• Title/Summary/Keyword: calcium absorption

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Modeling of the Parathyroid Hormone Response after Calcium Intake in Healthy Subjects

  • Ahn, Jae Eun;Jeon, Sangil;Lee, Jongtae;Han, Seunghoon;Yim, Dong-Seok
    • The Korean Journal of Physiology and Pharmacology
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    • v.18 no.3
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    • pp.217-223
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    • 2014
  • Plasma ionized calcium ($Ca^{2+}$) concentrations are tightly regulated in the body and maintained within a narrow range; thus it is challenging to quantify calcium absorption under normal physiologic conditions. This study aimed to develop a mechanistic model for the parathyroid hormone (PTH) response after calcium intake and indirectly compare the difference in oral calcium absorption from PTH responses. PTH and $Ca^{2+}$ concentrations were collected from 24 subjects from a clinical trial performed to evaluate the safety and calcium absorption of Geumjin Thermal Water in comparison with calcium carbonate tablets in healthy subjects. Indirect response models (NONMEM Ver. 7.2.0) were fitted to observed $Ca^{2+}$ and PTH data, respectively, in a manner that absorbed but unobserved $Ca^{2+}$ inhibits the secretion of PTH. Without notable changes in $Ca^{2+}$ levels, PTH responses were modeled and used as a marker for the extent of calcium absorption.

Effect of Lactose on Calcium Absorption Enhanced by Casein Phosphopeptides in the Rat Small Intestine (Casein Phosphopeptides 의 장관내(腸管內) 칼슘 흡수촉진(吸收促進)에 미치는 유당(乳糖)의 영향(影響))

  • Lee, Yeon-Sook;Naito, Hiroshi
    • Journal of Nutrition and Health
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    • v.15 no.1
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    • pp.1-8
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    • 1982
  • The effects of lactose on the formation of casein phosphopeptide (CPP), the increment of soluble calcium and the enhancement of calcium absorption by dietary casein in the intestinal tract were investigated. Rats were fed a lactose-free diet, 10% lactose diet and 30% lactose diet containing powdered milk. In rats receiving a lactose-free powdered milk diet, CPP formation was confirmed by gel filtration of the intestinal content on Sephadex G -25 and the amount of soluble calcium was increased in the small intestine and calcium absorption, measured by the ligated ideal loops in situ was enhanced. However, In rats receiving a powdered milk diet containing 10% lactose or 30% lactose, the similar effects were not seen. These observations indicate that CPP-stimulated effects on soluble calcium and calcium absorption in the small intestine are not dependent upon lactose.

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The Effect of Chicory Fructan Fiber on Calcium Absorption and Bone Metabolism in Korean Postmenopausal Women

  • Kim, Yun-Young;Jang, Ki-Hyo;Lee, Eun-Young;Yunhi Cho;Kang, Soon-Ah;Ha, Woel-Kyu;Ryowon Choue
    • Nutritional Sciences
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    • v.7 no.3
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    • pp.151-157
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    • 2004
  • The aim of this study was to investigate the effects of chicory fructan fiber supplementation on bone mineral density, apparent absorption of minerals and serum parameters related to bone turnover in postmenopausal women. Twenty-six healthy Korean postmenopausal women participated in the study. 1be participants were randomly divided into two groups in a double-blind parallel design and took one of the supplements for 3 months; either a placebo of 8g maltodextrins/sucrose mixture (control group) or 8g chicory fructan fiber (fructan group). During the 3-month experimental period no differences were found in bone mineral density (BMD) between the two groups. Apparent calcium absorption significantly increased by 42% in the fructan group, while that of the control group decreased by 29% as compared to the values at baseline. Urinary calcium excretion was not significantly different between the group;;. After 3 months, the level of serum alkaline phosphatase (ALP) was significantly lower in the fructan group than in the control group and deoxypyridinolin showed a trend toward a slight reduction. In conclusion, intake of chicory fructan fiber with a regular increases apparent calcium absorption in postmenopausal women.

Effects of sn-2 palmitic acid-fortified vegetable oil and fructooligosaccharide on calcium metabolism in growing rats fed casein based diet

