• 대한간호학회지
• /
• 제41권5호
• /
• pp.724-731
• /
• 2011

Purpose: The purpose of this study was to investigate the effectiveness of an educational intervention that used both cellular phones and the Internet to provide a short messaging service (SMS) relating to blood glucose, blood pressure, and serum lipid levels in postmenopausal women with impaired fasting glucose (IFG). Methods: Twenty-eight postmenopausal women were assigned to an intervention group and twenty-one postmenopausal women to a control group. The intervention was provided for 12 weeks. Patients in the intervention group were asked to access a web site by using a cellular phone or to use the Internet directly and input their blood glucose and blood pressure levels weekly. Participants were sent the optimal recommendations weekly by both cellular phone and Internet. Results: The intervention group had a mean decrease in systolic blood pressure (SBP) level of 8.1 mmHg but changes for the control group were not significant. There was a significant mean change in diastolic blood pressure (DBP) level for the intervention group (-7.7 mmHg). The mean change in the control group was not significant. Conclusion: This educational intervention using the Internet and a SMS by cellular phone improved levels of SBP and DBP in postmenopausal women with IFG.

• Journal of Periodontal and Implant Science
• /
• 제43권4호
• /
• pp.168-176
• /
• 2013

Purpose: The purpose of the current study was to examine the effect of dexamethasone (Dex) at various concentrations on the apoptosis and mineralization of human periodontal ligament (hPDL) cells. Methods: hPDL cells were obtained from the mid-third of premolars extracted for orthodontic reasons, and a primary culture of hPDL cells was prepared using an explant technique. Groups of cells were divided according to the concentration of Dex (0, 1, 10, 100, and 1,000 nM). A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was performed for evaluation of cellular viability, and alkaline phosphatase activity was examined for osteogenic differentiation of hPDL cells. Alizarin Red S staining was performed for observation of mineralization, and real-time polymerase chain reaction was performed for the evaluation of related genes. Results: Increasing the Dex concentration was found to reduce cellular viability, with an increase in alkaline phosphatase activity and mineralization. Within the range of Dex concentrations tested in this study, 100 nM of Dex was found to promote the most vigorous differentiation and mineralization of hPDL cells. Dex-induced osteogenic differentiation and mineralization was accompanied by an increase in the level of osteogenic and apoptosis-related genes and a reduction in the level of antiapoptotic genes. The decrease in hPDL cellular viability by glucocorticoid may be explained in part by the increased prevalence of cell apoptosis, as demonstrated by BAX expression and decreased expression of the antiapoptotic gene, Bcl-2. Conclusions: An increase in hPDL cell differentiation rather than cellular viability at an early stage is likely to be a key factor in glucocorticoid induced mineralization. In addition, apoptosis might play an important role in Dex-induced tissue regeneration; however, further study is needed for investigation of the precise mechanism.

• The Korean Journal of Physiology and Pharmacology
• /
• 제19권4호
• /
• pp.357-363
• /
• 2015

The purpose of this study was to compare the inhibitory effect of bevacizumab on human Tenon's fibroblasts (HTFs) cultured from primary and recurrent pterygium. Cultured HTFs were exposed to 2.0, 5.0, 7.5, and 15.0 mg/mL concentration of bevacizumab for 24 hours. The 3-[4,5-dimethylthiazol- 2-yl]-2,5-diphenyl tetrazolium bromide and lactate dehydrogenase leakage assays were then performed to assess fibroblast metabolism and viability. The matrix metalloproteinase (MMP), procollagen type I C terminal propeptide (PIP), and laminin immunoassays were performed to examine extracellular matrix production. Changes in cellular morphology were examined by phase-contrast and transmission electron microscopy. Both metabolic activity and viability of primary and recurrent pterygium HTFs were inhibited by bevacizumab in a dose-dependent manner, especially at concentrations greater than 7.5 mg/mL. Both types of HTFs had significant decreases in MMP-1, PIP, and laminin levels. Distinctly, the inhibitory effect of bevacizumab on MMP-1 level related with collagenase in primary pterygium HTFs was significantly higher than that of recurrent pterygium. Significant changes in cellular density and morphology both occurred at bevacizumab concentrations greater than 7.5 mg/mL. Only primary pterygium HTFs had a reduction in cellular density at a bevacizumab concentration of 5.0 mg/mL. Bevacizumab inhibits primary and recurrent pterygium HTFs in a dose-dependent manner, especially at concentrations greater than 7.5 mg/mL. As the primary HTFs produces larger amounts of MMP-1 compared to recurrent HTFs, significant reduction in MMP-1 level in primary pterygium HTFs after exposure to bevacizumab is likely to be related to the faster cellular density changes in primary pterygium HTFs.

• ETRI Journal
• /
• 제36권5호
• /
• pp.799-807
• /
• 2014

In this paper, we design a rake-based cellular radar receiver (CRR) scheme to detect a moving target located in a multipath environment. The modules of Doppler filter banks, threshold level test, and target detection module are newly introduced into the conventional rake receiver so that it can function as a radar system. The proposed CRR tests the Doppler-shift frequency and signal-to-noise ratio of the received signal against predefined threshold levels to determine detection and then calculates target velocities and ranges. The system performance is evaluated in terms of detection probability and the maximum detection range under a Nakagami-n channel that reflects the multipath environment.

