• Proceedings of the Korean Society of Applied Pharmacology
• /
• 2006.11a
• /
• pp.51-66
• /
• 2006

The field of cytochrome P450 pharmacogenomics has progressed rapidly during the past 25 years. Recently, conjugating enzymes including sulfotransferase, acetyltransferase, glucuronosyltransferase and glutathione transferase have been also extensively studied. All the major human drug-metabolizing P450 enzymes and some conjugating enzymes have been identified and cloned, and the major gene variants that cause inter-individual variability in drug response and are related to adverse drug reactions have been identified. This information now provides the basis for the use of predictive pharmacogenomics to yield drug therapies that are more efficient and safer. Today, we understand which drugs warrant dosing based on pharmacogenomics to improve drug treatment. It is anticipated that genotyping could be used to personalize drug treatment for vast numbers of subjects, decreasing the cost of drug treatment and increasing the efficacy of drugs and health in general. It is assumed that such personalized P450 gene-based treatment which is so-called tailor(order)-made drug therapy would be relevant for 10-20% of all drug therapy in the future.

• 한국약용작물학회:학술대회논문집
• /
• 2006.11a
• /
• pp.51-66
• /
• 2006

The field of cytochrome P450 pharmacogenomics has progressed rapidly during the past 25 years. Recently, conjugating enzymes including sulfotransferase, acetyltransferase, glucuronosyltransferase and glutathione transferase have been also extensively studied. All the major human drug-metabolizing P450 enzymes and some conjugating enzymes have been identified and cloned, and the major gene variants that cause inter-individual variability in drug response and are related to adverse drug reactions have been identified. This information now provides the basis for the use of predictive pharmacogenomics to yield drug therapies that are more efficient and safer. Today, we understand which drugs warrant dosing based on pharmacogenomics to improve drug treatment. It is anticipated that genotyping could be used to personalize drug treatment for vast numbers of subjects, decreasing the cost of drug treatment and increasing the efficacy of drugs and health in general. It is assumed that such personalized P450 gene-based treatment which is so-called tailor(order)-made drug therapy would be relevant for 10-20% of all drug therapy in the future.

• Biomolecules & Therapeutics
• /
• v.14 no.4
• /
• pp.183-188
• /
• 2006

The field of cytochrome P450 pharmacogenomics has progressed rapidly during the past 25 years. Recently, conjugating enzymes including sulfotransferase, acetyltransferase, glucuronosyltransferase and glutathione transferase have been also extensively studied. All the major human drug-metabolizing P450 enzymes and some conjugating enzymes have been identified and cloned, and the major gene variants that cause inter-individual variability in drug response and are related to adverse drug reactions have been identified. This information now provides the basis for the use of predictive pharmacogenomics to yield drug therapies that are more efficient and safer. Today, we understand which drugs warrant dosing based on pharmacogenomics to improve drug treatment. It is anticipated that genotyping could be used to personalize drug treatment for vast numbers of subjects, decreasing the cost of drug treatment and increasing the efficacy of drugs and health in general. It is assumed that such personalized P450 gene-based treatment which is so-called tailor(order)-made drug therapy would be relevant for 10-20% of all drug therapy in the future.

• Physical Therapy Rehabilitation Science
• /
• v.6 no.1
• /
• pp.14-19
• /
• 2017

Objective: To investigate the effect of performing three different bridge exercise conditions on the activities of four different muscles using surface electromyography (sEMG) in healthy young adults. Design: Cross-sectional study. Methods: A total of 20 healthy young adults (10 males, 10 females) voluntarily participated in this study. All subjects randomly performed three different bridge conditions as follows: general bridge exercise, isometric hip abduction (IHAB) with a blue Theraband (Hygenic Corp., USA), and isometric hip adduction (IHAD) with a Swiss ball (Hygenic Corp.). The muscle activities of bilateral erector spinae (ES), gluteus maximus (GM), biceps femoris (BF), and external oblique (EO) muscles during the bridge exercises were measured using sEMG. Subjects performed each of the three bridge conditions three times in random order and mean values were obtained. Results: For bilateral ES and BF, there was a significant increase in muscle activity in the IHAD condition compared to the general bridge and IHAB condition (p<0.05). For bilateral GM, there was a significant increase in muscle activity in the IHAB condition compared to the general bridge condition (p<0.05) and there was a significant increase in muscle activity in the IHAB condition compared to IHAD condition (p<0.05). For left EO, a significant increase was observed in the IHAD condition compared to the general bridge condition (p<0.05). Conclusions: ES and BF muscle activity increases were observed with hip adduction and increased GM activity was observed with hip abduction. These findings may be applicable within the clinical field for selective trunk and lower extremity muscle activation and advanced rehabilitation purposes.

