• The Journal of Korean Medicine
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• v.30 no.2
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• pp.30-45
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• 2009

Background: The safety of herbal products is an important issue in Korea. It is more complicated because of the concomitant use of conventional western drugs and herbal medicine, including prescribed medicine, folk herbs and food supplements. Although both western and traditional Korean medical doctors have studied on the safety of HMP, their results did not show relevant or consistent conclusions because of the poor quality of studies, including bias. Objectives: The aim of this study was to review the studies in Korea related to drug induced liver injury (DILI) systematically. We tried to estimate the proportion of causative materials of DILI and evaluate the clinical difference of DILIs from different materials. Methods: Systematic searches were performed on MedRIC and MEDLIS in Korea. The extraction of data as well as selective screening of the studies was carried out independently by two of the authors. There were no restrictions on the types of publication, including grey literature. Results: Twenty-one articles were included. Of them only 7 adapted prospective design and only 6 were published in peer-reviewed journals. The proportion of conventional drugs associated with hepatotoxic injuries in all DILI ranged from 15.8% to 83.3% and that of herbal medicine was from 28.9% to 44.7%. However, the criteria for herbal medicine were not clearly defined and concomitant medications were not fully investigated in most studies. There were limited objective data in the clinical differences of liver injuries from different materials and their results were conflicting. Conclusions: The causality assessments regarding DILI of herbal medicine were not performed properly and causative materials were misclassified in most of the studies published in Korea. These make the safety issue still ambiguous because of the limitations and lack of objectivity of the studies. More rigorous studies are required for clearly addressing these conflicting issues with cooperative investigation between traditional Korean and western medicine.

• Korean Journal of Digital Imaging in Medicine
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• v.9 no.1
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• pp.21-30
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• 2007

Our objective was to evaluate the CT attenuation coefficient and noise of spatial domain filtering as an alternative to additional image reconstruction using different kernels in abdominal CT. Derived from thin collimated source images was generated using abdomen B10 (very smooth), B20 (smooth), B30 (medium smooth), B40 (medium), B50 (medium sharp), B60 (sharp), B70 (very sharp) and B80 (ultra sharp) kernels. Quantitative CT coefficient and noise measurements provided comparable HU (hounsfield) units in this respect. CT attenuation coefficient (mean HU) values in the abdominal were 60.4$\sim$62.2 HU and noise (7.6$\sim$63.8 HU) in the liver parenchyma. In the stomach a mean (CT attenuation coefficient) of -2.2$\sim$0.8 HU and noise (10.1$\sim$82.4 HU) was measured. Image reconstructed with a convolution kernel led to an increase in noise, whereas the results for CT attenuation coefficient were comparable. Image medications of image sharpness and noise eliminate the need for reconstruction using different kernels in the future. CT images increase the diagnostic accuracy may be controlled by adjusting CT various kernels, which should be adjusted to take into account the kernels of the CT undergoing the examination.

• Korean Journal of Veterinary Research
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• v.40 no.3
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• pp.533-541
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• 2000

Biochemical and genetic analysis were carried out to investigate the potential recovery of pathogenecity or related mutations of Brucella abortus RB51 vaccine strains. RB51 strains were recovered from commercial vaccines, including related seed stocks from private companies in Republic of Korea, strain from USA, a reference strain from C university and a field isolate (Daehungjin) from aborted dairy cow after RB51 vaccination were compared with two identified virulent wild strains (S2308 and a field strain isolated from dairy cow in Korea) at the same conditions. All the strains examined, except identified pathogenic strains, revealed the identical characteristics to the original RB51 in biochemical properties, antigen and bacteriophage typing. Outer membrane protein (OMP) profiles from strains of RB51 showed the same patterns with standard RB51 in SDS-PAGE. In addition, Western blotting with the brucella specific monoclonal antibody also indicated that all the vaccine strains were completely deficient in their LPS compared to the pathogenic Br abortus strains. The differences in DNA structures among strains were also possible to detect after PCR. All vaccine strains, except S19, S1119-3, S1075, S544 and Br suis, were amplified a 178bp DNA fragment of eri-gene, and 364bp of IS711 elements. In contrast, 498bp DNA product was only found with Br abortus. Overall evidences in the present study confirmed that the RB51 strains for vaccine production in Korea did not originated from the phenomena of possible recovery of pathogenicity or related to any potential mutation event at all.

