• Journal of Chest Surgery
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• 제47권3호
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• pp.249-254
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• 2014

Background: Delirium after cardiac surgery is associated with serious long-term negative outcomes and high costs. The aim of this study is to evaluate neurobehavioral, hemodynamic, and sedative characteristics of dexmedetomidine, compared with the current postoperative sedative protocol (remifentanil) in patients undergoing open heart surgery with cardiopulmonary bypass (CPB). Methods: One hundred and forty two eligible patients who underwent cardiac surgery on CPB between April 2012 and March 2013 were randomly divided into two groups. Patients received either dexmedetomidine (range, 0.2 to $0.8\;{\mu}g/kg/hr$; n=67) or remifentanil (range, 1,000 to $2,500\;{\mu}g/hr$, n=75). The primary end point was the prevalence of delirium estimated daily via the confusion assessment method for intensive care. Results: When the delirium incidence was compared with the dexmedetomidine group (6 of 67 patients, 8.96%) and the remifentanil group (17 of 75 patients, 22.67%) it was found to be significantly less in the dexmedetomidine group (p<0.05). There were no statistically significant differences between two groups in the extubation time, ICU stay, total hospital stay, and other postoperative complications including hemodynamic side effects. Conclusion: This preliminary study suggests that dexmedetomidine as a postoperative sedative agent is associated with significantly lower rates of delirium after cardiac surgery.

• 대한수의학회지
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• 제42권1호
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• pp.123-130
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• 2002

To investigate the cardiopulmonary and anesthetic effects of propofol in dogs, experimental dogs were randomly divided into 4 groups (propofol infusion anesthesia, P/INF, propofol intermittent anesthesia, P/INTER, propofol induction anesthesia, P/ISO, thiopental Na induction anesthesia, T/ISO) and monitored analgesic and anesthetic effects, recovery time, body temperature, heart rate, mean arterial pressure, respiratory rate, systolic and diastolic pressure. In all groups, apnea was not observed. In the P/INF group, the respiratory rate(RR) was slightly decreased, but in the P/INTER group, RR was increased and shallowing. In the groups of P/ISO and T/ISO, the respiratory rate was decreased. Heart rate(HR) was increased after induction anesthesia in all groups, but gradually decreased. Mean arterial pressure(MAP) was decreased after injection anesthesia in the groups of P/INF and P/INTER. In the groups of P/ISO and T/ISO, however, MAP was slightly increased. Systolic and diastolic arterial pressure were gradually decreased after induction anesthesia, but not significantly. In the groups of P/INF and P/ISO, recovery time was shorter than the groups of P/INTER and T/ISO. In all groups, body temperature of animals was decreased gradually according to time but no significant changes were observed. Propofol injection doesn't make the complete loss of responses of animals, especially, in the P/INTER group. In the P/INF group, deep pain was present until the end of anesthetic period. During recovery period, any other side effects except incoordination were not monitored. The present study suggested that infusion anesthesia was superior to intermittent anesthesia as injection anesthetic agent, and propofol was better than thiopental Na as induction anesthetic agent.

• 한국화재소방학회논문지
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• 제18권1호
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• pp.13-17
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• 2004

Purpose: The purpose of this study is to predict a reasonable direction to design a pertinent educational program in the future by evaluating an adult CPR(Cardiopulmonary Resuscitation) skill performed by EMTs engaged in fire services organization and comparing the CPR success rate of factors as like a duty place and licensed year. Methods: We studied CPR skill by the use of a CPR manikin(Skillmeter Resusci Annie, Laerdal company). The study population consisted of 320 EMTs. Every EMT performed four cycle after investigating the manikin for 2 minutes. We regarded chest compression with 100 times in a minute as the 100% success rate. We analysed the skill of chest compression, ventilation and chest compression times success rate by the records printed in the CPR paper. Results: The average success rate of chest compression was 59.42$\pm$29.26% and ventilation 49.22$\pm$29.65%. The success rate of manual CPR was different between chest compression and ventilation. Also the success rate of chest compression times was high relatively as a 87.32$\pm$9.14%(p=0.000). For the CPR skill, ventilation was lowest as 49.22%. The factors such as duty place and licensed year did not influence the CPR success rate (p>0.001). Conclusion: We could have conclusion that CPR training should be shared more time in ventilation than in chest compression. Also we could reach to a conclusion that it is important to increase the times of CPR training for improving the accuracy of CPR and that the continuing education of CPR training frequency might be more than four times in a year.

