• Title/Summary/Keyword: cardiovascular disease

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The Relationship between Pattern Identification and Stroke Risk Factors of Acute Ischemic stroke Patients (급성기 허혈성 뇌경색 환자들의 변증 분형과 위험 요인들간의 관련성 연구)

  • Lee, Ji-Hyun;Doo, Kyeong-Hee;Lu, Hsu-Yuan;Shim, So-Ra;Park, Joo-Young;Cho, Seung-Yeon;Jung, Woo-Sang;Moon, Sang-Kwan;Park, Jung-Mi;Ko, Chang-Nam;Cho, Ki-Ho;Kim, Young-Suk;Bae, Hyung-Sup;Park, Seong-uk
    • The Journal of the Society of Stroke on Korean Medicine
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    • v.13 no.1
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    • pp.43-51
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    • 2012
  • Object : The purpose of this study was to evaluate the relationship between pattern identification (PI) and stroke risk factors, such as hypertension, diabetes mellitus, dyslipidemia, stroke history, obesity, abdominal obesity and metabolic syndrome. Methods : 46 patients with acute ischemic stroke were recruited from May 2012 to November, 2012. We analyzed the data of 32 patients, and pattern identification was identified by resident and specialist of Korean medicine. We analized patient's PI and risk factor by Fisher's exact test. Results : We found that Dampness-phlegm group was more related with patient's metabolic syndrome than non Dampness-Phlegm group. And Yin deficiency group had less relationship with patient's metabolic syndrome, obesity, abdominal obesity and dyslipidemia than non Yin deficiency group. Conclusions : According to the analysis, these results provide evidence for relationship between the Dampness-phlegm group, Yin deficiency and metabolic syndrome.

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A Study of Correlation Between Change in Pattern Identification and Scandinavian Stroke Scale in Ischemic Stroke Patient Who had Receive Traditional Korean Medical Treatment and Conservative Treatment (한·양방 병행치료를 시행한 뇌경색 환자의 변증지표 변화와 Scandinavian Stroke Scale의 상관관계에 대한 연구)

  • Lu, Hsu-yuan;Kim, Soo-kyung;Lee, Ji-hyun;Shim, So-ra;Park, Joo-young;Cho, Seung-yeon;Park, Seong-uk;Jung, Woo-sang;Moon, Sang-kwan;Park, Jung-mi;Cho, Ki-ho;Kim, Young-suk;Bae, Hyung-sup;Ko, Chang-nam
    • The Journal of the Society of Stroke on Korean Medicine
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    • v.13 no.1
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    • pp.24-32
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    • 2012
  • Object : The purpose of this study is to observe the correlation between change in pattern identification symptoms and scandinavian stroke scale in ischemic stroke patient who had receive traditional Korean medical treatment and conservative treatment. Methods : 43 subjects were recruited from patients with ischemic stroke within 30 days of onset. We chose the subjects who had at least one follow up session and had checked the score between last follow up session and first session in pattern identification and scandinavian stroke scale. We also assessed the correlation between pattern identification and scandinavian stroke scale. Results : There were significant negative correlation between pattern identification and scandinavian stroke scale in Fire-heat pattern and positive correlation in Dampness-phlegm pattern. Conclusions : This study provides evidence that collaborative treatment maybe effective in improving neurologic symptoms in ischemic stroke patients diagnosed as Fire-heat pattern. Further studies with larger scale and longer observation period, more neurologicscales scales, control group would be required.

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Perceptions of the Risk of Cardiovascular Disease in Middle-aged Male Taxi Drivers: Focus Group Interviews (중년남성 택시운전자의 심혈관질환 위험성에 대한 인식: 포커스그룹 인터뷰를 중심으로)

  • Park, Sun-Jung;Ko, Ga-Yeon;Park, Byung-Jun
    • Korean Journal of Occupational Health Nursing
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    • v.29 no.4
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    • pp.288-294
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    • 2020
  • Purpose: This study aimed to comprehensively examine middle-aged male taxi drivers' perceptions of the risk of cardiovascular disease. Methods: A qualitative method was used, with focus group interviews. The participants were middle-aged male taxi drivers who had been driving for more than ten years and for more than six hours daily. Results: The data were analyzed using qualitative thematic analysis. Middle-aged male taxi drivers' perceptions of the risk of cardiovascular disease were categorized into three main themes: "individual perceptions of cardiovascular disease", "possibility of behaviors for cardiovascular disease" and "motivations of behaviors for cardiovascular disease". Six sub-themes were extracted as follows: "perception of vulnerability", "perception of seriousness", "perception of profitability", "perception of disability", "self-awareness" and "advancing toward health care". Conclusion: It is necessary to invigorate support systems through measures including education, counseling, and web-based programs to prevent cardiovascular disease in middle-aged male taxi drivers.

Development of Castleman Disease in the Paravertebral Space Mimicking a Neurogenic Tumor

  • Kwak, Yu Jin;Park, Samina;Kang, Chang Hyun;Kim, Young Tae;Park, In Kyu
    • Journal of Chest Surgery
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    • v.52 no.1
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    • pp.51-54
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    • 2019
  • Castleman disease is a relatively rare disease, characterized by well-circumscribed benign lymph-node hyperplasia. The disease may develop anywhere in the lymphatic system, but is most commonly reported as unicentric Castleman disease in the mediastinum along the tracheobronchial tree. It is usually asymptomatic and detected on plain chest radiography as an incidental finding. We report an incidentally detected case of Castleman disease in the paravertebral space that was preoperatively diagnosed as a neurogenic tumor and treated by complete surgical resection.