• 한국생물공학회:학술대회논문집
• /
• 한국생물공학회 2000년도 춘계학술발표대회
• /
• pp.219-222
• /
• 2000

Physiological changes of Escherichia coli during the fed-batch fermentation process were characterized in this study. Overall cellular protein samples prepared at the different stage of fermentation were separated by 2-dimensional gel electrophoresis (2-DE), and differently expressed 15 proteins, Phosphotransferase enzyme I, GroEL, Trigger factor, ${\beta}$ subunit of ATP synthase, Transcriptional regulator KDGR, Phosphoglycerate mutase 1, Inorganic pyrophosphatase, Serine Hydroxymethyl-transferase, ${\alpha}$ subunit of RNA polymerase, Elongation factor Tu, Elongation factor Ts, Tyrosine-tRNA ligase, DnaK suppressor protein, Transcriptional elongation factor, 30S ribosomal protein S6 were identified using matrix-assisted laser desorption / ionization time-of-flight mass spectrometry (MALDI-TOF MS). When bacterial cells grow to high cell density, and IPTG-inducible heterologous protein is produced, expression level of overall cellular proteins was decreased. According to their functions in the cell, identified proteins were classified into three groups, proteins involved in transport process, small-molecule metabolism, and synthesis and modification of macromolecules.

• Clinical and Experimental Reproductive Medicine
• /
• 제39권1호
• /
• pp.1-9
• /
• 2012

The safety of human exposure to an ever-increasing number and diversity of electromagnetic field (EMF) sources both at work and at home has become a public health issue. To date, many in vivo and in vitro studies have revealed that EMF exposure can alter cellular homeostasis, endocrine function, reproductive function, and fetal development in animal systems. Reproductive parameters reported to be altered by EMF exposure include male germ cell death, the estrous cycle, reproductive endocrine hormones, reproductive organ weights, sperm motility, early embryonic development, and pregnancy success. At the cellular level, an increase in free radicals and $[Ca^{2+}]i$ may mediate the effect of EMFs and lead to cell growth inhibition, protein misfolding, and DNA breaks. The effect of EMF exposure on reproductive function differs according to frequency and wave, strength (energy), and duration of exposure. In the present review, the effects of EMFs on reproductive function are summarized according to the types of EMF, wave type, strength, and duration of exposure at cellular and organism levels.

• 대한전기학회논문지:시스템및제어부문D
• /
• 제51권4호
• /
• pp.160-166
• /
• 2002

Since conventional mobile robot control with one module has limitation to solve complex problems, there have been a variety of works on combining multiple modules for solving them. Recently, many researchers attempt to develop mobile robot controllers using artificial life techniques. In this paper, we develop a mobile robot controller using cellular automata based neural networks, where complex tasks are divided to simple sub-tasks and optimal neural structure of each sub-task is explored by genetic algorithm. Neural network modules are combined dynamically using the action selection mechanism, where basic behavior modules compete each other by inhibition and cooperation. Khepera mobile robot simulator is used to verify the proposed model. Experimental results show that complex behaviors emerge from the combination of low-level behavior modules.

• Journal of Information Processing Systems
• /
• 제10권3호
• /
• pp.384-394
• /
• 2014

The femtocell overlaid cellular network (FOCN) has been used to enhance the capacity of existing cellular systems. To obtain the desired system performance, both cross-tier interference and co-tier interference in an FOCN need to be managed. This paper proposes an interference management scheme that adaptively constructs a femtocell cluster, which is a group of femtocell base stations that share the same frequency band. The performance evaluation shows that the proposed scheme can enhance the performance of the macrocell-tier and maintain a greater signal to interference-plus-noise ratio than the outage level can for about 99% of femtocell users.

• Reproductive and Developmental Biology
• /
• 제35권4호
• /
• pp.503-510
• /
• 2011

Cellular uptake of nanoparticles for stem cell labeling and tracking is a critical technique for biomedical therapeutic applications. However, current techniques suffer from low intracellular labeling efficiency and cytotoxic effects, which has led to great interest in the development of a new labeling strategy. Using silica-coated nanoparticles conjugated with rhodamine B isothiocyanate (RITC) (SR), we tested the cellular uptake efficiency, biocompatibility, proliferation or differentiation ability with murine bone marrow derived hematopoietic stem/progenitor cells. The bone marrow hematopoietic cells showed efficient uptake with SR with dose or time dependent manner and also provided a higher uptake on hematopoietic stem/progenitor cells. Biocompatibility tests revealed that the SR had no deleterious effects on cell cytotoxicity, proliferation, or multi-differentiation capacities in vitro and in vivo. SR nanoparticles are advantageous over traditional labeling techniques as they possess a high level of cellular internalization without limiting the biofunctionality of the cells. Therefore, SR provides a useful alternative for gene or drug delivery into hematopoietic stem/progenitor cells for basic research and clinical applications.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제10권7호
• /
• pp.3397-3413
• /
• 2016

Considering that the layered cellular automata (LCA) are naturally fit for representing image data in various applications, a novel reverse iterative image encryption scheme based on LCA is proposed. Specifically, the plain image is set as the final configuration of an 8-layer CA, and some sequences derived from a random sequence are set as the pre-final configuration, which ensure that the same plain image will never be encrypted in the same way when encrypted many times. Then, this LCA is backward evolved by following some reversible two order rules, which are generated with the aid of a newly defined T-shaped neighborhood. The cipher image is obtained from the recovered initial configuration. Several analyses and experimental results show that the proposed scheme possesses a high security level and executive performance.