• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.10C
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• pp.1007-1016
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• 2005

This paper presents a feature extraction method for shape based retrieval of 3D models. Since the feature descriptor of 3D model should be invariant to translation, rotation and scaling, it is necessary to preprocess the 3D models to represent them in a canonical coordinate system. We use the PCA(Principal Component Analysis) method to preprocess the 3D models. Also, we apply that to make a MBR(Minimum Boundary Rectangle) and a circumsphere. The proposed algorithm is as follows. We generate a circumsphere around 3D models, where radius equals 1(r=1) and locate each model in the center of the circumsphere. We produce the concentric spheres with a different radius($r_i=i/n,\;i=1,2,{\ldots},n$). After looking for meshes intersected with the concentric spheres, we compute the curvature of the meshes. We use these curvatures as the model descriptor. Experimental results numerically show the performance improvement of proposed algorithm from min. 0.1 to max. 0.6 in comparison with conventional methods by ANMRR, although our method uses .relatively small bins. This paper uses $R{^*}-tree$ as the indexing.

• Journal of the Korean Dietetic Association
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• v.19 no.1
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• pp.1-13
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• 2013

The purpose of this study was to determine the optimal mixing condition of tomato powder and sugar for producing chiffon cake. The experiment was designed according to the central composite design of response surface, which yielded ten experimental points, including two replicates. Physiochemical and sensory properties were measured, and theses values applied to mechanical models. A canonical form and perturbation plot showed the influence of each ingredient on the final product mixture. The results of the physiochemical analysis of each sample showed significant differences in sweetness (P<0.01), color L (P<0.001), color a (P<0.001), color b (P<0.05), hardness (P<0.05), and cohesiveness (P<0.01). The sensory measurements were significantly different in color (P<0.05), appearance (P<0.05), flavor (P<0.05), sweetness (P<0.01), moistness (P<0.05), and overall acceptability (P<0.05). The optimal formulation, calculated using the numerical and graphical method, was determined to be 59.27 g tomato powder and 285.66 g sugar. The sensory evaluation showed significantly higher preferences in the color, flavor, appearance, texture, sweetness, tenderness, moistness and overall quality of the optimized chiffon cake compared to the controlled chiffon cake. The optimized chiffon cake also showed a high antioxidative activity compared to the controlled chiffon cake. Our results show that chiffon cake prepared with tomato powder enhances sensory characteristics and antioxidative activity.

• Korean journal of food and cookery science
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• v.24 no.1
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• pp.76-83
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• 2008

The aim of this study was to use arrowroot powder to develop a recipe for a nutritional cookie having the optimal composition of ingredients and texture to elict a strong preference response in all age groups. Wheat flour was partially substituted with arrowroot powder to reduce the wheat flour content of the cookie. Measurements were made and analyzed according to the Response Surface Methodology technique, which showed 16 experimental points including 2 replicates for arrowroot powder, yellow sugar and butter. The compositional and functional properties of the test were measured, and the values obtained were applied to a mathematical model. A canonical form and perturbation plot showed the influence of each ingredient on the final mixture product. The result of sensory evaluation showed very significant values for color (p<0.01), appearance (p<0.001), texture (p<0.05), overall quality (p<0.05), and flavor (p<0.05). Instrumental analysis showed significant values for lightness (p<0.001), redness (p<0.01), yellowness (p<0.01) and spread ratio (p<0.001). The optimal sensory ratios were determined to be 15g for the arrowroot powder, 70 g for sugar and 80 g for butter.

• Fisheries and Aquatic Sciences
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• v.17 no.1
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• pp.47-57
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• 2014

Thai Jasmine rice (Oryza sativa, long grain Indica var.) is popular in southeastern Asia and China due to its non-glutinous, fluffy texture and fragrant smell. However it has a high starch digestibility, which leads to an increased glycemic index (GI). Therefore it may require modified cooking methods for diabetes patients. The objectives of this study were to optimize the ratio of Thai Jasmine rice, sea tangle, and olive oil (CLTR) based on consumers' acceptance. The GI of plain cooked Thai Jasmine rice (CLR) was measured as a control. Sensory evaluation and response surface methodology were used to determine the optimal ratio. Texture analysis and nutritional evaluation were also performed on the optimal recipe of cooked Jasmine rice with sea tangle. A multiple regression equation was developed in quadratic canonical polynomial models. We used 26 trained Chinese panelists in their forties to rate color, flavor, adhesiveness, and glossiness, which we determined were highly correlated with overall acceptability. The optimal CLTR formula was 34.8% rice, 2.8% sea tangle, 61.9% water, and 0.5% olive oil. Compared to CLR, CLTR had a lower hardness, but a higher springiness and cohesiveness. However, CLR and CLTR had the same adhesiveness and chewiness. The addition of sea tangle and olive oil delayed retro-gradation of starch in CLTR and increased total dietary fiber, and protein and ash contents. The degree of gelatinization, and in vitro protein and starch digestibility of CLTR were lower than those of CLR. Based on Wolver' method, the GI of CLTR (52.9, incremental area under the glycemic-response curve, ignoring the area below fasting, as used for calculating the GI [Inc]) was lower compared with that of CLR (70.94, Inc), which indicates that CLTR is effective in decreasing and stabilizing blood glucose level, owing to its lower degree of gelatinization and starch digestibility. Our results show that CLTR can contribute to the development of a healthier meal for families and the fast food industry.

