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The Role of Primary Tumor Resection in Patients with Pleural Metastasis Encountered at the Time of Surgery

  • Park, Samina;Chung, Yongwoo;Lee, Hyun Joo;Park, In Kyu;Kang, Chang Hyun;Kim, Young Tae
    • Journal of Chest Surgery
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    • v.53 no.3
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    • pp.114-120
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    • 2020
  • Background: Evidence is lacking on whether the resection of lung parenchymal cancer improves the survival of patients with unexpected pleural metastasis encountered during surgery. We conducted a single-center retrospective study to determine the role of lung resection in the long-term survival of these patients. Methods: Among 4683 patients who underwent lung surgery between 1995 and 2014, 132 (2.8%) had pleural metastasis. After excluding 2 patients who had incomplete medical records, 130 patients' data were collected. Only a diagnostic pleural and/or lung biopsy was performed in 90 patients, while the lung parenchymal mass was resected in 40 patients. Results: The mean follow-up duration was 29.8 months. The 5-year survival rate of the resection group (34.7%±9.4%) was superior to that of the biopsy group (15.9%±4.3%, p=0.016). Multivariate Cox regression analysis demonstrated that primary tumor resection (p=0.041), systemic treatment (p<0.001), lower clinical N stage (p=0.018), and adenocarcinoma histology (p=0.009) were significant predictors of a favorable outcome. Interestingly, primary tumor resection only played a significant prognostic role in patients who received systemic treatment. Conclusion: When pleural metastasis is unexpectedly encountered during surgical exploration, resection in conjunction with systemic treatment may improve long-term survival, especially in adenocarcinoma patients without lymph node metastasis.

The First Case of Korean Boy with Mitochondrial Trifunctional Protein Deficiency Diagnosed by Acylcarnitine Profiles and DNA analysis : A Novel Mutation in the α-subunit of the Mitochondrial Trifunctional Protein and a Unusual Intergenic Sequence with Two Polymorphisms

  • Lee, Ji-Eun;Yoon, Hye-Ran;Paik, Kyung Hoon;Hwang, Jong Hee;Hwang, Soo-Jung;Shim, Jae-Won;Chang, Yun-Sil;Park, Won-Soon;Strauss, Arnold W.;Jin, Dong-Kyu
    • Journal of The Korean Society of Inherited Metabolic disease
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    • v.2 no.1
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    • pp.12-14
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    • 2002
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Influence of Environmental Exposures on Patients with Chronic Obstructive Pulmonary Disease in Korea

  • Hong, Yoonki;Lim, Myoung Nam;Kim, Woo Jin;Rhee, Chin Kook;Yoo, Kwang Ha;Lee, Ji-Hyun;Yoon, Ho Il;Kim, Tae-Hyung;Lee, Jin Hwa;Lim, Seong Yong;Lee, Sang Do;Oh, Yeon-Mok
    • Tuberculosis and Respiratory Diseases
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    • v.76 no.5
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    • pp.226-232
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    • 2014
  • Background: Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation and results from environmental factors and genetic factors. Although cigarette smoking is a major risk factor, other environmental exposures can influence COPD. The purpose of this study is to investigate the clinical characteristics of COPD according to the history of environmental exposure. Methods: The study population comprised of 347 subjects with COPD who were recruited from the pulmonary clinics of 14 hospitals within the Korean Obstructive Lung Disease Study Group. We classified environmental exposures according to history of living near factory, and direct exposure history to firewood or briquette. According to living environmental exposures, we compared the frequency of respiratory symptoms, pulmonary function, quality of life, exercise capacity, and computed tomography phenotypes. Results: Thirty-one subjects (8.9%) had history of living near factory, 271 (78.3%) had exposure history to briquette, and 184 (53.3%) had exposure history to firewood. Patients with history of living near a factory had a significantly longer duration of sputum, while patients with exposure to firewood tended to have lower forced expiratory volume in one second, and patients with exposure to briquette tended to have lower six minute walk distance. Conclusion: COPD subjects with the history of living near factory had more frequent respiratory symptoms such as sputum. Our data suggest that environmental exposure may influence clinical phenotype of COPD.

