• Title/Summary/Keyword: bound level

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Tissue distribution, excretion and effects on genotoxicity of tritium following oral administration to rats

  • Lee, Jei Ha;Kim, Cha Soon;Choi, Soo Im;Kim, Rae-Kwon;Kim, Ji Young;Nam, Seon Young;Jin, Young Woo;Kim, In Gyu
    • Nuclear Engineering and Technology
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    • v.51 no.1
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    • pp.303-309
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    • 2019
  • Tritium is an important nuclide that must be monitored for radiation safety management. In this study, HTO was orally administered to rats at the level of 37 kBq ($1{\mu}Ci$) or 370 kBq ($10{\mu}Ci$) to examine tissue distribution and excretion levels. After sacrifice, wet and dry tissue samples were weighed and analyzed for tissue free-water tritium (TFWT) and organically bound tritium (OBT). The mean tissue concentrations of TFWT (OBT) were 30.9 (17.8) and 4.4 (8.1) Bq/g on days 7 and 13 at the 37 kBq level and 30.8 (64.6) Bq/g on day 17 at the 370 kBq level. To assess the cytogenetic damage due to tritium exposure, a cytokinesis-blocked micronucleus (MN) assay was performed in blood samples from rats exposed to HTO for 14 and 21 days after oral administration. There was no significant difference in the MN frequencies between the control and exposed rats.

Extraction and Purification of Antitumor Protein-bound Polysaccharides from Mycelia of Lentinus edodes (표고버섯 균사체로부터 항암 단백다당체의 추출 및 정제)

  • Park, Ki-Moon;Lee, Byung-Woo
    • Korean Journal of Food Science and Technology
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    • v.30 no.5
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    • pp.1236-1242
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    • 1998
  • Korean Lentinus edodes SR-1 was cultured to multiply the mycelia in the complete broth medium (C/N=13.1) for mushroom, and protein-bound polysaccharides were extracted from the cultured broth containing mycelia (The whole cultured broth was used to increase the yields: 80% of protein-bound polysaccharides were existed at the cell wall of mycelia and 20% of those were secreted extracellularily in this culture). Protein-bound polysaccharides in the cultured broth containing mycelia were extracted by using three different methods: 1) Extraction with hot water, 2) Disintegration of cell wall by glass bead mill treatment before extraction with hot water, and 3) Cellulase treatment before extraction with hot water. The highest yield was obtained (930 mg polysaccharides/100 mL culture broth) when protein-bound polysaccharides were extracted with 2) method. The extracted crude protein-bound polysaccharides were purified using protease, DEAE-cellulose and Sephadex G-100. The growth inhibition activity for $P_{388}$, mouse leukemic cell, increased (53.7, 62.2, 93.7% and 97.4%) as the purification level increased. Protein-bound polysaccharides contained 46.1% of polysaccharides, 7.3% of protein, and trace amounts of minerals. Polysaccharides contained glucose, galactose, xylose and mannose. The content of proline and glycine were high, however, methionine and leucine were not found. The major minerals were Na, K, Zn, and Ca.

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Survey of Contaminants of Bound 3-MCPD in Food (식품 중 결합형 3-MCPD 오염실태조사)

  • Kong, Young-Woon;Park, Sung-Kug;Seo, Jung-Heok;Kim, Dong-Sul
    • Journal of Food Hygiene and Safety
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    • v.25 no.4
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    • pp.289-293
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    • 2010
  • 3-MCPD created in manufacture process was regulated in our country about soy sauce and HVP. The latest paper reported that Bound 3-MCPD is created as intermediate. Germany common risk assesment reported that Bound 3-MCPD must be reduced because Bound 3-MCPD can be created in estimation circle when this is hydrolyzed in human body, but the data about the toxity of Bound 3-MCPD is lack. Therefore, We analysis about 209 items food such as soy sauce, seasoning food and meat-eating manufactured goods using bound 3-MCPD analysis method developed recently. As result of survey, bound 3-MCPD detected in 8 items among 44 traditional sauce (0.02~0.28ppm), 8 of soup 12 items (0.01~0.96ppm), in 22 items of sauce 60 items (0.01~0.55ppm), in 16 items of meat-eating manufactured foods 30 items (0.04~0.18ppm), in 20 items of snack cookies 28 items (0.09~1.43ppm), in 8 in roasted oil foods 10 items (0.04~1.22ppm), in 6 items of peanut processed food 10 items (0.06~0.25ppm), in 1 of vegetable cream 15 items (0.05ppm). Detected level was lower than the result of monitored by other countries.

