pharmacophore for explaining interactions between hCOMT and a bisubstrate inhibitor. These results revealed a pharmacophore that should help in the development of new drugs for treating Parkinson's disease.

• 대한전자공학회:학술대회논문집
• /
• 대한전자공학회 2000년도 ITC-CSCC -2
• /
• pp.1107-1110
• /
• 2000

This paper proposes a selection procedure of geospatial data for location guidance map generation system. The selection procedure requires some targets appointed by users as input data and outputs generation. The procedure is embedded in a prototype of object-oriented GIS. We show sample maps generated by the system.

• 대한원격탐사학회:학술대회논문집
• /
• 대한원격탐사학회 2002년도 Proceedings of International Symposium on Remote Sensing
• /
• pp.191-196
• /
• 2002

From this year, KIGAM, one of Korean government-supported research institutes, has started new national program for digital geologic/natural resources infrastructure building. The goal of this program is to prepare digitally oriented infrastructure for practical digital database building, management, and public services of numerous types of paper maps related to geo-scientific resources or geologic thematic map sets: hydro-geologic map, applied geologic map, geo-chemical map, airborne radiometric/magnetic map, coal geologic map and off-shelf bathymetry map and so forth. As for digital infrastructure, several research issues in this topic are composed of: ISP (Information Strategy Planning), geo-framework modeling of each map set, pilot database building, cyber geo-mineral directory service system, and web based geologic information retrieval system upgrade which services Korean digital geologic maps scaled 1:50K. In this study, UML (Unified Modeling Language)-based data modeling of geo-data sets by and in KIGAM, among them, is mainly discussed, and its results are also presented in the viewpoint of digital geo-modeling ISP. It is expected this model is further progressed with the purpose of being a guidance or framework modeling for geologic thematic mapping and practical database building, as well as other types of national thematic map database building.

• 한국지역지리학회지
• /
• 제16권1호
• /
• pp.1-15
• /
• 2010

산도(山圖)는 가장 이상적이라고 생각하고 관찰한 지형을 풍수지리적 공간모형에 빗대어 표현한 지도로 풍수지리의 혈(穴)과 명당을 표현한 것이다. 본 연구는 중국 명나라 때 발간된 대표적인 풍수서인 "지리인자수지(地理人子須知)"에 게재된 산도를 분석하여 지형표현의 특징을 산도의 시점, 중심지향적 지도, 투시점, 이중적축척, 산론(山論), 혈의 세부적 표현 등의 세부항목으로 나누어 살펴보았다. "지리인자수지(地理人子須知)"에 게재된 산도의 지형표현 특징은 다음과 같다. 시점은 부감법이 사용되었으며 묘지의 중심, 즉 혈처를 중심으로 세밀하게 지형이 묘사되는 중심지향적 지도로 혈처 주위의 중요지형은 실제 지형보다 파장되거나 생략되는 경우가 많았다. 또한 묘지에서 판찰되지 않는 중요지형은 사점이동을 통해 관찰하고 이를 세밀하게 표현하였다. 산론 부분에는 지리적 위치와 산맥의 흐름과 체계, 풍수적 특징, 묘지의 좌향과 주변지형, 발복 정도를 설명하는 내용이 주를 이루고 있었다. 산도의 방위성은 상대적인 것이고, 축척의 개념이 드러나지 않으나 병당 공간과 거점도시 및 방위성을 갖는 지형을 표현하는 과정에서 아중적 축척을 사용하거나 근경 중경 원경을 묘사하는 과정에서 다중적 축척을 사용한 경우가 많았다.

• 한국지역지리학회지
• /
• 제17권1호
• /
• pp.40-57
• /
• 2011

山圖(산도)는 풍수지리적 길지, 즉 혈(穴)과 명당의 국면을 표현한 지도이다. 산도는 가정 이상적이라고 생각하고 관찰한 자연지형을 풍수지리적 공간모형에 빗대어 표현한 것이다. 본 연구는 국립중앙도서관과 서울대학교 규장각한국학연구원에 소장된 족보 중 "기계유씨족보(杞溪兪氏族譜)"와 "반남박씨세보(潘南朴氏世譜)"에 게재된 2개의 산도를 연구 대상으로 하여 족보(族譜)에 게재된 산도의 제작기법, 지형표현의 특징을 산도의 구도, 시점, 중심지향적 지도, 물의 흐름, 산론 등의 세부항목을 중심으로 살펴보았다. 연구 결과는 다음과 같다. 연구 대상 산도는 이원적 축척과 부감법을 사용하였으며 묘지를 중심으로 지형을 묘사하고 중요지형을 실제 지형보다 과장해서 표현하였다. 또한 묘지에서 관찰되지 않는 중요지형은 시점이동을 통해 관찰하고 이를 세밀하게 표현하였다. 산론(山論) 부분에는 지리적 위치와 산맥의 흐름과 체계, 풍수적 특징, 묘지의 좌향과 주변지형을 설명하는 내용이 주를 이루고 있었다.

