• Asian Pacific Journal of Cancer Prevention
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• v.15 no.6
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• pp.2685-2688
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• 2014

Background: To explore the prevalence of lymphocyte subgroups $CD3^+$ $CD4^+$ and $CD3^+$ $CD8^+$ and their surface receptors NKG2D and NKG2A in patients with non-small cell lung cancer (NSCLC). Materials and Methods: A total of 40 patients with NSCLC were divided into different groups according to different clinical factors (TNM staging, pathological patterns and genders) for assessment of relations with $CD3^+$ $CD4^+$ and $CD3^+$ $CD8^+$ and the surface receptors NKG2D and NKG2A of T lymphocytes in peripheral blood by flow cytometry. Results: Patients in the advanced group had evidently lower levels of $CD3^+$ $CD4^+$ but markedly higher levels of $CD3^+$ $CD8^+$ in peripheral blood than those with early lesions (p<0.05). In addition, NSCLC patients in the advanced group had obviously higher $CD3^+$ $CD4^+$ NKG2D and $CD3^+$ $CD8^+$ NKG2A expression rates but lower $CD3^+$ $CD4^+$ NKG2A and $CD3^+$ $CD8^+$ NKG2D expression rates (p<0.05). However, there were no significant differences between NSCLC patients with different genders and pathological patterns in expression levels of lymphocyte subgroups $CD3^+$ $CD4^+$ and $CD3^+$ $CD8^+$ and their surface receptors NKG2D and NKG2A. Conclusions: Unbalanced expression of surface receptors NKG2D and NKG2A in $CD3^+$ $CD4^+$ and $CD3^+$ $CD8^+$ lymphocytes may be associated with a poor prognosis, greater malignancy and immunological evasion by advanced cancers, related to progression of lung cancer.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.1
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• pp.86-98
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• 2014

This study examined a long-standing issue with its perverse results in the Korean capital markets, such as any variant financial profiles over time, affecting capital structure for the firms belonging to the chaebols. It may be of interest to identify these components from the perspectives of international investors and domestic policy makers to implement their contingent strategies on the target leverage, since the U.S. financial turmoils in the late 2000s. Regarding the evidence from the three hypothesis tests on the firms in the chaebols, this research found that the control variabels measuring profitability, business risk, and non-debt tax shields, showed their statistically significant relationships with the different types of a debt ratio. While FCFF(free cash flow to the firm) showed its significant influence to discriminate between the firms in the chaebols and their counterparts, not belonging to the chaebols, BDRELY as the ratio of liabilities to total assets, comprising the enhanced 'Dupont' system, only showed its statistically significant effect on leverage in the context of the parametric and nonparametric tests. In line with the results obtained from the present research, one may expect that a firm in the Korean chaebol, may control or restructure its present level of capital structure to revert to its target optimal capital structure towards maximizing the shareholders' wealth.

• Journal of Korean Society for Quality Management
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• v.14 no.2
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• pp.40-46
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• 1986

The decision maker has the job of torecasting capital investments and operating expenses to aid the decision making in choosing and evaluating present and future alternatives. The estimating function eventually analysis, evaluates and choose the alternatives. The analysis stemmed originally from a preliminary design of some sort, and eventually plans are started to investigate investment possibilites. This study provide the descounted cash flow and the present worth method. Despite any choice of an analytical method, there remains the problem of predicting certain future events. Therefore, these models dealing with optimum plant sizing, equipment replacement, and lease or buy will be discussed.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.12 no.19
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• pp.79-88
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• 1989

This characteristics of process industries are high capital intensity, relatively long and sequence dependent setup times, and extremely limited capacity resources. The lot sizing, sequencing and limited capacity resources factors must he considered for production scheduling in these industries. This paper presents a mixed integer programming model for production scheduling. The economic trade offs between capacitated lot sizing flow shop scheduling and sequence dependent setup times also be compared with SMITH-DANIELS's model. As a results, it is shown that this paper has lower total cost, more efficient throughput than SMITH-DANIELS's model.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.1
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• pp.1-17
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• 2016

The separated management and operation of commercial IP/optical multilayer networks makes network operators look for a unified control plane (UCP) to reduce their capital and operational expenditure. Software-defined networking (SDN) provides a central control plane with a programmable mechanism, regarded as a promising UCP for future optical networks. The general control and scheduling mechanism in SDN-based optical burst switching (OBS) networks is insufficient so the controller has to process a large number of messages per second, resulting in low network resource utilization. In view of this, this paper presents the burst-flow scheduling mechanism (BFSM) with a proposed scheduling algorithm considering channel usage. The simulation results show that, compared with the general control and scheduling mechanism, BFSM provides higher resource utilization and controller performance for the SDN-based OBS network in terms of burst loss rate, the number of messages to which the controller responds, and the average latency of the controller to process a message.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.11
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• pp.223-234
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• 2021

This study aims to examine whether operating cash flows influence banks' financial stability in Pakistan. The study employed annual panel data collected from annual reports of 20 commercial banks listed on the Pakistan Stock Exchange for the year 2011 to 2019. Free cash flow yield was taken as the dependent variable while cash flow ratio was selected as the independent variable, and net interest margin, income diversification, asset quality, financial leverage, the cost to income ratio, advance net of provisions to total assets ratio, capital ratio, financial performance, breakup value per share and bank size were taken as control variables. The study performed ordinary least square technique, random and fixed effects models, Hausman test, Lagrange multiplier test, descriptive and correlation analysis. Results showed that operating cash flows and net interest margin significantly and positively influenced banks' financial stability while the cost to income ratio and advances net of provisions to total assets ratio significantly and negatively associated with banks' financial stability. To improve financial stability, banks should become more cost-effective and enhance their liquidity levels by lowering lending activities. In the future, it would be useful to compare commercial and investment banks, also Islamic and conventional banks in the same research setting.

