• Journal of Korean Neurosurgical Society
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• v.37 no.2
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• pp.124-128
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• 2005

Objective: Congenital bilateral perisylvian syndrome(CBPS) has been defined as a characteristic malformative perisylvian polymicrogyria(PMG) in patients with clinical symptoms of pseudobulbar palsy and epileptic seizures. For the present study, we investigate clinicopathologic features of CBPS associated with timing of lesion formation. Methods: Clinicopathologic features of CBPS from 6 patients with surgical resection of the cerebral lesions due to medically intractable seizures were studied. Results: Seizure onset ranged from 1 to 10years (average 6.7years) of age, and average duration of seizure was 23years. All had complex partial seizures, and two patients had additional tonic clonic seizures. Magnetic resonance (MR) images showed polymicrogyria, atropic gyri with gliosis. In the histopathologic examination, the cortical lesions revealed features of ulegyria; atrophic and sclerotic gyri, laminar loss of neurons, extensive lobular gliosis throughout the gray and white matter, neuronoglial nodule formation, and many amyloid bodies. Unlayered or four-layered PMG was not identified. Conclusion: Above data suggest that CBPS might be caused by ulegyria resulting from developmental cortical defect during early fetal stage or acquired hypoxic/ischemic injury in prenatal or postnatal life.

• Transactions of the Korean Society of Automotive Engineers
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• v.14 no.2
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• pp.114-120
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• 2006

The basic effects of hydrogen addition for engine performance and emission were investigated in single cylinder research engine. Seven commercial injectors were tested to choose a suitable injector for hydrogen injection prior to its engine implementation. The hydrogen fuel leakage and flow rate were evaluated for each injector and KN3-1(Keihin, CO.) showed the best performance for hydrogen fuel. At the higher excess air ratio(${\lambda}=1.7$, 2.0), the better combustion stability was found with hydrogen addition even though its effect was small at lower excess air ratio (${\lambda}=1.0$, 1.3). Stable operation of the engine was even guaranteed at ${\lambda}=2.0$, if the amount of hydrogen gas was near 15% of total energy. In the lean region, ${\lambda}>1.3$, thermal efficiency was improved slightly while it was not clearly observed at ${\lambda}=1.0$, 1.3. It is considered that, in some cases, high temperature environment due to hydrogen combustion caused further heat loss to surroundings. Except for ${\lambda}=1.0$, with larger amount of hydrogen addition, CO was reduced drastically but it was emitted more at the leaner region. Nitric oxides(NOx) was increased a little more with hydrogen addition at ${\lambda}=1.0$, 1.3. However, at ${\lambda}>1.3$ its relative amount of emission was low. In addition, the amount of NOx was continuously decreased with hydrogen addition, but, at ${\lambda}=2.0$ the amount of NOx was lowered to 1/100 of that of ${\lambda}=1.0$. THC emission was significantly increased as air/fuel ratio was raised to leaner region due to misfire and partial burn.

• Reproductive and Developmental Biology
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• v.32 no.1
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• pp.39-43
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• 2008

Most studies on transgenic bioreactors have focused on expression levels of interest genes. In this study we examined whether transgenic bioreactors would inherit expression level of the Oansgene to long-term generations independently of transgene sources. We employed three transgenic mice, which were separately reported, carrying different transgenes and copy numbers, 27 kb of hLF and 22 kb of hIL-10 genomic sequences, and 1.3 kb of hTPO cDNA, respectively. Three females of the transgenic lineages crossbred with a wild-type male up to 20 generations to test transgenic frequencies of their progenies and to determine expression levels of the transgenes. Ultimately, transmission rates of kLF, hIL-10, and hTPO were $64.3{\pm}7.0$, $59.3{\pm}9.8$, and $56.1{\pm}9.7$, respectively, appeared following Mendelian pattern of inheritance. Notably, we found that levels of expressions of hLF, hIL-10, and hTPO in milk were sustained to high numbers of generations. No transgene silencing of expression was observed in every generations of all transgenic mice. In conclusion, we suggest that once established animal bioreactors could consistently transmit the transgene to continual generations, without loss of expressional activity, independently of transgene sources.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.11
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• pp.63-66
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• 1997