  • Lee, Yeon-Sook;Kang, Eun-Young;Park, Mi-Na;Choi, You-Young;Jeon, Jeong-Wook;Yun, Sung-Seob
    • Nutrition Research and Practice
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    • v.2 no.1
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    • pp.3-7
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    • 2008
  • This study was carried out to investigate the efficacy of sn-2 palmitic acid-fortified vegetable oil (Sn2PA) on calcium absorption and to confirm the synergistic effects of fructooligosaccharide on calcium absorption. Male SD rats were fed 6 kinds of casein based diets containing vegetable oil (control), sn-2 palmitic acid-fortified vegetable oil (Sn2PA) and Sn2PA with fructooligosaccharide(Sn2PAFO) in two levels of calcium (normal 0.5% and high 1.0%) for 3 weeks. Total lipids, cholesterol, triglyceride and calcium in blood were measured. Feces were collected using cages for 4 days. Serum concentrations of total lipids and calcium were not significantly different among groups. However, serum triglyceride was significantly decreased by fructooligosaccharide supplementation regardless of dietary calcium level. The lipid absorption was not significantly different among experimental groups. Calcium absorption was significantly higher in Sn2PAFO group than other groups. Calcium solubility of intestine was increased by sn-2 palmitic acid supplementation. These results suggest that sn-2 palmitic acid and fructooligosaccharide supplementation could be beneficial for baby foods including infant formula, with regard to increasing absorption of calcium by more soluble calcium in the small intestinal content.

Calcium Absorption Accelerating Effect of Chitosnn Oligosaccharides prepared by Ultrafiltration Membrane Enzymatic Reactor (한외여과막 효소반응기를 이용하여 제조한 키토산 올리고당의 칼슘흡수 촉진효과)

  • JEON You-Jin;KIM Gyu-Hyung;PARK Pyo-Jam;KIM Se-Kwon
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.32 no.3
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    • pp.247-251
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    • 1999
  • In spite of various bio-functionalities of chitosan, the effects in vivo were still ambiguous because of its low absorption on organism. Therefore, chitosan oligosaccharides (COSs) are necessary to elucidate for an efficient utilization in vivo. COSs were prepared from chitosan using ultrafiltration membrane enzymatic reactor system with MWCO (molecular weight cut-off) 3,000 Da of membrane. Calcium absorption accelerating effect using COSs was examined by two methods, in vitro and in vivo. In vitro experiment, calcium absorption by the addition of COSs in a mixture solution of calcium and phosphate was higher approximately $50\%$ than that by control. In vivo using rats, group taken the diet contained $1\%$ COSs anil calcium chloride decreased about $75\%$ of calcium content excreted from feces, and then, showed about $15\%$ increase in breaking force of femur. These results demonstrated that COSs definitely involved in calcium metabolism in vivo.

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Dietary Intake of Calcium and Absorption Rate of College Women in Korea ( I ) - Seoul Area - (한국인 성인 여자의 칼슘대사에 관한 연구 (I) - 서울 지방 -)

  • Lee, Hyun-Ok
    • Journal of Nutrition and Health
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    • v.13 no.1
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    • pp.37-41
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    • 1980
  • This study was designed to investigate calcium intake, calcium excretion, and calcium absorption rate of the college women in Korea. The subjects of this experiment were five healthy college women aged from 18 to 23 years who lived in Seoul. The period of this experiment was two weeks, the first week was spent in having an ordinary diet and the next week for the experimental diet. Two weeks later, the feces of subjects were collected. Results obtained by the present experiment were as follows: 1) The total food intake from the experimental diet daily was about $1600{\sim}2000g$. 2) The total calcium intake was about $270{\sim}585mg$ and $710{\sim}880mg$ for the ordinary diet and the experimental diet respectively. 3) The daily calcium excretion of feces was about $219{\sim}295mg$. 4) The calcium absorption rate of subjects was about $60{\sim}70%$.

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The Effects of Dietary Protein and Calcium Levels on Calcium Metabolism in Young Korean Women (한국여성의 단백질 및 칼슘섭취가 칼슘대사에 미치는 영향)

  • 구재옥
    • Journal of Nutrition and Health
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    • v.21 no.2
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    • pp.99-112
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    • 1988
  • This study was performed to investigate the effects of dietary protein and calcium levels on calcium metabolism in eight healthy Korean adult females. The 2-day metabolic study consisted of a 2 day adaptation period and three 6-day experimental periods. Three experimental diets were low protein low calcium(LPLCa : protein 44g, Ca 422mg), higher protein low calcium(HPLCa : protein 85g, Ca 365mg), and high protein high calcium (HPHCa : protein 84g, Ca 727mg). The apparent calcium absorption was likely to be affected by the calcium intake rather than by the protein intake. Average calcium absorption rate was about 23-29% of calcium intake. The calcium balance was -21.44mg for LPCa, -25.02mg for HPLCa, and -3.22mg for HPHCa. Avergae urinary calcium excretion was 127.7mg for LPLCa, 108.6mg for HPLCa, and 215.4mg for HPHCa. Urinary calcium excretion was more closely related to the changes of calcium intake rather than of protein intake. These results seemed to be due to the interactions between the high phosphours contained in the high protein diet and the little discrepancy of protein intake levels.

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