• 대한지역사회영양학회지
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• 제5권4호
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• pp.569-577
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• 2000

This study was carried out to investigate the feeding practices, growth status and correlation with maternal perceptions of breast feeding and lactation with infuts' feeding methods in the Pocheon area. The subjects were 103 infants ranging from 3 to 21 postpartum months and their mothers. The results obtained were as follows : In this survey, 36.9% of the infants were breast-feeding, while 53.4% of them were bottle-feeding, and 9.7% of them were mixed-feeding. The reason for bottle-feeding was due mainly to the lack of breast-milk secretion. Z-scores of weight-f3r-age and height-for-age were similar to Korean standards, but malnutrition and overnutrition were also noticed by kaup index and WLI. The average maternal perceptions of breast-feeding and lactation was 3.7 out of 10 possible points, the breast-feeding group scored 4.7, and formula-feeding and mixed-feeding group scored 3.0. That of BF group was higher than FF+MF groups and was positively correlated with growth status. Therefore to ensure proper growth of infants and to promote breast-feeding, efforts should be given to community nutritional services including nutrition education for the importance of colostrum and breast-milk, practical breast-feeding methods, and nutritional management during pregnancy. Also nutrition education for mothers will be continued to 1-3 postpartum months to promote successful breast-feeding.

• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10151-10156
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• 2015

4-Hydroxynonenal (4-HNE) is a stable end product of lipid peroxidation, which has been shown to play an important role in cell signal transduction, while increasing cell growth and differentiation. 4-HNE could inhibit phosphatase and tensin homolog (PTEN) activity in hepatocytes and increased levels have been found in human invasive breast cancer. Here we report that 4-HNE increased the cell growth of breast cancer cells as revealed by colony formation assay. Moreover, vascular endothelial growth factor (VEGF) expression was elevated, while protein levels of hypoxia inducible factor 1 alpha (HIF-$1{\alpha}$) were up-regulated. Sirtuin-3 (SIRT3), a major mitochondria NAD+-dependent deacetylase, is reported to destabilize HIF-$1{\alpha}$. Here, 4-HNE could inhibit the deacetylase activity of SIRT3 by thiol-specific modification. We further demonstrated that the regulation by 4-HNE of levels of HIF-$1{\alpha}$ and VEGF depends on SIRT3. Consistent with this, 4-HNE could not increase the cell growth in SIRT3 knockdown breast cancer cells. Additionally, 4-HNE promoted angiogenesis and invasion of breast cancer cells in a SIRT3-dependent manner. In conclusion, we propose that 4-HNE promotes growth, invasion and angiogenesis of breast cancer cells through the SIRT3-HIF-$1{\alpha}$-VEGF axis.

• 복식문화연구
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• 제22권6호
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• pp.943-954
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• 2014

The purpose of this study was to analyze the breast growth variation trends and characteristics of Korean adolescent girls based on 3D body measurements. Subjects were 174 girls aged between 13 and 18. 3D body scanning data were collected and the data were measured by Geomagic Design X program. The total of 18 anthropometric measurements and 4 index items were analyzed. The main results of this study are as follows: 1) Overall, the breast growth of adolescent girls got out of children's body shapes at the age of 14 and the adult's body shapes appeared remarkably at the age of 18. Before the age of 15, the adolescent girls' breast enlarged. 2) The surface lengths of upper body, which means the breast volume, showed significant growth above B cup groups rather than under A cup groups. The demand of B cup size (32.2%) was higher than A cup size (25.9%). And 35.6% of subjects' brassiere band size was 70. 3) The thorax grew evenly in the circumference, depth and breadth. The thoracic development related to the breast volume as well as the whole upper body's development. These results reveal that it is necessary to develop adolescent girls' brassiere reflecting on adolescent girls' breast growth variation trends and characteristics by age, breast size and thoracic development.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7553-7558
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• 2014

The Piwi subfamily comprises two argonaute (Ago) family proteins, which are defined by the presence of PAZ and Piwi domains, with well known roles in RNA silencing. Hiwi, a human Piwi subfamily member, has been shown to play essential roles in stem cell self-renewal and gametogenesis. Recently, accumulating reports have indicated that abnormal hiwi expression is associated with poorer prognosis of multiple types of human cancers, including examples in the breast. However, little is known about details of the oncogenic role of hiwi in breast cancers. In present study, we confirmed overexpression of hiwi in breast cancer specimens and breast cancer cell lines at both mRNA and protein levels. Thus both RT-qPCR and Western blot data revealed significantly higher hiwi in intratumor than peritumor specimens, overexpression being associated with tumor size, lymph node metastasis and histological grade. Hiwi overexpression was also identified in breast cancer cell lines, MDA-MB-231 and MCF-7, and gain-of-function and loss-of-function strategies were adopted to identify the role of hiwi in the MCF-7 cell growth. Results demonstrated that hiwi expression in MCF-7 cells was significantly up- or down-regulated by the two strategies. We next evaluated the influence of hiwi overexpression or knockdown on the growth of breast cancer cells. Both cell count and colony formation assays confirmed promoting roles of hiwi in MCF-7 cells, which could be inhibited by hiwi specific blockage by siRNAs. In summary, the present study confirmed overexpression of hiwi in breast cancer specimens and breast cancer cell lines, and provided e vidence of promotion by hiwi of cell growth. The results imply an oncogenic role of hiwi in breast cancers.

