• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.16 no.1
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• pp.76-80
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• 2005

Although primary neuroendocrine carcinomas(NEC) are uncommon tumors of the larynx, they represent the most common nonepidermoid malignancy of this organ. Whereas typical carcinoid tumors and small-cell carcinomas occur very rarely in the larynx, the majority of laryngeal NEC belong to a broad intermediate group between these two extremes of NEC. Through many case studies, a major protion of clinicopathologic characteristics of laryngeal NEC have been revealed; however, the gistogenesis of laryngeal NEC is still unknown. The only well-documented normal neuroendocrine structures of the larynx are paraganglions, but the incidence of laryngeal paragangliomas are much lower than that of NEC. Here, we report on three cases of NEC affecting the larynx and the results of searching for neuroendocriene cells in non-neoplastic larynx tissue.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.24 no.12A
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• pp.1868-1875
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• 1999

The design of LAI(Local Area Identifier), the first paging area for searching the mobile terminal has a close relation with the performance of paging channel in CDMA cellular network. This paper discussed the performance of the forward channel of IS-95 CDMA standard, known as the paging through the related messages such as call control message, channel assignment message, etc. Modeling and simulation work were conducted to quantify the performance of paging channel in terms of traffic handling capacity and blocking levels. The results shown are based on a specific system call model based on the operating system of cell cite. This serves as illustrative guidelines for the proper engineering of common control channel, which has a major impact on the overall performance of cellular network.

• Korean Journal of Environmental Biology
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• v.17 no.3
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• pp.217-232
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• 1999

The author made a special review on/red-tides from the following points: definition, terms, yearly progress of researches, causative organisms, searching the causes, toxins, a loss of lives, damages of aquatic products, reducing aquacultural damages and removal efficiency. Red-tides in Korea were caused by diatoms in the early 1960’s, in the end of 1970’s it was caused by non-toxic dinoflagellates when marine pollutions were growing more and more serious. In the end of 1980’s, red-tides were caused by toxic dinoflagellates. Red-tide was only found in selected areas at first, but recently large-scaled red-tides are frequently found in the southern coastal waters of Korea, causing huge losses of marine life. A plan is greatly needed to reduce the damaging red-tides, and removal systems need to be developed.

• Journal of Korean Medicine Rehabilitation
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• v.21 no.2
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• pp.189-202
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• 2011

Objectives : The objective of the review was to research related to Bangpungtongseong-san(Bofutsusho-san) in oriental medicine in South Korea. Methods : Oriental medicine advanced searching integrated system(OASIS), 4 Korean medical databases and 5 Korean medical journals were searched by using search terms as Bangpungtongseong-san or Bofutsusho-san. In order to see detail review, we classified all the searched studies into types, methods, purposes, outcome measures and main conclusions. Results : We found out total thirty one studies. There were seventeen experimental studies, four clinical studies, seven case reports and three literature reviews. The main thesis were related to metabolic syndrome, including obesity, hyperlipidemia and hypertension, etc. The studies about the safety and toxicity concluded Bangpungtongseong-san did not seem to affect toxicity. In the outcome measure, body mass index, serum biochemical analysis, cell study, abdominal computed tomography(CT) and bioelectrical impedance analysis were used. Conclusions : To improve more objective and continuous research in oriental medicine, further rigorous clinical trials using herbal medicines should be performed.

• Survey Research
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• v.5 no.1
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• pp.1-26
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• 2004

The aim of this study lies in answering the question "How to form weighting cells to enhance sample representativeness in telephone, Internet and mobile surveys\ulcorner". For this, we explored 2% raw data of Year 2000 Population and Housing Census of Korea looking for meaningful patterns for ownership of telephones, the usage of Internet and/or mobile phones. We found that telephone coverage rates vary significantly by household size; 84.6% for one member households, contrasting 98.5% for two-or-more member households. Thus, telephone survey samples need to be weighted differently in sub-groups by household size for proportional representation of target population. Searching socio-demographic factors influencing the use of Internet by C5.0 tree models, we found that education levels and the occupation (or housing type, the automobile ownership) are two most important factors in addition to gender and age. Thus, surveyor might form weighting cells by such factors at the stage of post-stratification or set quotas, a priori, proportional to size of the cells by such factors. For mobile surveys, we approached similarly and found that education levels and the occupation (or the automobile ownership, marriage status) are two additional factors that may be used in forming weighing cells or in setting quotas for cells.

• Archives of Pharmacal Research
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• v.25 no.2
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• pp.158-164
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• 2002

In the course of searching immunomodulators from natural sources, the protein-bound polysaccharide, CM-Ala, has been isolated from the water extract of Chelidonium majus L. (Papaveraceae). The immunostimulatory characteristics have been investigated in several experiments such as generation of activated killer (AK) cells, proliferation of splenocytes, activation of macrophages and granulocyte macrophage-colony forming cell (GM-CFC) assay. Of the fractions obtained using Sephacryl S200 column chromatography, CM-Ala was the most effective fraction that augmented the cytotoxicity against Yac-1 tumor cells from 0.88% to 34.18% by culturing with splenocytes for 5 days. CM-Ala also enhanced nitric oxide production by two fold in peritoneal macrophages and exhibited antitumor activity. It showed mitogenic activity on both spleen cells and bone marrow cells. CM-Ala induced proliferation of splenocytes by 84 fold and increased GM-CFC numbers by 1.48 fold over than the non-treated. On the contrary, CM-Ala had cytotoxic activity to a diverse group of tumor cells. From the above results, we proposed that CM-Ala has a possibility of an effective antitumor immunostimulator.

