• Bulletin of the Korean Chemical Society
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• v.21 no.5
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• pp.510-514
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• 2000

Molecular hydrogen dimer, ($H_2)_2$ is a weakly bound van der Waals complex. The configuration of two hydrogen molecules and the potential well structure of the dimer have been the subjects of various studies among chemists and astrophysicists. In this study, we used DFT, MCG2, and MCG3 methods to determine the structure and energy of the molecular hydrogen dimer. We compared the results with previously reported ab initio method results. The ab initio results were also recalculated for comparison. All optimized geometries obtained from the MP2 and DFT methods are T-shaped. The H-H bond lengths for the dimer are almost the same as those of monomer. The center-to-center distance depeds on the levels of theory and the size of the basis sets. The bond lengths of the $H_2$ molecule from the MCG2 and MCG3 methods are shown to be in excellent agreement with the experimental value. The geometry of optimized dimer is T-shaped, and the well depths for the dimerization potential are very small, being 23 $cm-^1$ and 27 $cm-^1$ at the MCG2 and MCG3 levels, respectively. In general the MP2 level of theory predicts stronger van der Waals than the DFT, and agrees better with the MCG2 and MCG3 theories.

• The Korean Journal of Physiology and Pharmacology
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• v.27 no.2
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• pp.187-196
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• 2023

Transient receptor potential canonical (TRPC) channels are non-selective calcium-permeable cation channels. It is suggested that TRPC4β is regulated by phospholipase C (PLC) signaling and is especially maintained by phosphatidylinositol 4,5-bisphosphate (PIP₂). In this study, we present the regulation mechanism of the TRPC4 channel with PIP₂ hydrolysis which is mediated by a channel-bound PLCδ1 but not by the G_qPCR signaling pathway. Our electrophysiological recordings demonstrate that the Ca²⁺ via an open TRPC4 channel activates PLCδ1 in the physiological range, and it causes the decrease of current amplitude. The existence of PLCδ1 accelerated PIP₂ depletion when the channel was activated by an agonist. Interestingly, PLCδ1 mutants which have lost the ability to regulate PIP₂ level failed to reduce the TRPC4 current amplitude. Our results demonstrate that TRPC4 self-regulates its activity by allowing Ca²⁺ ions into the cell and promoting the PIP₂ hydrolyzing activity of PLCδ1.

• Smart Structures and Systems
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• v.33 no.3
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• pp.177-188
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• 2024

The fatigue-induced sequential failure of a structure having structural redundancy requires system-level analysis to account for stress redistribution. System reliability-based design optimization (SRBDO) for preventing fatigue-initiated structural failure is numerically costly owing to the inclusion of probabilistic constraints. This study incorporates the Branch-and-Bound method employing system reliability Bounds (termed the B³ method), a failure-path structural system reliability analysis approach, with a metaheuristic optimization algorithm, namely grey wolf optimization (GWO), to obtain the optimal design of structures under fatigue-induced system failure. To further improve the efficiency of this new optimization framework, an additional bounding rule is proposed in the context of SRBDO against fatigue using the B³ method. To demonstrate the proposed method, it is applied to complex problems, a multilayer Daniels system and a three-dimensional tripod jacket structure. The system failure probability of the optimal design is confirmed to be below the target threshold and verified using Monte Carlo simulation. At earlier stages of the optimization, a smaller number of limit-state function evaluation is required, which increases the efficiency. In addition, the proposed method can allocate limited materials throughout the structure optimally so that the optimally-designed structure has a relatively large number of failure paths with similar failure probability.

• Corrosion Science and Technology
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• v.8 no.5
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• pp.171-176
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• 2009

