• Journal of Pharmaceutical Investigation
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• v.36 no.3
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• pp.209-215
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• 2006

Zaltoprofen, (2-(10,11-dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic acid) is an NSAID with powerful anti-inflammatory effects as well as an analgesic action on inflammatory pain. The purpose of the present study was to evaluate the bioequivalence of two zaltoprofen tablets, $Soleton^{\circledR}$ (CJ Corp.) and SCD Zaltoprofen (Samchundang Pharmaceutical Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The release of zaltoprofen from the two zatoprofen formulations in vitro was tested using KP Vlll Apparatus ll method with various dissolution media. Twenty six healthy male subjects, $23.2{\pm}2.26$ years in age and$64.7{\pm}8.08$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After a single tablet containing 80 mg as zaltoprofen was orally administered, blood samples were taken at predetermined time intervals and the concentrations of zaltoprofen in serum were determined using HPLC with UV detector. The dissolution profiles of two formulations were similar in all tested dissolution media. The pharmacokinetic parameters such as $AUC_t$, $C_{max}$ and $T_{max}$ were calculated, and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$, $C_{max}$ and untransformed $T_{max}$. The results showed that the differences between two formulations based on the reference drug, $Soleton^{\circledR}$ were 6.33, 5.91 and 17.7% for $AUC_t$, $C_{max}$ and untransformed $T_{max}$, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g.,log $1.01{\sim}1og\;1.11$ and log $0.928{\sim}1og\;1.18$ for $AUC_t$ and $C_{max}$, respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating SCD Zaltoprofen tablet was bioequivalent to $Soleton^{\circledR}$ tablet.

• Clinics in Shoulder and Elbow
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• v.19 no.2
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• pp.84-89
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• 2016

Background: The purpose of this study was to assess the results of arthroscopic bridging repair using a human dermis allograft in the treatment of massive irreparable rotator cuff tears. Methods: From November 2009 to April 2011, 12 patients underwent arthroscopic bridging repair using a human dermis allograft in the treatment of massive irreparable rotator cuff tears. Patients were followed for an average of 33.9 months. Clinical outcome was evaluated preoperatively and postoperatively using the mean University of California, Los Angeles (UCLA) score and the Korean Shoulder Scoring System (KSS). Magnetic resonance imaging (MRI) was performed postoperatively at an average of 6.5 months. Results: At a mean follow-up of 33.9 months (range, 25 to 42 months), 11 out of 12 patients were satisfied with their procedure. Patients showed significant improvement in their mean modified UCLA score from 15.9 preoperatively to 29.4 postoperatively (p=0.001). The mean KSS score improved from 45.6 preoperatively to 80.5 postoperatively (p=0.002). In MRI studies, 9 out of 12 patients had full incorporation of the graft into the native rotator cuff remnant. To date, there has been no intraoperative or postoperative complication from the graft procedure, such as infection or allograft rejection, in any patient. Conclusions: Arthroscopic bridging repair using a human dermis allograft can be considered as an option in treatment of select cases of massive irreparable rotator cuff tears, resulting in high patient satisfaction.

• Journal of Korea Society of Digital Industry and Information Management
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• v.9 no.3
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• pp.155-171
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• 2013

This research paper is focused on a theoretical study of the influences the structural factors and social capital within an industrial cluster have on innovative performance, and expanding the understanding of the influence through positive analyses based on public surveys. The study adopts a concept of social capital that can formulate a social relationship, and maintains that the social capital either works as a mediator for structural factors or independently exerts strong influences on innovative performance. In the research, the social capital is divided into two categories, bonding social capital and bridging social capital, and their influences are analyzed separately. The result of the analyses shows that unlike the traditional perception based on Korea's unique culture, the influence of bridging social capital is stronger than that of bonding social capital. It is also found that the structural factors exert influence by themselves on the contrary the previous study, simultaneously they still have influence upon innovative performance through bridging social capital calculated via the elements such as secondary relationships, network activity support and organizational openness.

