• The Korean Journal of Nuclear Medicine Technology
• /
• v.27 no.1
• /
• pp.66-70
• /
• 2023

Purpose It is intended to improve the management efficiency of personal dosimeters by analyzing and sharing personal dosimeter loss cases and loss prevention measures. Materials and Methods From 2017 to 2021, data on the number of lost personal dosimeters were collected at large hospitals, and the number of personal dosimeters issued and lost were investigated. Results In order to prevent loss by institution, methods such as the use of auxiliary rings, contact stickers and dosimeter necklaces were implemented. Conclusion Hospitals are a business that frequently changes clothes, such as surgical gowns and work clothes, so there is a lot of loss. In addition, it was confirmed that the loss rate increases as the number of personal dosimeters issued increases.

• Experimental and Molecular Medicine
• /
• v.50 no.12
• /
• pp.12.1-12.14
• /
• 2018

Osteoporosis develops with high prevalence in both postmenopausal women and hypogonadal men. Osteoporosis results in significant morbidity, but no cure has been established. Mesenchymal stem cells (MSCs) critically contribute to bone homeostasis and possess potent immunomodulatory/anti-inflammatory capability. Here, we investigated the therapeutic efficacy of using an infusion of MSCs to treat sex hormone-deficient bone loss and its underlying mechanisms. In particular, we compared the impacts of MSC cytotherapy in the two genders with the aim of examining potential gender differences. Using the gonadectomy (GNX) model, we confirmed that the osteoporotic phenotypes were substantially consistent between female and male mice. Importantly, systemic MSC transplantation (MSCT) not only rescued trabecular bone loss in GNX mice but also restored cortical bone mass and bone quality. Unexpectedly, no differences were detected between the genders. Furthermore, MSCT demonstrated an equal efficiency in rectifying the bone remodeling balance in both genders of GNX animals, as proven by the comparable recovery of bone formation and parallel normalization of bone resorption. Mechanistically, using green fluorescent protein (GFP)-based cell-tracing, we demonstrated rapid engraftment but poor inhabitation of donor MSCs in the GNX recipient bone marrow of each gender. Alternatively, MSCT uniformly reduced the $CD3^+T$-cell population and suppressed the serum levels of inflammatory cytokines in reversing female and male GNX osteoporosis, which was attributed to the ability of the MSC to induce T-cell apoptosis. Immunosuppression in the microenvironment eventually led to functional recovery of endogenous MSCs, which resulted in restored osteogenesis and normalized behavior to modulate osteoclastogenesis. Collectively, these data revealed recipient sexually monomorphic responses to MSC therapy in gonadal steroid deficiency-induced osteoporosis via immunosuppression/anti-inflammation and resident stem cell recovery.

• Korean Journal of Radiology
• /
• v.25 no.4
• /
• pp.374-383
• /
• 2024

Objective: To evaluate the diagnostic performance and image quality of 1.5-mm slice thickness MRI with deep learningbased image reconstruction (1.5-mm MRI + DLR) compared to routine 3-mm slice thickness MRI (routine MRI) and 1.5-mm slice thickness MRI without DLR (1.5-mm MRI without DLR) for evaluating temporal lobe epilepsy (TLE). Materials and Methods: This retrospective study included 117 MR image sets comprising 1.5-mm MRI + DLR, 1.5-mm MRI without DLR, and routine MRI from 117 consecutive patients (mean age, 41 years; 61 female; 34 patients with TLE and 83 without TLE). Two neuroradiologists evaluated the presence of hippocampal or temporal lobe lesions, volume loss, signal abnormalities, loss of internal structure of the hippocampus, and lesion conspicuity in the temporal lobe. Reference standards for TLE were independently constructed by neurologists using clinical and radiological findings. Subjective image quality, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) were analyzed. Performance in diagnosing TLE, lesion findings, and image quality were compared among the three protocols. Results: The pooled sensitivity of 1.5-mm MRI + DLR (91.2%) for diagnosing TLE was higher than that of routine MRI (72.1%, P < 0.001). In the subgroup analysis, 1.5-mm MRI + DLR showed higher sensitivity for hippocampal lesions than routine MRI (92.7% vs. 75.0%, P = 0.001), with improved depiction of hippocampal T2 high signal intensity change (P = 0.016) and loss of internal structure (P < 0.001). However, the pooled specificity of 1.5-mm MRI + DLR (76.5%) was lower than that of routine MRI (89.2%, P = 0.004). Compared with 1.5-mm MRI without DLR, 1.5-mm MRI + DLR resulted in significantly improved pooled accuracy (91.2% vs. 73.1%, P = 0.010), image quality, SNR, and CNR (all, P < 0.001). Conclusion: The use of 1.5-mm MRI + DLR enhanced the performance of MRI in diagnosing TLE, particularly in hippocampal evaluation, because of improved depiction of hippocampal abnormalities and enhanced image quality.