Antihyperlipidemic and Glycemic Control Effects of Mycelia of Inonotus obliquus Including Protein-bound Polysaccharides Extract in C57BL/6J Mice (C57BL/6J Mice에서 단백다당체 함유 차가버섯 균사체의 지질개선 및 혈당조절효과)

  • Kim, Min-A;Jeong, Yong-Seob;Chun, Gei-Taek;Cha, Youn-Soo
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.38 no.6
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    • pp.667-673
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    • 2009
  • The antihyperlipidemic and glycemic control effects of mycelia of Inonotus obliquus including protein-bound polysaccharides extract were investigated. In high fat diet-induced obese C57BL/6J mice, the mycelia of Inonotus obliquus including protein-bound polysaccharides extract showed significant decrease in epididymal fat tissue weight, blood triglyceride and VLDL level, triglyceride and total cholesterol level in liver, serum insulin and HOMA-IR level and AUC. Oral glucose tolerance test glucose level reduction were 4.9% (M150L; ${\beta}$-glucan 1.303 mg/kg bw), 9.5% (M150; ${\beta}$-glucan 2.606 mg/kg bw) after 180 min of glucose loading compared to H-C group. Besides, the mycelia of Inonotus obliquus including protein-bound polysaccharides extract treatment significantly increased glycogen contents in liver and adiponectin level in high fat diet-induced obese mice. In conclusion, the results showed that the mycelia of Inonotus obliquus including protein-bound polysaccharides extract possesses significant antihyperlipidemic and glycemic control effects in C57BL/6J mice.

Limiting CPU Frequency Scaling Considering Main Memory Accesses (주메모리 접근을 고려한 CPU 주파수 조정 제한)

  • Park, Moonju
    • KIISE Transactions on Computing Practices
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    • v.20 no.9
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    • pp.483-491
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    • 2014
  • Contemporary computer systems exploits DVFS (Dynamic Voltage/Frequency Scaling) technology for balancing performance and power consumption. The efficiency of DVFS depends on how much performance we get for larger power consumption due to elevated CPU frequency. Especially for memory-bounded applications, higher CPU frequency often does not result in higher performance. In this paper, we present an upper bound of CPU frequency scaling based on memory accesses. It is observed that the performance gain due to higher CPU frequency is limited by memory accesses (last level cache misses) per instructions by experiments. Using the results, we present the CPU frequency upper bound with little performance gain. Experimental results show that for a memory-bounded application, applying the frequency upper bound enhances the energy efficiency of the application by above 30%.

The Rapid Differentiation of Toxic Alexandrium and Pseudo-nitzschia Species Using Fluorescent Lectin Probes

  • Cho, Eun-Seob;Park, Jong-Gyu;Kim, Hak-Gyoon;Kim, Chang-Hoon;Rhodes, Lesley L.;Chung, Chang-Soo
    • Journal of the korean society of oceanography
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    • v.34 no.3
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    • pp.167-171
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    • 1999
  • Since toxic Alexandrium catenella and non-toxic A. fraterculus are morphologically similar, they are difficult to discriminate under the light microscope. However, a novel technology, such as fluorescein isothiocyanate (FITC)-conjugated lectin probes enables easy and rapid differentiation. Toxic A. catenella bound seven different lectins, whereas the non-toxic A. fratercuzus did not bind Arachis hypogaea (PNA) lectin. In addition, Pseudo-nitrschia species in this study were also difficult to identify to species level with light microscope techniques, but it was possible to classify them using fluorescent lectins. Pseudo-nitzschia multistriata, P. subfraudulenta and P. pungens bound Canavalia ensiformis (ConA), whereas P. subpaclfica did not, and P. pungens also bound Ricinus communis (RCA). These results imply that lectin could be used as a critical tool in the differentiation of P. multistriata, P. subfraudulenta and P. pungens. However, P. subpacifica was not differentiated by the lectins tested. Therefore, it isconcluded that lectin probes are useful for discriminating toxic A. catenella from non-toxic A. fraterculus, and for the identification of some Pseudo-nitzschia species. In addition, this method has a great potential to speed and detection between non-toxic and toxic harmful algal blooms (HABs) in Korean biotoxin monitoring systems.