• Journal of Forest and Environmental Science
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• v.33 no.4
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• pp.257-269
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• 2017

The study has piloted to find the Pattern of species distribution along environmental variables and disturbance in Raghunandan Reserve Forest. Shaltila and Shahapur beat of Raghunandan Hill Reserve Forest are situated in Chunarughat sub-district of Habiganj district between $24^{\circ}5^{\prime}-24^{\circ}10^{\prime}N$ and $91^{\circ}25^{\prime}-91^{\circ}30^{\prime}E$ under the Sylhet Forest Division. The Environmental variable and vegetation data were collected from 30 sample plots from each forest beat by using arbitrary sampling without preconceived bias. 51 species were found from Shaltila and 34 species found in Shahapur forest beat. Thus the dataset continued with total 85 species in 60 samples. To determine the relationships between tree species distribution and environmental variables, Canonical Correspondence Analysis (CCA) ordination method were performed separately for two forest beat. In CCA ordination, tree species showed significant variation along environmental gradients in terms of soil organic matter and disturbances (p<0.05) in the case of Shaltila forest. Potassium has a significant relationship with axis 1 and axis 2 in this forest. But Shahapur forest showed no significant relationship between species and environmental variables. Phosphorus has a significantly negative relationship with axis 2 in this forest. Disturbance played as a critical role of this forest thus influencing the distribution of species. The study showed that the distributions of tree species are strongly influenced by disturbance and organic matter in Shaltila and Shahapur forest beat showed no significant relationship between species and environmental variables. Future research should be included more environmental variables with larger study area that identify the most important environmental forces which will drive by species distribution findings in this forest.

• Animal cells and systems
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• v.9 no.3
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• pp.153-160
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• 2005

Most living organisms exhibit the circadian rhythm in their physiology and behavior. Recent identification of several clock genes in mammals has led to the molecular understanding of how these components generate and maintain the circadian rhythm. Many reports have implicated the photic induction of either mPer1 or mPer2 in the hypothalamic region called the suprachiasmatic nucleus (SCN) to phase shift the brain clock. It is now established that peripheral tissues other than the brain also express these clock genes and that the clock machinery in these tissues work in a similar way to the SCN clock. To determine the role of the two canonical clock genes, mPer1 and mPer2, in the peripheral clock shift, stable HEK293EcR cell lines that can be induced and stably express these proteins were prepared. By regulating the expression of these proteins, it could be shown that induction of the clock genes, either mPer1 or mPer2 alone is not sufficient to cause clock phase shifting in these cells. Our real-time PCR analysis on these cells indicates that the induction of mPER proteins dampens the expression of the clock-specific transcription factor mBmal1. Altogether, our present data suggest that mPer1 and mPer2 may not function in clock shift or take part in differential roles on the peripheral circadian clock.

• Molecules and Cells
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• v.39 no.4
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• pp.316-321
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• 2016

The receptor activator of nuclear factor ${\kappa}B$ (RANK) and its ligand RANKL are key regulators of osteoclastogenesis and well-recognized targets in developing treatments for bone disorders associated with excessive bone resorption, such as osteoporosis. Our previous work on the structure of the RANK-RANKL complex revealed that Loop3 of RANK, specifically the non-canonical disulfide bond at the tip, performs a crucial role in specific recognition of RANKL. It also demonstrated that peptide mimics of Loop3 were capable of interfering with the function of RANKL in osteoclastogenesis. Here, we reported the structure-based design of a smaller peptide with enhanced inhibitory efficiency. The kinetic analysis and osteoclast differentiation assay showed that in addition to the sharp turn induced by the disulfide bond, two consecutive arginine residues were also important for binding to RANKL and inhibiting osteoclastogenesis. Docking and molecular dynamics simulations proposed the binding mode of the peptide to the RANKL trimer, showing that the arginine residues provide electrostatic interactions with RANKL and contribute to stabilizing the complex. These findings provided useful information for the rational design of therapeutics for bone diseases associated with RANK/RANKL function.

