• Journal of The Korea Institute of Healthcare Architecture
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• v.19 no.4
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• pp.37-45
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• 2013

Purpose: With the rapid development of technology and individual life styles, Korea faces ever-increasing mental diseases caused by divorce, suicide, alcohol, drug addiction, and internet addiction. To reflect this, the quantitative expansion of mental health centers that make up is time. The purpose of this study is to understand the current situation of standard mental health centers by analysing Seoul's cases of mental health. First, this study presents the direction of mental health policy through specific examples about the function of public and private sectors. Second, advantages and disadvantages of the facilities will be delineated through in-depth comparisons and analyses, ultimately providing architectural quidelines for establishing future standard mental health center. Methods: Data were collected through literature research, field surveys, and expert interviews to standard mental health centers in Seoul. In the field investigation, we collected various data(architectural plan, dimension, photos) by visiting standard mental health centers. Data were analysed by content analysis. Results: The result of this study can be summarized into three points. The first one is that Mental health environment changing role of the mental health center is derived the spatial variations. The second one is that Standard Mental Health Center is divided into four sectors. Implications: It is necessary to give and architectural suggestion of mental health center in response to the proposal of the system.

• 한국정보디스플레이학회:학술대회논문집
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• 2009.10a
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• pp.1122-1124
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• 2009

Organic thin-film transistors (OTFTs) were fabricated by using the transfer patterning method. In order to remove Au pattern easily, UV-curable polymer mold was surface treated. Au source/drain (S/D) pattern was transferred to insulator-coated substrate surface. Fabricated OTFTs were compared to OTFTs using vacuum-deposited Au S/D. Additionally, transistor diodes were characterized.

• Proceedings of the Korean Society of Plant Pathology Conference
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• 2002.11a
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• pp.97.2-98
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• 2002

• Allergy, Asthma & Respiratory Disease
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• v.6 no.6
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• pp.315-321
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• 2018

Purpose: Radiocontrast media are widely used in medical imaging to improve diagnostic accuracy. However, studies on the adverse reactions of radiocontrast media in children are limited. We aimed to describe the characteristics of adverse reactions to radiocontrast media among children who had a computed tomography scan or magnetic resonance imaging in a tertiary university hospital. Methods: We retrospectively collected data on adverse reactions to radiocontrast media by the reporting system of a tertiary university hospital. We selected data from children under the age of 19 from July 2011 to December 2017 and analyzed their characteristics. We focused mainly on the characteristics of the index case which is defined by the first adverse event of each subject. Results: During the period, a total of 88,050 radiocontrast media-enhanced imaging studies were performed and 184 cases of adverse reactions were reported. A total of 71 were identified as index cases. Forty-nine (69.0%) were male and the mean age was $12.7{\pm}3.2$ years. The incidence of radiocontrast media-related adverse reactions was 0.09% and severe reactions were 0.002%. The most common clinical feature was skin manifestations (54.9%), followed by gastrointestinal symptoms (40.8%) and neuropsychiatric symptoms (7.4%). Conclusion: Adverse reactions to radiocontrast media rarely occur in children and the incidence of severe reactions is low. Most reactions are mild and are related to the skin and gastrointestinal system. This report would provide good evidence for establishing a management strategy in children scheduled for imaging studies using radiocontrast media.

• BMB Reports
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• v.55 no.12
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• pp.633-638
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• 2022

Liver regeneration is a well-known systemic homeostatic phenomenon. The N⁶-methyladenosine (m⁶A) modification pathway has been associated with liver regeneration and hepatocellular carcinoma. m⁶A methyltransferases, such as methyltransferase 3 (METTL3) and methyltransferase 14 (METTL14), are involved in the hepatocyte-specific-regenerative pathway. To illustrate the role of METTL14, secreted from non-parenchymal liver cells, in the initiation phase of liver regeneration, we performed 70% partial hepatectomy (PH) in Mettl14 heterozygous (HET) and wild-type (WT) mice. Next, we analyzed the ratio of liver weight to body weight and the expression of mitogenic stimulators derived from non-parenchymal liver cells. Furthermore, we evaluated the expression of cell cycle-related genes and the hepatocyte proliferation rate via MKI67-immunostaining. During regeneration after PH, the weight ratio was lower in Mettl14 HET mice compared to WT mice. The expressions of hepatocyte growth factor (HGF) and tumor necrosis factor (TNF)-α, mitogens derived from non-parenchymal liver cells that stimulate the cell cycle, as well as the expressions of cyclin B1 and D1, which regulate the cell cycle, and the number of MKI67-positive cells, which indicate proliferative hepatocyte in the late G1-M phase, were significantly reduced in Mettl14 HET mice 72 h after PH. Our findings demonstrate that global Mettl14 mutation may interrupt the homeostasis of liver regeneration after an acute injury like PH by restraining certain mitogens, such as HGF and TNF-α, derived from sinusoidal endothelial cells, stellate cells, and Kupffer cells. These results provide new insights into the role of METTL14 in the clinical treatment strategies of liver disease.

