• KSBB Journal
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• v.26 no.4
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• pp.283-292
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• 2011

Solid dispersion is one of well-established pharmaceutical techniques to improve the dissolution and consequent bioavailability of poorly water soluble drugs. It is defined as a dispersion of drug in an inert carrier matrix. Solid dispersions can be classified into three generations according to the carrier used in the system. First and second generations consist of crystalline and amorphous substances, respectively. Third generation carriers are surfactant, mixture of polymer and surfactants, and mixture of polymers. Solid dispersions can be generallyprepared by melting method and solvent method. While melting method requires high temperature to melt carrier and dissolve drug, solvent method utilizes solvent to dissolve the components. The improvement in dissolution through solid dispersions is attributed to reduction in drug particle size, improvement in wettability, and/or formation of amorphous state. The primary characteristics of solid dispersions, the presenceof drug in amorphous state, could be determined by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and fourier-transformed infrared spectroscopy (FTIR). In spite of the significant improvement in dissolution by solid dispersion technique, some drawbacks have limited the commercial application of solid dispersions. Thus, further studies should be conducted in a direction to improve the congeniality to commercialization.

• Korean Journal of Materials Research
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• v.27 no.8
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• pp.438-444
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• 2017

In this work, the effects of hydrogen reduction on the microstructure and thermoelectric properties of $(GeTe)_{0.85}(AgSbTe_2)_{0.15}$ (TAGS-85) were studied by a combination of gas atomization and spark plasma sintering. The crystal structure and microstructure of TAGS-85 were characterized by X-ray diffraction(XRD) and scanning electron microscopy (SEM). The oxygen content of both powders and bulk samples were found to decrease with increasing reduction temperature. The grain size gradually increased with increasing reduction temperature due to adhesion of fine grains in a temperature range of 350 to $450^{\circ}C$. The electrical resistivity was found to increase with reduction temperature due to a decrease in carrier concentration. The Seebeck coefficient decreased with increasing reduction temperature and was in good agreement with the carrier concentration and carrier mobility. The maximum power factor, $3.3{\times}10^{-3}W/mK^2$, was measured for the non-reduction bulk TAGS-85 at $450^{\circ}C$.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.16 no.2
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• pp.66-70
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• 2006

Various kind of structural defects are observed to be present on the oxidized surface of the silicon crystal which was previously damaged mechanically. The formation of such defects was found to depend on the amount of damage induced and the temperature of thermal oxidation. It was confirmed by the measurement of minority carrier life time that gettering capability decreases as the size of the defects increase. The strained layer which is formed due to smaller amount of damage or lower oxidation temperature believed to has higher capability of gettering over defects like dislocation loops or stacking faults.

• Special Issue of the Society of Naval Architects of Korea
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• 2017.10a
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• pp.93-104
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• 2017

IMO type C independent tank is one of the cargo containment system specified on IGC code. It is normally adopted for small and medium size liquefied gas carrier's cargo containment system and it can be applied to fuel tank of LNG fueled vessel. This study focuses on rule scantling process and evaluation methods in early design stage of type C independent tank. Actual design results of 22K LPG/Ammonia/VCM carrier's No.2 cargo tank are demonstrated. This paper presents the calculation methods of design acceleration and liquid height for internal design pressure as defined on IGC code. And this paper shows the applied results of classification rules about shell thickness requirement and buckling strength. Additionally this paper deals with evaluation methods of structural strength and cumulative fatigue damage using FE analysis.

• KSBB Journal
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• v.31 no.4
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• pp.300-311
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• 2016

Recently gene delivery has been designed newly using bioactive biomaterial and applied in the various field by many researchers. In this study, we proposed a new gene delivery system which has the capability of targeting effect in the specific tissue and remarkably enhanced transfection efficiency. We investigated $^1H-NMR$ spectroscopy, particle size analyzer and gel retardation to confirm the correct preparation of gene delivery. Also, we identified the hemo-compatibility of gene delivery by hemolysis assay, non-cytotoxicity by MTT test and transfection efficiency. The uptake mechanism of the gene carrier was confirmed using inhibitor agent such as sodium azide, indomethacin, quercetin, colchicine, and chloropromazine. As a results, it was identified that gene carrier prepared by in this study entered in the cell by the microtubule-dependent, energy-dependent and clathrin-mediated endocytosis pathway.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.15 no.5
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• pp.66-72
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• 2016

