• The KIPS Transactions:PartA
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• v.10A no.6
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• pp.635-642
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• 2003

The radical development of recent network technology provides the basic foundation which can establish a high speed and cheap cluster system. It is a general trend that conventional cluster systems are built as the system over a fixed level based on stabilized and high speed local networks. A multi-distributed web cluster group is a web cluster model which can obtain high performance, high efficiency and high availability through mutual cooperative works between effective job division and system nodes through parallel performance of a given work and shared memory of SC-Server with low price and low speed system nodes on networks. For this, multi-distributed web cluster group builds a sub-cluster group bound with single imaginary networks of multiple system nodes and uses the web distributed shared memory of system nodes for the effective data transmission within sub-cluster groups. Since the presented model uses a load balancing and parallel computing method of large-scale work required from users, it can maximize the processing efficiency.

• Journal of Electrical Engineering and Technology
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• v.12 no.5
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• pp.2031-2042
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• 2017

In this paper, a novel traffic flow control method based-on ramp metering and speed regulation using an adaptive sliding mode control (ASMC) method along with a deadzoned parameter adaptation law is proposed at a stochastic macroscopic level traffic environment, where the influence of the density and speed disturbances is accounted for in the traffic dynamic equations. The goal of this paper is to design a local traffic flow controller using both ramp metering and speed regulation based on ASMC, in order to achieve the desired density and speed for the maintenance of the maximum mainline throughput against disturbances in practice. The proposed method is advantageous in that it can improve the traffic flow performance compared to the traditional methods using only ramp metering, even in the presence of ramp storage limitation and disturbances. Moreover, a prior knowledge of disturbance magnitude is not required in the process of designing the controller unlike the conventional sliding mode controller. A stability analysis is presented to show that the traffic system under the proposed traffic flow control method is guaranteed to be uniformly bounded and its ultimate bound can be adjusted to be sufficiently small in terms of deadzone. The validity of the proposed method is demonstrated under different traffic situations (i.e., different initial traffic status), in the sense that the proposed control method is capable of stabilizing traffic flow better than the previously well-known Asservissement Lineaire d'Entree Autoroutiere (ALINEA) strategy and also feedback linearization control (FLC) method.

• Asian-Australasian Journal of Animal Sciences
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• v.24 no.10
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• pp.1372-1376
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• 2011

The content of Ca in milk exceeds the typical saturation level of Ca salts, which is necessary for neonate growth. This calcium is distributed between the casein micelles in the colloidal and aqueous phases. Information on the properties of calcium activity in the aqueous phase is limited compared with that on the properties of bound or sequestrated calcium. The objectives of this study were to evaluate the changes in calcium activity in fresh milk using an ion-selective electrode and to assess the relationship between calcium activity and milk production in hot season. Milk samples collected from 10 cows at the National Agricultural Research Center for Kyushu Okinawa Region in June to October (Min-Max: 7.2-$35.2^{\circ}C$, 24.3-100% RH) were analyzed on total calcium concentrations and calcium activity. We observed that the rectal temperature of the cows increased according to elevation of ambient temperature but that the pH of the collected milk ($6.61{\pm}0.01$ (Mean${\pm}$SEM)) was not significantly influenced by rectal and ambient temperature. Total calcium concentrations and calcium activity in fresh milk decreased in July (Min-Max: 21.1-$33.5^{\circ}C$, 48.9-100.0% RH) compared with the values after August (Min-Max: 18.1-$35.0^{\circ}C$, 26.5-96.2% RH) (p<0.05); however, there was no significant correlation between the two parameters. The ratio of calcium activity to total calcium concentration decreased after August compared with the values in June and July (p<0.05). The calcium activity in fresh milk was positively correlated with milk yield (r = 0.45, p<0.01) and negatively correlated with milk lactose content (r = -0.53, p<0.01). These results suggest that the calcium activity in milk could be affected by ambient temperature and might be associated with milking production in hot season.

• The Journal of the Korea Contents Association
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• v.15 no.4
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• pp.88-96
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• 2015

The universe of discourse presented in the visual image is bound up with the experience and culture of parties; its sender and recipient. Signification of visual message is revealed through the mutual independent process. The mechanism where production of signifiant by sender and reception of metaphoric signifiant function unconsciously can be applied to Lacan's theory;"The unconscious is structured like a language". By applying Lacan's metaphoric formula which takes linguistic approach to visual image it is suggested that analysis of signification is possible. This analysis can be a base for seeking varied level of signifiant presented in visual metaphor logically and practically. Metaphoric structure of the signifiant and the matrix analysis can develop a creative idea and propose a practical way for the visual image production. Thus empirical study about nastic response and the future analysis result is expected to be possible.

