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Effect of Plantaginis asiaticae Folium water extract on body fat loss in high fat-induced obese C57BL/6 mice (차전초 잎의 물 추출물이 고지방식이로 비만 유도된 C57BL/6 생쥐의 체지방 감소에 미치는 영향)

  • Kim, So Young;Jeong, Mi Jin;Kim, Yoo Jin;Lee, Un-Tak;Choo, Sung-Tae;Kim, Han-Hyuk;Kim, Mi Ryeo
    • The Korea Journal of Herbology
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    • v.33 no.2
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    • pp.59-67
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    • 2018
  • Objective : Plantago asiatica L. has been used for many years in Korea, China, and Japan for the treatment of many diseases such as anti-inflammatory, anti-asthma and diuretic. But the anti-obesity effect of Plantaginis asiaticae Folium has not been studied yet. Thus, this study aimed to demonstrate the anti-obesity efficacy of Plantaginis asiaticae Folium water extract (PAF) in high fat diet-induced obesity animal model. Method : Male, five-weeks old C57BL/6 mice were divided into 5 groups; ND (normal diet + 0.9% saline), HFD (high-fat diet + 0.9% saline), PC (high-fat diet + Garcinia cambogia 500 mg/kg), PAF 100, 300 (high-fat diet + PAF 100, 300 mg/kg. Treatments were performed daily for 6 weeks per os. We evaluated the changes of body weight, white adipose tissues weight, hepatic and fecal lipids level, pancreatic lipase activity and lipid profiles in plasma. Result : Body weights, adipose tissue weights and FER were significantly lower in mice fed the high-fat diet with PAF treatment than in mice fed the high-fat diet alone. In plasma, TG, TC, LDL-C, ATS and ALT levels significantly decreased in PAF groups compared with HFD group. Also, hepatic triglyceride (TG) levels decreased and fecal TG increased in PAF groups compared to HFD group. In addition, the activity of pancreatic lipase was decreased in the PAF groups compared to that of HFD group. Conclusion: These results suggest PAF extract is effective in preventing and improvement obesity, so it might be a potential and safe material for anti-obesity agent of weight control or functional supplements.

Skin Moisturizing Activity of Unripe Apple(Immature Fruit of Malus pumila) in Mice (풋사과 추출물의 피부 보습 효과)

  • Park, Hye Rim;Kim, Jae Kwang;Lee, Jae Kyoung;Choi, Beom Rak;Kim, Jong Dae;Ku, Sae Kwang;Jegal, Kyung Hwan
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.35 no.4
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    • pp.63-74
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    • 2022
  • Objectives : Skin aging is generally characterized by wrinkles, sagging, loss of elasticity roughness, pigmentation and dryness. This changes is caused by reducing the elements constituting the extracellular matrix contributing to the physiological properties of the skin, such as collagen fiber, elastic fiber, and hyaluronic acid. Adequate skin hydration is important to maintain normal skin function and reduce skin aging. The present study is objective to observe skin moisturizing effects of Unripe apple(UA, Immature fruit of Malus pumila Mill) in vivo and its underlying molecular mechanisms. Methods : ICR mice were orally administerd UA(100, 200 and 400mg/kg/day) for 8 weeks, and skin water contents and the expression of transforming growth factor (TGF)-𝛽1, ceramide, hyaluronan and collagen type I(COL1) were measured in dorsal back skin of the mice. Gene expression of hyaluronan synthase(HAS1, HAS2, HAS3), collagen synthase(COL1A1, COL1A2) and TGF-𝛽1 were also determined by realtime RT-PCR. Results : Skin water contents and the expression of TGF-𝛽1, ceramide, COL1 and hyaluronan were significantly increased in UA group(100, 200 and 400mg/kg/day) compared to vehicle control. The mRNA expression of HAS isoform(HAS1, HAS2, HAS3), COL1A1, COL1A2, and TGF-𝛽1 were also significantly increased by UA. Conclusions : UA has skin moisturizing effects and enhancement activities in skin function related components(COL1, hyaluronan, ceramide and TGF-𝛽1). These results suggested that UA can be a developing candidate for developing alternative skin protective agent or functional food ingredient.

