• The KIPS Transactions:PartC
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• v.8C no.2
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• pp.221-233
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• 2001

오늘날 이동 에이전트 기술은 네트워크 트래픽을 효과적으로 줄이고, 서버의 인터페이스를 바꾸지 않고 클라이언트의 다양한 요청을 융통성 있게 서비스할 수 있는 기술로 여겨지고 있다. 그러나 대부분의 이동 에이전트 시스템들은 그들 자신의 구조를 적용하고 다른 방법으로 구현되어, 특정 이동 에이전트 시스템에서 생성된 이동 에이전트는 다른 에이전트 시스템에서는 사용될 수 없다. 이러한 문제를 해결하기 위하여 OMG(Object Management Group)는 이질적인 에이전트 시스템간의 상호운용선(interoperability)을 증진시킬 목적으로 이동 에이전트와 에이전트 시스템간의 공통된 개념적인 모델에 대하여 기술한 MAF(Mobile Agent Facilities) 명세를 제안하였다. 본 논문에서는 OMG MAF 명세를 만족하는 자바 기반의 SMART 시스템에 관하여 기술한다. SMART 시스템은 MAF 명세에 따른 이동 에이전트간의 상호운용성을 지원하고, MAF 명세에서 권장하는 보안 모델을 기반으로 한 독자적인 보안 기능을 제공한다. 또한 보다 안정된 에이전트 시스템의 운영을 위하여 자체적인 에이전트 및 에이전트 시스템의 영속성(persistence)과 예외처리를 지원한다.

• The Journal of Internal Korean Medicine
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• v.27 no.1
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• pp.40-54
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• 2006

Objective: This study aimed to identify the different effects of GMCSBHT water-extract and ethanol-extract on Th1/Th2 differentiation by monitoring Th1/Th2 specific cytokine secretion patterns and the transcriptional activities of T-bet, GATA-3, c-maf, $INF{\gamma}$ and IL-4. Materials and Methods: Spleen cells from eight week-old BALB/c mice were cultured in GMCSBHT extracts containing medium without activation for 24 hours and with activation for 48 hours. CD4+ T cells were isolated and mRNA expression levels of $INF{\gamma}$, IL-4, T-bet, GATA-3, c-maf by RT-PCR and secretion cytokines levels of $IFN{\gamma}$, IL-4 by ELISA were analyzed. Results: GMCSBHT extracts didn't have mitogenic effects on the unstimulated CD4+ T cells. In Th1 skewed condition, GMCSBAHT water extract had no significant effects on mRNA expression levels of $IFN{\gamma}$, T-bet and c-maf, but inhibited mRNA expression levels of IL-4, GATA-3. It showed significantly increased secretion cytokine levels of $IFN{\gamma}$, but had no significant effect on secretion cytokine levels of IL-4. In Th2 skewed condition, GMCSBHT ethanol extract inhibited mRNA expression levels of $INF{\gamma}$, IL-4, GATA-3 and c-maf significantly, but had no significant effects on mRNA expression levels of T-bet. It had no significant effects on secretion cytokine levels of $INF{\gamma}$, but showed remarkable inhibitory effects on secretion cytokine levels of IL-4. Conclusion: Results suggest that on Th1/Th2 deviation, GMCSBHT water extract has both amplifying effects on Th1 differentiation and inhibitory effects on Th2, but GMCSBHT ethanol extract has stronger inhibitory effects on Th2 differentiation than on Th1.

• Korean Journal of Veterinary Research
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• v.47 no.3
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• pp.299-302
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• 2007

Neoheterobothrium hirame (N. hirame) is a large blood-feed gill-worm infecting the highly prized olive flounder. The present study was reported the occurrence and elimination of Neoheterobothrium infection from young cultured oliver flounder in the western coast of Korea. Flounder (weight 18-25 g, length 10-15 cm) were obtained from a cultured farm at Taean of Korea at May 2006. A lot of flounder died with serious anemia. We isolated N. hirame from the buccal cavity wall of dead flounder. Adult parasites were 5-15 mm in total length, with 4 pairs of clamps on the pedunculated haptor and isthmus region embedded in host tissue, while immature and sub-adults were identified the attachment to the gill filaments, rakers and arches with the clamps. All fish with infection were treated with 8% NaCl-supplemented seawater for 1 and 10 min at $22^{\circ}C$, respectively. The significant reduction in mortality (6.7%) was observed among fish treated with 8% salt water for 10 minutes, when compared with that of non-treatment group (100%).

