• Journal of Microbiology and Biotechnology
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• v.11 no.6
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• pp.907-914
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• 2001

A whole genome analysis for monitoring specific changes in gene expression, using microarrays or proteome profiling of the same, are the two tools that have already revolutionized current approaches for studying disease. These methods are particularly important in cancer research as there are many overexpressed genes, and their products remain uncharacterized. This article presents a general overview of these technologies and their applications for studying cancer.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.151-152
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• 2002

Bacterial infection is a very complex process in which both pathogenic microorganisms and host cells play crucial roles, and it is the outcome of interactions between the two participants. To elucidate the bacterial pathogenesis mechanisms, therefore, it is essential to understand the cellular and systemic responses of the host as well as the virulence factors of the pathogen. Infection of a host by pathogenic bacteria causes drastic changes in the physiology of host cells, leading to activation of a program of various gene expression. (omitted)

• Proceedings of the Korean Society of Plant Pathology Conference
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• 2005.04a
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• pp.85-85
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• 2005

• Proceedings of the Korea Society of Environmental Toocicology Conference
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• 2004.05a
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• pp.81-81
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• 2004

• Proceedings of the Korean Society of Plant Biotechnology Conference
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• 2004.10a
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• pp.132-132
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• 2004

• Proceedings of the Korean Society of Life Science Conference
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• 2003.05a
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• pp.67-67
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• 2003

• Proceedings of the Zoological Society Korea Conference
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• 2003.08a
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• pp.200.3-200
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• 2003

No Abstract, See Full Text

• Proceedings of the Korea Society of Environmental Toocicology Conference
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• 2004.11a
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• pp.30-31
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• 2004

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.142.2-142.2
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• 2003

The activation of the hepatic stellate cell (HSC) is a key step in liver fibrogenesis. We investigated the changes of global gene expression during activation in hepatic stellate cells using a rat cDNA microarray with 5, 000 sequence-verified clones. We identified osteopontin (OPN), a secreted matrix protein, as one of the upregulated factors. Northern analysis showed OPN mRNA was increasingly expressed during progressive activation of cultured rat HSCs and in models of experimental liver fibrosis. (omitted)

• Proceedings of the Korean Statistical Society Conference
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• 2002.05a
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• pp.99-104
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• 2002

cDNA 마이크로어레이자료를 이용한 분류방법은 수많은 유전자의 발현을 동시에 모니터링 할 수 있으므로 특정 질병간의 분자생물학적 변이를 이해하는데 있어 기존의 분류방법보다 신뢰성이 훨씬 높을 것으로 기대되고 있다 최근에 Dudoit et al.(2001)은 cDNA 마이크로어레이를 이용한 유전자발현자료의 분석에 있어 분류를 위한 여러 고전적인 판별분류기법 및 최근에 개발된 기법들을 비교, 평가하였다. 본 논문에서는 Dudoit et al.(2001)에서 다루지 않았던 많은 최신 기법들을 포함하여 인간의 종양 자료뿐만이 아니라 농작물을 포함한 동식물 자료에 적용하여 보다 폭넓은 비교연구를 하였다.