• 대한간호학회지
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• 제42권6호
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• pp.907-915
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• 2012

Purpose: A diagnosis of breast cancer is one of the most traumatic events that threatens a woman's life, but while women adapt to and overcome these threats, they not only experience negative aspects, but also growth. The purpose of this study was to identify the many factors that affect growth, and to provide fundamental information for nursing interventions, which can help the women in their growth. Methods: The participants in this study were 131 married women patients with breast cancer, who were on medical treatment in one of two university hospitals, in Seoul and Chungnam. Data were collected for posttraumatic growth, self-esteem, cancer coping questionnaire, marital intimacy, and body image. The data were analyzed using the SPSS 19.0 program (IBM). Results: Interpersonal cancer coping, intrapersonal cancer coping (planning) and self-esteem accounted for 29.0% of posttraumatic growth. Conclusion: These findings indicate that in order to help the women's growth after the trauma of breast cancer, it is necessary to enhance their self-esteem, and to develop psycho-social nursing supportive programs.

• Journal of Nutrition and Health
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• 제53권4호
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• pp.369-380
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• 2020

본 연구에서는 일반식이로의 식이 제한이 고지방식이로 촉진된 유방암의 성장과 전이에 미치는 영향과 그 기전을 알아보았다. 8주간 고지방식이를 섭취시킨 후 유방암을 유방 조직에 이식하거나 꼬리 정맥으로 통해 전이시켰으며, 암 생성 및 전이 후 HFC군은 고지방식이를, DR군은 일반식이로 전환시켜 사육하였다. 본 연구 결과, 원발성 유방암의 경우, HFC군과 DR군의 체중에는 차이가 없었으나 간과 비장, 신장 주변의 지방세포의 무게에서 유의한 차이를 보였다. DR군이 HFC군에 비해 유방암의 개시를 지연시켰으며, 유방암의 성장과 무게를 유의하게 감소시켰다. 일반식이로의 전환에 의한 유방암 성장 억제는 세포 분열 억제와 세포사멸을 조절하는 인자의 발현 감소에 의한 caspase-3의 활성 촉진에 의한 것으로 나타났다. 또한, 식이 제한은 폐로 전이된 유방암의 수를 유의미하게 감소시켰다. 본 실험 결과, 일반식이로의 제한은 고지방식이로 촉진된 유방암의 성장과 전이를 억제하는 효과를 나타내며, 이는 유방암 세포의 성장 억제와 사멸 유도에 의한 것으로 나타났다. 따라서, 유방암의 성장이나전이를 억제하기 위해서는 총 섭취 열량을 조절하고, 지방의 섭취량을 줄이는 균형 잡힌 식이를 섭취하도록 해야 할 것으로 사료된다.

• 대한지역사회영양학회지
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• 제1권1호
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• pp.47-60
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• 1996

This study was carried out to investigate growth performance, energy and protein metabolism of breast and formula fed infants from birth to 3 months postpartum. There were four groups : breast fed(BF) and three formula fed groups(FFM, FFN and FFP). There was no significant difference in the height of infants according to feeding method and formula brands. However, mean weight of FFM was significantly higher than that of FFP and BF at 1 and 3 months postpartum, respectively. Mean head circumference of FFN was lowest among groups. The average intake of breast milk was $781.4{\;}{pm}{\;}119.3m{\ell}/day$ and that of formula was $848.6{\;}{pm}{\;}118.5m{\ell}/day$. Mean apparent digestible energy intakes of formula-fed infants and breast-fed infants during 3months were 568.9 $\pm$146.9 kca1/day and 657.9$\pm$212.8 kca1/day, respectively. The average protein intake of brest-fed and formula-fed infants were 8.3$\pm$1.6g/day and 14.1$\pm$14.1 g/day, respectively. The protein intakes of formula-fed infants were significantly higher than those of breast-fed infants at 1, 2, 3 months. The apparent protein digestibility of breast-fed infants was singnificantly higher compared to formula fed infant. These data suggest that RDA for infants be established and breast feeding be encouraged.

