• Journal of Plant Biotechnology
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• v.36 no.4
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• pp.309-319
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• 2009

Transgenic plant cell cultures for the production of biopharmaceuticals including monoclonal antibodies, recombinant proteins have been regarded as an alternative platform in addition to traditional microbial fermentation and mammalian cell cultures. Plant-made pharmaceuticals (PMPs) have several advantages such as safety, cost-effectiveness, scalability and possibility of complex post-translational modifications. Increasing demand for the quantity and diversity of pharmaceutical proteins may accelerate the industrialization of PMP technology. Up to date, there is no plant-made recombinant protein approved by USFDA (Food and Drug Administration) for human therapeutic uses due to the technological bottlenecks of low expression level and slight differences in glycosylation. Regarding expression levels, it is possible to improve the productivity by using stronger promoter and optimizing culture processes. In terms of glycosylation, humanization has been attempted in many ways to reduce immune responses and to enhance the efficacy as well as stability. In this review article, all these respects of transgenic plant cell cultures were summarized. In addition, we also discuss the general characteristics of plant cell suspension cultures related with bioreactor design and operation to achieve high productivity in large scale which could be a key to successful commercialization of PMPs.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.32 no.6
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• pp.637-650
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• 2014

Geospatial research on emergency response in multi-level micro-spatial environments (e.g., multi-story buildings) that aims at understanding and analyzing human movements at the micro level has increased considerably since 9/11. Past research has shown that reducing the time rescuers needed to reach a disaster site within a building (e.g., a particular room) can have a significant impact on evacuation and rescue outcomes in this kind of disaster situations. With the purpose developing emergency response systems that are capable of using complex real-time geospatial information to generate fast-changing scenarios, this study develops a Spatiotemporal Optimal Route Algorithm (SORA) for guiding rescuers to move quickly from various entrances of a building to the disaster site (room) within the building. It identifies the optimal route and building evacuation bottlenecks within the network in real-time emergency situations. It is integrated with a Ubiquitous Sensor Network (USN) based tracking system in order to monitor dynamic geospatial entities, including the dynamic capacities and flow rates of hallways per time period. Because of the limited scope of this study, the simulated data were used to implement the SORA and evaluate its effectiveness for performing 3D topological analysis. The study shows that capabilities to take into account detailed dynamic geospatial data about emergency situations, including changes in evacuation status over time, are essential for emergency response systems.

• The Journal of the Korea Contents Association
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• v.5 no.6
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• pp.49-56
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• 2005

To reduce server bottlenecks in client-server computing, each client may have its own cache for later reuse. The pessimistic approach for cache management protocol leads to unnecessary waits, because, it can not be commit a transaction until the transaction obtains all requested locks. In addition, optimistic approach tends to make needless aborts. This paper suggests an efficient optimistic protocol that overcomes such shortcomings. In this paper, we present a simulation-based analysis on the performance of our scheme with other well-known protocols. The analysis was executed under the Zipf workload which represents the popularity distribution on the Web. The simulation experiments show that our scheme performs as well as or better than other schemes with low overhead.

• Industrial Engineering and Management Systems
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• v.15 no.4
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• pp.403-431
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• 2016

The objective of this study is to integrate the business, maintenance and production processes of a manufacturing system by incorporating errors. First, the required functions are estimated according to the historical data. The system activities are simulated by Visual SLAM software and the required outputs are obtained. Several outputs including lead times in different dimensions, total cost and production rates are computed through simulation. Finally, data envelopment analysis (DEA) is utilized in order to select the best option between the defined scenarios due to the multi-criteria feature of the problem. This is the first study in which the lead times, cost and production rates are simultaneously considered in the integrated system imposed of business, maintenance and production processes by incorporating errors. In the current study, the major bottlenecks of the system being studied are identified and suggested different strategies to improve the system and make the best decision.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2016.05a
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• pp.573-574
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• 2016

Before the Machine Socialization System used to connected between server and router. However, the data flow increases due to the poor performance of the router increased traffic, as a result, the loss of data when the problem occurred Collaboration between devices increases that have been interrupted. This action moves the server connected to the router is required to solve these problems. In this paper, by utilizing the cloud server to reduce bottlenecks proposed a system that can reduce the loss of data during cooperation between devices. In addition, by dividing the management unit and the sensor using the virtualization technology, we designed a system that can efficiently make use of the resource.

