• Journal of Korean Medical classics
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• v.36 no.2
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• pp.97-128
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• 2023

Objectives : This study aims to examine the efficacy and application of Cannabis according to its parts. Methods : Contents on efficacy, treatment, and application of Cannabis in Material Medica and other texts of East Asian Medicine were collected and interpreted to deduce each characteristic. Results : Cannabis was found to be applicable to various wind symptoms and wind stroke, various pain and injuries, skin diseases, blockage or leaking of urine or feces, disease related to genitalia and anus, chronic ague, women's disease related to menstruation, birth, pregnancy, and to have the effects of heightening perceptive and sensory organs, detoxification and anesthesia, stimulating hair growth, and eradicating parasites. It drives out wind-heat pathogenic qi, circulates qi and blood, which allowed it to be applied not only to blockages but to symptoms of leakage. In other words, Cannabis was used when both excess and deficiency diseases were present, the former caused by acute blockage and the latter accompanied by stagnation. Conclusions : Based on the findings of this study, future researches on the efficacy and application of Cannabis could be done more systematically. In line with recent trend of wide application of medical Cannabis, we hope for it to be more actively used in the field of East Asian Medicine based on objective evidence.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2019.10a
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• pp.6-6
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• 2019

대마는 인류가 이용해 온 가장 오래된 약제 중 하나로 그 원산지는 중앙아시아와 남아시아이다. 식물분류학적으로 대마속 일년생 식물로서 Cannabis sativa, Cannabis indica, Cannabis ruderalis 3종이 있으며, 우리나라에서 재배되고 있는 종은 Cannabis sativa이다. 대마 재배의 역사는 인류의 시작과 그 궤를 같이하며, 동 서양을 막론하고 고대 문명에서 대마에 대한 기록을 쉽게 찾아볼 수 있다. 기록에 의하면 병의 치료나 심리적 치유 및 신에게 제사를 올릴 때 제사장이 사용한 것으로 알려져 있다. 대마의 약효에 대하여는 B.C. 2737년 중국의 신농황제시대의 기록에 관절염과 통증등 의료목적으로 사용했던 최초의 기록이 있으며 본초강목과 동의보감에 저술되어 있다. 우리나라의 대마에 관한 문헌 기록은 삼국지 '위지동이전', 삼국사기 '동성왕편'과 삼국유사에 삼베를 사용한 기록이 있는 것으로 미루어 봤을 때 대마재배의 역사는 삼국시대 이전으로 볼 수 있다. 우리 민족은 생활 속에서 대마를 즐겨 사용하였으며 삼베로 의복과 멍석, 행주 그리고 칠공예품이나 신발등을 만들어 사용하였으며, 죽음에 이르러 삼베옷을 수의로 사용하였다. 대마의 용도는 뿌리, 줄기, 잎, 꽃대 그리고 씨앗까지 다양하게 이용된다. 전통적으로 줄기의 껍질을 이용한 섬유제품이 있으며 실, 의복 및 밧줄등이 있다. 대마 줄기의 속대는 종이, 건축자재, 연료로 사용된다. 씨앗의 경우 식품과 조류의 먹이, 생약으로 이용되고 씨앗의 기름은 연료, 화장품, 맛사지 오일등으로 사용되고 있다. 환각성분이 있어 마리화나 원료로 사용되는 꽃대와 잎은 의약품의 원료로 주목받고 있다. 대마에 관한 최초의 논문은 1843년에 Cannabis indica의 약효에 관한 것으로 보고되었다. 1850년부터 1937년까지 미국의 약전은 대마를 100가지 이상의 질병에 효과가 있는 주요 의약품으로 기재하고 있다. 세계적으로 여러 가지 이유로 대마를 의료 응용과 연구 및 사용을 제한하여 대마에 관한 연구가 침체되었다. 대마의 의학연구는 대마의 약효성분인 칸나비노이드의 발견과 그 구조 및 약효에 관한 연구가 시작되면서 1960년대부터 증가하였으며 2000년 이후에는 칸나비노이드 및 칸나비디올의 다양한 의학적 효과가 밝혀지면서 급격히 증가하고 있다. 대마에 포함된 성분의 의학적 효과가 입증되면서 대마 사용을 합법화한 국가가 증가하면서 대마 산업이 급부상하고 있으며, 의료용뿐만 아니라 기호용, 식품용, 그리고 주류 및 음료시장까지 확대되고 있다. 우리나라도 2019년 3월 질병 치료 목적 대마성분 의약품을 제한적으로 허용하는 마약류 관리에 관한 법률 일부 개정안이 시행되면서 의료용 대마에 관한 연구와 산업화에 관심이 증가하는 추세이다.

• 한국신재생에너지학회:학술대회논문집
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• 2008.10a
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• pp.74-76
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• 2008

Autohydrolysis at different temperature levels was applied as industrial hemp pretreatment technique for glucose generation. Main structural components removed by autohydrolysis was xylan, which is more sensitive in acidic hydrolysis condition than cellulose or lignin. Higher temperature reaction conditions promoted more biomass components (xylan) removal than lower temperature, which led to better respond to enzymatic saccharification of residual biomass after autohydrolysis. With $185^{\circ}C$ and 60 min, saccharification degree was 53.0% of cellulose in hemp woody core biomass.