• Molecules and Cells
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• v.41 no.2
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• pp.110-118
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• 2018

The objective of this study was to induce the production of isthmic organizer (IsO)-like cells capable of secreting fibroblast growth factor (FGF) 8 and WNT1 from human embryonic stem cells (ESCs). The precise modulation of canonical Wnt signaling was achieved in the presence of the small molecule CHIR99021 ($0.6{\mu}M$) during the neural induction of human ESCs, resulting in the differentiation of these cells into IsO-like cells having a midbrain-hindbrain border (MHB) fate in a manner that recapitulated their developmental course in vivo. Resultant cells showed upregulated expression levels of FGF8 and WNT1. The addition of exogenous FGF8 further increased WNT1 expression by 2.6 fold. Gene ontology following microarray analysis confirmed that IsO-like cells enriched the expression of MHB-related genes by 40 fold compared to control cells. Lysates and conditioned media of IsO-like cells contained functional FGF8 and WNT1 proteins that could induce MHB-related genes in differentiating ESCs. The method for generating functional IsO-like cells described in this study could be used to study human central nervous system development and congenital malformations of the midbrain and hindbrain.

• Journal of Korean Society of Transportation
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• v.20 no.7
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• pp.5-13
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• 2002

고도의 산업화성장에 따라 도시의 기능이 지역간의 완전분리가 아닌 경제적 사회적 상호 연관성이 점점 증가하고 그 내용도 복잡하고 다양해짐에 따라 이에 대한 체계적인 분석이 필요하게 되었으며, 그에 대한 연구 또한 활발히 진행되고 있다. 그러나 기존에 연구에서 제시하고 있는 각 지역단위별로 취업자수에 대한 고용자수 비율 또는 출근통행의 유출량에 대한 유입량 비율 등의 단순지표를 이용한 지역간의 경제적 의존성을 설명하는 데는 한계가 있다고 할 수 있다. 따라서 본 연구는 지역간의 경제적 연관관계 즉 경제적 의존성을 복합적이고 표준화 할 수 있는 계량치로 추정하기 위해 두 변수 집합간의 연관성을 추정하는데 매우 유용한 분석기법인 정준상관분석 기법을 이용하여 추정하고자 하였다. 이에 수도권 72개존의 출근통행자료을 이용하여 지역간의 경제적 의존성을 측정하였으며, 각 존들로 구성된 지역간의 정준상관계수 및 각 존들의 정준가 중계수를 통해 통계적으로 정산되어진 표준화된 계수를 산출하였다. 그 결과 대존의 경우 경기도와 인천시는 각각 0.9753. 0.2968 정도의 서울에 대한 경제적 의존정도를 보이는 것으로 나타나 서울에 대한 경기도의 경제적 의존성이 높은 것으로 나타났으며, 산출된 정준가중계수를 살펴보면 분당구와 서울시의 중구는 서울에 대한 경기도의 경제적 의존성에 가장 높은 영향을 미친 것으로 나타났으며, 또한 중존에 해당되는 인천의 3개 권역, 경기의 16개 권역의 서울 5개 권역에 대한 경제적 의존성도 분석되었다.

• Development and Reproduction
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• v.23 no.3
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• pp.213-221
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• 2019

The epididymal fat of mouse is a part of visceral fat deposit and is divided into the distal or proximal part based on its histochemical characteristics. Even though the formation of the epididymal fat pad begins before the birth, a detailed adipogenic procedure of the epididymal fat has not been revealed. The epididymal fat pad becomes enlarged and expended with age, and expressional changes of numerous genes are associated with the maturation of fat tissues. In the present research, expressional patterns of adipose tissue-related genes in the distal epididymal fat of mouse at 2, 5, 8, and 12 months of postnatal age were determined by a quantitative real-time polymerase chain reaction (PCR) analysis. The lowest transcript levels of fatty acid binding protein 4 (Fabp4), lipoprotein lipase (Lpl), delta like non-canonical Notch ligand 1 (Dlk1), peroxisome proliferator-activated receptor gamma (Pparg), leptin (Lep), adiponectin (Adipoq), and resistin (Retn) were detected at 2 months of age, except fatty acid synthase (Fasn) showing the lowest level at 5 months of age. Even though expression of Lep and Fabp4 were gradually increased until 12 months of age, significant increases of Pparg and Adipoq transcript levels were continued until 8 months of age. The transcript levels of Lpl, Rent, Dlk1, and Fasn were significantly increased at 8 months of age, compared with those at 2 months of age. The current findings suggest that the expansion of the distal epididymal fat of mouse during postnatal period would be companied with differential expression of various adipocyte-associated molecules.