• Korean Circulation Journal
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• v.52 no.8
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• pp.563-575
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• 2022

Hypertrophic cardiomyopathy (HCM) is one of the most common inheritable cardiomyopathies. Contemporary management strategies, including the advent of implantable cardioverter-defibrillators and effective anticoagulation, have substantially improved the clinical course of HCM patients; however, the disease burden of HCM is still high in Korea. Sudden cardiac death (SCD), atrial fibrillation and thromboembolic risk, dynamic left ventricular outflow tract (LVOT) obstruction, and heart failure (HF) progression remain important issues in HCM. SCD in HCM can be effectively prevented with implantable cardioverter-defibrillators. However, appropriate patient selection is important for primary prevention, and the 5-year SCD risk score and the presence of major SCD risk factors should be considered. Anticoagulation should be initiated in all HCM patients with atrial fibrillation regardless of the CHA2DS2-VASc score, and non-vitamin K antagonist oral anticoagulants are the first option. Symptomatic dynamic LVOT obstruction is first treated medically with negative inotropes, and if symptoms persist, septal reduction therapy is considered. The recently approved myosin inhibitor mavacamten is promising. HF in HCM is usually related to diastolic dysfunction, while about 5% of HCM patients show reduced left ventricular ejection fraction <50%, also referred to as "end-stage" HCM. Myocardial fibrosis plays an important role in the progression to advanced HF in patients with HCM. Patients who do not respond to guideline-directed medical therapy can be considered for heart transplantation. The development of imaging techniques, such as myocardial deformation on echocardiography and late gadolinium enhancement on cardiac magnetic resonance, can provide better risk evaluation and decision-making for management strategies in HCM.

• Korean Journal of Cleft Lip And Palate
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• v.15 no.1
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• pp.39-50
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• 2012

A submucous cleft palate(SMCP) is characterized by a midline deficiency or lack with/without incorrect positioning of muscular tissues in the soft palate, and by a bony defect in the midline or the center of the hard palate. Velopharyngeal incompetence(VPI) related to this SMCP has been managed by various surgical and prosthetic techniques. Because the individual diagnosis and treatment of SMCP patients was not easy to the speech pathologist and to the maxillofacial reconstructive surgeons, and for the better understanding and for the ideal approaches to the SMCP patients, we reviewed several recent articles about grading system in the SMCP caused by VPI, and summarized in this review article.

• The Bulletin of The Korean Astronomical Society
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• v.43 no.2
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• pp.53.3-54
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• 2018

On June 16 AT2018cow (ATLAS 18qqn) was discovered as a bright and fast-evolving transient in nearby universe z ~ 0.01. It brightened by more than 4 mag within a day, and its light curve was decayed rapidly and has a high luminous peak which is more luminous than most of core-collapse supernova. It also overall showed a blue color in an unprecedented case of transients. There have been attempts to explain this behavior with existing models, but most of them have been insufficient except for one - tidal disruption by intermediate-mass black hole. We began to monitor this transient from about 4 days after the discovery until August 21 in the optical bands with 1m-class telescopes over the world. Here, we present a light curve of AT2018cow in the B, V, R and I bands, and analyze its photometric properties and compare to other transients and models.

• JSTS:Journal of Semiconductor Technology and Science
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• v.11 no.3
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• pp.182-189
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• 2011

In this work, a tunneling field-effect transistor (TFET) based on heterojunctions of compound and Group IV semiconductors is introduced and simulated. TFETs based on either silicon or compound semiconductors have been intensively researched due to their merits of robustness against short channel effects (SCEs) and excellent subthreshold swing (SS) characteristics. However, silicon TFETs have the drawback of low on-current and compound ones are difficult to integrate with silicon CMOS circuits. In order to combine the high tunneling efficiency of narrow bandgap material TFETs and the high mobility of III-V TFETs, a Type-I heterojunction tunneling field-effect transistor (I-HTFET) adopting $Ge-Al_xGa_{1-x}As-Ge$ system has been optimized by simulation in terms of aluminum (Al) composition. To maximize device performance, we considered a nanowire structure, and it was shown that high performance (HP) logic technology can be achieved by the proposed device. The optimum Al composition turned out to be around 20% (x=0.2).

• Nutrition Research and Practice
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• v.9 no.1
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• pp.99-105
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• 2015

BACKGROUND/OBJECTIVES: Compelling evidence indicates that consumption of trans-fatty acids (TFA) is associated with a wide range of diseases. However, few validated tools for TFA intake assessment are available in Korea. We aimed to validate a food frequency questionnaire (FFQ) estimating usual intake of TFA in Korean adults. MATERIALS/METHODS: Eighty-two healthy adults completed an FFQ with a 3-day diet record (3DDR), and 58 completed a second FFQ at a 1-month interval. To assess the reproducibility of the FFQ, we compared estimated TFA intakes from each FFQ. To assess the validity, we compared estimates from the FFQ with those from the 3DDR. RESULTS: The FFQ was reproducible (Spearman r = 0.71) and provided modest correlations with the 3DDR (Spearman r = 0.38). After adjustment for total energy intake, the correlations increased (r = 0.45). Measurement-error correction also de-attenuated the correlations (r = 0.57). When quintiles of the FFQ and 3DDR were joint-classified, 9% on average were misclassified into extreme quintiles. CONCLUSIONS: Our findings suggest that the developed FFQ is reproducible and reasonably valid in categorizing individuals according to TFA intakes among healthy young and middle aged adults in Korea.