• Journal of International Academy of Physical Therapy Research
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• v.8 no.1
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• pp.1077-1083
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• 2017

The purpose of this study was to investigate the effects of stable and unstable bridging exercises on the EMG activity of abdominal muscles. Twenty healthy women participated in this study and the muscle activities of left-right rectus abdominis (RA), external oblique (EO), and internal oblique (IO) muscles were recorded during 4 bridging exercises (unilateral/ bilateral, stable/unstable). The activity of the right EO muscle was the highest during unilateral exercise in unstable condition, and left EO muscle also produced the same result. The activity of the right IO muscle was the highest during unilateral exercise in an unstable condition, and left IO muscle also produced the same result. The activity of the right RA muscle was the highest during unilateral exercise in a stable condition, and left RA muscle produced the same result. Unstable/unilateral (USUL) represented the highest activity among the 4 exercises. EO/IO muscles represented the highest activity during the USUL exercise, and RA did so during the stable/unilateral exercise. These results suggest that specific posture (USUL) can be administered targeting a specific side of abdominal muscles.

• The Journal of Korean Physical Therapy
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• v.28 no.1
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• pp.59-63
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• 2016

Purpose: The objective of this study was to identify determine the effect of the strap height on muscular activity of trunk and lower limbs muscles during bridging exercise with a sling. Methods: The subjects of the study were 17 healthy male adults. In order to For measurement of muscular activity, body surfaces electrodes were placed on areas including erector spinae, multifidus muscles, gluteus maximus, and hamstring and the results was were recorded based on three different heights of strap, which are Levels 1, 2, and 3. Results: The muscular activities in erector spinae, multifidus muscle, and gluteus maximus were significantly different in at all three heights (p<0.05)., Level 3 showed the highest the compared to Levels 1 and 2. In hamstring muscle, there was significant difference in levels 1 and 2, also and levels 1 and 3 (p<0.05),. Bbut there was no significant difference between 2 and 3. The ration of muscular activities in multifidus muscles/erector spinae and gluteus maximus/hamstrings were significantly different for all three strap heights (p<0.05). Also, Level 3 showed higher than 1 or 2. Conclusion: The results of this study suggests to adjustment of the level III, that which has high activity level of multifidus and gluteus maximus affecting trunk stability during bridging exercise using a sling.

• Journal of Information Technology Applications and Management
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• v.29 no.4
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• pp.35-49
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• 2022

Knowledge sharing occurs through voluntary interactions between human actors. In this paper, from the perspective of social interaction, the effect of transactive memory capability and social capital (bridging social capital and bonding social capital) on knowledge sharing intention was analyzed, and tenure was demonstrated as a moderating factor that can strengthen their relationship. Therefore, the results of this study are summarized as follows. First, it was verified that the transactive memory capability had a significant positive effect on the knowledge sharing intention. Second, it was found that the bridging social capital and bonding social capital held by individuals had a significant positive effect on knowledge sharing intention. Social capital is understood to form an individual's voluntary motivation for knowledge sharing. Third, it was verified that the moderating effect of tenure suggested in this study was not significant. Based on the results of this study, implications and future research directions were presented.

• Physical Therapy Korea
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• v.18 no.3
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• pp.49-58
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• 2011

The purpose of this study was to evaluate the effects of bridging stabilization exercise on balance ability and gait performance in elderly women. The subjects of this study were thirty-one elderly women over 65 years old in HongSung-Gun Senior Citizen Welfare Hall. The subjects were randomly assigned into one of three groups (trunk stabilization exercise on the mat, whole body vibration, and Swiss ball) and participated in each exercise program three times a week for 4 weeks. Each exercise began in the bridging position. The dynamic balance and gait were measured by limit of stability area using force plate, Berg Balance Scale (BBS), and Timed Up and Go Test (TUG). The results were as follows: 1) The limit of stability in three groups increased significantly in anterior-posterior and medial-lateral lean after 4-weeks intervention (p<.05). 2) There were no significant differences in the limit of stability among three groups after 4-weeks intervention (p>.05). 3) The BBS and TUG in three groups increased significantly after 4-weeks intervention (p<.05). 4) There were significant differences among three groups in BBS. Post-hoc test showed that Swiss ball exercise group was significantly higher than the mat and whole body vibration groups. 5) There were no significant differences TUG among three groups after 4-weeks intervention (p>.05). In conclusion, this study suggested that 4 weeks of the bridging stabilization exercises were effective on balance and gait in all three groups. Particularly Swiss ball exercise group showed higher improvement than two other exercise groups (mat, whole body vibration group).

