• Bulletin of the Korean Chemical Society
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• v.28 no.3
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• pp.379-385
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• 2007

Receptor-oriented pharmacophore-based in silico screening is a powerful tool for rapidly screening large number of compounds for interactions with a given protein. Inhibition of the enzyme catechol-Omethyltransferase (COMT) offers a novel possibility for treating Parkinson's disease. Bisubstrate inhibitors of COMT containing the adenine of S-adenosylmethionine (SAM) and a catechol moiety are a new class of potent and selective inhibitor. In the present study, we used receptor-oriented pharmacophore-based in silico screening to examine the interactions between the active site of human COMT and bisubstrate inhibitors. We generated 20 pharmacophore maps, of which 4 maps reproduced the docking model of hCOMT and a bisubstrate inhibitor. Only one of these four, pharmacophore map I, effectively described the common features of a series of bisubstrate inhibitors. Pharmacophore map I consisted of one hydrogen bond acceptor (to Mg2+), three hydrogen bond donors (to Glu199, Glu90, and Gln120), and one hydrophobic feature (an active site region surrounded by several aromatic and hydrophobic residues). This map represented the most essential pharmacophore for explaining interactions between hCOMT and a bisubstrate inhibitor. These results revealed a pharmacophore that should help in the development of new drugs for treating Parkinson's disease.

• Proceedings of the IEEK Conference
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• 2000.07b
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• pp.1107-1110
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• 2000

This paper proposes a selection procedure of geospatial data for location guidance map generation system. The selection procedure requires some targets appointed by users as input data and outputs generation. The procedure is embedded in a prototype of object-oriented GIS. We show sample maps generated by the system.

• Proceedings of the KSRS Conference
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• 2002.10a
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• pp.191-196
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• 2002

From this year, KIGAM, one of Korean government-supported research institutes, has started new national program for digital geologic/natural resources infrastructure building. The goal of this program is to prepare digitally oriented infrastructure for practical digital database building, management, and public services of numerous types of paper maps related to geo-scientific resources or geologic thematic map sets: hydro-geologic map, applied geologic map, geo-chemical map, airborne radiometric/magnetic map, coal geologic map and off-shelf bathymetry map and so forth. As for digital infrastructure, several research issues in this topic are composed of: ISP (Information Strategy Planning), geo-framework modeling of each map set, pilot database building, cyber geo-mineral directory service system, and web based geologic information retrieval system upgrade which services Korean digital geologic maps scaled 1:50K. In this study, UML (Unified Modeling Language)-based data modeling of geo-data sets by and in KIGAM, among them, is mainly discussed, and its results are also presented in the viewpoint of digital geo-modeling ISP. It is expected this model is further progressed with the purpose of being a guidance or framework modeling for geologic thematic mapping and practical database building, as well as other types of national thematic map database building.

• Journal of the Korean association of regional geographers
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• v.16 no.1
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• pp.1-15
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• 2010

A feng-shui map(山圖) represents the most ideal natural landform on a map of feng-shui space model, highlighting propitious spots and grave sites in terms of feng-shui. This study made an analysis into feng-shui maps featured in the Chinese feng-shui manual Jiriinjasuji published in the Ming dynasty of China and did research on the following points regarding the traits of landform expressions: viewpoints of feng-shui maps, perspective points, center-oriented maps, double map scales, mountain theories, detailed expressions of propitious spots, etc. The major characteristics of landform expressions in the Chinese feng-shui manual Jiriinjasuji are as follows: the viewpoint technique was aerial one; the maps were center-oriented, that is to say, the center of grave sites or propitious spot was depicted in detail; and often the important terrains around grave sites were exaggerated or delete compared with real landforms. In addition, other vital landforms not observed from grave sites were depicted with viewpoints moved and were represented in greater details' The part of mountain theories had the following points as their main subject matter: geographical locations, overall orientations of mountain ranges, topographical traits, grave seat directions, surrounding terrains and extent of fortune-bringing. The directions of the maps were relative and there was no definite concept of scales. But, there are many cases where the maps made use of the double scale technique when expressing the terrains that have propitious space, logistical cities or directional importance. Furthermore, they often utilized multiple scale in expressing near views, mid-range views and distant views.

• Journal of the Korean association of regional geographers
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• v.17 no.1
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• pp.40-57
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• 2011

A feng-shui map is a kind of map that features such propitious positions as fortune-bringing spots or ideal grave sites. The map is a representation of the most ideal natural terrains in terms of feng-shui perspectives. This study did research on two feng-shui maps registered on some genealogical tables in order to see how the map was drawn up. In addition, the detailed characteristics of landform expressions like the frame of the map, viewpoints, center-oriented mapping, water flow, mountain theories were delved into. The results of the research are as follows: the feng-shui maps for this research used the techniques of double scale and aerial view, described terrains with grave sites in their centers, and enlarged important terrains compared with surroundings for exaggeration purposes. In addition, other vital landforms not observed from grave sites were depicted with viewpoints moved and were represented in fine details. The part of mountain theories had the following points as their main subject matter: geographical locations, overall orientations of mountain ranges, topographical traits, grave seat directions and surrounding terrains.