• 한국신재생에너지학회:학술대회논문집
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• 2006.06a
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• pp.482-484
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• 2006

대마에 대한 분석 결과, 인피 섬유의 경우 리그닌 함량은 7.6%로 다른 목질계 바이오매스나 일년생 초본류와 비교하여 매우 낮은 리그닌 함량을 나타냈으며 탄수화물 함량은 65.4%로 목질계 바이오매스와 유사하고, 초본류보다는 오히려 높았다. 목부는 리그닌 및 탄수화물 함량이 활엽수와 유사한 경향을 나타내었는데 특히 높은 자일란의 함량이 확인되었다. 또한 회분 함량이 인피섬유와 목부에서 각각 5.0%와 2.3%로 낮은 값을 나타내어 당화 및 발효 공정에 적용될 때 회분에 의한 공정 장애(스케일링 등)의 가능성을 낮추어 줄 것으로 사료되었다. 최종적으로 이러한 화학적 분석을 통해 대체에너지 생산을 위한 자원으로서 대마의 가능성을 확인할 수 있었다.

• Journal of Life Science
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• v.34 no.3
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• pp.179-190
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• 2024

Cannabis sativa is a plant widely cultivated worldwide and has been used as a material for food, medicine, building materials and cosmetics. In this study, we assessed the functional effects of C. sativa stem and root extracts using network pharmacology and confirmed their novel functions. The components in stem and root ethanol extracts were identified by gas chromatography-mass spectrometry analysis, and networks between the components and proteins were constructed using the STICHI database. Functional annotation of the proteins was performed using the KEGG pathway. The effects of the extracts were confirmed in lysophosphatidylcholine-induced THP-1 cells using real-time PCR. A total of 21 and 32 components were identified in stem and root extracts, respectively, and 147 and 184 proteins were linked to stem and root components, respectively. KEGG pathway analysis showed that 69 pathways, including the MAPK signaling pathway, were commonly affected by the extracts. Further investigation using pathway networks revealed that terpenoid backbone biosynthesis was likely affected by the extracts, and the expression of the MVK and MVD genes, key proteins in terpenoid backbone biosynthesis, was decreased in LPC-induced THP-1 cells. Therefore, this study determined the diverse function of C. sativa extracts, providing information for predicting and researching the effects of C. sativa.

• Journal of Life Science
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• v.31 no.6
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• pp.581-586
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• 2021

The high fatality of COVID-19 (Corona Virus Disease 2019) is closely related to acute pneumonia and severe blood clot formation in brain, heart, kidney and lung. The use of low-molecular weight heparins has been shown to reduce the risk of thrombosis and reduce fatality rates among COVID-19 patients. In this study, we investigated the antithrombotic activity of different parts of C. sativa extracts to determine its potential in preventing blood clots in patients with thromboprophylaxis. The extracts of leaf, stem, root, immature flower and seed of C. sativa showed strong inhibitory activities on blood clot formation. In particular, the flower extract showed the strongest inhibitions against blood coagulation factors and thrombin. Strong hemolysis activities were observed in flower extract and seed extract, suggested that removal of the hemolysis active compounds in th extracts is necessary. This is a first report of anti-thrombosis activities of different parts of C. sativa extracts, and our results suggest that C. sativa extract has potential has a valuable bioresource for high-value products.

• Proceedings of the Korean Society of Crop Science Conference
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• 2005.04a
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• pp.110-111
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• 2005

• Proceedings of the Korean Society of Crop Science Conference
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• 1999.05a
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• pp.96-97
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• 1999

• Journal of Life Science
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• v.28 no.6
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• pp.688-696
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• 2018

Hemp seed (Cannabis sativa L.; HS), an annual herbaceous plant in the Cannabis genus, has been reported to play various biological functions in immunity increase, atherosclerosis, constipation, hyperlipidemia prevention, anti-inflammatory, and anti-cancer. In recently years, as superfood, the growing interest in the health care benefits of hemp seed has led to increased consumption. In this study, we investigated the effect of an ethanol extract of HS fermented with lactic acid bacteria (Lactobacillus plantarum KCTC 3107, L. plantarum KCTC 3108, L. brevis BHN-LAB128, L. paracasei BHN-LAB129). An antibacterial activity against Staphylococcus aureus and Bacillus cereus were 13.99 mm and 15.17 mm, respectively. The ethanol extracts of fermented hemp seed by lactic acid bacteria that the contents of total polyphenol, total flavonoid content, DPPH radical scavenging activity, SOD-like activity, and ${\alpha}$-glucosidase inhibitory activity were increased compared to non-fermented hemp seed. Also, tyrosinase inhibitory activity of the fermented hemp seed (FHS), known to melanin increasing substance was increased. In these results, we suggested that FHS have effects of anti-oxidant, ${\alpha}$-glucosidase inhibitory activity, and tyrosinase inhibitory activity. Hence, we proposed that FHS has possible to development as functional foods and cosmetics.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.41 no.5
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• pp.15-19
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• 2009

Ammonia soaking treatment was introduced for hemp woody core pretreatment to increase enzymatic saccharification of polysaccharides. Portions of the xylan, cellulose, and lignin were removed by aqueous ammonia soaking, which improved the enzymatic saccharification of cellulose and xylan. Following ammonia soaking, 37% ($50^{\circ}C$-6 day treatment) to 61% ($90^{\circ}C$-16 h treatment) of the cellulose was converted to glucose and 33% ($50^{\circ}C$-6 day treatment) to 48% ($90^{\circ}C$-16 h treatment) of the xylan to xylose. Cellulose responded better to enzymatic saccharification than did xylan after the ammonia soaking treatment. Aqueous ammonia soaking pretreatment was more effective than electron beam irradiation for increasing enzymatic saccharification of xylan and cellulose in hemp woody core.