With the advent of high speed digital signal processing chips, new digital techniques have been introduced to the hearing instrument. This advanced hearing instrument circuitry has led to the need or and the development of new fitting approach. A number of different fitting approaches have been developed over the past few years, yet there has been little agreement on which approach is the "best" or most appropriate to use. However, when we develop not only new hearing aid, but also its fitting method, the intensive subject-based clinical tests are necessarily accompanied. In this paper, we present an objective method to evaluate and predict the performance of hearing aids without the help of such subject-based tests. In the hearing impairment simulation (HIS) algorithm, a sensorineural hearing impairment model is established from auditory test data of the impaired subject being simulated. Also, in the hearing impairment simulation system the abnormal loudness relationships created by recruitment was transposed to the normal dynamic span of hearing. The nonlinear behavior of the loudness recruitment is defined using hearing loss unctions generated from the measurements. The recruitment simulation is validated by an experiment with two impaired listeners, who compared processed speech in the normal ear with unprocessed speech in the impaired ear. To assess the performance, the HIS algorithm was implemented in real-time using a floating-point DSP.

• Archives of Plastic Surgery
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• v.35 no.2
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• pp.169-173
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• 2008

Purpose: Sacrococcygeal pilonidal sinus is a chronic inflammatory disease that mostly affects young people, which warrants surgical intervention. Although many surgical methods have been suggested, an optimal surgical method remains controversial because of high recurrence rates and postoperative complications. The objective of this study is to evaluate the results of wide excision and coverage with fasciocutaneous advancement flap for the treatment of sacrococcygeal pilonidal sinus, and to assess the usefulness of this method Methods: From May 1995 to October 2006, the authors treated 19 patients with the use of coverage with fasciocutaneous flap after wide excision. The results were evaluated regarding recurrence rates, complications, and the change in sensitivity of the gluteal region after surgery. The follow-up period was 7 to 142 months (mean, 76 months). All patients were male. Results: Postoperative complications were wound infection at the suction drain insertion site and skin necrosis around the suture margin in one case, respectively. During the follow up period, only one recurrence (5.3%) was seen in fifth postoperative month, which was successfully treated by the same operative procedure. There was no other complications such as seroma, hematoma, wound dehiscence and flap loss. Extensive scarring and anatomic distortion did not occur in the reconstructed area. In addition, sensitivity of the gluteal region did not diminish. The aesthetic results were satisfactory for all patients as well. Conclusion: The authors advocate that fasciocutaneous flap closure be a good alternative method to cover defects after the excision of sacrococcygeal pilonidal sinus.

• Journal of Korean Society of Rural Planning
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• v.9 no.1 s.18
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• pp.65-75
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• 2003

As a pre-step research to make land-use planning in the region level, this study aims to analyze some probability pattern representing transition probabilities from farmland to others using the sequential detailed digital land-use maps. Kinki and Chubu regions of Japan, which have Osaka and Nagoya cities as their center places respectively, were selected as test regions in this study. The 10m grid land-use maps for four time series at every 5 year from 1977 to 1992 were used. In this study, the regions were divided into three sub-areas 10km, 20km, and 30km according to distance from center cities, respectively. The correlation coefficient (CC) between sub-areas with same distance in the two regions was calculated to analyze whether or not the two regions have common points in the pattern of land-use conversion probability from farmland to other types. The probability distribution of the converted areas which were moved to the urbanized area (residential, commercial, industrial, road, park and public facility areas) was about $40{\sim}70%$ for both all periods and sub-areas. According to distance from city centers, the probability moved to the urbanized area was about 60% at 10km area, and 40% at the 30km area, which means that the values we decreased gradually, while in the case moved to the forest and the etc areas, the values were increased slightly. The CC analysis from the paddy field and the dry field to the others separately showed that there is high correlation in the probability pattern between the two regions.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.6 no.1
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• pp.96-107
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• 2006

