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Linkage and association scan for tanning ability in an isolated Mongolian population

  • Paik, Seung-Hwan;Kim, Hyun-Jin;Lee, Seung-Bok;Im, Sun-Wha;Ju, Young-Seok;Yeon, Je-Ho;Jo, Seong-Jin;Eun, Hee-Chul;Seo, Jeong-Sun;Kim, Jong-Il;Kwon, Oh-Sang
    • BMB Reports
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    • v.44 no.11
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    • pp.741-746
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    • 2011
  • Tanning ability is important, because it represents the ability of the skin to protect itself against ultraviolet (UV) radiation. Here, we sought to determine genetic regions associated with tanning ability. Skin pigmentation was measured at the outer forearm and buttock areas to represent facultative and constitutive skin color, respectively. In our study population consisting of isolated Mongolian subjects, with common histories of environmental UV exposure during their nomadic life, facultative skin color adjusted by constitutive skin color was used to indicate tanning ability. Through linkage analysis and family-based association tests of 345 Mongolian subjects, we identified 2 potential linkage regions regulating tanning ability on 5q35.3 and 12q13.2, having 6 and 7 significant single nucleotide polymorphisms (SNPs), respectively. Those significant SNPs were located in or adjacent to potential candidate genes related to tanning ability: GRM6, ATF1, WNT1, and SILV/Pmel17.

The Management of Postpneumonectomy Empyema According to Modified Clagett's Procedure -Report of Four Cases- (항생제(抗生劑) 충전(充塡)에 의(依)한 농흉(膿胸)의 치료(治療) -Clagett 씨(氏) 방식(方式)의 원용(援用) <4예보고>-)

  • Kang, J.H.;Choi, S.S.;Lee, J.H.;Yoo, Y.S.;Yoo, H.S.
    • Journal of Chest Surgery
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    • v.9 no.1
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    • pp.102-106
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    • 1976
  • The management of infection occurring in the space which remains after removal of lung presents considerable difficulties both for the patient and the surgeon. We have during the past one year, developed a procedure, which has been successfully applied in 4 cases of postpneumonectomy empyema by modification of Clagett's procedure. All their underlying lung diseases were pulmonary tuberculosis. The diagnosis of postpneumonectomy empyema was confirmed by thoracentesis, and bacteriologic cultures were obtained in all patients. Dead space thoracis was irrigated with various kind of antiseptic Solutions and debrided, filled with antibiotics saline solutions. The patients had a smooth post operative course except one case and was discharged from the hospital on the 3 weeks post-operative day in average. The failure case was wound leaking & redeveloped empyema, & waiting for reoperation.

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Endobronchial Hamartoma -A Case Report- (Endobronchal Hamartoma 치험(治驗) 1례(例))

  • Kim, D.Y.;Choi, S.S.;Lee, J.H.;Yoo, Y.S.;Yoo, H.S.;Park, H.S.
    • Journal of Chest Surgery
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    • v.9 no.1
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    • pp.94-97
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    • 1976
  • In 1904, Albrecht first used the term "hamartoma" to refer to a congenital abnormal mixing of the normal components of an organ and is applied also to tumors found in many organs other than the lung. Though the term "hamartoma" of the lung have been used with the connection to the presence of cartilage, tumors that do not contain cartilagenous compont is also considered hamartoma. The authors experienced one case of endobronchial hamartoma. The patient, a 42-year-old woman, a teacher in a primary school, was admitted to our hospital with frequent attacks of hemoptysis. Bronchogram on the left disclosed abrupt blocking of bronchial filling at the bifurcation between postero-basal and lateral basal segmental bronchial substantiating a mass in the bronchial lumen. Left lower lobectomy was performed. The answer of pathology was benign endobronchial hamartoma. Postoperative course was uneventful. Discharged on 19th postoperative day.

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Potential Suppression of Dental Caries by Maltosyl-Mannitol Produced by Bacillus stearothermophilus Maltogenic Amylase

  • Cho Kil-Soon;Shin Sang-Ick;Cheong Jong-Joo;Park Kwan-Hwa;Moon Tae-Wha
    • Journal of Microbiology and Biotechnology
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    • v.16 no.3
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    • pp.484-486
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    • 2006
  • Maltosyl (G2)-mannitol, produced by the transglycosylation of mannitol with maltotriose by Bacillus stearothermophilus maltogenic amylase, was not found to support lactic acid production by Streptococcus sobrinus NRRL 14555. Furthermore, the synthesis of water-insoluble glucans from maltosyl-mannitol by S. sobrinus NRRL 14555 was much lower than that from xylitol or mannitol. Consequently, these results suggest that maltosyl-mannitol could be used as a noncariogenic sugar substitute in food products.