• Journal of the Korea Institute of Military Science and Technology
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• v.21 no.4
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• pp.497-507
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• 2018

Tactical networks are evolving into an All-IP based network for network centric warfare(NCW). Owing to the flexibility of IP based network, various military data applications including real-time and multi-media services are being integrated in tactical networks. Because each application has diverse Quality-of-service(QoS) requirements, it is crucial to develop a QoS provisioning method for guaranteeing QoS requirements efficiently. Conventionally, differentiated services(DiffServ) have been used to provide a different level of QoS for traffic flows. However, DiffServ is not designed to guarantee a specific requirement of QoS such as delay, loss, and bandwidth. Therefore, it is not suitable for military applications with a tight bound of QoS requirements. In this paper, we propose a multi-layer network virtualization scheme that allocates traffic flows having different QoS requirements to multiple virtual networks, which are constructed to support different QoS policies such as virtual network functions(VNFs), routing, queueing/active queue management(AQM), and physical layer policy. The experiment results indicate that the proposed scheme achieves lower delays and losses through multiple virtual networks having differentiated QoS policies in comparison with conventional networks.

• Journal of Microbiology and Biotechnology
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• v.23 no.10
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• pp.1381-1385
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• 2013

The centipede Scolopendra subpinipes mutilans is a medicinally important arthropod species. However, its transcriptome is not currently available and transcriptome analysis would be useful in providing insight into a molecular level approach. Hence, we performed de novo RNA sequencing of S. subpinipes mutilans using next-generation sequencing. We generated a novel peptide (scolopendrasin II) based on a SVM algorithm, and biochemically evaluated the in vitro antimicrobial activity of scolopendrasin II against various microbes. Scolopendrasin II showed antibacterial activities against gram-positive and -negative bacterial strains, including the yeast Candida albicans and antibiotic-resistant gram-negative bacteria, as determined by a radial diffusion assay and colony count assay without hemolytic activity. In addition, we confirmed that scolopendrasin II bound to the surface of bacteria through a specific interaction with lipoteichoic acid and a lipopolysaccharide, which was one of the bacterial cell-wall components. In conclusion, our results suggest that scolopendrasin II may be useful for developing peptide antibiotics.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.1B
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• pp.53-60
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• 2007

We investigate the end-to-end delay bounds in large scale networks with Differentiated services (DiffServ) architecture. It is generally understood that networks with DiffServ architectures, where packets are treated according to the class they belong, can guarantee the end-to-end delay for packets of the highest priority class, only in lightly utilized cases. We focus on tree networks, which are defined to be acyclic connected graphs. We obtain a closed formula for delay bounds for such networks. We show that, in tree networks, the delay bounds exist regardless of the level of network utilization. These bounds are quadratically proportional to the maximum hop counts in heavily utilized networks; and are linearly proportional to the maximum hop counts in lightly utilized networks. Considering that tree networks, especially the Ethernet networks are being accepted more and more for access networks as well as provider networks, we argue that based on these delay bounds DiffServ architecture is able to support real time applications even for a large network. Throughout the paper we use Latency-Rate (LR) server model, with which it has proven that FIFO and Strict Priority are LR servers to each flows in certain conditions.

• YAKHAK HOEJI
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• v.48 no.4
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• pp.247-253
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• 2004

