• Journal of agricultural medicine and community health
• /
• v.23 no.1
• /
• pp.51-64
• /
• 1998

This study was carried out during 3 years from March 1992 to March 1995, 140 healthy people and 140 C.V.A patients were investigated, at an oriental clinic in Taejon. The data collected was analysed using a SAS. The results are as follows. 1. The Relationships between patients who have undergone one or more abortion procedures and C.V.A occurrence. A statistical significant difference was recorded between the control group and the outpatients group of P<0.05 2. Number of years after initial C.V.A diagnosis before C.V.A symptom onset. within 1 years 52% (2-3 years, 3-4 years, 4-5 years, 5 years and over) 3. Additional diseases occurring after initial stroke 1 disease 50.7% (2, 3, 4, 5 or more) 4. Alcohol Consumption "A statistical significant difference was recorded between the control group and the outpatients group of" P<0.01 5. Previous Treatment Experience for stoke outpatients Oriental Hospital, clinic 64.3% (General Hospital, clinic, a public health center drug store, home remedies, etc) 6. Exercise Frequency Outpatients Regular 28.6%, Irregular 71.4% Control sample Regular 27%, Irregular 72.9% 7. Degree of Appetite "A statistical significant difference was recorded between the control group and the outpatients group of" P<0.01 8. People who include fish in their diet "A statistical difference was recorded between the control group and the outpatients group of" P<0.01.

• Genomics & Informatics
• /
• v.12 no.4
• /
• pp.195-202
• /
• 2014

Metabolic syndrome (MetS) is a complex disorder related to insulin resistance, obesity, and inflammation. Genetic and environmental factors also contribute to the development of MetS, and through genome-wide association studies (GWASs), important susceptibility loci have been identified. However, GWASs focus more on individual single-nucleotide polymorphisms (SNPs), explaining only a small portion of genetic heritability. To overcome this limitation, pathway analyses are being applied to GWAS datasets. The aim of this study is to elucidate the biological pathways involved in the pathogenesis of MetS through pathway analysis. Cohort data from the Korea Associated Resource (KARE) was used for analysis, which include 8,842 individuals (age, $52.2{\pm}8.9years$ ; body mass index, $24.6{\pm}3.2kg/m^2$). A total of 312,121 autosomal SNPs were obtained after quality control. Pathway analysis was conducted using Meta-analysis Gene-Set Enrichment of Variant Associations (MAGENTA) to discover the biological pathways associated with MetS. In the discovery phase, SNPs from chromosome 12, including rs11066280, rs2074356, and rs12229654, were associated with MetS (p < $5{\times}10^{-6}$), and rs11066280 satisfied the Bonferroni-corrected cutoff (unadjusted p < $1.38{\times}10^{-7}$, Bonferroni-adjusted p < 0.05). Through pathway analysis, biological pathways, including electron carrier activity, signaling by platelet-derived growth factor (PDGF), the mitogen-activated protein kinase kinase kinase cascade, PDGF binding, peroxisome proliferator-activated receptor (PPAR) signaling, and DNA repair, were associated with MetS. Through pathway analysis of MetS, pathways related with PDGF, mitogen-activated protein kinase, and PPAR signaling, as well as nucleic acid binding, protein secretion, and DNA repair, were identified. Further studies will be needed to clarify the genetic pathogenesis leading to MetS.

• Journal of the Korean Chemical Society
• /
• v.53 no.6
• /
• pp.784-792
• /
• 2009

In this study, we investigated the unsuitable cases for the hierarchy of the curriculum in science 'teaching-learning lesson plan' which is on the web site of the each city's support center for teaching and learning and Seoul Science Park with a purpose of giving helpful data for science teachers at lessons. The investigation is limited to 'Three states of matter' unit for the 7th grade and the content elements used at analysis was the "state changes of matter", "molecule" and "molecular model". The case found for unsuitable case for the hierarchy of the curriculum was phase equilibrium, ice crystal theory, peculiar property of water, classification of solid, thermal energy and physical change at the "state changes of matter". While the "molecular model" showed molecular motion and density. On the other hand, no case was found at "molecule".

• Geophysics and Geophysical Exploration
• /
• v.10 no.4
• /
• pp.275-284
• /
• 2007

For precise interpretation of magnetotelluric (MT) data distorted by irregular surface terrain, topography effects are investigated by computing apparent resistivities, phases, tippers and induction vectors for a three-dimensional (3D) hill-and-valley model. To compute MT responses for the 3D surface topography model, we use a 3D MT modeling algorithm based on an edge finite-element method which is free from vector parasites. Distortions on the apparent resistivity and phase are mainly caused by distorted currents that flow along surface topography. The distribution of tipper amplitudes over both hill and valley are the same, while the tipper points toward the center of hill and the base of the valley. The real part of induction vector also points in the same direction as that of tipper, while the imaginary part in the opposite direction.

• Journal of the Institute of Electronics Engineers of Korea CI
• /
• v.44 no.2 s.314
• /
• pp.1-10
• /
• 2007

Branch prediction accuracy is critical for the overall system performance. Branch miss-prediction penalty is the one of the significant performance limiters for improving processor performance, as the pipeline deepens and the instruction issued per cycle increases. In this paper, we propose "Dynamic Per-Branch History Length Fitting Method" by tracking the data dependencies among the register writing instructions. The proposed solution first identifies the key branches, and then it selectively uses the histories of the key branches. To support this mechanism, we provide a history length adjustment algorithm and a required hardware module. As the result of simulation, the proposed mechanism outperforms the previous fixed static method, up to 5.96% in prediction accuracy. Furthermore, our method introduces the performance improvement, compared to the profiled results which are generally considered as the optimal ones.