• Journal of Korean Society for Atmospheric Environment
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• v.23 no.4
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• pp.466-477
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• 2007

To understand particle pollution phenomena caused by vehicles, black carbon (BC) concentrations were continuously monitored using an aethalometer at a roadside in Seoul during the period of May 79 to 25, 2005. The BC concentration was highly fluctuated for a short duration, responding to the traffic situation on the road. The lowest BC concentration was observed between 2 and 5 a.m. The local highest BC concentrations were observed during the periods of both morning and evening rush hours. Change in traffic volume accounts for the trend of hourly averaged BC concentrations from the late evening to the morning. Particularly, the slower increase of BC concentration on Sunday seems to respond directly the lower traffic volume in the morning rush hours. From the comparison with a previous work, it is concluded that the BC concentration around midday hours might be dependent on the distance from a road.

• Archives of Pharmacal Research
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• v.27 no.11
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• pp.1154-1160
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• 2004

We investigated the neurotoxic effects of capsaicin (CAP) on pain sensitivity and on the expression of capsaicin receptor, the vanilloid receptor (VR1), in rats. High-dose application of CAP has been known to degenerate a large fraction of the sensory neurons. Although the neurotoxic effects of CAP are well documented, the effects of CAP on the vanilloid receptor (VR1) are not yet known. In this paper, we investigated the effects of high-dose application of CAP on the expression of VR1 in rats. Thermal and mechanical pain sensitivity was reduced when neonatal rats were treated with a high dose of CAP. This reduction of pain sensitivity was significantly decreased after initiating carrageenan-induced inflammation. The expression of VR1 in dorsal root ganglia (DRG) isolated from the CAP-treated rats was reduced compared to that from the vehicle-treated rats. Therefore, we can conclude that the neurotoxic effect of CAP is related to the decrease of VR1 expression.

• Journal of Institute of Control, Robotics and Systems
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• v.3 no.1
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• pp.32-39
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• 1997

One of the most important performance criteria in tuning the gain of position loop controller for CNC machining center is the contour error. In this papre we analyze contour error in the linear and circular interpolations for the axis-matched and mismatched cases. To have small contour errors, it is necessary to set the P gain for each axis to be same. And the D gain should be much smaller than the P gain. Baded on the analysis in the frequency domain, we propose a gain tuning method for the P and PD controllers. We show that the PD controller is better than the P controller. The effectiveness of this method is demonstrated by experiments.

• Journal of Engineering Education Research
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• v.19 no.4
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• pp.24-34
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• 2016

There's been few research to study the effects of CAC(Computing Accreditation Committee) evaluation, since start of CAC accreditation 10 years ago. The purpose of this paper is to find what computer engineering graduates perceive the effects of CAC accreditation and to suggest how CAC accreditation process can be improved. The research findings through survey are followings; First, computer engineering graduates' undergraduate education satisfaction is not high enough(3.28). Second, the computer engineering graduates don't recognize CAC accreditation necessary. Third, graduates who work in company chose design courses as the most helpful, while graduates who study in graduate school pursuing further career in master or doctor program chose major subjects. Lastly, graduates from accredited program do not think their completion of accreditation program influence their employment. Strategic approaches to make higher effectiveness of CAC accreditation system are suggested. First, improvement of curriculum and instruction method in CAC accredited program is required to satisfy the needs of students and industry. Second, efforts to inform students of understandings and necessity of accreditation are highly recommended. Third, industrial sector needs to understand CAC accreditation and give graduates from accredited program more incentives. Lastly, government support like Seoul Accord Activation Project should last for a while.

• International Journal of Korean Welding Society
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• v.1 no.2
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• pp.30-35
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• 2001

Nowadays, repair welding on in-service natural gas pipeline is a matter of primary concern of gas company. The main purpose of this study is to investigate the effects of welding conditions on the allowable heat input for crack-free welds and welds without burn-through onto in-service natural gas pipeline. First of all, single pass weld bead on plates of the various thickness was deposited to evaluate the penetration of weld metal, the depth of heat affected zone and the hardness of repair weld under various welding conditions. Also, finite element analysis has been conducted to validate experimental results of bead-on plate welds and to develop appropriate model for repair welding. The welding experiments of bead-on-plate weld confirmed the influence of plate thickness, heat input and welding process on safety. And, the finite element model was demonstrated by comparing experimental results. The agreement between the computed and measured values was shown to be generally good. Therefore, It is possible to predict the safety of repair welding under various welding conditions with experimental results and finite element analysis model.