• 생약학회지
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• 제31권3호
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• pp.264-267
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• 2000

Anti-human immunodeficiency virus (HIV) type I protease (PR) and anti-lipid peroxidation effects on Rosa davurica were investigated. Of the various parts tested from R. davurica, the water extracts of stem and leaves inhibited the HIV-1 PR activity by more than 45% at a concentration of $100\;{mu}g/mL$. Hyperoside from the percarp of title plant showed 25% inhibition on HIV-1 PR at $200\;{mu}M$. The methanol extract of the root of R. davurica reduced the level of lipid peroxides induced by bromobenzene in vivo.

• 대한화학회지
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• 제10권1호
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• pp.1-3
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• 1966

The organic yields (i.e. fraction of nuclear events resulting in organic compound formation) of the radioative neutron capture reactions of halogens in purified bromobenzene have been determined varying extraction time, at $100^{\circ}C$ for thermal effect, varying irradiation time, varying neutron flux and with additional U. V. irradiation. Among the important results are; (1) The organic yields show no remarkable fluctuations with time following neutron irradiation; (2) The organic yields show no change with thermal energy; (3) The organic yields of degassed samples are same in different length of irradiation time whereas the yields of the samples in open air appear to increase with increasing time of irradiation (4) The organic yields increase remarkably with increased neutron flux; (5) The organic yields show a sharp increase by additional U. V. irradiation after neutron irradiation.

• 한국미생물생명공학회:학술대회논문집
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• 한국미생물생명공학회 2004년도 Annual Meeting BioExibition International Symposium
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• pp.316-320
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• 2004

• Molecular & Cellular Toxicology
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• 제1권4호
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• pp.268-274
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• 2005

Bromobenzene (BB) is well known hepatotoxicant. Also, BB is an industrial solvent that arouses toxicity predominantly in the liver where it causes centrilobular necrosis. BB is subjected to Cytochrome P450 mediated epoxidation followed by either conjugation with glutathione, enzymatic hydrolysis or further oxidation. In this study, we focused on BB-induced gene expression at non-hepatotoxic dose. Mice were exposed to two levels of BB, sampled at 24 h, and hepatic gene expression levels were determined to evaluate dose dependent changes. When examining the toxic dose of BB treated group in other previous studies, genes related to heat shock protein, oxidative stress, and drug metabolism are expressed. Compared to these results, our study, in which non-toxic dose of BB was administrated, showed similar patterns as the toxic conditions above. The purpose of the study was to select genes that showed changes in relation to the differing dose through confirmation of the difference within transcriptomic boundaries, but those that are not detected by the existing classic toxicology tools in non-hepatotoxic dose.

• Bulletin of the Korean Chemical Society
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• 제32권2호
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• pp.659-663
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• 2011

The photodissociation dynamics of bromobenzene near 234 nm has been investigated using a two-dimensional photofragment ion-imaging technique coupled with a state-selective [2+1] resonance-enhanced multiphoton ionization (REMPI) scheme. The nascent Br atoms are produced by the primary C-Br bond dissociation, which leads to the formation of $C_6H_5$ ($\tilde{X}$) and Br($^2P_j$, j = 1/2, 3/2). The observed translational energy distributions have been fitted by a single Boltzmann function and two Gaussian functions. Trimodal translational energy distributions of Br($^2P_j$) have been assigned to the direct/indirect dissociation mechanisms originating from the initially excited $^3({\pi},{\pi}^*)$ state. The assignments have been confirmed by the recoil anisotropy and distribution width corresponding to the individual components.

• 대한약학회:학술대회논문집
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• 대한약학회 2000년도 NEW STRATEGY FOR DRUG DEVELOPMENT IN POST-GENOMIC ERA(대한약학회)
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• pp.237.3-238
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• 2000

• Bulletin of the Korean Chemical Society
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• 제15권9호
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• pp.772-774
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• 1994

The cobalt catalyzed carbonylation of bromobenzene having protected aldehyde group gives the corresponding ester in good yields, but 2-bromobenzaldehyde gives 3-alkoxyphthalide in the noticeable yield instead of alkyl 2-formylbenzoates.

• 환경생물
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• 제17권4호
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• pp.513-519
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• 1999

광양만 해수를 대상으로 총 17개의 조사정점을 선정, 1996년 7월부터 1997년 4월까지 계절별로 19종류의 VOCs를 분석.조사하였다. 조사대상 VOCs 중 methylene chloride, tetrachloromethane, 1, 1, 1-trichloroethane, trichloroethane, 1, 1, 1, 2-tetrachloroethane, trichloroethylene, bromoethane, dibromoethane, bromobenzene, 1-ethyl-3-methylbenzene등 총 10개 항목은 전체 조사지점 및 조사 시기 동안에 검출되지 않았으며, chloroform, 1, 2-dichloroethane, ethylbenzene, benzene, toluene, m, p-xylene, methylethylketone, styrene, hexane 등의 조사항목은 소량의 범위에서 조사시기와 정점을 달리하여 검출되었다. 특히 chloroform과 toluene은 0.6~49.9$\mu$g/1, 0.42~48.3$\mu$g/1로서 높은 농도의 범위를 나타내었으며, 검출빈도도 다른 조사 대상 VOCs에 비해 높은 것으로 조사되었다. 이화학적 환경요인과 VOCs와의 상관관계에서 toluene만이 수온(r=-0.524), pH(r=0.319)가 비교적 높은 상관성을 보였으며 나머지 항목은 매우 낮은 상관성을 보였다. VOCs 상호간의 상관성에서 benzene의 경우 toluene, m, p-xylene, ethylbenzene과 높은 상관계수(r=0.549~0.662)를 보였다. 이러한 결과는 광양만에서 VOCs의 배출이 같은 시기에 이루어지고 있음을 시사하는 것으로 추측된다.

• 생약학회지
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• 제29권3호
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• pp.231-236
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• 1998

Three flavonoid glycosides have been isolated from the aerial part of Armoracia rusticana P. (Cruciferae) in Korea and identified by means of spectral analysis as $kaempferol-3-O-{\beta}-D-xylofuranoside(l)$, $kaempferol-3-O-{\beta}-D-galactopyranoside(2)$ and $kaempferol-3-O-{\beta}-D-xylofuranosyl(1\rightarrow2)-b{\beta}-D-galactopyranoside(3)$. When 1 mg/ml of the methanol extract from the aerial part of this plant was added, lipid peroxide formation in the bromobenzene-treated rat liver decreased by 64%. Among the components isolated from title plant, compounds 2 and 3 reduced the formation of lipid peroxide by 16% and 39% respectively at the concentration of ${10}^{-1}$ mg/ml.

• Natural Product Sciences
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• 제7권2호
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• pp.49-52
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• 2001

Anti-lipid peroxidative activity and phytochemical study on the leaves of Glycine max Meer. were investigated. The methanol extract of the leaves of G. max reduced the level of lipid peroxides induced by bromobenzene in vitro. From the leaves of this plant, apigenin, genistein $7-O-{\beta}-D-glucopyranoside$, kaempferol $3-O-{\beta}-D-glucopyranoside$, and kaempferol 3-O-sophoroside were isolated and characterized by spectral data.