• The Transactions of the Korea Information Processing Society
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• v.3 no.6
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• pp.1386-1396
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• 1996

In the distributed multimedia application, high throughput and low delay is one of the most important QoS(Quality of Service) requirement. Emerging high speed communication offers transmission rate above Gbps, but it can not be utilized efficiently by the performance bottlenecks of communication protocols. To overcom the problem, we propose a horizontal processing architecture that processes data as soon as it arrive from the network. Unfortunately, the OSI protocol stack often imposes ordering constraints that prevent concurrent processing of the protocol layers. By using a fixed packet format, the network layer through the presentation layer are processed in parallel. Our prototype shows that the proposed model has performance improvement up to 61% more advantage than the conventional approach.

• ETRI Journal
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• v.38 no.5
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• pp.922-933
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• 2016

IP header compression schemes offer a valuable measure for bandwidth preservation. Such schemes have been practically implemented in infrastructure-based IP networks for point-to-point links. However, minimal research and practical implementation efforts have been conducted in the direction of an IP header compression strategy that can meet the peculiar requirements of multi-hop ad hoc wireless networks. In this paper, we present a practically implemented multi-hop IP header compression scheme using the Robust Header Compression (ROHC) protocol suite. The scheme runs on a novel identifier (ID) based networking architecture, known as an ID-based ad hoc network (IDHOCNET). IDHOCNET additionally solves a number of bottlenecks of pure IP-based ad hoc networks that have emerged owing to IP address auto-configuration service, distributed naming and name resolution, and the role of an IP address as an identifier at the application layer. The proposed scheme was tested on a multi-hop test bed. The results show that the implemented scheme has better gain and requires only O (1) ROHC contexts.

• Journal of the Korean Institute of Telematics and Electronics S
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• v.35S no.5
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• pp.1-10
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• 1998

Satellite communication is getting more important in the coming 21st century because of its wide areas sevice capability, ease of access, and fast channel establishment. As such, satellite communication networks will be the basis of the global communication system in cooperation with the ground ATM networks. In this paper, we consider an efficient transmission methodology of ATM cells over the satellite communication channel. We first analyze possible bottlenecks and performance deterioration factors in the case, and then propose an enhanced cell trasmission mechanism. In order to use satellite channel for ATM cell transmission, the application of complicated channel coding is inevitable. However, the forwared error control such as convolutional encoding brings forth burst errors, which calls for the application of some kind of interleaving mechanism to randomize the burst errors at the receiver. Another aspect which should b econsidered in satellite communication system is the inherent transmission delay, which can be very considered in satellite communication system is te inherent transmission delay, which can be very critical to the delay-sensitive ATM traffic. Therefore, we propose that the processing delay at the block interleaving stage should be controlled propose a variable-size block interleaving mechanism which utilizes the predicted transmission delay for each traffic in the queues of the transmitter. According to the computer simulation, the proposed mechanism could improve the overall performance by drastically reducing the ATM cell drop rate owing to the excessive transmission delay.

• Journal of Broadcast Engineering
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• v.24 no.6
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• pp.974-982
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• 2019

Real-time 360 VR (Virtual Reality) stereo image acquisition technique based on game engine was proposed. However, GPU (Graphics Processing Unit) resource is not fully utilized due to bottlenecks. In this paper, we propose an improved GPU scheduling technique to solve the bottleneck of the existing technique and measure the performance of the proposed technique using the sample games of the commercial game engine. As a result, proposed technique showed an improvement of performance up to 70% and usage of GPU resources more evenly compared existing technique.

• Journal of KIISE:Computing Practices and Letters
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• v.8 no.1
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• pp.36-45
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• 2002

This paper introduces the design and implementation of a flash memory simulator to emulate a real flash memory. Since this simulator provides exact execution time information and parameter testing functions as well as the type, total capacity, block size, and page size of flash memory, it can be used as a real flash memory as viewed by the operating system. Furthermore, the simulator provides time logging functions of the internal routines of the flash memory management software allowing the monitoring of bottlenecks within the software. Finally, we show the performance measurements of applications under the Linux operating systems on both the simulator and a test board verifying the simulator's use as a replacement for real flash memory.