• Korean Chemical Engineering Research
• /
• v.50 no.4
• /
• pp.627-631
• /
• 2012

Sodium borohydride, $NaBH_4$, shows a number of advantages as hydrogen source for portable proton exchange membrane fuel cells (PEMFCs). The durability of Co-P-B/Cu catalyst for sodium borohydride hydrolysis reaction was studied. The effect of reaction temperature, $NaBH_4$ concentration, NaOH concentration and calcination temperature of catalyst on the durability of Co-P-B/Cu catalyst were measured. The gel formed during hydrolysis reaction affected the durability of catalyst (loss of catalyst). Formation of gel increased the loss of the catalyst. When $NaBH_4$ concentration was high and reaction temperature was higher than $60^{\circ}C$, loss of catalyst was low because gel was not formed. But under the temperature of $40^{\circ}C$, loss of catalyst increased due to gel formation When $NaBH_4$ concentration was 40 weight % and the reaction temperature was $40^{\circ}C$, the loss of catalyst increased as the NaOH concentration increased. As the calcination temperature of catalyst decreased, the loss of catalyst decreased and the activity of catalyst decreased. Calcination of the catalyst at high temperature enhanced the durability of catalyst but diminished the activity of catalyst.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.22 no.11
• /
• pp.2573-2584
• /
• 1997

In this paper, Ca, Sn substitute YIC(Yttrium Iron Garnet) ceramics were fabricated with Al substitutions in Fe sites. The strip-line circulator was designed and the properties of fabricated ciculator were measured. When the electric, magnetic and microwave properties were measured in Ca, Sn substituted YIG with Al subsititions, the relative permittivity and perfmeability in microwave frequencies were 15.623 and 0.972, repectively. For $Y_{2.4}Ca_{0.3}Sn_{0.3}Fe_{5-x}Al_xO_{12}$ garnet ceramics sintered at $1450^{\circ}C$, the ferrimagnetic resonance line width $\Delta{H}$) of 42 Oe and the saturation magnetization of 487 G were measured at 10 GHz. The strip-line circulator was simulated with 3-D FEM(Finite Element Method) software and designed to have insertion loss of 0.8dB, return loss of 25dB, isolation of 35dB at the center frequency of 1.9GHz. The fabricated strition loss of 0.8B, reture loss of 25dB, isolation of 35dB at the center frequency of 1.9GHz. The fabricated strip-line junction circulator using above YIG ceramics had insertion loss of 0.869dB, return loss of 26.955dB, isolation of 44.409dB at the center frequency of 1.9GHz.

• Journal of Life Science
• /
• v.18 no.4
• /
• pp.580-584
• /
• 2008

$O^6-methylguanine-DNA$ methyltransferase (MGMT) is a DNA repair protein that protects cells against the carcinogenic effects of alkylating agents. The loss of MGMT expression was commonly known due to hypermethylation of CpG islands in its promoter region. We evaluated the expression of MGMT by immunohistochemistry in order to examine the relationship between loss of MGMT expression and clinicopathological characteristics in 74 Korean patients with non-small cell lung cancers. Loss of MGMT was detected in 25 (33.8%) of 74 cases. The loss of MGMT expression was frequently seen in the adenocarcinoma than in the squamous cell carcinoma (p=0.021). However, there was no significant differences between loss of MGMT expression and other clinicopathological characteristics, including age, gender, smoking status, tumor size, tumor T stage, and lymph node metastasis (p>0.05). In conclusion, loss of MGMT expression was related with the histologic type of lung cancer. Further methylation study of MGMT promoter is needed to evaluate the relationships with immunohistochemical expression of MGMT and to clarify the role of MGMT in lung cancer.