Gearboxes are mechanical components that transmit power by adjusting input and output speed and torque. Their design requirements include small size, light weight, and long lifespan. We have investigated the effects of carrier pinhole position error on the load sharing and load distribution characteristics of a planetary gear set with four planet gears. The simulation model for a simple planetary gear set was developed and verified by comparing analytical results with a putative model. Then, we derived the load sharing and load distribution characteristics under various pinhole position error conditions using the prototypical simulation model. The results showed that the mesh load factor and face load factor increased with the pinhole position error, which then influenced the safety factor for tooth bending strength and surface durability.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.10A
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• pp.950-957
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• 2007

In this paper, a recursive intercarrier interference (ICI) cancellation technique for cooperative space-time block coded orthogonal frequency division multiplexing (STBC-OFDM) with different carrier frequency offsets (CFOs) is proposed. Also, different CFOs existing in a cooperative STBC-OFDM system is shown to produce phase difference in the received signal, causing noise enhancement effect in the STBC decoding process. The performance degradation caused by the noise enhancement effect can be effectively reduced by a proposed ML-based recursive ICI cancellation technique. It is shown by computer simulation that the proposed recursive ICI cancellation technique is effective in reducing ICI, especially for STBC-OFDM systems with a large FFT size and large CFOs.

• Journal of Pharmaceutical Investigation
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• v.40 no.6
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• pp.373-378
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• 2010

In order to develop a topical preparation which has a high occlusive property with skin moisturization, nano-structured lipid carrier (NLC) systems along with solid lipid nanoparticle (SLN) were designed. Various NLC dispersions were successfully formulated with Compritol 888 ATO as a solid lipid, Labrafil M 1944 CS as an oil, and Tween 80 as a surfactant. The increase of oil content (5 to 50%) led to the decrease in the occlusion factor in the order of SLN > NLC-5 > NLC-15 = NLC-30 > NLC-50. Particle size of lipid particulates was in the range of 100 to 160 nm. NLC-based carbogels were prepared by the employment of humectants such as urea, glycerin, and Tinocare GL to carbomer gel. NLC-30 gel formulations containing 4 or 8 % of lipid particles showed improved occlusive effect in vitro, compared to NLC-free gel base. Even though NLC-free gel base revealed comparable occlusion effect by itself, the occlusion factor of 4 % NLC-30 gel was about 2-fold higher than that of NLC-free gel base.

• Journal of IKEEE
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• v.7 no.2 s.13
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• pp.230-235
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• 2003

A small and integrated MMIC VCO(Voltage Controlled Oscillator) at Ka-band has been developed. This oscillator was designed as Clapp-Gouriet type scheme, fabricated, and implemented on the carrier. This was connected to an alumna substrate on the carrier providing output port for module, utilizing ribbon and wire bonding technique allowing the loss of 0.2dB. This VCO module showed the excellent performance.

• Journal of Positioning, Navigation, and Timing
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• v.10 no.4
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• pp.263-269
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• 2021

The carrier-based differential global navigation satellite system (CD-GNSS) has been garnering significant attention as a promising technology for unmanned vehicles for its high accuracy. The CD-GNSS systems to be used for safety-critical applications should provide a certain level of integrity. The integrity of these systems must be analyzed under various conditions, including fault-free and satellite fault conditions. The systems should be able to detect the faults that can cause large biases on the user position errors and quantify the integrity risk by computing the protection level (PL) to protect the user against the faults that are left undetected. Prior work has derived and investigated the PL for the fault-free condition. In this study, the integrity of the CD-GNSS system under the fault condition is analyzed. The position errors caused by the satellite's fault are compared with the fault-free PL (PL_H0) to verify whether the integrity requirement can be met without computing the PLs for the fault conditions. The simulations are conducted by assuming the ephemeris fault, and the position errors are evaluated by changing the size of the ephemeris faults that missed detection. It was confirmed that the existing fault monitors do not guarantee that the position error under the fault condition does not exceed the PL_H0. Further, the impact of the faults on the position errors is discussed.