• Journal of Pharmaceutical Investigation
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• v.27 no.4
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• pp.287-293
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• 1997

To make a stable o/w emulsion, the effects of egg lecithin as an emulsifier and polyvinylpyrrolidone (PVP) as an auxiliary emulsifier on the physical stability of emulsion were investigated. The oil-in-water emulsion system was manufactured by microfluidizer and evaluated the physical stability. Average particle size and size distribution of emulsion was measured by dynamic light scattering analyzer and interfacial tension was measured. From the interfacial tension tested, critical micelle concentration of the egg lecithin was 0.1 %w/v and optimal concentration for the preparation of emulsion was 1.0 %w/v. The mean particle size was about $0.2\;{\mu}m$ which was suitable for injections. The short-term accelerated stability studies were conducted by centrifugation, freeze-thaw method and shaking of the emulsion samples. The addition of PVP was caused the reduction in the particle size and improved the physical stability of emulsion. These results suggested that a mixed interfacial film comprising the egg lecithin and PVP was formed at the o/w interface and it was effective in preventing phase separation under thermic or mechanical stress. We used antineoplaston A10 (A10) as a model drug which is peptide and amino acid derivative having a action to the living organism against the development of neoplastic growth by a nonimmunological progress. It has a poor solubility in water and there may be a difficulty in formulation of A10. Emulsion formulation study about A10 was performed. Solubility of A10 in emulsion was about five times as high as that in water. From the results of solubility and partition coefficient, almost A10 molecules in o/w emulsion exist in the interface between oil and water.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.6
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• pp.513-523
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• 2017

aim of this study was to analyze the effectiveness of improved self - management leadership competence through 'self - management leadership'. This study aims to contribute to the development of self - management competency curriculum of universities. The subjects of this study were students who took core competency classes at D university in Seoul. The study group consisted of 221 subjects in the experimental group,who took the contents and 204 participants in the control group,who did not take the contents. The experimental group showed higher improvement than the control group. The experimental group showed greater improvement. In addition, the goal management competence was the highest in terms of the improved competence recognized by students who took courses in self-management and leadership. An analysis of the perceptions about self-management leadership competence enhancement showed that among self-management, goal management, relationship formation, leadership, collaboration, an goal management competence was improved the most. In the self - management domain, the highest improvement was observed in the areas of personality, self - reflection, self - confidence. In the goal management area, the areas of time management, goal setting, and vision were the most improved. Communication, listening, interpersonal relationship, and coaching questions showed the most perceived improvement among the relationship formation. In terms of leadership competency, problem solving and influence were the most improved areas, For collaboration competency, it was found that competency was the most improved at team play.

• Journal of Korean Society of Environmental Engineers
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• v.27 no.12
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• pp.1270-1276
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• 2005

When gas/particle partitioning of PAHs in the atmosphere approached an equilibrium state, the slope of linear regression between gas/particle partitioning coefficient($logK_p$) and subcooled liquid vapour pressure($logP_L^O$) was -1. But it was alleged that the slope of equilibrium state might not be -1 in real atmospheric environment due to heterogeneous characteristics of particulate matter. In This study, it would be found if gas/particle partitioning of PAHs segregated with particle size in equilibrium state was based on the hypothesis mentioned above. We have calculated the slopes of $logK_p$ v.s. $logP_L^O$ after collecting 10 set samples which consisted of particulate and vaporous phases. The slope was close to -1 in equilibrium states. But despite of equilibrium state, all slopes segregated with particle size were not close to -1 and those were gentler with larger particle size. The difference of slopes in equilibrium states was almost against the assumption of gas/particle partitioning theory. When the gas/particle partitioning was due to adsorption, the desorption enthalpy was different in each particle size. When it was absorption, the activity coefficient was different. The difference of desorption enthalpy and activity coefficient in each particle size indicate the heterogeneous characteristics of the bulk particle. This may be the reason for slope variation with particle size even though in an equilibrium state.