• Korean Journal of Veterinary Research
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• v.47 no.3
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• pp.303-308
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• 2007

The high mortality (65.5%) of young olive flounder (Paralichthys olivaceus) showing skin ulcers occurred in fish obtained from a commercial cultured farm at Donghae on the eastern coast of Korea at March 2006. The dorsal skin showed ulcer lesions and large amount of mucus. We isolated Ichthyobodo sp. from the gill, and Vibrio anguillarum from the liver and kidney of dead and diseased fish. All of the fish infected with the V anguillarum and Ichthyobodo sp. were treated with 100 ppm formalin for 1 h, and treated with oxolinic acid for 4 h at $22^{\circ}C$, respectively. The formalin treated group was observed the low mortality (2.9%) when compared with high mortality of non-treated (82.9%), and of antibiotic treated group (85.9%) against mixed infections by Vibrio anguillarum and Ichthyobodo sp. organisms. We confirmed complete elimination against mixed infections of Vibrio anguillarum and Ichthyobodo sp. with 100 ppm formalin treatment.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2003.06a
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• pp.1877-1880
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• 2003

We were interest in Deburring using MAF(magnetic abrasive finishing) method. So Magnetic inductor was designed and manufactured to generate proper magnetic induction fer deburring the burr formed in drilling SM45C. We experienced according to the Rotational speed, table feed rate, grain size of powder and working gap are changed to investigate the effect on deburring. At this time we experienced in abrasive effect mainly.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.10a
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• pp.241-244
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• 2002

Deburring is conducted using MAF(magnetic abrasive finishing) method. Magnetic inductor is designed and manufactured to generate proper magnetic induction far deburring the burr formed in drilling SM45C. Rotational speed, table feed rate, grain size of powder and working gap are changed to investigate the effect on deburring.

• International Journal of Oral Biology
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• v.32 no.1
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• pp.1-5
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• 2007

Receptor activator of nuclear factor ${\kappa}B$ ligand (RANKL) induces osteoclast formation from hematopoietic cells via up-regulation of positive regulators, including $NF-{\kappa}B$, c-Fos, microphthalmia transcription factor (Mitf), PU.1, and nuclear factor of activated T cells (NFAT) c1. In addition to the positive regulation by these transcription factors, RANKL appears to regulate negative regulators such as MafB and inhibitors of differentiation (Ids). Ids and MafB are abundantly expressed in osteoclast precursors, bone marrowderived monocyte/macrophage lineage cells (BMMs). Expression levels of these genes are significantly reduced by RANKL during osteoclastogenesis. Overexpression of these genes in BMMs inhibits the formation of tartarate-resistant acid phosphatase (TRAP)-positive multinuclear osteoclasts by down-regulation of NFATc1 and osteoclast-associated receptor (OSCAR), which are important for osteoclast differentiation. Furthermore, reduced expression of these genes enhances osteoclastogenesis and increases expression of NFATc1 and OSCAR. Taken together, RANKL induces osteoclastogenesis via up-regulation of positive regulators as well as down-regulation of negative regulators.

• Korean Journal of Veterinary Research
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• v.47 no.3
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• pp.291-298
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• 2007

Olive flounder, Paralichthys olivaceus is one of the most important cultured fish in Korea, its farming has been negatively impacted by viral, bacterial and parasitic diseases. Streptococcal infection was considered as a serious problem because of significant economic losses in olive flounder farm industry. The development and evaluation of vaccine for protection against infection by this agent were required. We evaluated the safety and efficacy of ${\beta}$-hemolytic Streptococcus (S.) iniae vaccine on olive flounder Three hundreds of flounders (weight $119.8{\pm}20.7g$, body length $22.6{\pm}1.4cm$) were reared in 0.5 tons aquaria in land-marine tank system. Seawater was provided from the sea of Inchon in Korea, and water temperature was set to $22^{\circ}C$ and $25^{\circ}C$ in the vaccination and challenge test, respectively. We used the formalin-inactivated ${\beta}$-hemolytic S. iniae (F2K) vaccine (M VAC INIAE; Kyoritsu seiyaku, Japan) originated in Japan. The vaccine was intraperitoneally administered to fish. Both of vaccinated group and control group were challenged with intraperitoneally injection by virulent S. iniae SI-36 isolates with $1.0{\times}10^7CFU/fish$ at 3 weeks after vaccination. Difference on mortality of control and vaccinated group (90.0 and 15.0%, 76.5 and 8.0% respectively) at two trials were found significant (p<0.05), and relative percent survival were 83.4% and 89.5%, respectively. The dead fishes were showed dark pigmentation of skin, abdominal extension, hemorrhagic ascites, and liver necrosis, and isolated the S. iniae strain from ascites, liver and kidney. We confirmed the safety and efficacy of ${\beta}$-hemolytic S. iniae vaccine by determinations of the optimal management condition and artificial challenge test in olive flounder.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2007.06a
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• pp.277-278
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• 2007

• The KIPS Transactions:PartC
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• v.10C no.4
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• pp.493-500
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• 2003

In this paper, we defined agent interface standard and messages for the control and management of agent. Agent interface is defined by messages exchanged between each component of the agent system environment, such as agent, agent system that creates and controls the agent, client that requests the service, agent master that mediates the service, agent manager that performs management functions of the agent. Agent interface is defined after the MAF of the OMG and the agent standard of the FIPA. Experiments are done for the application using agent interface and messages of this paper. The test network was the content distribution network using agent service, and we controled and managed the test network through the agent interface.