• Journal of The Korean Society of Integrative Medicine
• /
• v.3 no.4
• /
• pp.43-51
• /
• 2015

Purpose : This study examines the effect of trunk stabilization program on the body balance, lung capacity, and muscular activity of the rectus abdominis and external oblique of healthy adults. Method : A survey was conducted for 20 students of K University located in the city of Y in Gyeongsangbuk-do Province of Korea. The trunk stabilization program consisted of a hollowing exercise, curl-up, bridging exercise, and birddog exercise. This was performed 14 times in total (7 times a week for two weeks). For analysis, good balance was used to measure both static and dynamic balancing ability. A peak flow meter was used to measure the maximum expiratory flow, and MP150 was used to measure muscular activity of the rectus abdominis and external oblique. Result : After the trunk stabilization program, the participants showed a difference in score and time taken to achieve static and dynamic balance, and muscular activity of the rectus abdominis and external oblique at a statistically significant level (p<0.05). However, no significant difference was observed in the left-to-right distance and front-to-back distance in a dynamic balance, and the lung capacity (p>0.05). Conclusion : The results showed that the trunk stabilization program was effective in enhancing both static and dynamic balancing ability and muscular activity. It also increased the lung capacity although the change was not at a statistically significant level.

• Journal of the Korean Society of Physical Medicine
• /
• v.8 no.1
• /
• pp.11-18
• /
• 2013

PURPOSE: The purpose of this study was to investigate the difference of trunk muscles activity during abdominal hollowing and bracing contraction in various position. METHODS: This pilot test was carried out in a volunteer sample of normal adults(n=24) without a history of low back pain or injury. 24 subjects were randomly allocated to three groups(n=8) as a contraction method respectively. In hooklying position, trunk muscles activity of subjects was measured using EMG in various bridging position. RESULTS: Abdominal bracing contraction made to more great trunk deep and superficial muscles activity than hollowing contraction.(p<0.00) Especially, Multifidus activity was the biggest.(p<0.00) CONCLUSION: The result from this study showed that abdominal bracing contraction made to more balancing activity of trunk muscles than abdominal hollowing contraction. Thus, It will good for trunk muscles unbalanced LBP patient to improve lumbar stabilization.

• Journal of The Korean Society of Inherited Metabolic disease
• /
• v.5 no.1
• /
• pp.116-125
• /
• 2005

Orthotopic liver transplantation is the treatment of choice for inherited metabolic diseases. However, the supply of donor organs is limiting and therefore many patients cannot benefit from this therapy. In contrast, hepatocytes can be isolated from a single donor liver. They can be transplanted into several recipients, and this procedure may help overcome the shortage of donor livers. A great deal of work with animal models indicates that hepatocytes transplanted into the liver or spleen can survive, function, and participate in the normal regenerative process. Recent clinical studies suggest that hepatocyte transplantation may be useful for bridging patients to whole organ transplantation and for providing metabolic support during liver failure and for replacing whole organ transplantation in certain inherited metabolic diseases. Nowadays, hepatocytes from various stem cells have been regarded as an another cell source for treatment of inherited metabolic diseases. Although cell therapy using stem cells for inherited metabolic disease patient has been accepted only as an experimental trial yet, hepatocytes from stem cells can solve a lot of obstacles in the treatment of inherited metabolic diseases.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
• /
• v.23 no.1
• /
• pp.1-6
• /
• 2017