• Korean Journal of Remote Sensing
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• v.4 no.1
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• pp.31-40
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• 1988

Low-cost microcomputer systems can be assembled which possess computing power, color display, memory, and storage capacity approximately equal to graphic workstactions. A low-cost, flexible, and user-friendly IBM/PC/XT/AT based image processing system has been developed and named as KMIPS(KAIST (Korea Advanced Institute of Science & Technology) Map and Image Processing Station). It can be easily utilized by the resource managers who are not computer specialists. This system can: * directly access Landsat MSS and TM, SPOT, NOAA AVHRR, MOS-1 satellite imagery and other imagery from different sources via magnetic tape drive connected with IBM/PC; * extract image up to 1024 line by 1024 column and display it up to 480 line by 672 column with 512 colors simultaneously available; * digitize photographs using a frame grabber subsystem(512 by 512 picture elements); * perform a variety of image analyses, GIS and terrain analyses, and display functions; and * generate map and hard copies to the various scales. All raster data input to the microcomputer system is geographically referenced to the topographic map series in any rater cell size selected by the user. This map oriented, georeferenced approach of this system enables user to create a very accurately registered(.+-.1 picture element), multivariable, multitemporal data sets which can be subsequently subsequently subjected to various analyses and display functions.

• Korean Journal of Human Ecology
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• v.7 no.1
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• pp.69-80
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• 2004

The purpose of this study is to suggest methods for the community design through users' behavior study in apartment housing. This study was approached by using both theoretical investigation and empirical research. The theoretical investigation actualized the concept of community design in apartment housing through a literature survey. The empirical survey focused on seeking out a user-oriented design criteria based on the analysis of residents' usage behavior and mental map. The results of this study are as follow: First. regarding the analysis of the residents' attitude toward the share community space(SCS), it was found that the SCS made a sense as community facilities in apartment housing. Second, regarding the SCS through the metal map, it was shown that the sketch map analysis was a useful research method for the community design by actualizing the residents' behavior characteristics. Third. as to the results of analyzing the metal map, it was found that the considered characteristics in recognition of the SCS were related to the liking with the main paths, cross nodes of the moving line, the location of center. and the complexity. In conclusion, the SCS is the main of community design in apartment housing and the above characteristics in recognition are useful as the guidelines in the SCS planning.

• Bulletin of the Korean Chemical Society
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• v.30 no.9
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• pp.2083-2086
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• 2009

Human vascular endothelial growth factor receptor 2 (hVEGFR2) is an important signaling protein involved in angiogenesis and attractive drug target in cancer therapy. It has been reported that flavonols, a class of flavonoids, have anti-angiogenic activity in various cancer cell lines. We performed receptor-oriented pharmacophore based in silico screening for identification of hVEGFR2 inhibitors from flavonol database. By comparing with three X-ray complex structures of hVEGFR2 and its inhibitors, we evaluated the specific interactions between inhibitors and receptors and determined a single pharmacophore map. This map consisted of four features, a hydrogen bonding acceptor (HBA) on Cys917, two hydrogen bonding donors on Glu917 (HBD1) and Glu883 (HBD2), and one hydrophobic interaction (Lipo) with Val846, Ala864, Val897, Val914 and Phe1045 of hVEGFR2. Using this map, we searched a flavonol database including 9 typical flavonols and proposed that five flavonols, kaempferol, quercetin, fisetin, morin, and rhamnetin can be potent inhibitors of hVEGFR2. 3-OH of C-ring and 4’-OH of B-ring of flavonols are the essential features for hVEGFR2 inhibition. This study will be helpful for understanding the mechanism of inhibition of hVEGFR2 by natural products.

• Journal of The Korean Society of Agricultural Engineers
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• v.63 no.3
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• pp.13-26
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• 2021

Recent drought events in the South Korea and the magnitude of drought losses indicate the continuing vulnerability of the agricultural drought. Various studies have been performed on drought hazard assessment at the regional scales, but until recently, drought management has been response oriented with little attention to mitigation and preparedness. A vulnerability assessment is introduced in order to preemptively respond to agricultural drought and to predict the occurrence of drought. This paper presents a method for spatial, Geographic Information Systems-based assessment of agricultural drought vulnerability in South Korea. It was hypothesized that the key 14 items that define agricultural drought vulnerability were meteorological, agricultural reservoir, social, and adaptability factors. Also, this study is to analyze agricultural drought vulnerability by comparing vulnerability assessment according to weighting method. The weight of the evaluation elements is expressed through the Analytic Hierarchy Process (AHP), which includes subjective elements such as surveys, and the Entropy method using attribute information of the evaluation items. The agricultural drought vulnerability map was created through development of a numerical weighting scheme to evaluate the drought potential of the classes within each factor. This vulnerability assessment is calculated the vulnerability index based on the weight, and analyze the vulnerable map from 2015 to 2019. The identification of agricultural drought vulnerability is an essential step in addressing the issue of drought vulnerability in the South Korea and can lead to mitigation-oriented drought management and supports government policymaking.

• Proceedings of the KSRS Conference
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• 2003.11a
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• pp.340-342
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• 2003

Location based services based on positions of moving objects are expanding the business area gradually. The location is included all estimate position of the future as well as the position of the present and the past. Location based routing service is active business application in which the position information of moving objects is applied efficiently. This service includes the trajectory of past positions, the real-time tracing of present position of special moving objects, and the shortest and optimized paths combined with map information. In this paper, we describes the location based routing services is extend in distributed web GIS environment. Web GIS service systems provide the various GIS services of analyzing and displaying the spatial data with friendly user - interface. That is, we propose the efficient architecture and technologies for servicing the location based routing services in distributed web GIS environment. The position of moving objects is acquired by GPS (Global Positioning System) and converted the coordinate of real world by map matching with geometric information. We suppose the swapping method between main memory and storages to access the quite a number of moving objects. And, the result of location based routing services is wrapped the web-styled data format. We design the schema based on the GML. We design these services as components were developed in object-oriented computing environment, and provide the interoperability, language-independent, easy developing environment as well as re - usability.