• Journal of Korean Society for Quality Management
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• v.33 no.3
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• pp.156-160
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• 2005

We consider practical experimental design strategies and analysis to find out whether a modified method give better results than the standard method. The most practical design strategy is for experimenter to make r successive runs under the current standard method and then, change the standard method to a modified method to make another r successive runs under a modified method. To test a statistically significant difference between the population mean of the standard method and a modified method, additional recent data for sufficient number of consecutive responses under the standard method is needed to construct external reference distribution(Box, et al., 1968). Upon those informations unavailable, the practical design strategy is to run the experiment by split plot designs. In this paper, two types of split plot designs are proposed and how to determine efficiently the number of repetition within a given method and replication of those two methods are discussed based on results of the level of significance ${\alpha}$= 0.05 and the power being at least 0.9 at the detectable difference of ${\mu}_2-{\mu}_1=1.5{\times}{\sigma}$.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.46 no.2
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• pp.159-166
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• 2018

In this study, the internal structural design, dynamic characteristics and load analyses of the small scaled rotor blade required for LCH(Light Civil Helicopter) main rotor wind tunnel test were carried out. The test is performed to evaluate the aerodynamic performance and noise characteristics of the LCH main rotor system. Therefore, the Mach-scale technique was appled to design the small scaled blade to simulate the equivalent aerodynamic characteristics as the full scale rotor system. It is necessary to increase the rotor speed to maintain the same blade tip speed as the full scale blade. In addition, the blade weight, section stiffness, and natural frequency were scaled according to the Mach-type scaling factor(${\lambda}$). For the design of skin, spar, torsion box, which are the main components of the blade, carbon and glass fiber composite materials were adopted, and composite materials are prepreg types that can be supplied domestically. The KSec2D program was used to evaluate the section stiffness of the blade. Also, structural loads and dynamic characteristics of the Mach scale blade were investigated through the comprehensive rotorcraft analysis program CAMRADII.

• Korean Journal of Biological Psychiatry
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• v.10 no.1
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• pp.62-69
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• 2003

Corticotropin-releasing factor(CRF) and neuropeptide Y(NPY) are known to play important roles in mediating stress responses and stress-related behavior. To elucidate the role of neuropeptides in response to the condition that had paired with traumatic event, we observed the changes of CRF and NPY by immunohistochemistry using a conditioned footshock paradigm. Male Sprague-Dawley rats were placed in a shuttle box and exposed to 20 pairings of a tone(< 70dB, 5sec) followed by a footshock(FS, 0.8mA, 1sec) over 60min. A second group was exposed to the tone-footshock pairings, returned to the homecage for 2days, and then reexposed to the test chamber and 20tones alone for 60min, prior to sacrifice. Control groups were : a) sacrificed without exposure to FS ; b) exposed to the tone-footshock pairings and then sacrificed two days later ; or c) exposed to the chamber and tones alone, returned to the homecage for 2days and then reexposed to the chamber and 20tones over 60min prior to sacrifice. CRF was increased in animals exposed to FS or the aversive condition(context and tone) that had paired to FS in bed nucleus of the stria terminalis (BNST) compared to the control. NPY was increased by FS in amygdala and PVN, but the condition previously associated with FS results in slight increase only in amygdala area. These results suggest that the BNST appears to be the mostly involved neural circuit in response to explicit cues previously paired with footshock. Moreover, this study raise the possibility that increased CRF peptide in the BNST in response to re-exposure to the aversive condition may underlie, in part, the experience of conditioned fear-related anxiety behavior.

• Journal of the Korean Society of Costume
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• v.18
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• pp.373-381
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• 1992

Woman in Choson era had various kind of accdssories like rings, ear ring, ornamentak hairpins and so on. Among them their favorite was the Norigae, the pendent trinket. With the embroidered ornament at its center, beads and knots were attached to the upper and lower part, and it was hung with a tassel. It was carried on the string of the Chogori. norigae oreginated in waist string of Three Countries era(Sills, Paekje and Koguryo) ; had been changed with the development of fashion, embroidery and the influence of Buddhistic culture. The differences between Embroidered Norigae and Norigae are following. If the ornament at its center is made of such jewels as gold, silver, jade and the like, it is called Norigae. But if the ornament at its center is made of the embroidered Norigae. Such a Embroidered Norigae in which perfume was contained, was as a perfume box or a perfume bag and was carried on the strings of Chogori by Danjak(single work). The Differences between ancient Embroidered Norigae of late Choson era and modern Embroidered Norigae are Following; 1) The type of main body-the embroidered ornament at its center was mainly embroidered with the shape of animals in both of ancient Embroidered Norigae was usually formes like a bat and that of modern Embroidered Norigae like butterfly. 2) plants were adapted as the main design of ancient Embroidered Norigae, but plants and animals as that of modern Embroidered Norigae. 3) The colors of the background and the design are usually red in both ancient and modern Embroidered norigae. 4) The tassels of ancient Embroidered Norigae were mode in the shape of srick and a strawberry. but the tassels of modern Embroidered Norigae were mainly made in the shape of a stick. 5) Nowadays the beauty of external form is considered more important while the symbol of main body was considered more important in Choson era. 6) The role of Thidon in the composition of Embroidered Norigae is declined and a lot of main bodies are used in modern Embroidered Norigae. 7) Modern Korean people are apt to choose Embroidered Norigae depending upon the design of main body and the traditional Korean beauty. 8) Modern people who desire to get new thing, try to make the design of main body various. As their cognition of Korean tradition is of the increase, the restoration of ancient Embroidered Norigae to its original form has been accom