• Proceedings of the KIEE Conference
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• 1993.07b
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• pp.923-928
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• 1993

Genetic algorithms are powerful optimization methods based on the mechanism of natural genetics and natural selection. Genetic algorithms reduce chance of searching local optima unlike most conventional search algorithms and especially show good performances in complex nonlinear optimization problems because they do not require any information except objective function value. This paper presents a new model based on sexual reproduction in nature. In the proposed Sexual Reproduction model(SR model), individuals consist of the diploid of chromosomes, which are artificially coded as binary string in computer program. The meiosis is modeled to produce the sexual cell(gamete). In the artificial meiosis, crossover between homologous chromosomes plays an essential role for exchanging genetic informations. We apply proposed SR model to optimization of the design parameters of Single-sided Linear Induction Motor(SLIM). Sequential Unconstrained Minimization Technique(SUMT) is used to transform the nonlinear optimization problem with many constraints of SLIM to a simple unconstrained problem, We perform optimal design of SLIM available to FA conveyer systems and discuss its results.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.27 no.4
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• pp.87-100
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• 2014

Objectives : This study is aimed to analyse immunohistochemical research trend on psoriasis and consider the results in terms of Korean medicine. Methods : We analyse both immunohistochemical research papers and Korean medical papers on psoriasis, which I searched using KISS(Korean studies Information Service System) and OASIS(Oriental Medicine Advanced Searching Integrated System). Results : Psoriasis is characterized by hyperporliferation of the epidermis, inflammatory cell accumulation and increased tortuosity and dilatation of dermal papillary blood vessels. Recently, angiogenesis is considered to play a major role in pathogenesis of psoriasis. Conclusion : In Korean medicine, blood-tonifying, blood-cooling and blood-activating medicinal herbs have generally been used to treat psoriasis. I consider these herbs which also treat vessel problem can have an effect on angiogenesis of psoriasis.

• The Korea Journal of Herbology
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• v.38 no.4
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• pp.31-43
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• 2023

Objectives : The objective of this study was to investigate the phytochemistry and pharmacological activities of Cirsium setidens. Methods : Domestic and international articles about Cirsium setidens were investigated. A review was perfoemed via DB searching engine such as Sci.Direct, Springer, DBpia, KISS, Google scholar, Kipris, and so on. Total 73 listed literature were classified by compound analysis and pharmacological efficacy. Results : C. setidens contains pectolinarin and its glycoside, pectolinarigenin as index compounds, and linarin, apigenin, diosmetin, scopoletin, acacetin, cirsimarin, cirsimaritin, setidenosides A and B, silymarin, hispidulin, 92 volatile compounds, and 15 fatty acids. The Pharmacological activities of C. setidens has been reported to inhibit of platelet aggregation and fat accumulation in the liver, inhibit to hepatitis, anti-cancer, antibacterial, skin improvement, hair growth, liver protection, anti-diabetic, anti-inflammatory, sedative. Also, It has been reported the effect of cholesterol-lowering and anti-obesity, neuroprotective effects, increasing human stem cell viability, inhibiting osteoclast formation and osteogenic differentiation. Conclusion : This reviews showed that C. setidens which has been traditionally used for the treatment of inflammation and hypertension, has anticancer and river protective effect, as well as hair loss and diet. In order to maximize the efficacy of C. setidens, research has also begun on the effect of processing processes such as fermentation or fine powdering and combining natural plant resources.

• The Journal of Korean Medicine
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• v.42 no.3
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• pp.153-164
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• 2021

Objectives: The aim of this study is to investigate the effect of Heat-sensitive Moxibustion on Benign Prostatic Hyperplasia Methods: We searched articles from Academic Journals(CAJ) online databases, Oriental Medicine Advanced Searching Integrated System (OASIS), Searching key words were '前列腺增生', '熱敏灸' and '열민구', '전립선비대'. The search range included randomized controlled trials (RCTs). Among the articles published to 2020, 10 articles were found. After review the title, abstract and original, 3 articles were selected finally to rule out treatment combined with completely different treatments. Result: The Heat-sensitive moxibustion at acupoints in the treatment of Benign prostatic hyperplasia were significantly superior to control group after treatment in the symptoms of patients, IPSS, QOL, PVR and Qmax(P<0.05). The Heat-sensitive moxibustion can significantly reduce the incidence of temporary urinary incontinence after Transurethral resection of the prostate(TURP) and improve life quality and satisfaction of patients(P<0.05). The individualized desensitization saturated time and amount of Heat-sensitive moxibustion is superior effective to general amount and time of traditional moxibustion in the total effective rate, IPSS, Ru and Qmax(P<0.01) for Benign prostatic hyperplasia. Conclusion: Heat sensitive moxibustion directly transfer heat to the source of a disease. So it can be considered as a good treatment for Benign prostate hypertrophy. It was also shown a better effect on BPH compared to traditional moxibustion, According to the thermo principles of tumor, if the tumor cell's death temperature of 43℃ is reached, that can cause tumor degeneration. Therefore I think Heat sensitive moxibustion can be applied to various tumor disease. The results of this study could be applied to clinical treatment of BPH. However, additional large-scale clinical researches should be conducted.