• Journal of Korean Dental Science
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• v.17 no.1
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• pp.45-52
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• 2024

Purpose: To investigate the 5-year outcome of dental implants placed in a grafted maxillary sinus using recombinant human bone morphogenetic protein-2 (rhBMP-2). Materials and Methods: We retrospectively analyzed 27 implants after maxillary sinus floor augmentation (MSFA) using rhBMP-2 in 16 patients between January 2016 and March 2017. The study evaluated two outcome variables: (1) 5-year cumulative survival and success rate of the implant after functional loading and (2) marginal bone loss (MBL) for implant failure. Results: The average residual bone height was 4.78±1.53 mm. The healing period before loading was 8.35±2.34 months. The crown-to-implant ratio was 1.31±0.26. The 5-year cumulative survival and success rate after functional loading were 100% and 96.3%, respectively. The 5-year average MLB was 0.89±0.82 mm. Conclusion: Placing dental implants with MSFA using rhBMP-2 is a reliable procedure with favorable long-term survival and success rates.

• Korean Journal of Artificial Intelligence
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• v.12 no.1
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• pp.1-6
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• 2024

Recently, various techniques are being applied through the development of medical AI, and research has been conducted on the application of super-resolution AI models. In this study, evaluate the results of the application of the super-resolution AI model to brain CT as the basic data for future research. Acquiring CT images of the brain, algorithm for brain and bone windowing setting, and the resolution was downscaled to 5 types resolution image based on the original resolution image, and then upscaled to resolution to create an LR image and used for network input with the original imaging. The SRCNN model was applied to each of these images and analyzed using PSNR, SSIM, Loss. As a result of quantitative index analysis, the results were the best at 256×256, the brain and bone window setting PSNR were the same at 33.72, 35.2, and SSIM at 0.98 respectively, and the loss was 0.0004 and 0.0003, respectively, showing relatively excellent performance in the bone window setting CT image. The possibility of future studies aimed image quality and exposure dose is confirmed, and additional studies that need to be verified are also presented, which can be used as basic data for the above studies.

• IMMUNE NETWORK
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• v.22 no.5
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• pp.43.1-43.12
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• 2022

Osteoclasts (OCs) are clinically important cells that resorb bone matrix. Accelerated bone destruction by OCs is closely linked to the development of metabolic bone diseases. In this study, we screened novel chemical inhibitors targeting OC differentiation to identify drug candidates for metabolic bone diseases. We identified that 1,3-dibenzyl-5-fluorouracil, also named OCI-101, is a novel inhibitor of osteoclastogenesis. The formation of multinucleated OCs is reduced by treatment with OCI-101 in a dose-dependent manner. OCI-101 inhibited the expression of OC markers via downregulation of receptor activator of NF-κB ligand and M-CSF signaling pathways. Finally, we showed that OCI-101 prevents ovariectomy-induced bone loss by suppressing OC differentiation in mice. Hence, these results demonstrated that OCI-101 is a good drug candidate for treating metabolic bone diseases.

• KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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• v.29 no.3
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• pp.211-221
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• 2023

This study was conducted as a basic study for the selection of tags suitable for logistics management in the palletized unit-load unit and the development of various technologies to activate the palletized unit-load shipment of agricultural products through local APCs. Three types of passive RFID tags of UHF 900 MHz and one type of active RFID tag of 2.4 GHz band designed and manufactured through this study were used to analyze the receiving strength according to the tag's attachment location and distance of the palletized unit-load of agricultural products. In the passive RFID tag, there was a large difference in receiving strength by the tag's attachment location and a large amount of data loss depending on the distance within 30 m, whereas, in the active RFID tag, it was superior to the passive tags in terms of both receiving strength and data loss. Therefore, active tags are desirable from the perspective of multiple identification of warehouses with large spaces in relation to the application of RFID tags for palletized unit-loads of agricultural products, but the development of low-power technologies such as software wakeup power management as well as hardware to minimize battery power consumption is necessary.

• Journal of Microbiology and Biotechnology
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• v.34 no.3
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• pp.689-699
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• 2024

Colitis is a major gastrointestinal disease that threatens human health. In this study, a synbiotic composed of inulin and Pediococcus acidilactici (P. acidilactici) was investigated for its ability to alleviate dextran sulfate sodium (DSS)-induced colitis. The results revealed that the synbiotic, composed of inulin and P. acidilactici, attenuated the body weight loss and disease activity index (DAI) score in mice with DSS-mediated colitis. Determination of biochemical indicators found that the synbiotic increased anti-oxidation and alleviated inflammation in mice. Additionally, histopathological examination revealed that colonic goblet cell loss and severe mucosal damage in the model group were significantly reversed by the combination of inulin and P. acidilactici. Moreover, synbiotic treatment significantly reduced the levels of IL-1β, TNF-α, and IL-6 in the serum of mice. Thus, a synbiotic composed of inulin and P. acidilactici has preventive and therapeutic effects on DSS-induced colitis in mice.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.7 no.6
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• pp.38-47
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• 2008

In this paper, the narrow band-pass filter with compact-size using the ${\lambda}g/2$ open stubs is proposed. The filter size is reduced by realization of transmission line at second harmonics and at the same time the power can be transferred to the output by using the fundamental wave generated in the resonator and the transmission line in which the impedance mismatch technique is adopted. Thus, the proposed filter can be reduced to half-length of horizontal transmission line than the conventional one. The experimental results show that insertion loss is 1.58 dB and return loss is 9.86 dB, and the fractional bandwidth is 10 % at the center frequency of 5.8 GHz. The filter size is $10.34{\times}18.56\;mm2$.

