• Title/Summary/Keyword: caring efficacy

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Biomarkers and Surrogate Endpoints for Development of New Drug on Pulmonary Disease (폐질환 치료제의 효율적인 신약개발을 위한 생체표지자 및 대리결과 변수)

  • Seo, Jeong-Won;Lee, Byung-Yo;Chae, Jung-Woo;Son, Chu-Young;Kang, Won-Ku;Chae, Han-Jung;Kwon, Kwang-Il
    • YAKHAK HOEJI
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    • v.54 no.2
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    • pp.75-90
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    • 2010
  • Biomarkers are likely to be important in the study of various pulmonary diseases for many reasons. Research efforts in developing biomarkers and surrogate endpoints of lung diseases have resulted in the identification of new risk factors and novel drug targets, as well as the establishment of treatment guidelines. Government agencies, academic research institutions, diagnostic industries, and pharmaceutical companies all recognize the importance of biomarkers in new drug development and advancing therapies to improve public health. In drug development, biomarkers are used to evaluate early signals of efficacy and safety, to select dose, and to identify the target population. Identification of suitable end points not only would help investigators design appropriate clinical trials but would assist clinicians in caring for this patient population. Though the area of pulmonology has received much attention in the past decades, it still lags behind with regard to the development of biomarkers, particularly those of health effects and susceptibility. This review critically summarized several biomarker researches such as Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) study with objectives of identifying the parameters that predict disease progression of COPD, as well as biomarkers that may serve as surrogate end-points.

Comparisons of physical Fitness, Self Efficacy, Instrumental Activities of Daily Living, and Quality of Life between Institutionalized and Noninstitutionalized Elderly (가정노인과 양로원노인의 체력, 자기효능, 일상생활활동능력 및 삶의 질에 관한 연구)

  • 노유자;김춘길
    • Journal of Korean Academy of Nursing
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    • v.25 no.2
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    • pp.259-278
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    • 1995
  • This study was done to investigate levels of physical fitness, self efficacy(SE), instrumental activities of daily living(IADL), and quality of life (QL), and their relationships among the elderly Data were collected from 47 noninstitutionalized elderly dwell-ing in their own homes and 43 institutionalized elderly living in homes for older people. The ages of the subjects were 65 years and over. The data were col lected from January 20th to February 20th, 1995. Physical fitness was measured with T.K. K dyna mometer, grip dynamometer, stop watch, and Purdue pegboard. Structured questionnaires developed by Kim by Lawton & Brody, and by Ro were adopted to measure SE, IADL, and QL, respectively. The data were analyzed using t-test, ANOVA, and Pearson correlation coefficients. The results were as follows : 1. The noninstitutionalized elderly had higher scores in such measures of physical fitness as body weight, skinfold thickness, flexibility and coordination as compared to the institutionalized elderly. 2. On the following measures of physical fitness, men showed higher levels than women ; in height when standing, height when sitting, body weight, and muscle strength. Women had more trunk flexibility than men. 3. Muscle strength was positively correlated with height when standing, height when sitting, and body weight. The following measures of physical fitness, muscle strength, flexibility and coordi nation, were negatively correlated with "up and go”. 4. The noninstitutionalized elderly had higher scores in SE(t=2.28, p<0.05), IADL(t=2.24, p<0.05), and QL(t=2.41, p<0.05) as compared to the institutionalized elderly. 5. SE was positively correlated with both IADL(r=0.41, p<0.001) and QL(r=0.54, p<0.001), and the latter two variables were a positively correlated (r=0.30, p<0.001). 6. SE was positively correlated with the physical fitness measures of height when standing, body weight, strength of leg muscles, strength of back muscles, grip strength, and level of touching the floor, but negatively correlated with "up and go”. 7. Positive correlations were revealed between IADL and the physical fitness measures of height, strength of leg muscles, level of trunk muscle extension, level of touching the floor, and coordination. The IADL was negatively correlated with “up and go”. 8. QL was positively correlated with body weight (r=0.28, p<0.01) and skinfold thickness (r=0.26, p<0.05). 9. Age was negatively correlated with the physical fitness measures of height when standing, height when sitting, “up and go”, strength of leg muscles, strength of back muscles, grip strength, level of trunk muscle extension, and coordination. 10. Age was also negatively correlated with SE (r=-0.24, p<0.05) and IADL(r=-0.22, p<0.05). The above results suggest that caring elderly in their own homes were more effective and that nursing interventions to enhance physical fitness, SE, IADL, and QL especially for the institutionalized elderly are stressed.