• 대한원격탐사학회지
• /
• 제4권1호
• /
• pp.31-40
• /
• 1988

Low-cost microcomputer systems can be assembled which possess computing power, color display, memory, and storage capacity approximately equal to graphic workstactions. A low-cost, flexible, and user-friendly IBM/PC/XT/AT based image processing system has been developed and named as KMIPS(KAIST (Korea Advanced Institute of Science & Technology) Map and Image Processing Station). It can be easily utilized by the resource managers who are not computer specialists. This system can: * directly access Landsat MSS and TM, SPOT, NOAA AVHRR, MOS-1 satellite imagery and other imagery from different sources via magnetic tape drive connected with IBM/PC; * extract image up to 1024 line by 1024 column and display it up to 480 line by 672 column with 512 colors simultaneously available; * digitize photographs using a frame grabber subsystem(512 by 512 picture elements); * perform a variety of image analyses, GIS and terrain analyses, and display functions; and * generate map and hard copies to the various scales. All raster data input to the microcomputer system is geographically referenced to the topographic map series in any rater cell size selected by the user. This map oriented, georeferenced approach of this system enables user to create a very accurately registered(.+-.1 picture element), multivariable, multitemporal data sets which can be subsequently subsequently subjected to various analyses and display functions.

• 한국가정과학회지
• /
• 제7권1호
• /
• pp.69-80
• /
• 2004

The purpose of this study is to suggest methods for the community design through users' behavior study in apartment housing. This study was approached by using both theoretical investigation and empirical research. The theoretical investigation actualized the concept of community design in apartment housing through a literature survey. The empirical survey focused on seeking out a user-oriented design criteria based on the analysis of residents' usage behavior and mental map. The results of this study are as follow: First. regarding the analysis of the residents' attitude toward the share community space(SCS), it was found that the SCS made a sense as community facilities in apartment housing. Second, regarding the SCS through the metal map, it was shown that the sketch map analysis was a useful research method for the community design by actualizing the residents' behavior characteristics. Third. as to the results of analyzing the metal map, it was found that the considered characteristics in recognition of the SCS were related to the liking with the main paths, cross nodes of the moving line, the location of center. and the complexity. In conclusion, the SCS is the main of community design in apartment housing and the above characteristics in recognition are useful as the guidelines in the SCS planning.

• Bulletin of the Korean Chemical Society
• /
• 제30권9호
• /
• pp.2083-2086
• /
• 2009

Human vascular endothelial growth factor receptor 2 (hVEGFR2) is an important signaling protein involved in angiogenesis and attractive drug target in cancer therapy. It has been reported that flavonols, a class of flavonoids, have anti-angiogenic activity in various cancer cell lines. We performed receptor-oriented pharmacophore based in silico screening for identification of hVEGFR2 inhibitors from flavonol database. By comparing with three X-ray complex structures of hVEGFR2 and its inhibitors, we evaluated the specific interactions between inhibitors and receptors and determined a single pharmacophore map. This map consisted of four features, a hydrogen bonding acceptor (HBA) on Cys917, two hydrogen bonding donors on Glu917 (HBD1) and Glu883 (HBD2), and one hydrophobic interaction (Lipo) with Val846, Ala864, Val897, Val914 and Phe1045 of hVEGFR2. Using this map, we searched a flavonol database including 9 typical flavonols and proposed that five flavonols, kaempferol, quercetin, fisetin, morin, and rhamnetin can be potent inhibitors of hVEGFR2. 3-OH of C-ring and 4’-OH of B-ring of flavonols are the essential features for hVEGFR2 inhibition. This study will be helpful for understanding the mechanism of inhibition of hVEGFR2 by natural products.

• 한국농공학회논문집
• /
• 제63권3호
• /
• pp.13-26
• /
• 2021

Recent drought events in the South Korea and the magnitude of drought losses indicate the continuing vulnerability of the agricultural drought. Various studies have been performed on drought hazard assessment at the regional scales, but until recently, drought management has been response oriented with little attention to mitigation and preparedness. A vulnerability assessment is introduced in order to preemptively respond to agricultural drought and to predict the occurrence of drought. This paper presents a method for spatial, Geographic Information Systems-based assessment of agricultural drought vulnerability in South Korea. It was hypothesized that the key 14 items that define agricultural drought vulnerability were meteorological, agricultural reservoir, social, and adaptability factors. Also, this study is to analyze agricultural drought vulnerability by comparing vulnerability assessment according to weighting method. The weight of the evaluation elements is expressed through the Analytic Hierarchy Process (AHP), which includes subjective elements such as surveys, and the Entropy method using attribute information of the evaluation items. The agricultural drought vulnerability map was created through development of a numerical weighting scheme to evaluate the drought potential of the classes within each factor. This vulnerability assessment is calculated the vulnerability index based on the weight, and analyze the vulnerable map from 2015 to 2019. The identification of agricultural drought vulnerability is an essential step in addressing the issue of drought vulnerability in the South Korea and can lead to mitigation-oriented drought management and supports government policymaking.

• 대한원격탐사학회:학술대회논문집
• /
• 대한원격탐사학회 2003년도 Proceedings of ACRS 2003 ISRS
• /
• pp.340-342
• /
• 2003

Location based services based on positions of moving objects are expanding the business area gradually. The location is included all estimate position of the future as well as the position of the present and the past. Location based routing service is active business application in which the position information of moving objects is applied efficiently. This service includes the trajectory of past positions, the real-time tracing of present position of special moving objects, and the shortest and optimized paths combined with map information. In this paper, we describes the location based routing services is extend in distributed web GIS environment. Web GIS service systems provide the various GIS services of analyzing and displaying the spatial data with friendly user - interface. That is, we propose the efficient architecture and technologies for servicing the location based routing services in distributed web GIS environment. The position of moving objects is acquired by GPS (Global Positioning System) and converted the coordinate of real world by map matching with geometric information. We suppose the swapping method between main memory and storages to access the quite a number of moving objects. And, the result of location based routing services is wrapped the web-styled data format. We design the schema based on the GML. We design these services as components were developed in object-oriented computing environment, and provide the interoperability, language-independent, easy developing environment as well as re - usability.