• Nutrition Research and Practice
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• v.3 no.3
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• pp.247-252
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• 2009

The present study was to investigate the nutritional status and factors related to malnutrition in end-stage renal disease (ESRD) patients requiring hemodialysis (HD) in South Korea. Subjects were ESRD outpatients from general hospitals or HD centers in Seoul referred to the dialysis clinic for maintenance HD care. A total of 110 patients (46 men and 64 women; mean ages $58.6{\pm}1.0y$) were eligible for this study. The family history of chronic renal failure (CRF) was considered positive if a patient reported having either a first-degree or second-degree relative with CRF. Malnutrition was defined as a triceps skinfold thickness or mid-ann muscle circumference below the fifth percentile for age and sex and forty-seven of the 110 patients were malnourished. Almost all (94%) patients had anemia (hemoglobin: <13 g/dL for men and <12 g/dL for women). Energy intake was below the recommended intake levels of energy [30-35 kcal/kg ideal body weight (IBW)] and protein (1.2 g/kg IBW) in 60% of patients. The duration of HD was longer in malnourished HD patients (P=0.0095). Malnutrition was more prevalent in women (P=0.0014), those who never smoked (P=0.0007), nondiabetic patients (P=0.0113), and patients with bone diseases (P=0.0427), adequate HD (spKt/$V{\geq}1.2$) (P=0.0178), and those with a family history of CRF (P=0.0255). Multiple logistic regression was used to examine the relationship between malnutrition and potential risk factors. After adjusting for age, sex, and other putative risk factors for malnutrition, the OR for malnutrition was greater in HD patients with a family history of CRF (OR, 3.290; 95% CI, $1.003{sim}10.793$). Active nutrition monitoring is needed to improve the nutritional status of HD patients. A family history of CRF may be an independent risk factor for malnutrition in Korean HD patients. A follow-up study is needed to investigate whether there is a causal relationship between a family history of CRF and malnutrition in Korean ESRD patients.

• Journal of the Korean Society of School Health
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• v.11 no.1
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• pp.111-121
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• 1998

This is the study to the effect that the problems of the protective institution where the whole health of school is performed should be solved for the purpose of much more effective school business after investigating the situations of the management about health system in the elementary school of seoul city The subjects of the research are five students of the school which practices health class in the protective institution, five students of the school which puts health class to practice in each classroom and five nursing teachers who work for each elementary school Its data resulted from that from July to September 1997, I visited five schools in person at Kang nam ku, Dong chak ku, Yong san ku, Kwan ak ku, Kang dong ku and then I met and talked with the nursing teacher and the children Through this inspection and interpretation, I could figure out such things as follows. 1 The structure of the nursing room is so small that it has quite a few things inconvenient for the children and the nursing teacher to use together So for the sake of the health in school, first of all, Its size has to be larger 2. The name as the protective institution has to be changed into the health room. And the room for rest cure, dressing room, counselling room and the room for the health education should be equipped with the inside of health room 3 The nursing teacher as a health teacher has to carry out the health class at a health room. 4 It was required that the principal and the Ministry of Education should be highly interested in the health of school In particular, the advice for instructing expert agents about the health and the cooperation of the principal was urgently demanded. Through the result above, the health of school will be accomplished not only in first-aid treat and injection but also in the education about health as a main duty And the nursing teacher also can play a role as a teacher for health fully The programming, practice and estimation of the health room of the business for health in school will be feedback.

• Journal of Bio-Environment Control
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• v.26 no.4
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• pp.249-257
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• 2017