• Korean Institute of Interior Design Journal
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• v.26 no.4
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• pp.42-56
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• 2017

In Korea, which has three sides of the sea, various waterfront spaces are being developed and developed along with various coastal landscapes. However, there are a lot of cases that do not consider the regional characteristic of the coast or the characteristic of the coastal landscape. In many cases, the street facilities cause the landscape degradation and the use inconvenience because of incongruity with the scenery, aging and lax management. Therefore, it is necessary to reflect the specificity of the coastal landscape in planning and directing the street facilities, harmonizing with the surrounding natural environment, and consideration of sustainability. However, there is no research or planning index for sustainable street facilities considering the coastal characteristics. Therefore, this study suggests plan elements to improve the sustainability of the street facilities on the shore and proposes them as basic plan elements, and suggests what kind of improvements should be made to improve the sustainability of coastal facilities in Korea. Based on the plan elements derived from the plan, we checked the problems and complementary points of coastal street facilities in Korea by analyzing the current status of the street facilities around the Jeju Island beach from a sustainable point of view, and suggested plan indicators that should be supplemented to improve sustainability. We surveyed the street facilities such as walkway blocks, benches, pagoda, drinking fountain, trash cans, bicycle shelters, fences, guide maps, streetlights, and shower rooms in 10 beaches in Jeju Island. This study analyzed the sustainability characteristics of the each factor of these facilities by surveying the reflectivity of the 23 plan indicators from the six aspects derived from the sustainability planning factor as conformity, partial reflection, non - reflection, and nonconformity. The results of the analysis showed that the functional aspect was the highest with 68.3%, the material aspect (53%), the landscape aspect (22.3%), the productive aspect (14.7%) and the morphological aspect (12.2%), and maintenance / management (10.6%). In addition, the facilities with the lowest fitness in each aspect are bicycle shelter in landscape aspect, bicycle storage box and trash can in form aspect, shower room in material aspect, trash can in functional aspect, showroom, guide maps and drinking fountain in product aspect, showroom In maintenance aspect. In order to improve the sustainability of coastal facilities in the future, it is necessary to complement the administrative and landscape aspects. In coastal facilities, it is necessary to consider the sustainability planning index, especially for showers, taking into account the specificity of beaches. Consideration should be given to various aspects of sustainability for bike shelters and trash facilities. Through this study, we have proposed the plan elements to systematize, supplement, and improve the planning index for sustainability improvement in coastal facilities planning.

• Progress in Medical Physics
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• v.14 no.3
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• pp.196-202
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• 2003

In 3-dimensional conformal radiation therapy (3D-CRT) and intensity-modulated radiation therapy (IMRT), many studies on reducing setup error have been conducted in order to focus the irradiation on the tumors while sparing normal tissues as much as possible. As one of these efforts, we developed an image enhancement and registration tool for simulators and portal images that analyze setup errors in a quantitative manner. For setup verification, we used simulator (films and EC-L films (Kodak, USA) as portal images. In addition, digital-captured images during simulation, and digitally-reconstructed radiographs (DRR) can be used as reference images in the software, which is coded using IDL5.4 (Research Systems Inc., USA). To improve the poor contrast of portal images, histogram-equalization, and adaptive histogram equalization, CLAHE (contrast limited adaptive histogram equalization) was implemented in the software. For image registration between simulator and portal images, contours drawn on the simulator image were transferred into the portal image, and then aligned onto the same anatomical structures on the portal image. In conclusion, applying CLAHE considerably improved the contrast of portal images and also enabled the analysis of setup errors in a quantitative manner.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.40 no.2
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• pp.221-227
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• 2016