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Policy Model for Securing and Utilizing Foreign Brains - focusing on the Higher Education - (외국인 인재 유치 및 활용을 위한 정책 모형 연구 - 고등교육기관을 중심으로 -)

  • Shin, Jun-Woo;Kwon, Jang-Woo;Lee, Jung-Mann
    • The Journal of the Korea Contents Association
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    • v.10 no.3
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    • pp.423-435
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    • 2010
  • The number of professionals in the science and engineering fields decreases all over the world. Especially in Korea, the declining rate of both the laborable and economically active population, aging of the population at the fastest level, and the declining birth rate make it tougher to secure the core brains of the future. After speculation of all programs above, some common factors have been derived and every program appeared to have the support for each level of inducing, caring, and utilizing. And the means of support could be categorized into the financial, legal, and social aspects. Lastly, a logical tool called Systems Thinking has been applied to the FLS Conditions and the Brain Internalization Process to assure the efficacy and applicability of the models. This is to minimize any de facto side effects by analyzing all 'feedback loops' stemming from the models. And the 'causal loop diagrams' have been utilized to come with the complementary measures. Such series of verification could convince the virtue of the models. Governments and universities can make use of the FLS Conditions and the Brain Internalization Process so the policies or plans about the foreign brains can be built in a uniformized and consistent framework. I hope, as a result, the international competency of Korea to induce and utilize the foreign brains be raised with the constant and standardized formality.

Development and Evaluation of Family Life Culture Education Program in Preparation for the Reunification of Korea aimed at Pre-Service Home Economics Teachers (예비 가정과교사를 위한 통일대비 가정생활문화교육 프로그램의 개발과 평가)

  • Lee, Yoon-Jung;Kim, Yookyung;Song, Jieun;An, Soon-Hee;Lee, Yonsuk;Lee, Yhe-Young;Lee, Hana;Lim, Jung Ha;Chung, Soon Hwa;Jung, Min-Young;Han, Youngsun
    • Journal of Korean Home Economics Education Association
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    • v.29 no.1
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    • pp.125-143
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    • 2017
  • This program aimed at preparing the pre-service teachers to teach about North Korean family life culture to secondary school students, by promoting the understanding and acceptance of cultural differences between the two Koreas. Based on the literature review, the educational contents were developed to reflect general aspects of North Korean family life. The program was implemented with 35 undergraduate students in a home economics teacher education program. The program consists of 15 units of 150-minute instructional sessions. The first three introductory sessions dealt with the definitions of family life culture and multiculturalism, as well as a historical review of South-North relationship. The following nine sessions were devoted to North Korean family life culture in five different domains: consumption and leisure, family and child-caring, food and dietary life, housing and neighborhood life, and clothing/fashion. During the final two weeks, pre-service teachers conducted mock-teaching. For evaluation, pre- and post-session scores on general teaching efficacy and understanding of cultural differences were compared using paired t-tests. The pre-/post-test results confirmed that the program was successful in promoting the understanding and acceptance of cultural differences between two Koreas of pre-service teachers.

Symbolism of the Ginseng Culture in Korean Lifestyle (한국인 생활 속 인삼 문화의 상징성)

  • Soonjong Ock
    • Journal of Ginseng Culture
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    • v.6
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    • pp.35-50
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    • 2024
  • "Culture refers to the behavioral and lifestyle patterns that a society has shared and transmitted within the community over a long period. Ginseng, frequently encountered in the daily life of Koreans through tools, crafts, folklore, and poetry, holds a deep place in the behavioral and lifestyle patterns of the Korean people. Ginseng, engraved in everyday objects, crafts, and poems, is symbolic in our culture as a representation of longevity and well-being. Ginseng elegantly depicted on ceramics serves as a symbol of longevity along with aesthetic beauty. The common inclusion of ginseng in ritual items in mountain deity beliefs, particularly represented by the 'Bullocho' (不老草) ginseng, reflects a strong belief in the mystical qualities of ginseng associated with longevity and prosperity. The incorporation of ginseng into commonly used everyday tools such as rice cakes, dining tables, decorations, matches, and fans suggests that ginseng was considered a talisman symbolizing health and longevity, kept close as a wish for good fortune. Rice cakes, often presented at ceremonies like ancestral rites, 60th-anniversary celebrations, weddings, and birthdays, had ginseng patterns carved into them as a way for our ancestors to inscribe the spirit and health-symbolizing ginseng onto the food. In family communities, ginseng patterns are frequently found on utensils related to eating, such as chopsticks, spoons, tea cups, and trays. Among the various folklore related to ginseng being passed down, the most prevalent are anecdotes illustrating its efficacy. Ginseng, gifted and exchanged as a symbol of gratitude in letters and poems, goes beyond being a mere medicinal herb to embody friendship and blessings. The symbolism of ginseng, as revealed in everyday objects, artworks, poems, and letters, can be summarized as follows: 1. In folklore and legends, ginseng symbolized filial piety offered to parents. 2. It represented gratitude sent to respected teachers and close friends. 3. Ginseng depicted on daily objects and artworks not only showcased aesthetics but also played a magical role in symbolizing longevity and well-being. Ginseng patterns on items like rice cake molds and dining tables embody the spirit of a caring community, wishing for longevity and prosperity."