• Journal of the Korean Electrochemical Society
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• v.12 no.1
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• pp.61-67
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• 2009

Flow-field design has much influence over the performance of proton exchange membrane fuel cell (PEMFC) because it affects the pressure magnitude and distribution of the reactant gases. To obtain the pressure magnitude and distribution of reactant gases in five kinds of flow-field designs, computational fluid dynamics (CFD) analysis was performed. After the CFD analysis, a single cell test was carried out to obtain the performance values. As expected, the pressure differences due to different flow-field configurations were related to the PEMFC performance because the actual performance results showed the same tendency as the results of the CFD analysis. A large pressure drop resulted in high PEMFC performance. The single serpentine configuration gave the highest performance because of the high pressure difference magnitudes of the inlet/outlet. On the other hand, the parallel flow-field configuration gave the lowest performance because the pressure difference between inlet and outlet was the lowest.

• Tuberculosis and Respiratory Diseases
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• v.53 no.3
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• pp.253-264
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• 2002

Background : It has been reported that the expression of protein which influences on the cell cycle is significantly involved in the development, progress, treatment response, and survival of cancer, and also that the degree of expression of p27 and CDK4 is related to the prognosis. Recent research has revealed that uteroglobin, tumor suppressor gene, is related to cell cycle. This study is focused on the relations between expression of proteins related to cell cycle and clinical index of and survival of NSCLC. Methods : We examined immunohistochemically specimens of 110 surgically resected NSCLCs for expression of p27, CDK, Uteroglobin. Tissue array slide were obtained from 110 surgically resected NSCLCs. Immunohistochemical staining was performed by immuno-peroxidase technique using avidin-biotinylated horseradish peroxidase complex. Results : In 110 patients with resected NSCLCs, the ratio of male to female was 87:13, the median age was $56.43{\pm}9.41$ yrs. The positive staining of p27 was detected in 75% of the cases. A non-statistically significant trend toward increased p27 expression was observed in smoker and squamous cell cancer. The positive staining of CDK4 was detected in 89%, which was the highest expression of protein among 3 types. The survival ratio of CDK4 negative staining group was higher than that of positive staining group, which was significant diffrernce(P<0.05). There was no association between p27 or uteroglobin expression and survival. Conclusion : The expression degree of CDK4 is related to the prognosis. This findings suggests that the measurement of CDK4 may be useful in identifying patient at high risk for disease recurrence and survival.

• Journal of the Optical Society of Korea
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• v.18 no.6
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• pp.650-656
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• 2014

We propose a novel active fiber design for selectively generating cylindrical vector beams (CVBs) or cylindrical vector modes (CVMs) which can be applied to conventional fiber lasers. A fiber is designed to have a ring-shaped core refractive index profile which can lead to the best overlap between the active dopant distribution profile and the lowest-order CVM (LCVM) field profile. Therefore, the overlap factor (OVF) of the LCVM becomes even higher than that of the fundamental mode. We emphasize that this condition cannot be satisfied by a conventional step-index core fiber (SICF) but by the ring-doped core fiber (RDCF). Because the lasing threshold is inversely proportional to the OVF, the LCVM can predominantly be stimulated even without going through special procedures to impose extra loss mechanisms to the fundamental mode. We numerically verify that the OVF of the LCVM with the doped ions can significantly exceed that of the fundamental mode if the proposed fiber design is applied. In addition, an RDCF of the proposed fiber design can also operate in a regime containing no higher-order modes besides the LCVM, so that it can selectively and efficiently generate the LCVM without being disrupted by the parasitic lasing of the higher-order modes. We highlight that an optimized RDCF can lead to a >30 % higher OVF ratio than a SICF having the same doped area. The proposed model is expected to be useful for enhancing the efficiency of generating CVBs in an all-fiber format.

• Food Science and Biotechnology
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• v.17 no.2
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• pp.234-240
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• 2008

The optimal conditions for the production of branched dextrin from com starch (CSBD) using branching enzyme (BE) were established by investigating the degree of retrogradation of the gelatinized starch. The physicochemical properties of CSBD prepared using the established process were evaluated. It was found that physicochemical properties of com starch were greatly modified by BE treatment. CSBD had a higher dextrose-equivalent value and water solubility than the corresponding control. On the other hand, the viscosities in gelatinized solution and amylose contents of CSBD were lower than those of the control. A high-performance size-exclusion chromatography/multiangle laser light scattering/retractive index (HPSEC/MALLS/RI) system showed that the average molecular weight of CSBD was lower than that of the control. The pasting viscosities of CSBD were stable during the entire temperature cycle. In general, the BE treatment resulted in the retrogradation during storage being lower for CSBD than for the control.

• Asian Journal of Atmospheric Environment
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• v.12 no.2
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• pp.127-138
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• 2018

This study measured indoor and outdoor levels of hydrocarbon volatile organic compounds (VOCs), such as benzene, toluene, ethylbenzene, and xylene isomers (collectively referred to as BTEX), as well as 13 carbonyl compounds, at 20 homes in Seoul, South Korea. Along with the sampling of BTEX and carbonyls, indoor concentrations of the air pollutants nitrogen oxide (NO) and carbon dioxide ($CO_2$) were also measured at each home. These measurements were used to understand the characteristics of BTEX and carbonyls by calculating the various ratios and correlation coefficients between measured contaminant levels. We found that carbonyls were mostly originated from indoor sources, while BTEX were originated from both indoor and outdoor sources. A high correlation between indoor levels of NO and BTEX indicated that traffic emissions were also an important sources of BTEX.