• 한국산학기술학회:학술대회논문집
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• 한국산학기술학회 2011년도 추계학술논문집 1부
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• pp.170-173
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• 2011

Therapeutic hypothermia(TH) improves neurological outcomes and reduces mortality among survivors of out-of-hospital cardiac arrest. Animal and human studies have shown that TH results in improved salvage of the myocardium, reduced infarct size, reduced left ventricular remodeling and better long-term left ventricular function in settings of regional myocardial ischemia. This study is to investigate the effect of TH on post-resuscitation myocardial dysfunction and survival time after cardiac arrest and resuscitation in a rat model of myocardial infarction (MI). Thoracotomies were performed in 10 Male Sprague-Dawley rats weighing 450-550 g. MI was induced by ligation of the left anterior descending coronary artery (LAD). Ninety min after LAD ligation, ventricular fibrillation induction and subsequent cardiopulmonary resuscitation was performed before defibrillation attempts. Animals were randomized to two groups: a) Acute MI-Normothermia b) Acute MI-Hypothermia ($32^{\circ}C$ for 4 h). Myocardial functions, including cardiac output, left ventricular ejection fraction, and myocardial performance index were measured echocardiographically together with duration of survival. Ejection fraction, cardiac output and myocardial performance index were $54.74{\pm}9.16$, $89.00{\pm}8.89$, $1.30{\pm}0.09$ respectively and significantly better in the TH group than those of the normothermic group at the first 4 h after resuscitation($32.20{\pm}1.85$,$41.60{\pm}8.62$,$1.77{\pm}0.19$)(p=0.00). The survival time of the hypothermic group ($31.8{\pm}14.8$ h) was greater than that of the normothermic group($12.3{\pm}6.5$ h, p<0.05). This study suggested that TH attenuated post resuscitation myocardial dysfunction in acute MI and would be a potential strategy in post resuscitation care.

• Journal of Korean Medical Science
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• 제33권51호
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• pp.328.1-328.12
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• 2018

Background: In cardiac arrest, the survival rate increases with the provision of bystander cardiopulmonary resuscitation (CPR), of which the initial response and treatment are critical. Telephone CPR is among the effective methods that might increase the provision of bystander CPR. This study aimed to describe and examine the improvement of neurological outcomes in individuals with out-of-hospital acute cardiac arrest by implementing the nationwide, standardized telephone CPR program. Methods: Data from the emergency medical service-based cardiac arrest registry that were collected between 2009 and 2014 were used. The effectiveness of the intervention in the interrupted time-series study was determined via a segmented regression analysis, which showed the risk ratio and risk difference in good neurological outcomes before and after the intervention. Results: Of 164,221 patients, 148,403 were analyzed. However, patients with unknown sex and limited data on treatment outcomes were excluded. Approximately 64.3% patients were men, with an average age of 63.7 years. The number of bystander CPR increased by 3.3 times (95% confidence interval [CI], 3.1-3.5) after the intervention, whereas the rate of good neurological outcomes increased by 2.6 times (95% CI, 2.3-2.9 [1.6%]; 1.4-1.7). The excess number was identified based on the differences between the observed and predicted trends. In total, 2,127 cases of out-of-hospital cardiac arrest (OHCA) after the intervention period received additional bystander CPR, and 339 cases of OHCA had good neurological outcomes. Conclusion: The nationwide implementation of the standardized telephone CPR program increased the number of bystander CPR and improved good neurological outcomes.

• 한국컴퓨터정보학회논문지
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• 제24권10호
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• pp.175-182
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• 2019

이 연구는 경찰관에게 실시한 기본인명소생술 훈련의 효과를 증명하기 위해 실시되었고, 연구대상자는 K 경찰관 중 10명의 실험군과 10명의 대조군으로, 교육프로그램은 60분 이론과 30분 실습을 포함하였다. 기본인명소생술 술기 측정은 미국심장협회에서 제시한 응급 심혈관 치료의 가이드라인을 따랐다. 결과는 다음과 같다. 실험군에서 현장확인기술, 1차 평가수행기술 및 기본인명소생술 능력(심장압박, 인공호흡, 의학적 평가)이 대조군에 비하여 높게 나타났다. 결론적으로, 이 연구결과는 시뮬레이션 교육프로그램이 전통적인 이론실습강의보다 경찰관의 임상술기능력을 향상시키는데 효과적이라는 것을 증명하였다. 그러므로 시뮬레이션 교육프로그램을 심정지 응급치료에 대한 교육프로그램으로 적용하는 것을 제안한다.

• 융합정보논문지
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• 제9권11호
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• pp.227-233
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• 2019

본 연구는 병원 전 환경에서 기계식 가슴압박기(LUCAS)와 수기심폐소생술의 비교실험을 통해 가슴압박의 질을 평가하고 기계적 가슴압박기를 사용한 효과적인 전문심장소생술을 제안하는데 그 목적이 있다. 병원 전 심정지상황을 가정하고 구급대원이 3인 1조로 현장에서 수기심폐소생술과 LUCAS를 이용한 심폐소생술을 적용하고, 구급차로 이송하며 수기심폐소생술과 LUCAS를 이용한 심폐소생술을 시행하였다. 연구결과는 다음과 같다. 첫째, 현장과 이송중의 수기심폐소생술의 비교결과 현장에서 수기심폐소생술이 평균압박깊이와 압박률, 이완율에서 유의한 차이가 나타났다(p<.001). 둘째, 현장에서 수기심폐소생술과 LUCAS를 비교한 결과 LUCAS가 압박률, 이완율에서 유의한 차이가 나타났다(p<.001). 셋째, 구급차로 이송중 수기심폐소생술과 LUCAS를 비교한 결과 평균압박깊이, 압박률, 분당압박횟수에서 유의한 차이를 보였다(p<.001). 위와 같은 결과로 보아 LUCAS는 적절한 압력으로 가슴압박을 수행할 수 있고, 그 동안 구급대원의 전문기도기 삽입, 정맥로 확보 등의 전문심장소생술을 추가적으로 수행할 수 있으며 환자의 소생률을 높이는데 기여할 것이다.