• Journal of the Korean Chemical Society
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• v.37 no.9
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• pp.787-792
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• 1993

Semiempirical MNDO calculations are employed to study relation properties on bridging OH group with Al-O(P-O) bond length and Al-O-P bond angle of structural characteristics using birdging $(OH)_3AlOP(OH)_3$ and $(OH)_3AlOHP(OH)_3^+$ model culster. We know that the O-H bond dissociation energy of bridging OH group is increased with increasing Al-O(P-O) bond length and decreasing Al-O-P bond angle. The bridging OH group is formed into enlarged Al-O(P-O) bond length and shortened Al-O-P bond angle in bridging oxygen atom by a hydrogen migration. The negative net charge of bridging oxygen atom is increased with longer Al-O-P bond angle, while the positive net charge is decreased with longer Al-O-P bond angle.

• Physical Therapy Korea
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• v.14 no.4
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• pp.21-27
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• 2007

The purposes of this study were to compare core muscle activities with and without the use of Pilates resistive equipment during bridging exercises and to investigate the efficacy of a Pilates device. Fourteen healthy individuals (6 males, 8 females) between 20 to 26 years of age were examined. They were engaged in a bridging exercise with and without a magic circle. Three consecutive repetitions of each exercise were performed. Surface electromyography (sEMG) was used to measure the electrical activities of the right side internal oblique, the adductor longus, the multifidus, and the gluteus maximus muscles. Normalized EMG activities were compared using a paired t-test and the level of significance was set at =.05. The results showed that the EMG activities of the internal oblique (p=.0078), the adductor longus (p=.0007), and the gluteus maximus (p=.0001) muscles were significantly higher when using the magic circle during the Pilates bridging exercise. Also, statistically significant change existed in the multifidus muscle (p=.0106). The bridging exercise, combined with hip adduction using the magic circle, may enhance core stabilization. Therefore, using a magic circle during hip adduction combined with bridging exercise may be recommended usefully for individuals wanting to strength the core muscles. Further research is needed to access the nature of motor control of the Pilates mat exercises and to deliver exercise intervention for lower back pain patients.

• Physical Therapy Korea
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• v.27 no.1
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• pp.87-92
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• 2020

Background: Bridging exercises are used to enhance the functional stability of the lumbopelvic region in clinical settings. Although most of the studies on bridging exercises have compared the complete activation of the trunk muscles, some recent studies have examined the functional stability of the trunk and the lumbopelvic region and assessed the appropriate recruitment of the local and global muscles during different task levels. Objects: The purpose of this study was to investigate the changes in muscle thickness in the transverse abdominis (TrA), internal oblique (IO), and external oblique (EO) muscles during a common bridging exercise on an unstable surface and to determine whether these changes differ based on the surface used. Methods: Twenty-five healthy young adults (8 males, 17 females) were recruited. The subjects were randomly assigned to either the exercise progression with a sling bridge group or the ball bridging exercise progression group, each with three stages of increasing difficulty. Each position was measured three times with an ultrasonic diagnostic imaging system, and the mean values were recorded for analysis. Results: No significant differences were observed between the TrA, IO, or EO muscle thickness ratios between the sling and ball exercise groups (p > 0.05). There were also no significant differences in the EO muscle thickness ratios between the tasks irrespective of whether the sling or ball was used. However, the TrA and IO thickness ratios in both groups were significantly greater during stages 2 and 3 compared to stage 1. Conclusion: The results suggest that the use of slings and balls during bridging exercises is effective in activating the deep abdominal muscles.