Purpose: The purpose of this study was to explore the influence of a sling suspension exercise with abdominal drawing-in maneuver (ADIM) on the thickness of abdominal muscles. Method: Twenty healthy young women volunteered for this study, and they were randomly assigned to either the control group or experimental group. Subjects of both groups performed the ADIM in standard method. And subjects of the experimental group underwent a structured sling exercises additionally, which consists of bridging exercise on supine, elbow support and trunk control exercise on prone, and trunk flexion exercises. The exercises were performed thirty minutes per day, 3 times a week for a 4-week period. Thickness of abdominal muscles (transverse abdominis; TrA, internal obliques; IO and external obliques; EO) was measured by using real-time ultrasonography. Results: After the intervention, subjects of the experimental group appeared to be significantly increased for the thickness of the TrA (p<.05). However, significant difference weren't found for the IO and EO (p>.05). Conclusion: These findings suggest that sling suspension exercise with the ADIM may be favorably used to augment trunk stabilizing effort by increasing TrA thickness. Further studies need in this field.

• The Journal of Korean Physical Therapy
• /
• v.31 no.1
• /
• pp.62-66
• /
• 2019

Purpose: This study examined the most efficient exercise position to activate the gluteus medius (GM) and tensor fascia latae (TFL) in hip abduction in side-lying (HA-SL), clam in side-lying (CL-SL), and sling bridging in side-lying (SB-SL), which are the most representative GM exercises. Methods: Twenty-four healthy male adults aged from 20 to 40 years, whose body mass index was under 25, participated in this experiment. While all participants conducted three different positions with a counterbalanced manner, such as in AB, CL, and BR, activation of the GM and TFL was measured using 8-channel wireless EMG. Exercise was performed for 10 seconds three times in total with a five minute-break session. Results: Significant differences in GM and TFL activation were observed among the three positions (p<0.05). The highest activation of 60.69 was observed in BR followed in order by 46.03 and 12.92 in HA-SL and CL, respectively. TFL activation in HA-SL was 42.01, followed in order by 35.98 and 14.01 in BR and CL, respectively. On the other hand, there was no significant difference in TFL muscle activation between BR and HA-SL. Conclusion: These findings suggest that both BR and HA-SL in GM can be done selectively. CL has remarkably low muscle activation in GM and TFL, which makes it less valuable in GM and TFL exercise. In conclusion, selective BR and HA-SL exercise should be applied to maximally and effectively activate the GM.

• Physical Therapy Rehabilitation Science
• /
• v.12 no.1
• /
• pp.26-32
• /
• 2023

Objective: This study attempted to compare the effects of bridge exercise using a sling according to the angle of the ankle to confirm the effective lower extremity muscle activation posture of patients with patellofemoral pain syndrome(PFPS). Design: Cross-sectional study Methods: Seventeen patients with PFPS were recruited and the muscle activities of the vastus medialis, vastus lateralis, rectus femoris, and gluteus maximus were measured according to the ankle position (dorsiflexion, neutral, plantar flexion). After measuring the maximum number of isometric contractions of vastus medialis, vastus lateralis, rectus femoris, and gluteus maximus, bridging exercise using a sling according to each ankle posture was applied to measure lower extremity muscle activity. The evaluation was performed 3 times for 10 seconds. The three ankle postures were randomly performed and the average values were compared. Results: As a result of this study, the vastus medialis muscle showed high muscle activity in the order of dorsiflexion, plantar flexion, and neutral position bridge exercise (p<0.05). And the vastus lateralis showed high muscle activity in the order of dorsiflexion, neutral, and plantar flexion (p<0.05). However, rectus femoris and gluteus maximus did not show significant muscle activity according to the ankle posture, but muscle activity was highest in the dorsiflexion posture. Conclusions: As a result of this study, muscle activity was high in the order of vastus medialis and vastus lateralis during ankle dorsiflexion. This is thought to be a major factor that can be applied in various ways in clinical practice according to the ankle angle when treating PFPS patients.