• Title/Summary/Keyword: cell mechanics

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Computational analysis of heart mechanics using a cell-autonomic nerve control-hemodynamic system coupled model (세포-신경계-혈류역학 시스템 통합모델에 의한 심장역학 분석)

  • Jun, Hyung-Min;Shim, Eun-Bo
    • Proceedings of the KSME Conference
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    • 2007.05b
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    • pp.2941-2946
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    • 2007
  • A model of the cardiovascular system coupling cell, hemodynamics and autonomic nervecontrol function is proposed for analyzing heart mechanics. We developed a comprehensive cardiovascular model with multi-physics and multi-scale characteristics that simulates the physiological events from membrane excitation of a cardiac cell to contraction of the human heart and systemic blood circulation and ultimately to autonomic nerve control. Using this model, we delineatedthe cellular mechanism of heart contractility mediated by nerve control function. To verify the integrated method, we simulated a 10% hemorrhage, which involves cardiac cell mechanics, circulatory hemodynamics, and nerve control function. The computed and experimental results were compared. Using this methodology, the state of cardiac contractility, influenced by diverse properties such as the afterload and nerve control systems, is easily assessed in an integrated manner.

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MEMS based micro-fuel processor

  • Kundu, Arunabha;Jang, J.H.;Lee, H.R.;Jung, C.R.;Gil, J.H.;Kim, S.H.;Cha, H.Y.
    • Proceedings of the Korean Society of Precision Engineering Conference
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    • 2006.10a
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    • pp.611-612
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    • 2006
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Stability Assessment of Lead Sulfide Colloidal Quantum Dot Based Schottky Solar Cell

  • Song, Jung-Hoon;Kim, Jun-Kwan;An, Hye-Jin;Choi, Hye-Kyoung;Jeong, So-Hee
    • Proceedings of the Korean Vacuum Society Conference
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    • 2012.08a
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    • pp.413-413
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    • 2012
  • Lead sulfide (PbS) Colloidal quantum dots (CQDs) are promising material for the photovoltaic device due to its various outstanding properties such as tunable band-gap, solution processability, and infrared absorption. More importantly, PbS CQDs have large exciton Bohr radius of 20 nm due to the uniquely large dielectric constants that result in the strong quantum confinement. To exploit desirable properties in photovoltaic device, it is essential to fabricate a device exhibiting stable performance. Unfortunately, the performance of PbS NQDs based Schottky solar cell is considerably degraded according to the exposure in the air. The air-exposed degradation originates on the oxidation of interface between PbS NQDS layer and metal electrode. Therefore, it is necessary to enhance the stability of Schottky junction device by inserting a passivation layer. We investigate the effect of insertion of passivation layer on the performance of Schottky junction solar cells using PbS NQDs with band-gap of 1.3 eV. Schottky solar cell is the simple photovoltaic device with junction between semiconducting layer and metal electrode which a significant built-in-potential is established due to the workfunction difference between two materials. Although the device without passivation layer significantly degraded in several hours, considerable enhancement of stability can be obtained by inserting the very thin LiF layer (<1 nm) as a passivation layer. In this study, LiF layer is inserted between PbS NQDs layer and metal as an interface passivation layer. From the results, we can conclude that employment of very thin LiF layer is effective to enhance the stability of Schottky junction solar cells. We believe that this passivation layer is applicable not only to the PbS NQDs based solar cell, but also the various NQDs materials in order to enhance the stability of the device.

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Mechanical Analysis of heart muscle using a computational model of cardiac myocyte (심근세포 모델을 이용한 심장근육의 역학적 분석)

  • 심은보;김헌영;임채헌
    • Proceedings of the Korean Society of Precision Engineering Conference
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    • 2004.10a
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    • pp.1176-1179
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    • 2004
  • A new cell-cross bridge mechanics model is proposed to analyze the mechanics of heart muscle. Electrophysiology of a cardiac cell is numerically approximated using the previous model of human ventricular myocyte. Ion transports across cell membrane initiated by action potential induce excitation-contraction mechanism in the cell via cross bridge dynamics. Negroni and Lascano model (NL model) is employed to compute the tension of cross bridge closely related to ion dynamics in cytoplasm.

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The Role of Biomechanics in Tissue Engineering (조직공학에서 생체역학의 역할)

  • Park, Kwi-Deok
    • Proceedings of the KSME Conference
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    • 2008.11a
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    • pp.1458-1460
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    • 2008
  • Tissue engineering is an interdisciplinary field that utilizes the principles of engineering and life sciences toward the creation of biological substitutes. Traditionally, major components of tissue engineering are cells, scaffolds, growth factors and recently biomechanical aspects have been given much attention. A large number of studies have reported that mechanical signals are of particular interest in either encouraging or inhibiting cellular responses. In tissue engineering, cell adhesion is a very important step, because quality of adhesion may determine a cell fate in the future. Elasticity of cell-adhesive substrate is found critical in regulating stem cell differentiation. Cells exert different contractile forces for cell migration, depending on substrate mechanics. Though tissue engineering is very interactive with diverse expertise, for a breakthrough, principles of biomechanics in tissue and cell level needs to be fully understood.