The main shaft is one of the key components connecting the rotor hub and gear box of a wind power generator. Typically, main shafts are manufactured by open die forging method. However, the main shaft for large MW class wind generators is designed to be hollow in order to reduce the weight. Additionally, the main shafts are manufactured by a casting process. This study aims to develop a manufacturing process for hollow main shafts by the open die forging method. The design of a forging process for a solid main shaft and hollow shaft was prepared by an open die forging process design scheme. Finite element analyses were performed to obtain the flow stress by a hot compression test at different temperature and strain rates. The control parameters of each forging process, such as temperature and effective strain, were obtained and compared to predict the suitability of the hollow main shaft forging process. Finally, high productivity reflecting material utilization ratio, internal quality, shape, and dimension was verified by the prototypes manufactured by the proposed forging process for hollow main shafts.

• Biomolecules & Therapeutics
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• v.25 no.5
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• pp.511-518
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• 2017

Ultraviolet (UV) irradiation is a relevant environment factor to induce cellular senescence and photoaging. Both autophagy- and silent information regulator T1 (SIRT1)-dependent pathways are critical cellular processes of not only maintaining normal cellular functions, but also protecting cellular senescence in skin exposed to UV irradiation. In the present studies, we investigated whether modulation of autophagy induction using a novel synthetic SIRT1 activator, heptasodium hexacarboxymethyl dipeptide-12 (named as Aquatide), suppresses the UVB irradiation-induced skin aging. Treatment with Aquatide directly activates SIRT1 and stimulates autophagy induction in cultured human dermal fibroblasts. Next, we found that Aquatide-mediated activation of SIRT1 increases autophagy induction via deacetylation of forkhead box class O (FOXO) 1. Finally, UVB irradiation-induced cellular senescence measured by $SA-{\beta}-gal$ staining was significantly decreased in cells treated with Aquatide in parallel to occurring SIRT1 activation-dependent autophagy. Together, Aquatide modulates autophagy through SIRT1 activation, contributing to suppression of skin aging caused by UV irradiation.

• Biomolecules & Therapeutics
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• v.28 no.6
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• pp.561-568
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• 2020

We examined the anticancer effects of a novel sirtuin inhibitor, MHY2256, on HCT116 human colorectal cancer cells to investigate its underlying molecular mechanisms. MHY2256 significantly suppressed the activity of sirtuin 1 and expression levels of sirtuin 1/2 and stimulated acetylation of forkhead box O1, which is a target protein of sirtuin 1. Treatment with MHY2256 inhibited the growth of the HCT116 (TP53 wild-type), HT-29 (TP53 mutant), and DLD-1 (TP53 mutant) human colorectal cancer cell lines. In addition, MHY2256 induced G0/G1 phase arrest of the cell cycle progression, which was accompanied by the reduction of cyclin D1 and cyclin E and the decrease of cyclin-dependent kinase 2, cyclin-dependent kinase 4, cyclin-dependent kinase 6, phosphorylated retinoblastoma protein, and E2F transcription factor 1. Apoptosis induction was shown by DNA fragmentation and increase in late apoptosis, which were detected using flow cytometric analysis. MHY2256 downregulated expression levels of procaspase-8, -9, and -3 and led to subsequent poly(ADP-ribose) polymerase cleavage. MHY2256-induced apoptosis was involved in the activation of caspase-8, -9, and -3 and was prevented by pretreatment with Z-VAD-FMK, a pan-caspase inhibitor. Furthermore, the autophagic effects of MHY2256 were observed as cytoplasmic vacuolation, green fluorescent protein-light-chain 3 punctate dots, accumulation of acidic vesicular organelles, and upregulated expression level of light-chain 3-II. Taken together, these results suggest that MHY2256 could be a potential novel sirtuin inhibitor for the chemoprevention or treatment of colorectal cancer or both.

• Journal of the Korean Society for Nondestructive Testing
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• v.29 no.4
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• pp.316-322
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• 2009

This paper presents a preliminary study to monitor the lateral behavior of pile foundation using multiplexed fiber Bragg grating(FBG) sensors. In the Preliminary study, an 1.7 meter long cantilever beam with the shape of square hollow box was fabricated and tested under the static loading. Four FBG sensors were multiplexed in a single optical fiber and installed into the top and bottom of the cantilever beam. The strains are directly measured from FBG sensors followed by curvature calculations based on the plane section assumption. Vertical deflections are then estimated using the regression analyses based on the geometric relationships. It has been found that excellent correlation with conventional sensing system was observed. The success of the test encourages the use of the FBG sensing system as a monitoring system for pile foundations. However, further consideration should be given in the case of the sensor malfunction for the practical purpose.