• Journal of the Microelectronics and Packaging Society
• /
• v.28 no.2
• /
• pp.39-44
• /
• 2021

In this paper, two types of BPF(Band Pass Filter) which are hair-pin and interdigital have been designed for millimeter-wave application using two types of material which are LCP(Liquid Crystal Polymer) and PTFE(Polytetrafluoroethylene) and also, their performances such as bandwidth, insertion loss, and in-band flatness are compared. The proposed BPF are designed as third-order filters, and their pass band is from 26.5 GHz to 27.3 GHz. Interdigital BPF using PTFE substrate has most wide -3 dB S21 bandwidth of 7.8 GHz and hair-pin BPF using LCP substrate has most narrow -3 dB S21 bandwidth among the proposed four BPF. For in-band insertion loss, hair-pin BPF using PTFE substrate achieves low insertion loss better than -0.667 dB, and hair-pin BPF using LCP substrate exhibits relatively high insertion loss among the proposed four BPF better than -0.937 dB. However, the maximum difference in insertion loss performance among the proposed four BPF is 0.27 dB, which is too small to negligible. For in-band flatness, interdigital BPF using PTFE substrate shows greatest performance of 0.017 dB, and hair-pin BPF using LCP substrate exhibits the lowest performance of 0.07 dB. There are tiny difference in in-band flatness performance of 0.053 dB. As a results, it is considered that the BPF using LCP substrate can derive the performances similar to that of the BPF using PTFE substrate in Millimeter-wave band.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.22 no.2
• /
• pp.438-445
• /
• 2008

Dodam formula (Dodam) has been used for neurodegenerative disease in Oriental medicine. Dodam is capable of protecting diverse kinds of cells from damage caused by a variety of toxic stimuli. In the present study, we investigated the underlying protective mechanism of Dodam on rotenone-induced cytotoxicity in rat neuroblastoma Neuro-2A cells. Treatment with Neuro-2A cells with rotenone caused the loss of cell viability, and condensation and fragmentation of nuclei, which was associated with the elevation of ROS level, and lipid peroxidation, the increase in Bax/Bcl-2 ratio. Rotenone induced mitochondrial dysfunction characterized by mitochondrial membrane potential loss and cytochrome-c release. These phenotypes induced by rotenone were reversed by pretreatment with Dodam. Our results suggested that major features of rotenone-induced neurotoxicity are partially mediated by mitochondrial dysfunction and oxidative stress, and that Dodam markedly protects Neuro-2A cells from oxidative injury. These data indicated that Dodam might provide a useful therapeutic strategy in treatment of the neurodegenerative diseases caused by oxidative injuries.

• Journal of the Institute of Electronics Engineers of Korea TC
• /
• v.49 no.4
• /
• pp.47-52
• /
• 2012

We have designed the waveguide to microstrip transition using a probe structure for the center frequency of 200 GHz transceiver. The waveguide to microstrip transition is composed of probe, taper and microstrip transmission line. For design of the transition, we simulated the lengths and width of the probe and the taper to optimize the center frequency and the bandwidth using HFSS simulation tool from Ansoft. The transition is designed back-to-back structure. From the simulation results, the transition exhibits that insertion loss is below - 0.81 dB and the return loss less than -10 dB in range of 186 ~ 210 GHz.

• Transactions on Electrical and Electronic Materials
• /
• v.10 no.2
• /
• pp.49-52
• /
• 2009

Barium strontium calcium titanate powders were prepared with the sol-gel method. Ferroelectric $(Ba_{0.54}Sr_{0.36}Ca_{0.1})TiO_3$(BSCT) thick films were fabricated by the screen-printing method on alumina substrate. Then we investigated the structural and dielectric properties of the BSCT thick films at different sintering temperatures. The thermal analysis showed that the BSCT polycrystalline perovskite phase formed at around $660^{\circ}C$. The X-ray diffraction analysis showed a cubic perovskite structure with no second phase present in all of the BSCT thick films. The average grain size and the thickness of the specimens sintered at $1450^{\circ}C$ were about $1.6{\mu}m$ and $45{\mu}m$, respectively. The relative dielectric constant increased and the dielectric loss decreased as the sintering temperature was increased; for BSCT thick films sintered at $1450^{\circ}C$ the values of the dielectric constant and the dielectric loss were 5641 and 0.4%, respectively, at 1 kHz.