The chloride threshold level (CTL) in mixed concrete containing, ordinary Portland cement (OPC), pulverized fuel ash (PFA) ground granulated blast furnace slag (GGBS), and silica fume (SF) is important for study on corrosion of reinforced concrete structures. The CTL is defined as a critical content of chloride at the steel depth of the steel which causes the breakdown of the passive film. The criterion of the CTL represented by total chloride content has been used due to convenience and practicality. In order to demonstrate a relationship between the CTL by total chloride content and the CTL by free chloride content, corrosion test and chloride binding capacity test were carried out. In corrosion test, Mortar specimens were cast using OPC, PFA, GGBS and SF, chlorides were admixed ranging 0.0, 0.2, 0.4, 0.8, 1.0, 1.5, 2.0, 2.5 and 3.0% by weight of binder. All specimens were cured 28 days, and then the corrosion rate was measured by the Tafel's extrapolation method. In chloride binding capacity, paste specimens were casting using OPC, PFA, GGBS and SF, chlorides were admixed ranging 0.1, 0.2, 0.3, 0.5, 1.0, 1.5, 2.0, 2.5 and 3.0% by weight of binders. At 28days, solution mixed with the powder of ground specimens was used to measure binding capacity. All specimens of both experiments were wrapped in polythene film to avoid leaching out of chloride and hydroxyl ions. As a result, the CTL by total chloride content ranged from 0.36-1.44% by weight of binders and the CTL by free chloride content ranged from 0.14-0.96%. Accordingly, the difference was ranging, from 0.22 to 0.48% by weight of binder. The order of difference for binder is OPC > 10% SF > 30% PFA > 60% GGBS.

• Journal of Society of Preventive Korean Medicine
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• v.6 no.1
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• pp.36-50
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• 2002

Health industry, a knowledge based high value-added industry, is being considered as a strategic area for the 21C and many advanced countries are making every endeavors for the promotion of health industry along with information technology, new materials, and mechatronics. Korean health industry, however, has been excluded from the governmental supports as well as bound by strict regulation so far, and there is a significant gap in technology compared with advanced countries. In 21C, technology is the main factor of national competitiveness and that is why the role of R&D institutes are so important in the high level of competition to cope with the technology protection policies of advanced countries. In this article, with Directory of Korean R&D Institutes published by Korea Industry Technology Association, I reviewed the trends of R&D institute of health industry. Main findings of the research can be summarized as follows. The portion of health industry R&D institute is 3.6% of total R&D institute but the amount of R&D investment is over than 5% This means health industry are knowledge based and R&D intensified industry, meanwhile the variations of same industry R&D institutes of health industry is huge in R&D investments and other activities. Regional distributions of health industry institutes show some kind of different patterns in each industry areas. Medical devices and Medical informatics's preference of metropolitan region are distinguished with other industry areas. Many of the institutes are located in same site of it's company rather than operating separate building for R&D specific uses. It is better for transforming ideas to products and close cooperation of research body with product lines, but it is a handicap for networking and communicating with other research institutions too. It takes 18.4yrs for bearing R&D institute on the average. For a long times 'copy products' or 'me too products' policies were easy way to maintain business entities. But recently, it is recognized that research activities are essential component of sustaining it's own business firms. This means technology itself is leading power of corporation itself in the high level of competition.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.5
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• pp.917-922
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• 2016

Recently, energy harvesting, in which energy is collected from RF signals, has been regarded as a promising technology to improve the lifetime of sensors by alleviating the lack of power supply problem. In this paper, we try to propose an efficient algorithm for simultaneous wireless information and power transfer. At first, we find the lower bound of water-level using the probability density function of channel, and derive the solution of power allocation in energy harvesting networks. In addition, we derive an efficient power splitting method for satisfying the minimum required harvested energy constraint. The simulation results confirm that the proposed scheme improves the average data rate while guaranteeing the minimum required harvested energy constraint, compared with the conventional scheme. In addition, the proposed algorithm can reduce the computational complexity remarkably with insignificant performance degradation less than 10%, compared to the optimal solution.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.13 no.8
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• pp.1571-1579
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• 2009

This paper proposes a P2P(Peer-to-Peer) streaming protocol which allows various QoS(Qualify of Service) requirements of video streaming to be supported for various personal IPTV applications in ubiquitous Internet environments. The proposed P2P streaming protocol takes fairly short startup delay, guarantees end-to-end delay bound and bandwidth requirements, and supports reliability level of video streaming for an IPTV application. The QoS-based P2P streaming protocol can properly use not only the advantages of scalability, availability, and ubiquity of P2P streaming but also complement its disadvantages of performance and reliability so that various types of personal IPTV applications can be properly implemented in the existing broadband Internet environments.