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A Lower Bound Estimation on the number of LUT′s in Time-Multiplexed FPGA Synthesis (시분할 FPGA 합성에서 LUT 개수에 대한 하한 추정 기법)

  • Eom, Seong-Yong
    • Journal of KIISE:Computer Systems and Theory
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    • v.29 no.7
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    • pp.422-430
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    • 2002
  • For a time-multiplexed FPGA, a circuit is partitioned into several subcircuits, so that they temporally share the same physical FPGA device by hardware reconfiguration. In these architectures, all the hardware reconfiguration information called contexts are generated and downloaded into the chip, and then the pre-scheduled context switches occur properly and timely. Since the maximum number of the LUT's required in the same time determines the size of the chip used in the synthesis, it needs to be minimized, if possible. Many previous work use their own approaches, which are very similar to either scheduling method in high level synthesis or multi-way circuit partitioning method, to solve the problem. In this paper, we propose a method which estimates the lower bound on the number of LUT's without performing any actual synthesis. The estimated lower bounds help to evaluate the results of the previous work. If the estimated lower bound on the number of LUT's exactly matches the number of LUT's of the result from the previous work, the result must be optimal. In contrast, if they do not match, the following two cases are expected : the more exact lower bound may exist, or we might find the new synthesis result better than the result from the previous work. Experimental results show that our lower bound estimation method is very accurate. In almost al] cases experimented, the estimated lower bounds on the number of LUT's exactly match those of the previous synthesis results respectively, implying that the best results from the previous work are optimal as well as our method predicted the exact lower bound for those examples.

Packet scheduling algorithm for guaranteed bound and firewall property of delay performance (지연의 상한 보장과 안정성을 고려한 패킷 스케쥴링 알고리즘)

  • 정대인
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.27 no.5C
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    • pp.435-444
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    • 2002
  • In this paper, a novel packet scheduling algorithm, so-called the CSL algorithm is discussed, whereby the firewall property as well as the deterministic delay bound guarantee are supported in session level. Lots of simulation studies validate those properties of the CSL algorithm. The CSL algorithm is distingushable from the well- known EDD scheme in terms of the firewall property. Regarding the implementation complexity, the CSL algorithm turns out to be of 0(1) besides the sorting overhead. Owing to the maintained generic fair queueing structure in the CSL algorithm, a various fair queueing schemes can be applied with minor modification. For the TCP/IP network which is vulnerable to the misbehaving traffic sources, the firewall property of the CSL algorithm is quite useful for the advanced quality of services.

Effect of Energy Harvesting on Stable Throughput in Cooperative Relay Systems

  • Pappas, Nikolaos;Kountouris, Marios;Jeon, Jeongho;Ephremides, Anthony;Traganitis, Apostolos
    • Journal of Communications and Networks
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    • v.18 no.2
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    • pp.261-269
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    • 2016
  • In this paper, the impact of energy constraints on a two-hop network with a source, a relay and a destination under random medium access is studied. A collision channel with erasures is considered, and the source and the relay nodes have energy harvesting capabilities and an unlimited battery to store the harvested energy. Additionally, the source and the relay node have external traffic arrivals and the relay forwards a fraction of the source node's traffic to the destination; the cooperation is performed at the network level. An inner and an outer bound of the stability region for a given transmission probability vector are obtained. Then, the closure of the inner and the outer bound is obtained separately and they turn out to be identical. This work is not only a step in connecting information theory and networking, by studying the maximum stable throughput region metric but also it taps the relatively unexplored and important domain of energy harvesting and assesses the effect of that on this important measure.

Prediction of Chloride Profile considering Binding of Chlorides in Cement Matrix

  • Song, Ha-Won;Lee, Chang-Hong;Ann, Ki Yong
    • Corrosion Science and Technology
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    • v.8 no.2
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    • pp.81-88
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    • 2009
  • Chloride induced corrosion of steel reinforcement inside concrete is a major concern for concrete structures exposed to a marine environment. It is well known that transport of chloride ions in concrete occurs mainly through ionic/molecular diffusion, as a gradient of chloride concentration in the concrete pore solution is set. In the process of chloride transport, a portion of chlorides are bound in cement matrix then to be removed in the pore solution, and thus only the rest of chlorides which are not bound (i.e. free chlorides) leads the ingress of chlorides. However, since the measurement of free/bound chloride content is much susceptible to environmental conditions, chloride profiles expressed in total chlorides are evaluated to use in many studies In this study, the capacity of chloride binding in cement matrix was monitored for 150 days and then quantified using the Langmuir isotherm to determine the portions of free chlorides and bound chlorides at given total chlorides and the redistribution of free chlorides. Then, the diffusion of chloride ion in concrete was modeled by considering the binding capacity for the prediction of chloride profiles with the redistribution. The predicted chloride profiles were compared to those obtained from conventional model. It was found that the prediction of chloride profiles obtained by the model has shown slower diffusion than those by the conventional ones. This reflects that the prediction by total chloride may overestimate the ingress of chlorides by neglecting the redistribution of free chlorides caused by the binding capacity of cement matrix. From the evaluation, it is also shown that the service life prediction using the free chloride redistribution model needs different expression for the chloride threshold level which is expressed by the total chlorides in the conventional diffusion model.