Water Level Prediction on the Golok River Utilizing Machine Learning Technique to Evaluate Flood Situations

  • Pheeranat Dornpunya;Watanasak Supaking;Hanisah Musor;Oom Thaisawasdi;Wasukree Sae-tia;Theethut Khwankeerati;Watcharaporn Soyjumpa
    • Proceedings of the Korea Water Resources Association Conference
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    • 2023.05a
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    • pp.31-31
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    • 2023
  • During December 2022, the northeast monsoon, which dominates the south and the Gulf of Thailand, had significant rainfall that impacted the lower southern region, causing flash floods, landslides, blustery winds, and the river exceeding its bank. The Golok River, located in Narathiwat, divides the border between Thailand and Malaysia was also affected by rainfall. In flood management, instruments for measuring precipitation and water level have become important for assessing and forecasting the trend of situations and areas of risk. However, such regions are international borders, so the installed measuring telemetry system cannot measure the rainfall and water level of the entire area. This study aims to predict 72 hours of water level and evaluate the situation as information to support the government in making water management decisions, publicizing them to relevant agencies, and warning citizens during crisis events. This research is applied to machine learning (ML) for water level prediction of the Golok River, Lan Tu Bridge area, Sungai Golok Subdistrict, Su-ngai Golok District, Narathiwat Province, which is one of the major monitored rivers. The eXtreme Gradient Boosting (XGBoost) algorithm, a tree-based ensemble machine learning algorithm, was exploited to predict hourly water levels through the R programming language. Model training and testing were carried out utilizing observed hourly rainfall from the STH010 station and hourly water level data from the X.119A station between 2020 and 2022 as main prediction inputs. Furthermore, this model applies hourly spatial rainfall forecasting data from Weather Research and Forecasting and Regional Ocean Model System models (WRF-ROMs) provided by Hydro-Informatics Institute (HII) as input, allowing the model to predict the hourly water level in the Golok River. The evaluation of the predicted performances using the statistical performance metrics, delivering an R-square of 0.96 can validate the results as robust forecasting outcomes. The result shows that the predicted water level at the X.119A telemetry station (Golok River) is in a steady decline, which relates to the input data of predicted 72-hour rainfall from WRF-ROMs having decreased. In short, the relationship between input and result can be used to evaluate flood situations. Here, the data is contributed to the Operational support to the Special Water Resources Management Operation Center in Southern Thailand for flood preparedness and response to make intelligent decisions on water management during crisis occurrences, as well as to be prepared and prevent loss and harm to citizens.

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Study on the economic losses in the industrial sector in case of a Mt. Baekdu eruption scenario (백두산 화산재해로 인한 산업부문 피해액 산정에 관한 연구)

  • Choi, Eun-Kyeong;Yu, Soonyoung;Kim, Sung-Wook;Yoon, Seong-Min
    • Journal of International Area Studies (JIAS)
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    • v.18 no.3
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    • pp.145-168
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    • 2014
  • Given the distance from Mt. Baekdu, volcanic ash will have the direct impact on South Korea in case Mt. Baekdu erupts. Ash fall deposits or particulate matters(PM10) in the air will cause damages in various sectors. In particular, the PM10 impact on the manufacturing sector when the ash disperses in Korea is needed to be assessed since South Korea's manufacturing sector accounts for more than 30% of GDP. Meanwhile the economic impacts of PM10, including Asian dust, have been researched in Korea as the events become frequent, and losses in the manufacturing have been also reported. This study is to identify vulnerable sectors to volcanic ash in the korean industry, and to assess economic losses in case of a Mt. Baekdu eruption scenario, based on the historical loss experience with particulate matters. Study results show that airline, precision such as electronics and semiconductors, distribution, shipbuilding, car, leisure, glass, dairy farming are vulnerable to volcanic ash, or PM10. The economic losses in both car and shipbuilding industry is estimated to 46.49 billion Korean won due to shutdown for 6 hours in case of a Mt. Baekdu eruption scenario.

Design and Fabrication of Dual Linear Polarization Stack Antenna for 4.7GHz Frequency Band (4.7 GHz 대역에서 동작하는 이중 선형편파 적층 안테나의 설계 및 제작)

  • Joong-Han Yoon;Chan-Se Yu
    • The Journal of the Korea institute of electronic communication sciences
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    • v.18 no.2
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    • pp.251-258
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    • 2023
  • In this paper, we propose DLP(Dual Linear Polarization) stack antenna for private network. The proposed antenna has general stack structure and design airgap between two substrate to obtain the maximum gain. Also, to improve cross polarization isolation, two feeding port is designed to separate for each substrate. The size of each patch antenna is 17.80 mm(W1)×16.70 mm(L1) for lower patch and 18.56 mm(W2)×18.73 mm(L2) for upper patch, which is designed on the FR-4 substrate which thickness (h) is 1.6 mm, and the dielectric constant is 4.3, and which is 40.0 mm(W)×40.0 mm(L) for total size of substrate. From the fabrication and measurement results, bandwidths of 100 MHz (4.74 to 4.84 GHz) for feeding port 1, and 150 MHz (4.67 to 4.82 GHz) for feeding port 2 are obtained on the basis of -10 dB return loss and transmission coefficient S21 is got under the -20 dB. Also, cross polarization isolation between each feeding port obtained