• Journal of Korean Dental Science
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• v.3 no.1
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• pp.11-16
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• 2010

Objective : This prospective study sought to verify the stability of three types of short implants measuring 7mm or less. Materials and methods : Implants measuring 7mm or less were placed in patients at multicenter dental clinics in Korea, China, Taiwan, and Singapore. Initial stability, intraoperative and postoperative complications, crestal bone loss, and survival rate of the implant were prospectively evaluated. Results : The primary stability of a 6-mm implant was lower than that of a 7-mm implant. The marginal bone loss of short implants measuring less than 7mm was minimal. Complications such as wound dehiscence, implant mobility, and peri-implant mucositis developed, and these were associated with initial implant failure. The short-term survival rate of 6-mm implant was 93.7%, and that of 7-mm implant, 96.6%. Conclusion : Short implant for the mandible with insufficient height for the residual ridge can be selectively used. Poor primary stability and wound dehiscence can cause osseointegration failure and alveolar bone loss.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.22 no.12
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• pp.1116-1123
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• 2011

In this paper, we studied the propagation of the radio wave in the human body for WBAN system and proposed the path-loss models applicable in the MICS and ISM frequency band. Human Tissues are composed of complicate organ. So it is difficult to measure to insert the probe in human body. Accordingly, the equations were modelled by electromagnetic analysis using the numerical phantom based on the real human. The numerical analysis used XFDTD 6.5 of Remcom co. in commercial software based on the Finite-Difference Time-Domain method. Human body model used a standard adult Korean model developed by ETRI. The proposed channel models will be very helpful to design the WBAN system.

• Journal of Physiology & Pathology in Korean Medicine
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• v.32 no.4
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• pp.291-297
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• 2018

The purpose of pilot clinical trial is to evaluate the efiicacy and safety of Needle-Embedding acupuncture therapy on TEWL(Transepidermal Water Loss) and Skin hydration. A total of 24 human who visited Dongshin Oriental Medical Center from December 1st, 2016 to July 31st, 2017 were included in the pilot clinical trial. Needle-Embedding acupuncture therapy performed at Gokji(LI11). We observed change of TEWL(Transepidermal Water Loss), Skin hydration before and after Needle-Embedding acupuncture therapy. In the primary endpoint, index of TEWL showed a statistically insignificant decline ($8.5{\pm}2.12{\rightarrow}7.8{\pm}1.53g/h/m^2$). Index of skin hydration showed a statistically significant result ($38.2{\pm}6.77{\rightarrow}36.8{\pm}6.64$). To evaluate the safety, Adverse events and Vital sign check were conducted and there were no problem. And when the physical response, self-awareness, skin system, musculoskeletal pain, and other abnormal responses were assessed 60 minutes and 24 hours and 7 days after Needle-Embedding acupuncture therapy at Gokji(LI11) for stability assessment, Adverse events disappeared during a pilot clinical trial. According to the above pilot clinical trial, it is suggested Needle-Embedding acupuncture therapy were effective for Skin moisturizing and safe.

• Bulletin of the Korean Chemical Society
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• v.27 no.10
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• pp.1641-1647
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• 2006

Vibrational relaxation and competitive C-$H_{methyl}$ and C-$H_{ring}$ bond dissociations in vibrationally excited methylpyrazine in the collision with HF have been studied by use of classical trajectory procedures. The energy lost by the vibrationally excited methylpyrazine upon collision is not large and it increases slowly with increasing total vibrational energy content between 20,000 and 45,000 $cm^{-1}$. Above the energy content of 45,000 $cm^{-1}$, however, energy loss decreases. The temperature dependence of energy loss is negligible between 200 and 400 K, but above 45,000 $cm^{-1}$ the energy loss increases as the temperature is raised. Energy transfer to or from the excited methyl C-H bond occurs in strong collisions with HF, that is, relatively large amount of translational energy is transferred in a single step. On the other hand, energy transfer to the ring C-H bond occurs in a series of small steps. When the total energy content ET of methylpyrazine is sufficiently high, either or both C-H bonds can dissociate. The C-$H_{methyl}$ dissociation probability is higher than the C-$H_{ring}$ dissociation probability. The dissociation of the ring C-H bond is not the result of the direct intermolecular energy flow from the direct collision between the ring C-H and HF but the result of the intramolecular flow of energy from the methyl group to the ring C-H stretch.