• The Korean Journal of Physiology
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• v.14 no.1
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• pp.7-13
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• 1980

In the previous experiment, authors have shown that during the latter half of estrous cycle there was an increase in plasma testosterone level in the rats stimulated with hCG. To determine the physiologic significance of elevated plasma testosterone, changes of the plasma concentrations of TeBG and testosterone following hCG stimulation were analyzed in the rats having a regular 5 day cycle. The rats were divided into three groups; the control, the rats stimulated with single hCG on the day of proestrus and stimulated with hCG throughout the entire cycle. Blood samples were obtained once a day for an estrous cycle and analyzed for the binding capacity of TeBG using ammonium sulphate precipitation method and testosterone concentration by means of radioimmunoassay. Followings were the results; 1) There was no significant variation in the binding capacity of TeBG in peripheral blood during the estrous cycle of the control rats. 2) No cyclic variation in the binding capacity of TeBG was observed in the rats stimulated with single hCG on proestrus. although the levels tended to be higher in the rats with stimulation than in the control rats. 3) Continual stimulation of hCG produced a marked increase in the binding capacity of TeBG especially on the day of metaestrus. 4) The changes in the plasma level of testosterone followed the same basic pattern seen in the TeBG binding capacity. 5) From above results, the followings were suggested. a. hCG related increase of the binding capacity of TeBG is probably secondary to a modest increase in estrogen as well. b. hCG related increase of plasma testosterone in female rats is not entirely due to excess production rather in part due to decreased metabolism induced by the rise in TeBG. c. It seems likely that most of elevated testosterone shown in the rat stimulated with hCG is bound to TeBG and only small portion is unbound form which influence cellular activity. It is rather possible that an increase in TeBG could augment estrogen activity.

• Journal of Computing Science and Engineering
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• v.1 no.1
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• pp.56-73
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• 2007

Demands have been growing in safety-critical application fields for producing networked real-time embedded computing (NREC) systems together with acceptable assurances of tight service time bounds (STBs). Here a service time can be defined as the amount of time that the NREC system could take in accepting a request, executing an appropriate service method, and returning a valid result. Enabling systematic composition of large-scale NREC systems with STB certifications has been recognized as a highly desirable goal by the research community for many years. An appealing approach for pursuing such a goal is to establish a hard-real-time (HRT) component model that contains its own STB as an integral part. The TMO (Time-Triggered Message-Triggered Object) programming scheme is one HRT distributed computing (DC) component model established by the first co-author and his collaborators over the past 15 years. The TMO programming scheme has been intended to be an advanced high-level RT DC programming scheme that enables development of NREC systems and validation of tight STBs of such systems with efforts far smaller than those required when any existing lower-level RT DC programming scheme is used. An additional goal is to enable maximum exploitation of concurrency without damaging any major structuring and execution approaches adopted for meeting the first two goals. A number of previously untried program structuring approaches and execution rules were adopted from the early development stage of the TMO scheme. This paper presents new concrete justifications for those approaches and rules, and also discusses new extensions of the TMO scheme intended to enable further exploitation of concurrency in NREC system design and programming.

• Clinical and Experimental Reproductive Medicine
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• v.16 no.2
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• pp.131-138
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• 1989

The present study was designed to develop a new method for the determination of estrogen receptor in porcine uterus using frozen sections. Cryostat sections were incubated with $^3H$-estradiol($^3H$-$E_2$) in the presence or absence of diethylstilbestrol(DES) and the radioactivity of 3H-E2 bound to estrogen receptor(ER) was detected. The level of specific estrogen receptor was determined by Scatchard analysis. The highest ratio of specific binding against total binding was achieved in 3 sec. tions(5mm x 5mm) which was corresponded to lOO${\mu}$/ml protein concentration. Optimal binding was obtained during incubation with $^3H$-$E_2$ for 30 minutes at 23$^{\circ}C$ after treatment of sections with acetone for 20 seconds. Three time-washing of sections was proved to be appropriate for the removal of unbound 3H-E2. 200-fold molar excess of DES was substituted for the binding of $^3H$-$E_2$ to ER sufficiently(binding efficiency of 54.8%). ER was saturated with 4nM of $^3H$-$E_2$ and its dissociation constant was 0.1nM. ER assay using frozen sections(Histological radioreceptor assay, HRRA) was significantly correlated with radioreceptor assay for estradiol(RRA, 0.976 , p