• Journal of Korean Society for Quality Management
• /
• v.40 no.3
• /
• pp.347-358
• /
• 2012

Purpose: Given the mixture components - process variables experimental data, we propose the strategy to find the proper combined model. Methods: Process variables are factors in an experiment that are not mixture components but could affect the blending properties of the mixture ingredients. For example, the effectiveness of an etching solution which is measured as an etch rate is not only a function of the proportions of the three acids that are combined to form the mixture, but also depends on the temperature of the solution and the agitation rate. Efficient designs for the mixture components - process variables experiments depend on the mixture components - process variables model which is called a combined model. We often use the product model between the canonical polynomial model for the mixture and process variables model as a combined model. Results: First we choose the reasonable starting models among the class of admissible product models and practical combined models suggested by Lim(2011) based on the model selection criteria and then, search for candidate models which are subset models of the starting model by the sequential variables selection method or all possible regressions procedure. Conclusion: Good candidate models are screened by the evaluation of model selection criteria and checking the residual plots for the validity of the model assumption. The strategy to find the proper combined model is illustrated with examples in this paper.

• The Korean Journal of Food And Nutrition
• /
• v.27 no.5
• /
• pp.929-939
• /
• 2014

The purpose of this study was to determine the optimal mixing ratio of Gynura procumbens and milk in the preparation of beef patties. The experiment was designed according to the central composite design for estimating the response surface, demonstrating 10 experimental points including 2 replicates for Gynura procumbens and milk. The physical, mechanical and sensory properties of the test materials were measured, and a canonical form and perturbation plot were used to show the influence of each ingredient on the final product mixture. Results of the measurements showed significant increases or decreases in the following properties: dough moisture (p<0.05); beef patty a (p<0.001) and b (p<0.001); hardness (p<0.01), adhesiveness (p<0.05), chewiness (p<0.05), and gumminess (p<0.05). In addition, the sensory measurements showed significant improvements in color (p<0.001), flavor (p<0.05), greasy (p<0.05) and overall quality (p<0.05). The optimum formulation calculated from the numerical and graphical analysis was 1.75 g Gynura procumbens and 20.44 g of milk.

• The Bulletin of The Korean Astronomical Society
• /
• v.43 no.1
• /
• pp.55.1-55.1
• /
• 2018

Studies on rotation-powered pulsars with strong surface magnetic field may help us clarify the unclear link between magnetars and canonical radio pulsars because the magnetar-like emission is expected to be observed. PSR J1119-6127 associated with SNR G292.2-0.5 has a high magnetic field of $4.1{\times}1013$ gauss, and a young characteristic age of ~1700 years can be served as the good candidate to compare with magnetars and rotation-powered pulsars. The glitch accompanied by the radiative changes detected in 2007 is the first case we observed for a rotationally powered radio pulsar. This pulsar experienced magnetar-like outbursts in mid. 2016, similar to the 2006 transition occurred on the other radio-quiet rotation-powered pulsar with strong surface magnetic field, PSR J1846-0258. In this talk, I'll report the investigation with X-ray and gamma-ray data of this magnetar-like pulsar. A sudden decrease in the gamma-ray emission at the GeV band was detected immediately after the X-ray outburst. Accompanying with the disappearance of the radio pulsation, the gamma-ray pulsation cannot be resolved as well after the outburst. We tried to derive the timing behavior and some intriguing features of this pulsar in this work corresponding to the outburst using the Swift data, NuSTAR and XMM observations.

• Journal of Korean Society on Water Environment
• /
• v.33 no.3
• /
• pp.311-325
• /
• 2017

Habitat suitability index (HSI) of 17 benthic macroinvertebrate taxa, which were lotic insects of generic category except Potamanthidae in mayfly, was developed for three physical habitat factors (current velocity, water depth and substrate) based on an ecological monitoring in a Korean stream (Gapyeong). Weibull model was used as a probability density function to analyze the distribution of individual abundance related with physical factors, which showed it was so available. Number of species and total individual abundance increased along with the increase of current velocity and the mean diameter of substrate, and decreased along with the increase of water depth. Most taxa showed a clear preference for a fast current velocity, shallow water depth and coarse substrate except Ephemera, Potamanthidae (mayfly), and Plectrocnemia (caddisfly) which were rheophobic, potamophilic and lithophobious. Based on the canonical correspondence analysis, the relative importance of each factor was determined as follows: current velocity > substrate > water depth.

• Journal of muscle and joint health
• /
• v.21 no.1
• /
• pp.46-54
• /
• 2014

Purpose: This study was designed to explore the stage distribution of subjects according to stages of change for exercise and to identify factors that could discriminate subjects in various stages. Methods: The sample consisted of 182 subjects who had metabolic syndrome. The instruments used in this study were the stage placement instrument for exercise, the metabolic syndrome knowledge and metabolic syndrome health belief scale, and the metabolic syndrome exercise self efficacy scale. Data were analyzed using chi-square, ANOVA, and discriminant analysis by using the SPSS 19.0 program. Results: For exercise stages, exercise efficacy, occupation, and exercise benefit showed high standardized canonical discriminant function coefficients. Subjects in precontemplation/contemplation stage for exercise were more likely to have occupations, had less exercise efficacy and exercise benefit than those in other stage. Conclusion: This study implies that the level of exercise efficacy and exercise benefit of subjects in precontemplation/contemplation stage need to be enhanced in developing exercise program incorporating the stage of change for metabolic syndrome patients.