Cephalometric Evaluation of the Midfacial Soft Tissue Changes on Smiling (두부규격 방사선 사진을 이용한 미소 시의 중안면부 연조직의 변화량 측정)

  • Cheon, Kang-Yong;Shin, Dong-Whan;Chun, Won-Bae;Kim, Soo-Ho;Kim, Eu-Gene;Park, Hyong-Wook;Cho, Jin-Yong;Yun, Jun-Yong;Seo, Mi-Hyun;Lee, Won-Deok;Suh, Je-Duck;Lee, Ho
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.34 no.6
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    • pp.421-425
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    • 2012
  • Purpose: The aim of this study is to compare the soft tissue changes of the midfacial area at the repose position and the natural smiling position for the improvement of evaluation and planning in the orthognathic surgery. Methods: The total of 30 subjects, 15 male and 15 female, were included in this study. The metal point landmarks were placed at the cheek, orbital rim, subpupil, and nasal base. The movements of the landmarks were evaluated at the repose position and smiling position in the lateral and posteroanterior cephalograms. Paired t test and correlation analysis were used for the evaluation of the soft tissue changes statistically. Results: In the lateral cephalograms, the cheek point (4.49 mm in female, 4.87 mm in male) showed the most distant movement. All points presented significant movements, except the orbital rim and nasal base point in male. Cheek point presented significant positive correlation between the horizontal and vertical change in male. Subpupil point presented significant positive correlation between horizontal and vertical change in both male and female. In the posteroanterior cephalograms, the nasal base point (5.41 mm in female, 6.30 mm in male) showed the most distant movement. Subpupil point and nasal base point presented significant movements in both female and male. Nasal base point presented significant negative correlation between the horizontal and vertical change in both male and female. In the lateral and posteroanterior cephalograms, the positional changes of all points presented significant positive correlation with each other in both female and male. Conclusion: The cheek point in the sagittal view and the nasal base point in the frontal view showed the most distant movement on smile. In the sagittal view, the subpupil point and cheek point moved anteriorsuperiorly on smile. In the frontal view, the nasal base points moved laterosuperiorly on smile. In both the sagittal and frontal view, the positional changes of all point were highly correlated to each other. These results may be used in the soft tissue references for the treatment planning of the dentofacial deformity patients.

On Determinig Experimental Points in Central Composite Designs

  • Park, Byoung-Chul;Park, Sung-Hyun
    • Journal of the Korean Statistical Society
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    • v.15 no.2
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    • pp.131-142
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    • 1986
  • By using the tool for finding influential cases in regrssion, we investigate teh properties of three types of diagonal elements of the hat matrix in central designs. From thses results, we determine the experimental points at axes ad teh number of replicates as the center and the otherpoints so that the experimental points give approximatly same influences to estimatoe teh response surface.

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Nonresponse in Repeated Surveys

  • Park, Hyeon-Ah;Na, Seong-Ryong;Jeon, Jong-Woo
    • Communications for Statistical Applications and Methods
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    • v.14 no.3
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    • pp.593-600
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    • 2007
  • Under repeated surveys, missing values often appear for various reasons and are replaced by new samples. It is investigated that the existing estimator in repeated survey by Jessen (1942), which has been originally developed for the new samples of fixed size, can be used in such situation where the size of new samples is random. It is shown that the proposed estimator has smaller variance than the sample mean.

Goheung Radio Interferometer and its Applications for Youth

  • Ha, Ji-Sung;Park, Yong-Sun;Han, Junghwan;Kang, Wonseok;Lee, Sang-Gak
    • The Bulletin of The Korean Astronomical Society
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    • v.40 no.1
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    • pp.83.2-83.2
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    • 2015
  • The Goheung radio interferometer with three 1.8-m antennas has been installed at National Youth Space Center in Goheung, Korea. The interferometric observation of the Sun using the Goheung radio interferometer was carried out and the observed data was analysed to construct the radio contour map of the Sun in 2014. The specifications of Goheung radio interferometer and the synthesized interferometer map of the Sun are provided. As a science activity center for youth, we currently provide students some experimental activities based on the principle of radio observation and interferometer. Our goal is to encourage youth to be interested in astronomy by engaging real experience of radio observation and constructing a synthesized interferometer map with observed data.

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The Social Competence of Children with Reference to Day Care Center`s Structural, Process Variables and Demographic Variables (보육시설의 구조적, 과정적 변인 및 인구통계학적 특성에 따른 유아의 사회적 능력)

  • 전춘애;이미숙
    • Journal of Families and Better Life
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    • v.20 no.1
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    • pp.115-124
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    • 2002
  • The purpose of this study is to examine the social competence of children with reference to day care center's structural, process variables and demographic variables. The subjects were 156 children who attend day care center, aged from 3 to 5 years and 9 teachers in Seoul or the province of KyungkiDo. Data were gathered via the structured Questionnaires distributed to the teachers to rate children's social competence and their own job satisfaction. And two observers rated teacher-child interaction in day care center The major findings are as follows The variables predicting children's social competence were child's sex, age, period of attendance in day care center, teacher's job satisfaction, and group size. Especially this study suggests that teachers who are highly satisfied with their job and small group size influence children's social competence positively.