• Economic Analysis
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• v.25 no.2
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• pp.132-176
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• 2019

We use a time-varying parameter vector auto regression (TVP-VAR) model to understand the impact of U.S. monetary policy normalization on Korean financial markets and capital accounts. The U.S. monetary policy is represented by the federal funds rate, term premium and credit spread. During the U.S. monetary contraction period of 2004 to 2006, changes in the federal funds rate presented negative pressure on Korean financial markets. The changes in federal funds rate also led to a simultaneous contraction in inward and outward capital flows. However, the effects of a federal funds rate shock has been reduced since 2015. On the other hand, the effects of U.S. term premiums is getting stronger after the period of quantitative easing (QE). The influence of the U.S. credit spread also significantly increased after the global financial crisis. Simulation results show that a rise in the U.S. credit spread, which can be triggered by a contractionary monetary policy, can pose a larger adverse impact on the Korean economy than a rise in the federal funds rate itself. As for capital flows, a U.S. monetary policy contraction causes an outflow of foreign investment, but the repatriation of overseas investment by Korean residents can offset this outflow.

• Journal of Navigation and Port Research
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• v.37 no.2
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• pp.181-186
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• 2013

In a corporate financing, the decision of optimal capital structure is becoming more critical issues and still remaining a problem to be solved though many of researcher have studied. Particularly, shipping companies need a huge amount of capital finance for new vessel's capacity and then they are considering what is the best capital structure. In this point of view, this study tries to investigate the determinants of debit maturity structure focused on the Korean shipping industry. As results of panel regression analysis, firm size, liquidity, chance of growth, good cash flow are major determinants of debit expiration structure in the Korean shipping companies.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.5
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• pp.2044-2062
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• 2018

Information theory progression along with the advancements being made in the field of Vehicular Ad hoc NETworks (VANETs) supports the use of coding-aware opportunistic routing for efficient data forwarding. In this work, we propose and investigate an adaptive coding-aware routing scheme in a specific VANET scenario known as a vehicular platoon. Availability of coding opportunities may vary with time and therefore, the accurate identification of available coding opportunities at a specific time is a quite challenging task in the highly dynamic scenario of VANETs. In the proposed approach, while estimating the topology of the network at any time instance, a forwarding vehicle contemplates the composition of multiple unicast data flows to encode the correct data packets that can be decoded successfully at destinations. The results obtained by using OMNeT++ simulator reveal that higher throughput can be achieved with minimum possible packet transmissions through the proposed adaptive coding-aware routing approach. In addition, the proposed adaptive scheme outperforms static transmissions of the encoded packets in terms of coding gain, transmission percentage, and encoded packet transmission. To the best of our knowledge, the use of coding-aware opportunistic routing has not been exploited extensively in available literature with reference to its implications in VANETs.

• International Neurourology Journal
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• v.22 no.4
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• pp.275-286
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• 2018

Purpose: OnabotulinumtoxinA (BoNT-A) is a promising therapy for treating neurogenic detrusor overactivity (NDO) in individuals with spinal cord injury (SCI). This systematic review and meta-analysis aimed to carry out an in-depth review and to make an objective estimation of the efficacy and safety of BoNT-A on NDO after SCI. Methods: The PubMed, Embase, and Cochrane databases were searched for all relevant articles published from 2001 to 2016 that referred to NDO, SCI, and BoNT-A or botulinum toxin A. All data were recorded in an Excel spreadsheet by 2 individual reviewers. Review Manager version 5.3 was used to carry out the meta-analysis. Results: This analysis included 17 studies involving 1,455 patients. Compared with placebo and baseline, BoNT-A was effective in increasing maximum cystometric capacity, volume at first involuntary detrusor contraction, cystometric bladder capacity (all P<0.00001), compliance (P=0.001), and the number of patients with complete dryness (P=0.0003), and decreasing detrusor pressure, the number of patients with no involuntary detrusor contractions, the maximum flow rate, the incidence of detrusor overactivity (all P<0.00001), and the number of urinary incontinence episodes (P=0.001). There were no statistically significant differences between doses of 200 U and 300 U or between injections into the detrusor and submucosa. There were no life-threatening adverse events. Conclusions: BoNT-A is effective and safe in treating NDO after SCI. There were no statistically significant differences between doses of 200 U and 300 U or between injecting into the detrusor and submucosa. However, more high-quality randomized controlled trials are still needed.