• Reproductive and Developmental Biology
• /
• v.36 no.1
• /
• pp.39-47
• /
• 2012

Ovarian cancer is the most lethal gynecological malignancy, and specific biomarkers are important needed to improve diagnosis, prognosis, and to forecast and monitor treatment efficiency. There are a lot of pathological factors, including reactive oxygen species (ROS), involved in the process of cancer initiation and progression. The oxidative modification of proteins by ROS is implicated in the etiology or progression of disorders and diseases. In this study, a labeling experiment with the thiol-modifying reagent biotinylated iodoacetamide (BIAM) revealed that a variety of proteins were differentially oxidized between normal and tumor tissues of ovarian cancer patients. To identify cysteine oxidation-sensitive proteins in ovarian cancer patients, we performed comparative analysis by nano-UPLC-$MS^E$ shotgun proteomics. We found oxidation-sensitive 22 proteins from 41 peptides containing cysteine oxidation. Using Ingenuity program, these proteins identified were established with canonical network related to cytoskeletal network, cellular organization and maintenance, and metabolism. Among oxidation-sensitive proteins, the modification pattern of Collagen alpha-1(VI) chain (COL6A1) was firstly confirmed between normal and tumor tissues of patients by 2-DE western blotting. This result suggested that COL6A1 might have cysteine oxidative modification in tumor tissue of ovarian cancer patients.

• Ocean Systems Engineering
• /
• v.1 no.1
• /
• pp.17-28
• /
• 2011

The purpose of this paper is to demonstrate the efficacy of modeling a surface effect ship's air-cushion flexible seal utilizing a two-dimensional beam under steady state conditions. This effort is the initial phase of developing a more complex three-dimensional model of the air-seal-water fluid-structure interaction. The beam model incorporates the seal flexural rigidity and mass with large deformations while assuming linear elastic material response. The hydrodynamic pressure is derived utilizing the OpenFOAM computational fluid dynamic (CFD) solver for a given set of steady-state flow condition. The pressure distribution derived by the CFD solver is compared with the pressure required to deform the seal beam model. The air pressure, flow conditions and seal geometry are obtained from experimental analysis. The experimental data was derived from large-scale experimental tests utilizing a test apparatus of a canonical surface effect ship's flexible seal in a towing tank over a variety of test conditions.

• Annual Conference on Human and Language Technology
• /
• 2015.10a
• /
• pp.23-28
• /
• 2015

본 논문에서는 한국어 트리플 생성 시스템의 정확도를 향상시키기 위한 distant supervision 기반의 신뢰도 측정 방법을 제안한다. 기존의 많은 패턴 기반의 트리플 생성 시스템에는 distant supervision의 기본 가정으로 인해 다수의 오류 패턴이 발생할 여지가 크다. 기존의 연구에서는 오류 패턴을 제거하기 위하여 발생 빈도, 공기 횟수 등의 통계에 기반하여 간접적으로 신뢰도를 측정하였다. 본 논문에서는 한국어 패턴과 영어 프로퍼티 사이의 의미 유사도를 측정함으로써 통계에 기반한 방법보다 더 정확한 신뢰도 측정 방법을 제안한다. 비지도 학습 방법인 워드임베딩을 활용하여 어휘의 의미를 학습하고, 이들 사이의 유사도를 측정한다. 한국어 패턴과 영어 프로퍼티의 어휘 불일치 문제를 해결하기 위하여 정준상관분석을 활용하였다. 실험 결과에 따르면 본 논문에서 제안한 패턴 신뢰도 측정 방법은 통계 기반의 방법에 비해 정확률이 9%나 더 높은 트리플 집합을 생성함을 보여주어, 의미 유사도를 반영한 신뢰도 측정이 기존의 통계 기반 신뢰도 측정보다 고품질 트리플 생성에 더 적합함을 확인하였다.

• Molecules and Cells
• /
• v.22 no.3
• /
• pp.275-284
• /
• 2006

The molecular components that generate and maintain circadian rhythms of physiology and behavior in mammals are present both in the brain (suprachiasmatic nucleus; SCN) and in peripheral tissues. Examination of mice with targeted disruptions of either mPer1 or mPer2 has shown that these two genes have key roles in the SCN circadian clock. Here we show that loss of the clock gene mPer2 affects forced locomotor performance in mice without altering muscle contractility. A proteomic analysis revealed that the anterior tibialis muscles of the mPer2 knockout mice had higher levels of glycolytic enzymes such as triose phosphate isomerase and enolase than those of either the wild type or mPer1 knockout mice. In addition, the level of expression of HSP90 in the mPer2 mutant mice was also significantly higher than in wildtype mice. These results suggest that the reduced locomotor endurance of the mPer2 knockout mice reflects a greater dependence on anaerobic metabolism under stress conditions, and that the two canonical clock genes, mPer1 and mPer2, play distinct roles in the physiology of skeletal muscle.

• Development and Reproduction
• /
• v.24 no.3
• /
• pp.167-176
• /
• 2020

The fat pad defined as the epididymal fat is located at the head part of the epididymis. However, another fat mass is present near the caudal epididymis, named tail epididymal fat. The present research was focused to determine the expression of adipocyte-associated molecules in the mouse tail epididymal fat at different postnatal ages, including 2, 5, 8, and 12 months of age. The quantitative real-time PCR analysis showed continuous increases of expression levels of delta like non-canonical Notch ligand 1, leptin, and resistin as postnatally aged. The transcript level of peroxisome proliferator-activated receptor gamma was the highest at 5 months of age, remaining at a steady level until 12 months of age. Expression levels of fatty acid binding protein 4, leptin, and adiponectin were significantly increased until 8 months of age, persisting the level at 12 months of age. The transcript level of fatty acid synthase was significantly increased at 8 months of age, without a further change of the level at 12 months of age. These findings exhibited the expression of adipocyte-associated genes which were also detected at the ordinary epididymal fat pad. However, expression patterns of these genes in the tail epididymal fat are different with those in the distal and proximal epididymal fat, suggesting distinct characteristics and/or functions of the tail epididymal fat.