A Study on Effects of the Fall Prevention in the Rehabilitation Pilates Exercise (노인의 재활 필라테스 운동이 낙상 예방 효과에 대한 고찰)

  • Ji-Sun Kim
    • Journal of the Korean Applied Science and Technology
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    • v.40 no.2
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    • pp.290-300
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    • 2023
  • This study was understood the risk mechanism of falls in the elderly and reviewed previous research data to see if the principle of Pilates rehabilitation exercise could have a positive effect on balance ability and postural stabilization in the elderly, and the purpose of this study is to present literature-based data on the fall prevention effect of rehabilitation Pilates exercise. First, the rehabilitation Pilates exercise makes it available for strengthening the center of the body to stabilize the spine and pelvis and stimulates the nerve root, thereby having an effect on the balance and the joint stabilization. Second, a proprioceptive sensory impairment and a musculoskeletal degenerative disease due to aging increase the loss of balance ability and the instability in posture maintenance, thereby coming to raise the risk of a fall damage caused by the difficulty in performing motor functions and by the gait disturbance. Third, the rehabilitation Pilates exercise leads to improving the core muscle strength in older adults, resulting in being capable of expecting the betterment in the balance and the reaction time motor function. And there is a positive impact on the improvement in body imbalance and on the stability in movement involved in the fall prevention, resulting in being able to suggest the possibility of likely contributing to a reduction in a fall risk rate. In conclusion, the rehabilitation Pilates as the elderly exercise program showed effects on the improvement in the body's muscular strength, on the upgrade in a sense of balance, and on the stabilization of core. Thus, it was considered to diminish the risk factors for a fall damage caused by musculoskeletal degeneration and to be capable of preventing a serious disorder of activity due to a chronic senile disease.

Alice Springs Orogeny (ASO) Footprints Tracing in Fresh Rocks in Arunta Region, Central Australia, Using Uranium/Lead (U-Pb) Geochronology

  • Kouame Yao;Mohammed O. Idrees;Abdul-Lateef Balogun;Mohamed Barakat A. Gibril
    • Economic and Environmental Geology
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    • v.56 no.6
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    • pp.817-830
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    • 2023
  • This study investigates the age of the surficial rocks in the Arunta region using Uranium-Lead (U-Pb) geochronological dating. Rock samples were collected at four locations, Cattle-Water Pass (CP 1610), Gough Dam (GD 1622 and GD 1610), and London-Eye (LE 1601), within the Strangways Metamorphic Complex and crushed by selFragging. Subsequently, the zircon grains were imaged using Cathodoluminescence (CL) analysis and the U-Pb (uranium and lead) isotope ratios and the chrono-stratigraphy were measured. The imaged zircon revealed an anomalous heterogeneous crystal structure. Ellipses of the samples at locations GD1601, CP1610, and GD1622 fall below the intercept indicating the ages produced discordant patterns, whereas LE1601 intersects the Concordia curve at two points, implying the occurrence of an event of significant impact. For the rock sample at CP1610, the estimated mean age is 1742.2 ± 9.2 Ma with mean squared weighted deviation (MSWD) = 0.49 and probability of equivalence of 0.90; 1748 ± 15 Ma - MSWD = 1.02 and probability of equivalence of 0.40 for GD1622; and 1784.4 ± 9.1 Ma with MSWD of 1.09 and probability of equivalence of 0.37 for LE1601. But for samples at GD1601, two different age groups with different means occurred: 1) below the global mean (1792.2 ± 32 Ma) estimated at 1738.2 ± 14 Ma with MSWD of 0.109 and probability of equivalence of 0.95 and 2) above it with mean of 1838.22 ± 14 Ma, MSWD of 1.6 and probability of equivalence of 0.95. Analysis of the zircon grains has shown a discrepancy in the age range between 1700 Ma and 1800 Ma compared to the ASO dated to have occurred between 440 and 300 Ma. Moreover, apparent similarity in age of the core and rim means that the mineral crystallized relatively quickly without significant interruptions and effect on the isotopic system. This may have constraint the timing and extent of geological events that might have affected the mineral, such as metamorphism or hydrothermal alteration.

Design of a Displacement and Velocity Measurement System Based on Environmental Characteristic Analysis of Laser Sensors for Automatic Mooring Devices (레이저 센서의 환경적 특성 분석에 기반한 선박 자동계류장치용 변위 및 속도 측정시스템 설계)

  • Jin-Man Kim;Heon-Hui Kim
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.29 no.7
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    • pp.980-991
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    • 2023
  • To prevent accidents near the quay caused by a ship, ports are generally designed and constructed through navigation and berthing safety assessment. However, unpredictable accidents such as ship collisions with the quay or personal accidents caused by ropes still occur sometimes during the ship berthing or mooring process. Automatic mooring systems, which are equipped with an attachment mechanism composed of robotic manipulators and vacuum pads, are designed for rapid and safe mooring of ships. This paper deals with a displacement and velocity measurement system for the automatic mooring device, which is essential for the position and speed control of the vacuum pads. To design a suitable system for an automatic mooring device, we first analyze the sensor's performance and outdoor environmental characteristics. Based on the analysis results, we describe the configuration and design methods of a displacement and velocity measurement system for application in outdoor environments. Additionally, several algorithms for detecting the sensor's state and estimating a ship's velocity are developed. The proposed method is verified through some experiments for displacement and speed measurement targeted at a moving object with constant speed.