• Journal of Convergence for Information Technology
• /
• v.7 no.4
• /
• pp.139-149
• /
• 2017

This study tries to examine the effect of positive and negative parents' attitudes on adolescents' smartphone dependency, and prove the meditating effect of poor attachment between the two variables in the times of convergence. For the study, the data from the Korean Children and Youth Panel Survey were analyzed by utilizing the path analysis, the data from 1,971. The results are as follows: First, positive and negative parents' attitudes influenced adolescents' poor attachment. Second, positive and negative parents' attitudes had a effect on adolescents' smartphone dependency. Third, parents' attttudes directly influenced adolescents' smart phone dependency and its' effect was indirectly mediated by the subjects's poor attachment.

• Food Science and Biotechnology
• /
• v.16 no.1
• /
• pp.127-132
• /
• 2007

[ ${\alpha},\;{\alpha}$ ]-Trehalose was efficiently modified by a transgalactosylation reaction of Escherichia coli ${\beta}-galactosidase$ using lactose as a donor to yield two galactosyl trehalose trisaccharides. The reaction products of trehalose by the enzyme were observed by thin layer chromatography (TLC) and high performance anion exchange chromatography (HPAEC) and were purified by BioGel P2 gel permeation chromatography and recycling preparative HPLC. Liquid chromatography-mass spectrometry (LC-MS) and ^{13}C$ nuclear magnetic resonance (NMR) analyses revealed that the structures of the main products were $6^2-{\beta}-D-galactosyl$ trehalose (1) and $4^2-{\beta}-D-galactosyl$ trehalose (2). A reaction of 30%(w/v) trehalose and 15%(w/v) lactose at pH 7.5 and $45^{\circ}C$ resulted in a total yield of approximately 27-30% based on the amount of trehalose used. The galactosyl trehalose products were not hydrolyzed by trehalose. In addition the mixture of transfer products (9:1 ratio of 1 to 2) showed higher thermal stability than glucose, lactose, and maltose, but less than trehalose, against heat treatment over $100^{\circ}C$ at pH 4 and 7. It also exhibited better thermal stability than sucrose at pH 4 alone.

• Korean Journal of Community Nutrition
• /
• v.14 no.6
• /
• pp.734-745
• /
• 2009

Diabetes mellitus is the prevalent disease among older adults. The purpose of this study was to implement and evaluate the nutrition education program for diabetes mellitus patients aged 60 and over. The one group pretest and posttest design was employed to evaluate the program effectiveness. Nutrition education program for diabetes mellitus patients was carried out at the public healthy center in Guri city. The 38 out of 63 patients completed education program. They received four sessions of group education during four weeks. Nutrition education materials (booklet, leaflet) for older adults were provided to participants. Data about blood glucose, blood pressure, nutrition and diabetes mellitus knowledge, dietary behavior, dietary intake by 24-hour recalls were collected before and after nutrition education to evaluate the program effectiveness. All data were statistically analyzed using SAS package (ver.8.2) and significant difference was evaluated by $X^2$-test, paired t-test and Wilcoxon signed rank test. Study results showed that blood pressure and blood glucose were slightly decreased after nutrition education but they did not reach statistical significance. There were positive changes in nutrition knowledge and dietary behavior. The total score of nutrition and diabetes knowledge increased significantly (p < 0.001), and the total score of dietary behavior was improved (p < 0.05) after nutrition education. Dietary intakes of most of nutrients examined were not significantly different between pre- and post-test. Based on study results, it appears that nutrition education program for the aged diabetes mellitus patients might effectively increase nutrition knowledge, dietary behavior and diet quality. This nutrition education program can be used at the public health centers or senior centers for the management of diabetes mellitus for older adults.

• Journal of Microbiology and Biotechnology
• /
• v.22 no.10
• /
• pp.1446-1451
• /
• 2012

Levodopa or L-3,4-dihydroxyphenylalanine (L-DOPA) is the precursor of the neurotransmitter dopamine. L-DOPA is a famous treatment for Parkinson's disease symptoms. In this study, electroenzymatic synthesis of L-DOPA was performed in a three-electrode cell, comprising a Ag/AgCl reference electrode, a platinum wire auxiliary electrode, and a glassy carbon working electrode. L-DOPA had an oxidation peak at 376 mV and a reduction peak at -550 mV. The optimum conditions of pH, temperature, and amount of free tyrosinase enzyme were pH 7, $30^{\circ}C$, and 250 IU, respectively. The kinetic constant of the free tyrosinase enzyme was found for both cresolase and catacholase activity to be 0.25 and 0.4 mM, respectively. A cyclic voltammogram was used to investigate the electron transfer rate constant. The mean heterogeneous electron transfer rate ($k_e$) was $5.8{\times}10^{-4}$ cm/s. The results suggest that the electroenzymatic method could be an alternative way to produce L-DOPA without the use of a reducing agent such as ascorbic acid.

• Journal of the Society of Disaster Information
• /
• v.9 no.2
• /
• pp.188-194
• /
• 2013

As the high speed railroad line increases, researches on developing a more economic high speed railroad bridge system have been actively conducted. In this paper, a new type of prestressed concrete girder based on the bi-prestressing technique, which can introduce additional prestress, is presented. The additional prestress can be introduced using a wedge-shaped pin bar into the upper part of the girder section. The applicability of the new girder technique to the high speed railroad bridge is verified via the dynamic stability analysis. Dynamic moving load analyses using the KTX train load are conducted on bridge systems with the span lengths of 30m, 35m, and 40m, respectively. The results of the analysis show that all bridge systems satisfy the limits prescribed in the design specifications to ensure structural stability, driving safety, and ride quality.