We investigated the hypoglycemic effect of formula containing Euonymus alatus (EA) and Mori Folium (MF) in multiple low dose (MLD) streptozotocin (STZ)-induced diabetic rats. In order to iduce hyperglycemic state 25 mg/kg of STZ was injected intraperitoneally for 5 consecutive days. SD rats were randomly divided into diabetic control and treatment groups. Treatment groups were administered with either 250 mg/kg of EA and 250 mg/kg of MF (E1Ml), or 500 mg/kg of EA mixed with same dose of MF (E2M2) for 3 weeks. Blood glucose levels and body weights were measured every 5th or 6th day. E1Ml and E2M2 both significantly reduced food intake, water intake, and fasting blood and urine glucose levels as compared to those in diabetic control group in a dose dependent manner. Body weight in diabetic control group was increased slightly after 3 weeks. Treatment group, however, showed gradual increase in body weights during 3 week-period. While plasma insulin levels of the diabetic control group were decreased to the level of 387$\pm$14 pg/ml from 534$\pm$36 pg/ml, those levels in E1Ml and E2M2-treated groups were both markedly increased by 13% and 26%, respectively. Urine glucose levels in E1Ml and E2M2-treated groups were also remarkably reduced by 17 and 26% compared to the levels of diabetic control group. While expression of membrane-bound glucose transporter-4 (GLUT-4) protein in skeletal muscle was reduced by 45% in diabetic control compared to the normal control, GLUT-4 protein expressions in E1Ml and E2M2-treated groups were augmented by 2 and 3.5 times compared to the diabetic control, respectively. Pancreatic HE staining experiments showed that E2M2-treated group revealed much less infiltrated mononuclear cells, indicating that E2M2 efficiently blocked insulitis induced by multiple low dose streptozotocin. Taken together, we conclude that formula containing EA and MF may prevent or delay the development of hyperglycemia through overexpression of GLUT-4 protein in skeletal muscle and prevention of insulitis.

• Journal of Integrative Natural Science
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• v.3 no.3
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• pp.143-147
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• 2010

Since it is of great importance to know how a ligand binds to a receptor, there have been a lot of efforts to improve the quality of prediction of docking poses. Earlier efforts were focused on improving search algorithm and scoring function in a docking program resulting in a partial improvement with a lot of variations. Although these are basically very important and essential, more tangible improvements came from the reduction of search space. In a normal docking study, the approximate active site is assumed to be known. After defining active site, scoring functions and search algorithms are used to locate the expected binding pose within this search space. A good search algorithm will sample wisely toward the correct binding pose. By careful study of receptor structure, it was possible to prioritize sub-space in the active site using "receptor-based pharmacophores" or "hot spots". In a sense, these techniques reduce the search space from the beginning. Further improvements were made when the bound ligand structure is available, i.e., the searching could be directed by molecular similarity using ligand information. This could be very helpful to increase the accuracy of binding pose. In addition, if the biological activity data is available, docking program could be improved to the level of being useful in affinity prediction for a series of congeneric ligands. Since the number of co-crystal structures is increasing in protein databank, "Ligand-Guided Docking" to reduce the search space would be more important to improve the accuracy of docking pose prediction and the efficiency of virtual screening. Further improvements in this area would be useful to produce more reliable docking programs.

• Proceedings of the SCSK Conference
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• 2003.09a
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• pp.35-49
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• 2003

In this study, in an attempt to search for functional cosmetic ingredients from higher fungal, we have produced exopolysaccharides (GF-l, approximately carbohydrate 75％, protein 25％) and polysaccharide (GF-2) of mycelium extract, by submerged culture of Grifolafrondosa. For applications in anti-aging cosmetic field, we investigated the diverse biological activities. Antioxidant activity and inhibition of Matrixmetalloproteinases (MMPs) were investigated enzymatic assays by measuring the superoxide scavenging activity using xanthine-xanthine oxidase system and the proteolytic activity of MMPs using EnzChek Collagenase/Gelatinase kits, respectively. GF-l polysacchairde showed inhibition of superoxide radical by 90％ at a concentration of 0.2％ (w/v) and inhibition of collagenase by 45％ at 0.2％ (w/v). GF-2 polysaccharide of mycelium extract also exhibited good antioxidant activity. However, MMPs inhibition activity was relatively lower level compared to GF-l polysaccharides. The treatment of human dermal fibroblast (HDF) with GF-l and GF-2 polysaccharides increased the proliferation of fibroblast by approximately 23-25％ at a concentration of 0.5％ (w/v), also showed collagen synthesis increase in HDF by about 50％ at 0.5％ (w/v) compared to that of untreated control. We also report the moisturizing effects of polysaccharides in cosmetic products (O/W emulation) and its own ingredient, in vitro and in vivo. The GF-1 polysaccharide showed higher moisturizing ability than sodium hyaluronate, which is the most commonly used moisturizers ingredient. These results suggest the GF-l polysaccharide, protein-bound polysaccharide, may be used as an ingredient for new moisturizing and anti-aging cosmeceuticals.