Air Pollution Exposure and Cardiovascular Disease

  • Lee, Byeong-Jae;Kim, Bumseok;Lee, Kyuhong
    • Toxicological Research
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    • v.30 no.2
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    • pp.71-75
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    • 2014
  • Ambient air pollution (AAP) and particulate matters (PM) have been closely associated with adverse health effects such as respiratory disease and cardiovascular diseases. Previous studies have examined the adverse health effects associated with short- and long-term exposure to AAP and outdoor PM on respiratory disease. However, the effect of PM size ($PM_{2.5}$ and $PM_{10}$) on cardiovascular disease has not been well studied. Thus, it remains unclear how the size of the inhalable particles (coarse, fine, or ultrafine) affects mortality and morbidity. Airborne PM concentrations are commonly used for ambient air quality management worldwide, owing to the known effects on cardiorespiratory health. In this article, we assess the relationship between cardiovascular diseases and PM, with a particular focus on PM size. We discuss the association of $PM_{2.5}$ and $PM_{10}$, nitrogen dioxide ($NO_2$), and elemental carbon with mortality and morbidity due to cardiovascular diseases, stroke, and altered blood pressure, based on epidemiological studies. In addition, we provide evidence that the adverse health effects of AAP and PM are more pronounced among the elderly, children, and people with preexisting cardiovascular and respiratory conditions. Finally, we critically summarize the literature pertaining to cardiovascular diseases, including atherosclerosis and stroke, and introduce potential studies to better understand the health significance of AAP and PM on cardiovascular disease.

Development of a Cardiovascular Disease Resilience Scale (심혈관질환용 회복력(Cardiovascular Disease Resilience) 측정도구 개발 및 평가)

  • Shin, Su-Jin
    • Korean Journal of Adult Nursing
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    • v.22 no.2
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    • pp.161-170
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    • 2010
  • Purpose: The purpose of this study was to develop a Cardiovascular Disease Resilience (CDR) scale to evaluate disease specific resilience for recovery. Methods: The study was conducted as follows: items generation, and test of validity and reliability. Items were developed via literature review, review of instruments, and data acquired from the interviews. In order to test validity and reliability, seven panels of experts reviewed the preliminary questionnaire and then data were collected from 550 cardiovascular disease patients. Factor analysis, Pearson correlation, ANOVA, and Cronbach's alpha were used to analyze the data. Results: In the preliminary stage, forty-four items were generated. A reduction to 40 items was accomplished through content validity analysis. Factor analysis extracted 7 factors with a total of 25 items. The CDR items were moderately correlated with the subscales of the CD-RISC (Connor-Davidson Resilience Scale) and the mean score of CDR was associated with quality of life measured with CD-QOL (Cardiovascular Disease Quality of Life). Cronbach's ${\alpha}$=.84. Conclusion: Content validity, construct validity, criterion validity, and reliability of the CDR were established. The CDR is a reliable and valid instrument which the resilience of cardiovascular disease specific recovery state can be evaluated.

Successful Surgical Treatment of Cardiac Complication of Graves Disease

  • Min, Jooncheol;Kim, Woong-Han;Jang, Woo Sung;Choi, Eun Seok;Cho, Sungkyu;Choi, Kwang Ho
    • Journal of Chest Surgery
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    • v.47 no.3
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    • pp.294-297
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    • 2014
  • Cardiac complications such as arrhythmia and heart failure are common in Graves disease. Early detection and proper treatment of hyperthyroidism are important because cardiac complications are reported to be reversible if the thyroid function is normalized by medical treatment. We report here a case of cardiac complication of Graves disease that was too late to reverse with medical treatment and required surgical treatment.

KSP inhibitor SB743921 induces death of multiple myeloma cells via inhibition of the NF-κB signaling pathway

  • Song, In-Sung;Jeong, Yu Jeong;Nyamaa, Bayalagmaa;Jeong, Seung Hun;Kim, Hyoung Kyu;Kim, Nari;Ko, Kyung Soo;Rhee, Byoung Doo;Han, Jin
    • BMB Reports
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    • v.48 no.10
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    • pp.571-576
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    • 2015
  • SB743921 is a potent inhibitor of the spindle protein kinesin and is being investigated in ongoing clinical trials for the treatment of myeloma. However, little is known about the molecular events underlying the induction of cell death in multiple myeloma (MM) by SB743921, alone or in combination treatment. Here, we report that SB743921 induces mitochondria-mediated cell death via inhibition of the $NF-{\kappa}B$ signaling pathway, but does not cause cell cycle arrest in KMS20 MM cells. SB743921-mediated inhibition of the $NF-{\kappa}B$ pathway results in reduced expression of SOD2 and Mcl-1, leading to mitochondrial dysfunction. We also found that combination treatment with SB743921 and bortezomib induces death in bortezomib-resistant KMS20 cells. Altogether, these data suggest that treatment with SB743921 alone or in combination with bortezomib offers excellent translational potential and promises to be a novel MM therapy.