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Multi-scale model for coupled piezoelectric-inelastic behavior

  • Moreno-Navarro, Pablo;Ibrahimbegovic, Adnan;Damjanovic, Dragan
    • Coupled systems mechanics
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    • v.10 no.6
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    • pp.521-544
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    • 2021
  • In this work, we present the development of a 3D lattice-type model at microscale based upon the Voronoi-cell representation of material microstructure. This model can capture the coupling between mechanic and electric fields with non-linear constitutive behavior for both. More precisely, for electric part we consider the ferroelectric constitutive behavior with the possibility of domain switching polarization, which can be handled in the same fashion as deformation theory of plasticity. For mechanics part, we introduce the constitutive model of plasticity with the Armstrong-Frederick kinematic hardening. This model is used to simulate a complete coupling of the chosen electric and mechanics behavior with a multiscale approach implemented within the same computational architecture.

Effect of particle size on direct shear deformation of soil

  • Gu, Renguo;Fang, Yingguang;Jiang, Quan;Li, Bo;Feng, Deluan
    • Geomechanics and Engineering
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    • v.28 no.2
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    • pp.135-143
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    • 2022
  • Soils are natural granular materials whose mechanical properties differ according to the size and composition of the particles, so soils exhibit an obvious scale effect. Traditional soil mechanics is based on continuum mechanics, which can not reflect the impact of particle size on soil mechanics. On that basis, a matrix-reinforcing-particle cell model is established in which the reinforcing particles are larger-diameter sand particles and the matrix comprises smaller-diameter bentonite particles. Since these two types of particles deform differently under shear stress, a new shear-strength theory under direct shear that considers the stress concentration and bypass phenomena of the matrix is established. In order to verify the rationality of this theory, a series of direct shear tests with different reinforcing particle diameter and volume fraction ratio are carried out. Theoretical analysis and experimental results showed that the interaction among particles of differing size and composition is the basic reason for the size effect of soils. Furthermore, the stress concentration and bypass phenomena of the matrix enhance the shear strength of a soil, and the volume ratio of reinforcing particles has an obvious impact on the shear strength. In addition, the newly proposed shear-strength theory agrees well with experimental values.

Determination of the linear elastic stiffness and hygroexpansion of softwood by a multilayered unit cell using poromechanics

  • Gloimuller, Stefan;de Borst, Karin;Bader, Thomas K.;Eberhardsteiner, Josef
    • Interaction and multiscale mechanics
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    • v.5 no.3
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    • pp.229-265
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    • 2012
  • Hygroexpansion of wood is a known and undesired characteristic in civil engineering. When wood is exposed to changing environmental humidity, it adsorbs or desorbs moisture and warps. The resulting distortions or - at restrained conditions - cracks are a major concern in timber engineering. We herein present a multiscale model for prediction of the macroscopic hygroexpansion behavior of individual pieces of softwood from their microstructure, demonstrated for spruce. By applying poromicromechanics, we establish a link between the swelling pressure, driving the hygroexpansion of wood at the nanoscale, and the resulting macroscopic dimensional changes. The model comprises six homogenization steps, which are performed by means of continuum micromechanics, the unit cell method and laminate theory, all formulated in a poromechanical framework. Model predictions for elastic properties of wood as functions of the moisture content closely approach corresponding experimental data. As for the hygroexpansion behavior, the swelling pressure has to be back-calculated from macroscopic hygroexpansion data. The good reproduction of the anisotropy of wood hygroexpansion, based on only a single scalar calibration parameter, underlines the suitability of the model. The multiscale model constitutes a valuable tool for studying the effect of microstructural features on the macroscopic behavior and for assessing the hygroexpansion behavior at smaller length scales, which are inaccessible to experiments. The model predictions deliver input parameters for the analysis of timber at the structural scale, therewith enabling to optimize the use of timber and to prevent moisture-induced damage or failure.

Mesoscopic study on historic masonry

  • Sejnoha, J.;Sejnoha, M.;Zeman, J.;Sykora, J.;Vorel, J.
    • Structural Engineering and Mechanics
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    • v.30 no.1
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    • pp.99-117
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    • 2008
  • This paper presents a comprehensive approach to the evaluation of macroscopic material parameters for natural stone and quarry masonry. To that end, a reliable non-linear material model on a meso-scale is developed to cover the random arrangement of stone blocks and quasi-brittle behaviour of both basic components, as well as the impaired cohesion and tensile strength on the interface between the blocks and mortar joints. The paper thus interrelates the following three problems: (i) definition of a suitable periodic unit cell (PUC) representing a particular masonry structure; (ii) derivation of material parameters of individual constituents either experimentally or running a mixed numerical-experimental problem; (iii) assessment of the macroscopic material parameters including the tensile and compressive strengths and fracture energy.