• 한국컴퓨터정보학회논문지
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• 제24권11호
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• pp.179-185
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• 2019

이 연구는 심폐소생술 중 거울을 활용한 시각적 효과를 이용했을 때 가슴압박의 질을 비교함으로써, 좀 더 나은 물리적 요소를 제공하여 효과적인 심폐소생술을 할 수 있도록 하는데 기초자료를 제공하고자 시행 되었다. 무작위 교차방법(Randomized Crossover Design)에 의한 실험 연구로 BLS Health Care-Provider 자격을 이수한 28명을 대상으로 가슴압박 시행 시 깊이, 속도, 압박 대이완의 비율, 팔의 각도, 용이성 등을 측정하였다. 수집된 자료는 SPSS Ver. 23.0 for Win 통계프로그램을 이용하여 분석하였다. 본 연구의 결과를 종합해 보면 심폐소생술에서 가슴압박 시행 시 거울을 활용한 가슴압박 방법을 이용한다면 효율적인 가슴압박을 할 수 있었고, 가슴압박의 평균 깊이, 압박 대 이완 비율, 팔의 각도, 구조자의 자세가 나아져 가슴압박의 질적 지표가 향상되었음을 알 수 있었다. 하지만 거울을 활용한 가슴압박 방법에 대해 다양한 환경요소 및 직군에 대하여 추가적인 연구를 통해 임상적 활용의 가능성을 확인하는 것이 필요 할 것이다.

• The Journal of Korean Physical Therapy
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• 제31권5호
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• pp.322-327
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• 2019

Purpose: This study examined the influence of the maximal aerobic capacity on the two-year cardiac-related re-hospitalization in patients with heart failure with a reduced ejection fraction (HFrEF) in Korean society. Methods: The maximal aerobic capacity of the study population (n=95, male 63%) was evaluated using a cardiopulmonary exercise (CPX) testing system. Each patient was followed up for two years to divide the HFrEF patients into two groups according to cardiac-related re-hospitalization: re-hospitalization (RH) group (n=29, 30%) and no re-hospitalization (NRH) group (n=66, 70%). Results: The relative peak $VO_2$ (mL/kg/min, p<0.001), exercise duration (p<0.001), respiratory exchange ratio ($VCO_2/VO_2$, p=0.001), systolic blood pressure (SBP) reserve (p=0.004), heart rate (HR) reserve (p=0.007), SBP max (p=0.02), and HR max (p=0.039) were significantly lower in the RH group than the NRH group during the CPX test. On the other hand, the ventilatory efficiency (VE/VCO2 slope, p=0.02) and age (p=0.022) were significantly higher in the RH group than in the NRH group. In binary logistic regression analysis, the relative peak $VO_2$ (p=0.001, Wald Chi-square 10.137) was the strongest predictive factor on cardiac-related re-hospitalization, which was followed by $VCO_2/VO_2$ (p=0.019, Wald Chi-square 5.54). On the other hand, age (p=0.063, Wald Chi-square 3.445) did not have a significant influence on cardiac related re-hospitalization. Conclusion: The maximal aerobic capacity, especially the relative peak $VO_2$, is the strongest factor on cardiac-related re-hospitalization within two years in patients with HFrEF in Korean society.

• 한국응급구조학회지
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• 제23권2호
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• pp.109-123
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• 2019

Purpose: This study aimed to propose an effective one-rescuer infant cardiopulmonary resuscitation (CPR) chest compression technique by comparing the differences in efficacy, convenience, and pain levels between the two thumb-encircling and two finger techniques. Methods: Subjects were randomized to perform either two-thumb-encircling or two-finger technique for 8 minutes each on infant CPR manikins. After the chest compression, a survey was administered to the subjects to measure convenience and pain levels according to compression method. Results: Total compression depth over 8 minutes was significantly deeper for the two-thum-encircling technique ($43.5{\pm}4.8mm$) compared with the two-finger technique ($32.6{\pm}5.4mm$) (p<0.001). In terms of compression depth measured at 1-minute intervals, compression depth with the two-finger technique decreased from $38.3{\pm}4.23mm$ to $29.0{\pm}6.79mm$, whereas compression depth with the two-thumb-encircling technique did not show a significant change (from $43.7{\pm}4.12mm$ to $43.4{\pm}5mm$). The results of the survey indicated that, the majority of subjects found the two-thumb-encircling technique to be the most comfortable technique for compression depth (n=29, 64.4%). The majority of subjects (n=31, 68.9%) answered that the two-finger technique resulted in the most pain. Conclusion: Comparison of efficacy of the two-thumb-encircling and two-finger-techniques in the performance of one-rescuer infant CPR revealed that the two-thumb-encircling technique was more effective in maintaining chest compression depth.