• 대한간호학회지
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• 제44권5호
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• pp.515-524
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• 2014

Purpose: The purpose of this study was to identify whether the couple perceived breast cancer as a traumatic event, to evaluate the association among posttraumatic growth, dyadic adjustment, and quality of life and to explore the predictors affecting quality of life of the couple. Methods: A cross-sectional comparative survey design was utilized. Participants were 57 couples recruited from a national cancer center in Korea. Data were analyzed using paired t-test, McNemar test and independent t-test. On the basis of variables found to be significantly associated with quality of life, multiple regression was used to examine the simultaneous influence of multiple predictors. Results: Breast cancers survivors and spouses perceived breast cancer as a traumatic event (43.9% and 24.6%, respectively). The global quality of life was explained by perception as trauma (${\beta}$= -19.79) and posttraumatic growth (${\beta}$=0.46) in survivors, and perception as trauma (${\beta}$= -18.81) and dyadic adjustment (${\beta}$=0.53) in spouses. Conclusion: Results suggest that future research should use qualitative methods to evaluate why contemplating reasons for cancer contributed to posttraumatic growth, examine other potential predictors of quality of life such as dyadic adjustment and intimacy, and identify links between posttraumatic growth and other psychological outcomes such as distress and well-being, using prospective analyses.

• 대한간호학회지
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• 제40권2호
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• pp.277-286
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• 2010

Purpose: This study was done to investigate the effects of breast-feeding education and support services on rate of breast-feeding three and six months after birth, and the effect on infant's growth (weight, height, body mass index [BMI]). The experimental group which had both education and support services was compared with the control group which had only breast-feeding education. Methods: This study was a quasi-experimental study with a time-series design. The participants were 39 mothers who were hospitalized for childbirth. Twenty mother were assigned to the experimental group and 19 mothers, to the control group. The breast feeding education was done during hospitalization, and support services were provided once a week after discharge for a month (a total 4 times) by a maternity ward nurse. Data regarding breast-feeding rate at one month after childbirth was collected by phone call; the breast-feeding rates at three and six months after childbirth were collected in a visit to the families. The child's weight and height were also measured during the visit. Results: The experimental group had a statistically significant higher rate for frequency of breast-feeding at one, three and six months after childbirth than the control group. However, there was no meaningful difference between the two groups for infant growth. Conclusion: The results of this study suggest that breast-feeding education is helpful for a start, but support services are also necessary to sustain breast-feeding.

• 한국환경성돌연변이발암원학회지
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• 제24권2호
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• pp.51-66
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• 2004

Retinoids, better known as vitamin A, have been reported to inhibit the growth of several breast cancer cell lines in culture and to reduce breast tumor growth in animal models. Furthermore, retinoids can augment the action of other breast cancer cell growth inhibitors both in vitro and in vivo. Clinically, interest has increased in the potential use of retinoids for the prevention and treatment of human breast cancer. We have examine the effect of all-trans retinoic acid(tRA) and 9-cis retinoic acid(9-cis RA) on human breast cancer cell(MCF-10A, T47-D, MCF-7) proliferation using MTT assay and cell cycle analysis(FACS). Overexpression of cyclin D1 protein is observed in the majority of breast cancers, suggesting that dysregulated expression of cyclin D1 might be a critical event in breast cancer carcinogenesis. We investigated whether tRA and 9-cis RA might affect expression of cyclin D1 on human breast cancer cells(MCF-10A, T47-D, MCF-7) using RT-PCR and west-ern bolt. In MCF-10A cells, either tRA or 9-cis RA treatment did not affect the cell proliferation. In T47-D cells and MCF-7 cells, either tRA or 9-cis RA treatment showed the inhibition of the cell proliferation over control cells and also inhibit the estrogen stimulated cell proliferation when it was given together with estrogen. The effect of retinoids was dose- and time- dependent. T47-D cells treated with 1.0 $\muM$ tRA undergo G0/G1-phase arrest by Day 5. MCF-7 cells treated with 1.0 $\muM$ tRA undergo S-phase arrest by Day 5. All-trans retinoic acid(tRA) and 9-cis retinoic acid(9-cis RA) inhibited the cyelin D1 mRNA and protein expression levels of human MCF-7 and T47-D breast carcinoma cells in vitro. The data indicate that retinoids can reduce cyclin D1 expression levels in a variety of breast cell lines in vitro and result in inhibition of cell proliferation. tRA-mediated growth inhibition and cyclin D1 expression inhibition is more potent than 9-cis RA mediated that. tRA-mediated inhibition effect is more potent on T47-D cells than on MCF-7 cells. Our data suggest that retinoids activity is different according to property of cell lines. Future chemoprevention of breast cancer studies using retinoids will be necessary to determine the mechanism of the retinoids-mediated growth inhibition.