Agastache rugosa, is a perennial medicinal plant commonly used in Chinese herbalism, and may have anti-atherogenic and antibacterial properties. Here in this study, we investigated the growth and variations in antioxidant contents of A. rugosa in response to nutrient solution and photosynthetic photon flux density (PPFD) with artificial lighting for a hydroponics culture. Fluorescent light at 150, and $200{\mu}mol{\cdot}m^{-2}{\cdot}s^{-1}$ PPFD with a 16/8 (light/dark) photoperiod, combined with four different nutrient solutions [developed by Horticulture experiment station in Japan (HES), University of Seoul (UOS), Europe vegetable research center (EVR), Otsuka-house 1A (OTS)], were used in a hydroponics culture system for 6 weeks. The shoot and root dry weights of A. rugosa grown with the OTS were significantly higher than those of other nutrient solutions. The amount of tilianin was the highest grown with the OTS, followed by EVR, HES, and UOS. Total acacetin content was the highest in A. rugosa grown under EVR which was statistically similar with OTS. The A. rugosa grown under $200{\mu}mol{\cdot}m^{-2}{\cdot}s^{-1}$ PPFD produced higher fresh weight and both acacetin and tilianin contents than that grown under $150{\mu}mol{\cdot}m^{-2}{\cdot}s^{-1}$ PPFD. The present results suggested that OTS along with $200{\mu}mol{\cdot}m^{-2}{\cdot}s^{-1}$ PPFD could be an optimum growing condition for better growth and higher accumulation of tilianin and acacetin contents in A. rugosa with hydroponic culture systems in a plant factory.

• Journal of architectural history
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• v.14 no.1 s.41
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• pp.71-87
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• 2005

4 royal palaces are currently remained from capital city (Seoul) of 'Cho-Sun(朝鮮)' period. In these palaces, 'Main hall of Royal Palace(正殿)' is the center of the Royal Palaces. The 'Main hall of Royal Palace' of the Royal Palace was the best building of that time. Therefore there were many studies about the 'Main hall of Royal Palace'. But these studies were individual studies of these 'Main hall of Royal Palace'. Therefore, this study is to analyze and compare 4 'Main hall of Royal Palace' of the Royal palaces. It is to study the proportion regarding the Diameter of the pillar, the Height, the pillar and pillar Interval's Distance, and the arrangement of 'Kong-Po(bracket sets)'. With these studies, it is to prove that the 'Main hall of Royal Palace' is the building which high construction technique of this time is expressed. Result of this study is as followings; First, the proportion of pillar height(H) to its diameter(D) average from H=8.0 to 8.5D. Only the Myeong-Jeong-Jeon omitted the 'Go-Ju(高柱)' in the 'Toi-Kan (退間)' to place Ea-Jwa(御座). Second, Second, the proportion of diameter of the pillar of 'Eoi-Bu-Pyeong-Ju(外部平柱)' and 'Nae-Jin-Go-Ju(內陣高柱)' average D1(Diameter of 'Eoi-Bu-Pyeong-Ju') =0.91D2 (Diameter of 'Nae-Jin-Go-Ju'). In regards to the height, the single floor 'Main hall of Royal Palace' and double floor 'Main hall of Royal Palace' seems to be different. The height proportion of the double floor 'Main hall of royal palace' is H1(Height of 'Eoi-Bu-Pyeong-Ju')=0.34H2(Height of 'Nae-Jin-Go-Ju') and single floor 'Main hall of Royal Palace' has a proportion of H1=0.62H2. Third, in Geun-Jeong-Jeon, with the proportion of height and diameter of the pillar, interval's distance between pillars and diameter, the pillar interval distance and height, of 'Ea-kan(御間)' from the 'Toi-Kan' is different from 'Main hall of Royal Palace'. This is because the structure of 'Toi-Kan' of Geun-Jeong-Jeon is not stable. In order to reinforce this, 'Gui-Go-Ju(隅高柱)' of the Geun-Jeong-Jeon jut out $4{\sim}7%$ more compared to In-Jeong-Jeon. Fourth, when comparing double floor 'Main hall of royal palace' of Geun-Jeong-Jeon and In-Jeong-Jeon, based on distance of 'Eoi-Bu-Pyeong-Ju' and 'Nae-Jin-Go-Ju' of lower level, the 'Sang-Bu-Pyeong-Ju(上部平柱)' of Geun-Jeong-Jeon jut out $4{\sim}7%$ more compared to the In-Jeong-Jeon and also It becomes thicker. Fifth, the arrangement of 'Kong-Po' on the front row of 'Gan(間)' had to do with the change of side 'Gan'. Even though the Geun-Jeong-Jeon and the In-Jeong-Jeon were double floors, the arrangement of the 'Kong-Po' is different because the number of side bay is different.