Standards for Applying Reasonable Receive Bandwidth to Suppress Metal Artifacts in MRI (MRI 검사 시 금속 인공물 억제를 위한 합리적인 수신대역폭 적용 기준)

  • Se-Jong Yoo;Min-Cheol Jeon;Nam-Yong An;Soon-Yong Kwon;Seong-Ho Kim
    • Journal of the Korean Society of Radiology
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    • v.17 no.7
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    • pp.1115-1122
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    • 2023
  • This study aimed to present reasonable reception bandwidth application standards for the purpose of suppressing metal objects during MRI examinations. For this purpose, T2 contrast images were acquired using high-speed spin echo technology on a phantom made of screws for spinal surgery, and metal objects were detected. In addition, images were obtained by increasing the reception bandwidth from 100 Hz/PX to 800 Hz/PX by 100 Hz/PX. The metal artifacts were determined as the sum of the areas of the signal attenuation area and the signal accumulation area. In addition, Pearson correlation analysis was performed to analyze the pattern of metal artifacts according to imaging variables. As a result, the signal accumulation area did not change significantly as the reception bandwidth increased (p>0.05), but the signal loss area and the area of metal artifacts decreased as the reception bandwidth increased (p<0.05). Interestingly, the area of metal objects decreased to a maximum in the section where the reception bandwidth was increased from 100 Hz/PX to 200 Hz/PX, consistent with the section where the echo spacing was reduced to a maximum due to the increase in reception bandwidth. In addition, the correlation analysis results also showed that the eco spacing was more related to the signal attenuation area and the area of metal objects than to the reception bandwidth. Therefore, if the reception bandwidth is increased for the purpose of reducing metal objects, it is reasonable to set it based on a value that minimizes the echo spacing in consideration of image quality factors.

A 2×2 MIMO Spatial Multiplexing 5G Signal Reception in a 500 km/h High-Speed Vehicle using an Augmented Channel Matrix Generated by a Delay and Doppler Profiler

  • Suguru Kuniyoshi;Rie Saotome;Shiho Oshiro;Tomohisa Wada
    • International Journal of Computer Science & Network Security
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    • v.23 no.10
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    • pp.1-10
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    • 2023
  • This paper proposes a method to extend Inter-Carrier Interference (ICI) canceling Orthogonal Frequency Division Multiplexing (OFDM) receivers for 5G mobile systems to spatial multiplexing 2×2 MIMO (Multiple Input Multiple Output) systems to support high-speed ground transportation services by linear motor cars traveling at 500 km/h. In Japan, linear-motor high-speed ground transportation service is scheduled to begin in 2027. To expand the coverage area of base stations, 5G mobile systems in high-speed moving trains will have multiple base station antennas transmitting the same downlink (DL) signal, forming an expanded cell size along the train rails. 5G terminals in a fast-moving train can cause the forward and backward antenna signals to be Doppler-shifted in opposite directions, so the receiver in the train may have trouble estimating the exact channel transfer function (CTF) for demodulation. A receiver in such high-speed train sees the transmission channel which is composed of multiple Doppler-shifted propagation paths. Then, a loss of sub-carrier orthogonality due to Doppler-spread channels causes ICI. The ICI Canceller is realized by the following three steps. First, using the Demodulation Reference Symbol (DMRS) pilot signals, it analyzes three parameters such as attenuation, relative delay, and Doppler-shift of each multi-path component. Secondly, based on the sets of three parameters, Channel Transfer Function (CTF) of sender sub-carrier number n to receiver sub-carrier number l is generated. In case of n≠l, the CTF corresponds to ICI factor. Thirdly, since ICI factor is obtained, by applying ICI reverse operation by Multi-Tap Equalizer, ICI canceling can be realized. ICI canceling performance has been simulated assuming severe channel condition such as 500 km/h, 8 path reverse Doppler Shift for QPSK, 16QAM, 64QAM and 256QAM modulations. In particular, 2×2MIMO QPSK and 16QAM modulation schemes, BER (Bit Error Rate) improvement was observed when the number of taps in the multi-tap equalizer was set to 31 or more taps, at a moving speed of 500 km/h and in an 8-pass reverse doppler shift environment.