Citrin deficiency resulting from mutations of SLC25A13is associated with two major clinical phenotypes; neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) and adult-onset type 2 citrullinemia (CTLN2). In Korea, 7 cases of citrin deficiency have been diagnosed based on biochemical and molecular findings. Four NICCD cases were identified by newborn screening using MS/MS or presenting symptoms like cholestatic jaundice. They are all males, presenting with conjugated hyperbilirubinemia, elevated liver enzymes, hypoalbuminemia, mild hyperammonemia, elevated citrullin, methionine and threonine. All of them have been spontaneously recovered from hepatic manifestation by the age of 6-8 months. Mutation analysis has been performed using their genomic & cDNAs obtained from skin fibroblasts. They turned out to be compound heterozygotes carrying each of 851del4, IVS11+1G>A, and IVS13+1G>A. Three CTLN2 patients were identified. Two adult male patients presented with a sudden loss of consciousness, seizure, vomiting, hyperammonemia and citrullinemia in their twenties. They carried an IVS13+1G>A, 851del4, and IVS11+1G>A mutant alleles. The other CTLN2 patient was 52 year old female patient, manifesting lethargy, altered consciousness, irritability and hyperammonemia. Similar clinical symptoms had recurred at the delivery of first and second babies in her past medical history. She was managed by hemodialysis and survived with neurological sequellae. Also, we screened the presence of 9 common mutations in 500 Korean newborns using dried blood spot of filter papers. Only a allele carried 854del4 mutation. In conclusion, the entire picture of citrin deficiency in Korea including incidence, genotype, clinical features and natural courses, is still vague at the present time.

• Food Science of Animal Resources
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• v.38 no.3
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• pp.476-486
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• 2018

In this study, the droplet size distribution, rheological properties, and stability of dairy cream-based emulsions homogenized with different sucrose fatty acid ester (SFAE, a non-ionic small-molecule emulsifier) concentrations (0.08%, 0.16%, and 0.24% w/w) at different homogenization pressures (10 MPa and 20 MPa) were examined. Homogenization at a high pressure resulted in a smaller droplet size and narrower droplet size distribution. The D[4,3] (volume-weighted mean) and D[3,2] (surface-weighted mean) values of the emulsions decreased with an increase in the SFAE concentration. The flow properties of the emulsions homogenized with SFAE showed shear-thinning (n=0.21-0.46) behavior. The apparent viscosity (${\eta}_{a,10}$) and consistency index (K) of the homogenized emulsions were lower than those of the control sample that is non-homogenized and without SFAE, and decreased with an increase in SFAE concentration. The storage modulus (G') and loss modulus (G") of all emulsions homogenized with SFAE were also lower than those of the control sample. The stability of all emulsions with SFAE did not show any significant change for 30 d at $5^{\circ}C$. However, the emulsions stored at $40^{\circ}C$ were unstable over the storage period. Therefore, the addition of SFAE enhanced the stability of dairy cream emulsions during storage at refrigeration temperature ($5^{\circ}C$).

• Journal of Conservation Science
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• v.26 no.2
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• pp.191-201
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• 2010

This study was focused on conservation treatment and restoration of the monument for Jo Heon and the Soldiers in Chilbaeguichong. The monument has been ruined by bombing in the era of Japanese colonial(1940) and restored in 1971. Nevertheless, it still showed serious problems such as loss of original form, structural instability, and unnatural appearance. In order to improve its conservation state, the stele basement which was lost by bombing was restored and combined with body and top stones. The broken part of the top stone was also restored with new material through provenance interpretation.

• Journal of Pharmacopuncture
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• v.23 no.1
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• pp.25-29
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• 2020

Objectives: Heavy menstrual bleeding has a significant effect on women's daily life and health consequences for theirs. Attention to women's and girls' menstrual health is critical for their health. This study presents the results of a novel research on the effect of chamomile capsule on the amount of bleeding, and the duration and interval of menstrual cycles. Methods: The current study was a randomized, double-blind, clinical trial, which was carried out on 118 female students living in dorms of Guilan University of Medical Sciences. The participants were divided into two groups of 59, each receiving either chamomile capsule 250 mg or placebo three times a day, for an interval beginning from 7 days before the starting menstruation till the next onset. Higham chart is the pictorial blood loss assessment to determine the amount and duration of menstrual bleeding. Data were analyzed using SPSS version 20. Alpha was set at 0.05 for all analyses. Results: The average amount of bleeding in the chamomile group decreased after taking the capsule (p = 0.001). However, statistical tests did not show any significant difference in terms of duration and interval between two bleeding in both the experimental and control groups (p > 0.05). Conclusion: The present study showed that the chamomile capsule decreases the amount of menstrual bleeding and can be used as a therapeutic method. Conclusion:The present study showed that the chamomile capsule decreases the amount of menstrual bleeding and can be used as a therapeutic method.